{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:06:31Z","timestamp":1785391591617,"version":"3.55.0"},"reference-count":232,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T00:00:00Z","timestamp":1664064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>It is already well-known that visceral adipose tissue is inseparably related to the pathogenesis, activity, and general outcome of inflammatory bowel disease (IBD). We are getting closer and closer to the molecular background of this loop, finding certain relationships between activated mesenteric tissue and inflammation within the lumen of the gastrointestinal tract. Recently, relatively new data have been uncovered, indicating a direct impact of body fat on the pattern of pharmacological treatment in the course of IBD. On the other hand, ileal and colonic types of Crohn\u2019s disease and ulcerative colitis appear to be more diversified than it was thought in the past. However, the question arises whether at this stage we are able to translate this knowledge into the practical management of IBD patients or we are still exploring the scientific background of this pathology, having no specific tools to be used directly in patients. Our review explores IBD in the context of obesity and associated disorders, focusing on adipokines, creeping fat, and possible relationships between these disorders and the treatment of IBD patients.<\/jats:p>","DOI":"10.3390\/nu14193983","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T03:34:17Z","timestamp":1664163257000},"page":"3983","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Impact of Obesity on the Course of Management of Inflammatory Bowel Disease\u2014A Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Agata","family":"Michalak","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Medical University of Lublin, Jaczewski St 8, 20-954 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7198-4428","authenticated-orcid":false,"given":"Beata","family":"Kasztelan-Szczerbi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Medical University of Lublin, Jaczewski St 8, 20-954 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halina","family":"Cicho\u017c-Lach","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Medical University of Lublin, Jaczewski St 8, 20-954 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Adolph, T.E., Meyer, M., Schw\u00e4rzler, J., Mayr, L., Grabherr, F., and Tilg, H. (2022). The metabolic nature of inflammatory bowel diseases. Nat. Rev. Gastroenterol. Hepatol., Online ahead of print.","DOI":"10.1038\/s41575-022-00658-y"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1056\/NEJMra2002697","article-title":"Pathophysiology of Inflammatory Bowel Diseases","volume":"383","author":"Chang","year":"2020","journal-title":"N. Engl J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1146\/annurev-immunol-042617-053055","article-title":"Translating Immunology into Therapeutic Concepts for Inflammatory Bowel Disease","volume":"36","author":"Uhlig","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"7247238","DOI":"10.1155\/2019\/7247238","article-title":"A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease","volume":"2019","author":"Guan","year":"2019","journal-title":"J. Immunol. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"7528","DOI":"10.3748\/wjg.v26.i47.7528","article-title":"Prevalence and associated factors of obesity in inflammatory bowel disease: A case-control study","volume":"26","author":"Losurdo","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1054\/clnu.2001.0503","article-title":"Crohn\u2019s disease clinical course and severity in obese patients","volume":"21","author":"Blain","year":"2002","journal-title":"Clin. Nutr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1097\/MIB.0000000000000560","article-title":"Impact of Obesity on the Management and Clinical Course of Patients with Inflammatory Bowel Disease","volume":"21","author":"Seminerio","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1159\/000262276","article-title":"A brief report of the epidemiology of obesity in the inflammatory bowel disease population of Tayside, Scotland","volume":"2","author":"Steed","year":"2009","journal-title":"Obes. Facts"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Bhagavathula, A.S., Clark, C.C.T., Rahmani, J., and Chattu, V.K. (2021). Impact of Body Mass Index on the Development of Inflammatory Bowel Disease: A Systematic Review and Dose-Response Analysis of 15.6 Million Participants. Healthcare, 9.","DOI":"10.3390\/healthcare9010035"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.cgh.2021.06.049","article-title":"Obesity is Associated With Increased Risk of Crohn\u2019s disease, but not Ulcerative Colitis: A Pooled Analysis of Five Prospective Cohort Studies","volume":"20","author":"Chan","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7868","DOI":"10.3748\/wjg.v22.i35.7868","article-title":"Interaction of obesity and inflammatory bowel disease","volume":"22","author":"Harper","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/ije\/dyu045","article-title":"Body mass index and risk of autoimmune diseases: A study within the Danish National Birth Cohort","volume":"43","author":"Basit","year":"2014","journal-title":"Int. J. Epidemiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/MIB.0000000000000283","article-title":"Measures of obesity and risk of Crohn\u2019s disease and ulcerative colitis","volume":"21","author":"Khalili","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1002\/ibd.21539","article-title":"Maternal obesity induces sustained inflammation in both fetal and offspring large intestine of sheep","volume":"17","author":"Yan","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/oby.21816","article-title":"Maternal high-fat diet consumption enhances offspring susceptibility to DSS-induced colitis in mice","volume":"25","author":"Bibi","year":"2017","journal-title":"Obesity"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: A systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1007\/s00384-022-04180-0","article-title":"Effects of ethnicity and socioeconomic status on surgical outcomes from inflammatory bowel disease","volume":"37","author":"Stamatiou","year":"2022","journal-title":"Int. J. Colorectal Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/00054725-200108000-00013","article-title":"Epidemiology of inflammatory bowel disease in Asia","volume":"7","author":"Yang","year":"2001","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Alghoul, Z., Yang, C., and Merlin, D. (2022). The Current Status of Molecular Biomarkers for Inflammatory Bowel Disease. Biomedicines, 10.","DOI":"10.3390\/biomedicines10071492"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Liu, C., Zhan, S., Tian, Z., Li, N., Li, T., Wu, D., Zeng, Z., and Zhuang, X. (2022). Food Additives Associated with Gut Microbiota Alterations in Inflammatory Bowel Disease: Friends or Enemies?. Nutrients, 14.","DOI":"10.3390\/nu14153049"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Gubatan, J., Boye, T.L., Temby, M., Sojwal, R.S., Holman, D.R., Sinha, S.R., Rogalla, S.R., and Nielsen, O.H. (2022). Gut Microbiome in Inflammatory Bowel Disease: Role in Pathogenesis, Dietary Modulation, and Colitis-Associated Colon Cancer. Microorganisms, 10.","DOI":"10.3390\/microorganisms10071371"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Murtagh, A., Cooney, L., Higginbotham, C., and Heavey, P. (2022). Dietary practices, beliefs and behaviours of adults with inflammatory bowel disease: A cross-sectional study. Ir. J. Med. Sci., Online ahead of print.","DOI":"10.26226\/morressier.619bdac3be545488cfae5103"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1007\/s00384-022-04190-y","article-title":"Systematic review and meta-analysis: Association between obesity\/overweight and surgical complications in IBD","volume":"37","author":"Jiang","year":"2022","journal-title":"Int. J. Colorectal Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/ajg.2012.453","article-title":"Body mass index and the risk for Crohn\u2019s disease and ulcerative colitis: Data from a European Prospective Cohort Study (The IBD in EPIC Study)","volume":"108","author":"Chan","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Gubatan, J., Barber, G.E., Nielsen, O.H., Juhl, C.B., Maxwell, C., Eisenberg, M.L., and Streett, S.E. (2022). Paternal Medications in Inflammatory Bowel Disease and Male Fertility and Reproductive Outcomes: A Systematic Review and Meta-Analysis. Clin. Gastroenterol. Hepatol., Epub ahead of print.","DOI":"10.1016\/j.cgh.2022.07.008"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Patel, A., Krishna, S.G., Patel, K., Gray, D.M., Mumtaz, K., Stanich, P.P., Hinton, A., and Hussan, H. (2022). Rising Rates of Severe Obesity in Adults Younger Than 50 Correspond to Rise in Hospitalizations for Non-malignant Gastrointestinal Disease. Dig. Dis. Sci., Epub ahead of print.","DOI":"10.1007\/s10620-022-07589-3"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1007\/s00384-022-04185-9","article-title":"A national study of pregnancy-related maternal and fetal outcomes in women with inflammatory bowel disease","volume":"37","author":"Tarar","year":"2022","journal-title":"Int. J. Colorectal Dis."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Chan, J., Telang, R., Kociszewska, D., Thorne, P.R., and Vlajkovic, S.M. (2022). A High-Fat Diet Induces Low-Grade Cochlear Inflammation in CD-1 Mice. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23095179"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Hyun, C.K. (2021). Molecular and Pathophysiological Links between Metabolic Disorders and Inflammatory Bowel Diseases. Int. J. Mol. Sci, 22.","DOI":"10.3390\/ijms22179139"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"376","DOI":"10.4103\/1319-3767.87177","article-title":"Metabolic syndrome frequency in inflammatory bowel diseases","volume":"17","author":"Yorulmaz","year":"2011","journal-title":"Saudi J. Gastroenterol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/apt.16879","article-title":"Meta-analysis: Prevalence of, and risk factors for, non-alcoholic fatty liver disease in patients with inflammatory bowel disease","volume":"55","author":"Zamani","year":"2022","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1093\/ibd\/izab199","article-title":"The Impact of NAFLD on Hospitalization Outcomes in Patients With Inflammatory Bowel Diseases: Nationwide Analysis","volume":"28","author":"Noorian","year":"2022","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"6465","DOI":"10.3748\/wjg.v25.i43.6465","article-title":"Metabolic syndrome attenuates ulcerative colitis: Correlation with interleukin-10 and galectin-3 expression","volume":"25","author":"Jovanovic","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"De Filippis, A., Ullah, H., Baldi, A., Dacrema, M., Esposito, C., Garzarella, E.U., Santarcangelo, C., Tantipongpiradet, A., and Daglia, M. (2020). Gastrointestinal Disorders and Metabolic Syndrome: Dysbiosis as a Key Link and Common Bioactive Dietary Components Useful for their Treatment. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21144929"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1136\/gut.2009.199679","article-title":"New IBD genetics: Common pathways with other diseases","volume":"60","author":"Lees","year":"2011","journal-title":"Gut"},{"key":"ref_36","first-page":"3989","article-title":"Evaluation of insulin resistance and beta cell activity in patients with inflammatory bowel disease","volume":"26","author":"Kahraman","year":"2022","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4239\/wjd.v13.i2.126","article-title":"Inflammatory bowel disease and diabetes: Is there a link between them?","volume":"13","author":"Sang","year":"2022","journal-title":"World J. Diabetes"},{"key":"ref_38","first-page":"4344905","article-title":"Glucocorticosteroids and the Risk of NAFLD in Inflammatory Bowel Disease","volume":"2022","author":"Sokal","year":"2022","journal-title":"Can. J. Gastroenterol. Hepatol."},{"key":"ref_39","unstructured":"Rodriguez-Duque, J.C., Calleja, J.L., Iruzubieta, P., Hern\u00e1ndez-Conde, M., Rivas-Rivas, C., Vera, M.I., Garcia, M.J., Pascual, M., Castro, B., and Garc\u00eda-Blanco, A. (2022). Increased risk of MAFLD and Liver Fibrosis in Inflammatory Bowel Disease Independent of Classic Metabolic Risk Factors. Clin. Gastroenterol. Hepatol., Epub ahead of print."},{"key":"ref_40","first-page":"5818","article-title":"Multifaceted pathogenesis of liver steatosis in inflammatory bowel disease: A systematic review","volume":"25","author":"Spagnuolo","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"7113","DOI":"10.3748\/wjg.v27.i41.7113","article-title":"Non-alcoholic fatty liver disease in patients with intestinal, pulmonary or skin diseases: Inflammatory cross-talk that needs a multidisciplinary approach","volume":"27","author":"Rivera","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Gibiino, G., Sartini, A., Gitto, S., Binda, C., Sbrancia, M., Coluccio, C., Sambri, V., and Fabbri, C. (2021). The Other Side of Malnutrition in Inflammatory Bowel Disease (IBD): Non-Alcoholic Fatty Liver Disease. Nutrients, 13.","DOI":"10.3390\/nu13082772"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.mce.2009.08.018","article-title":"Adipose tissue as an endocrine organ","volume":"316","author":"Galic","year":"2010","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1079\/BJN20041213","article-title":"Adipokines: Inflammation and the pleiotropic role of white adipose tissue","volume":"92","author":"Trayhurn","year":"2004","journal-title":"Br. J. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1053\/j.jrn.2004.09.034","article-title":"Adipose tissue and its relation to inflammation: The role of adipokines","volume":"15","author":"Axelsson","year":"2005","journal-title":"J. Ren. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/biof.185","article-title":"Adipokines: Biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity","volume":"37","author":"Conde","year":"2011","journal-title":"Biofactors"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jaci.2005.02.023","article-title":"Adipose tissue, adipokines, and inflammation","volume":"115","author":"Fantuzzi","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/ncprheum0674","article-title":"Adipokines as emerging mediators of immune response and inflammation","volume":"3","author":"Lago","year":"2007","journal-title":"Nat. Clin. Pract. Rheumatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s11894-022-00840-x","article-title":"Impact of Obesity on Inflammatory Bowel Disease","volume":"24","author":"Khakoo","year":"2022","journal-title":"Curr. Gastroenterol. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4103\/sjg.sjg_30_21","article-title":"Obesity in inflammatory bowel disease: A review of its role in the pathogenesis, natural history, and treatment of IBD","volume":"27","author":"Johnson","year":"2021","journal-title":"Saudi J. Gastroenterol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.regpep.2007.02.002","article-title":"Increased colonic apelin production in rodents with experimental colitis and in humans with IBD","volume":"142","author":"Han","year":"2007","journal-title":"Regul. Pept."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.bcp.2018.01.011","article-title":"Adipokine apelin ameliorates chronic colitis in Il-10-\/- mice by promoting intestinal lymphatic functions","volume":"148","author":"Ge","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.3389\/fimmu.2018.01974","article-title":"Adipokines and Their Role in Intestinal Inflammation","volume":"9","author":"Weidinger","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1007\/s10620-017-4806-5","article-title":"Association between Adipokines Levels with Inflammatory Bowel Disease (IBD): Systematic Reviews","volume":"62","author":"Morshedzadeh","year":"2017","journal-title":"Dig. Dis. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1016\/j.biochi.2012.05.018","article-title":"Immunological functions of leptin and adiponectin","volume":"94","author":"Carbone","year":"2012","journal-title":"Biochimie"},{"key":"ref_56","first-page":"94","article-title":"Association of Leptin with Total and Free Testosterone: Results from the National Health and Nutrition Examination Surveys","volume":"1","author":"Lima","year":"2020","journal-title":"Androg. Clin. Res. Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"bqaa204","DOI":"10.1210\/endocr\/bqaa204","article-title":"The Importance of Leptin to Reproduction","volume":"162","author":"Childs","year":"2021","journal-title":"Endocrinology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1046\/j.1365-2796.2000.00678.x","article-title":"Mechanisms behind gender differences in circulating leptin levels","volume":"247","author":"Wahrenberg","year":"2000","journal-title":"J. Intern. Med."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Misch, M., and Puthanveetil, P. (2022). The Head-to-Toe Hormone: Leptin as an Extensive Modulator of Physiologic Systems. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23105439"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"600","DOI":"10.25122\/jml-2021-0153","article-title":"Leptin hormone and its effectiveness in reproduction, metabolism, immunity, diabetes, hopes and ambitions","volume":"14","author":"Alburghaif","year":"2021","journal-title":"J. Med. Life"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/ajhb.22279","article-title":"Leptin and adiponectin: Distribution and associations with cardiovascular risk factors in men and women of the general population","volume":"24","author":"Andreasson","year":"2012","journal-title":"Am. J. Hum. Biol."},{"key":"ref_62","first-page":"161","article-title":"Adipokines in diabetes and cardiovascular diseases","volume":"32","author":"Kralisch","year":"2007","journal-title":"Minerva Endocrinol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.atherosclerosis.2007.11.015","article-title":"The relation of leptin and insulin with obesity-related cardiovascular risk factors in US adults","volume":"200","author":"Reis","year":"2008","journal-title":"Atherosclerosis"},{"key":"ref_64","first-page":"568343","article-title":"Role of leptin in the activation of immune cells","volume":"2010","author":"Najib","year":"2010","journal-title":"Mediators Inflamm."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"875","DOI":"10.4049\/jimmunol.168.2.875","article-title":"Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis","volume":"168","author":"Busso","year":"2002","journal-title":"J. Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1093\/rheumatology\/kel157","article-title":"Towards a pro-inflammatory and immunomodulatory emerging role of leptin","volume":"45","author":"Otero","year":"2006","journal-title":"Rheumatology"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1358\/dnp.2006.19.1.966243","article-title":"Leptin: A metabolic hormone that functions like a proinflammatory adipokine","volume":"19","author":"Otero","year":"2006","journal-title":"Drug News Perspect."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Izquierdo, A.G., Crujeiras, A.B., Casanueva, F.F., and Carreira, M.C. (2019). Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?. Nutrients, 11.","DOI":"10.3390\/nu11112704"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000115365","article-title":"Adipokines in obesity","volume":"36","author":"Ahima","year":"2008","journal-title":"Front. Horm. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.immuni.2007.01.011","article-title":"A key role of leptin in the control of regulatory T cell proliferation","volume":"26","author":"Procaccini","year":"2007","journal-title":"Immunity"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"622468","DOI":"10.3389\/fimmu.2020.622468","article-title":"The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease","volume":"11","author":"Kiernan","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.immuni.2007.02.002","article-title":"The leptin connection: Regulatory T cells and autoimmunity","volume":"26","author":"Hasenkrug","year":"2007","journal-title":"Immunity"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-981-15-6407-9_8","article-title":"Adipose Tissue T Regulatory Cells: Implications for Health and Disease","volume":"1278","author":"Bradley","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1016\/S0024-3205(00)00827-4","article-title":"Elevated serum leptin concentrations induced by experimental acute inflammation","volume":"67","author":"Gualillo","year":"2000","journal-title":"Life Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1086\/314740","article-title":"Circulating leptin during experimental endotoxemia in humans","volume":"179","author":"Granowitz","year":"1999","journal-title":"J. Infect. Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1210\/jcem.83.1.4610","article-title":"Plasma leptin levels are increased in survivors of acute sepsis: Associated loss of diurnal rhythm, in cortisol and leptin secretion","volume":"83","author":"Bornstein","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"R33","DOI":"10.1186\/cc8911","article-title":"The diagnostic value of serum leptin monitoring and its correlation with tumor necrosis factor-alpha in critically ill patients: A prospective observational study","volume":"14","author":"Yousef","year":"2010","journal-title":"Crit Care"},{"key":"ref_78","first-page":"E658","article-title":"Serum leptin concentrations and their relation to metabolic abnormalities in human sepsis","volume":"276","author":"Carlson","year":"1999","journal-title":"Am. J. Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/mpa.0b013e3180332e62","article-title":"Decreased serum leptin concentration in patients with chronic pancreatitis","volume":"34","author":"Adrych","year":"2007","journal-title":"Pancreas"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"724","DOI":"10.3899\/jrheum.080626","article-title":"Circulating leptin and adiponectin concentrations during tumor necrosis factor blockade in patients with active rheumatoid arthritis","volume":"36","author":"Popa","year":"2009","journal-title":"J. Rheumatol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1080\/15384101.2015.1041684","article-title":"Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation","volume":"14","author":"Fazolini","year":"2015","journal-title":"Cell Cycle"},{"key":"ref_82","first-page":"471","article-title":"Expression and release of leptin and proinflammatory cytokines in patients with ulcerative colitis and infectious diarrhea","volume":"63","author":"Biesiada","year":"2012","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1440-1746.2003.03300.x","article-title":"Leptin levels in the acute stage of ulcerative colitis","volume":"19","author":"Tuzun","year":"2004","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.2147\/TCRM.S140618","article-title":"Are adipocytokines inflammatory or metabolic mediators in patients with inflammatory bowel disease?","volume":"13","author":"Kahraman","year":"2017","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_85","first-page":"8561","article-title":"The role of chemokines and adipokines as biomarkers of Crohn\u2019s disease activity: A systematic review of the literature","volume":"13","author":"Mello","year":"2021","journal-title":"Am. J. Transl Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/00054725-200606000-00005","article-title":"Profiling adipocytokine secretion from creeping fat in Crohn\u2019s disease","volume":"12","author":"Paul","year":"2006","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_87","first-page":"3336","article-title":"Positive association between leptin serum levels and disease activity on endoscopy in inflammatory bowel disease: A case-control study","volume":"15","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1097\/01.MIB.0000200345.38837.46","article-title":"Circulating levels of leptin, adiponectin, resistin, and ghrelin in inflammatory bowel disease","volume":"12","author":"Karmiris","year":"2006","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"7314","DOI":"10.3748\/wjg.v11.i46.7314","article-title":"Plasma leptin and ghrelin concentrations in patients with Crohn\u2019s disease","volume":"11","author":"Nishi","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.imbio.2013.04.020","article-title":"Leptin antagonist ameliorates chronic colitis in IL-10\u2212\/\u2212 mice","volume":"218","author":"Singh","year":"2013","journal-title":"Immunobiology"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1136\/gut.2003.027136","article-title":"Leptin receptor expression on T lymphocytes modulates chronic intestinal inflammation in mice","volume":"53","author":"Siegmund","year":"2004","journal-title":"Gut"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.beem.2005.07.008","article-title":"Adipocytokines: Leptin\u2014The classical, resistin\u2014The controversical, adiponectin\u2014The promising, and more to come","volume":"19","author":"Koerner","year":"2005","journal-title":"Best Pract Res. Clin. Endocrinol. Metab."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/cc10021","article-title":"Clinical review: Adiponectin biology and its role in inflammation and critical illness","volume":"15","author":"Robinson","year":"2011","journal-title":"Crit. Care"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1463-1326.2005.00510.x","article-title":"Adiponectin\u2014A key adipokine in the metabolic syndrome","volume":"8","author":"Whitehead","year":"2006","journal-title":"Diabetes Obes. Metab."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Aljafary, M.A., and Al-Suhaimi, E.A. (2022). Adiponectin System (Rescue Hormone): The Missing Link between Metabolic and Cardiovascular Diseases. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14071430"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1748-1716.2005.01502.x","article-title":"The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity","volume":"186","author":"Dyck","year":"2006","journal-title":"Acta Physiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"H1231","DOI":"10.1152\/ajpheart.00765.2011","article-title":"Adiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease","volume":"302","author":"Xu","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"6153","DOI":"10.1074\/jbc.M109.088708","article-title":"Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype","volume":"285","author":"Ohashi","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1016\/j.biochi.2012.06.008","article-title":"Anti-inflammatory and anti-atherogenic properties of adiponectin","volume":"94","author":"Ohashi","year":"2012","journal-title":"Biochimie"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.metabol.2010.09.003","article-title":"Serum total adiponectin in nonalcoholic fatty liver disease: A systematic review and meta-analysis","volume":"60","author":"Polyzos","year":"2011","journal-title":"Metabolism"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1210\/jcem.86.5.7463","article-title":"Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia","volume":"86","author":"Weyer","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_102","first-page":"55","article-title":"Adipose tissue inflammation in obesity and metabolic syndrome","volume":"8","author":"Nishimura","year":"2009","journal-title":"Discov. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.diabet.2007.08.002","article-title":"Adiponectin: An update","volume":"34","year":"2008","journal-title":"Diabetes Metab."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cca.2007.01.026","article-title":"Adiponectin as an anti-inflammatory factor","volume":"380","author":"Ouchi","year":"2007","journal-title":"Clin. Chim. Acta"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jaci.2007.10.018","article-title":"Adiponectin and inflammation: Consensus and controversy","volume":"121","author":"Fantuzzi","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1136\/ard.2011.150813","article-title":"Association of circulating adiponectin levels with progression of radiographic joint destruction in rheumatoid arthritis","volume":"70","author":"Giles","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/B978-0-12-398313-8.00014-2","article-title":"Adiponectin and interleukin-6 in inflammation-associated disease","volume":"90","author":"Li","year":"2012","journal-title":"Vitam Horm."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.2174\/092986712803833119","article-title":"Adiponectin in autoimmune diseases","volume":"19","author":"Toussirot","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Choi, H.M., Doss, H.M., and Kim, K.S. (2020). Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21041219"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Brezovec, N., Perdan-Pirkmajer, K., \u010cu\u010dnik, S., Sodin-\u0160emrl, S., Varga, J., and Lakota, K. (2021). Adiponectin Deregulation in Systemic Autoimmune Rheumatic Diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22084095"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.pharep.2016.04.016","article-title":"Common links between metabolic syndrome and inflammatory bowel disease: Current overview and future perspectives","volume":"68","author":"Michalak","year":"2016","journal-title":"Pharmacol. Rep."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1136\/gut.2004.046516","article-title":"Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn\u2019s disease","volume":"54","author":"Yamamoto","year":"2005","journal-title":"Gut"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1053\/j.gastro.2006.11.026","article-title":"Adiponectin deficiency protects mice from chemically induced colonic inflammation","volume":"132","author":"Fayad","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1053\/j.gastro.2006.06.015","article-title":"Effect of adiponectin on murine colitis induced by dextran sulfate sodium","volume":"131","author":"Nishihara","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.regpep.2006.02.001","article-title":"Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells","volume":"134","author":"Ogunwobi","year":"2006","journal-title":"Regul. Pept."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"G591","DOI":"10.1152\/ajpgi.00269.2014","article-title":"Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1","volume":"308","author":"Sideri","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"6569","DOI":"10.1074\/jbc.M115.712646","article-title":"Adiponectin confers protection from acute colitis and restricts a B cell immune response","volume":"292","author":"Obeid","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35053000","article-title":"The hormone resistin links obesity to diabetes","volume":"409","author":"Steppan","year":"2001","journal-title":"Nature"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"96","DOI":"10.2174\/138920309787315239","article-title":"Role of resistin in insulin sensitivity in rodents and humans","volume":"10","author":"Barnes","year":"2009","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_120","first-page":"259","article-title":"Human resistin: Found in translation from mouse to man","volume":"22","author":"Schwartz","year":"2011","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"R111","DOI":"10.1186\/ar3836","article-title":"Resistin in idiopathic inflammatory myopathies","volume":"14","author":"Cerezo","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"960","DOI":"10.3892\/ol.2012.865","article-title":"Expression of the adipocytokine resistin and its association with the clinicopathological features and prognosis of pancreatic ductal adenocarcinoma","volume":"4","author":"Jiang","year":"2012","journal-title":"Oncol. Lett."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/j.1476-5381.2011.01369.x","article-title":"Resistin: Functional roles and therapeutic considerations for cardiovascular disease","volume":"165","author":"Jamaluddin","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.clim.2009.07.013","article-title":"The role of resistin as a regulator of inflammation: Implications for various human pathologies","volume":"133","author":"Gay","year":"2009","journal-title":"Clin. Immunol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1124\/jpet.108.136721","article-title":"New role of resistin in lipopolysaccharide-induced liver damage in mice","volume":"325","author":"Beier","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.3899\/jrheum.110237","article-title":"Resistin levels in lupus and associations with disease-specific measures, insulin resistance, and coronary calcification","volume":"38","author":"Baker","year":"2011","journal-title":"J. Rheumatol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4149\/endo_2010_01_25","article-title":"Resistin and visfatin: Regulators of insulin sensitivity, inflammation and immunity","volume":"44","author":"Stofkova","year":"2010","journal-title":"Endocr. Regul."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1161\/HYPERTENSIONAHA.107.095257","article-title":"Association of plasma resistin with glomerular filtration rate and albuminuria in hypertensive adults","volume":"50","author":"Ellington","year":"2007","journal-title":"Hypertension"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Menzaghi, C., Salvemini, L., Fini, G., Thompson, R., Mangiacotti, D., Di Paola, R., Morini, E., Giorelli, M., De Bonis, C., and De Cosmo, S. (2012). Serum resistin and kidney function: Afamily-based study in non-diabetic, untreated individuals. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038414"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/sj.ki.5000089","article-title":"Elevated resistin levels in chronic kidney disease are associated with decreased glomerular filtration rate and inflammation, but not with insulin resistance","volume":"69","author":"Axelsson","year":"2006","journal-title":"Kidney Int."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1111\/j.1749-6632.2010.05875.x","article-title":"Adipokines as novel biomarkers and regulators of the metabolic syndrome","volume":"1212","author":"Deng","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/2047-783X-18-12","article-title":"Leptin, resistin and visfatin: The missing link between endocrine metabolic disorders and immunity","volume":"18","author":"Shehzad","year":"2013","journal-title":"Eur. J. Med. Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1097\/MEG.0b013e3282f16251","article-title":"Resistin is an inflammatory marker of inflammatory bowel disease in humans","volume":"19","author":"Konrad","year":"2007","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1097\/MEG.0b013e3282202bca","article-title":"The effect of infliximab on circulating levels of leptin, adiponectin and resistin in patients with inflammatory bowel disease","volume":"19","author":"Karmiris","year":"2007","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1038\/s41467-021-24235-0","article-title":"Predicting disease course in ulcerative colitis using stool proteins identified through an aptamer-based screen","volume":"12","author":"Soomro","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_136","first-page":"275","article-title":"Circulating levels of WISP-1 (Wnt1-inducible signaling pathway protein 1) and other selected adipokines in children with inflammatory bowel disease","volume":"71","author":"Kubickova","year":"2022","journal-title":"Physiol. Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1084\/jem.20030382","article-title":"Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids","volume":"198","author":"Wittamer","year":"2003","journal-title":"J. Exp. Med."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cca.2020.02.008","article-title":"Chemerin in immune response and gastrointestinal pathophysiology","volume":"504","author":"Jacenik","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.peptides.2018.08.012","article-title":"Diagnostic value of chemerin in lower gastrointestinal diseases-a review","volume":"108","author":"Sochal","year":"2018","journal-title":"Peptides"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/ibd.21091","article-title":"Circulating levels of chemerin and adiponectin are higher in ulcerative colitis and chemerin is elevated in Crohn\u2019s disease","volume":"16","author":"Weigert","year":"2010","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/cmi.2014.14","article-title":"Chemerin, a novel player in inflammatory bowel disease","volume":"11","author":"Buechler","year":"2014","journal-title":"Cell Mol. Immunol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"e12497","DOI":"10.14814\/phy2.12497","article-title":"Local chemerin levels are positively associated with DSS-induced colitis but constitutive loss of CMKLR1 does not protect against development of colitis","volume":"3","author":"Dranse","year":"2015","journal-title":"Physiol. Rep."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"e74119","DOI":"10.1073\/pnas.2205574119","article-title":"Epithelial chemerin-CMKLR1 signaling restricts microbiota-driven colonic neutrophilia and tumorigenesis by up-regulating lactoperoxidase","volume":"119","author":"Lin","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/cmi.2014.15","article-title":"Chemerin aggravates DSS-induced colitis by suppressing M2 macrophage polarization","volume":"11","author":"Lin","year":"2014","journal-title":"Cell Mol. Immunol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.autrev.2014.07.001","article-title":"Obesity in autoimmune diseases: Not a passive bystander","volume":"13","author":"Versini","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1097\/MEG.0000000000000617","article-title":"Chemerin, visfatin, and vaspin serum levels in relation to bone mineral density in patients with inflammatory bowel disease","volume":"28","author":"Terzoudis","year":"2016","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"6912","DOI":"10.3748\/wjg.v20.i22.6912","article-title":"Serum adipokines in inflammatory bowel disease","volume":"20","author":"Waluga","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/jcla.21901","article-title":"Serum Visfatin Levels in Ulcerative Colitis","volume":"30","author":"Dogan","year":"2016","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"339","DOI":"10.15403\/jgld-3504","article-title":"Serum Visfatin as a Diagnostic Marker of Active Inflammatory Bowel Disease","volume":"30","author":"Saadoun","year":"2021","journal-title":"J. Gastrointestin. Liver Dis."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.4049\/jimmunol.178.3.1748","article-title":"Visfatin, an adipocytokine with proinflammatory and immunomodulating properties","volume":"178","author":"Moschen","year":"2007","journal-title":"J. Immunol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.tips.2015.04.014","article-title":"Adipokines in health and disease","volume":"36","author":"Fasshauer","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s10620-013-2905-5","article-title":"High serum vaspin concentrations in patients with ulcerative colitis","volume":"59","author":"Morisaki","year":"2014","journal-title":"Dig. Dis. Sci."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.tem.2014.03.009","article-title":"Role of anti-inflammatory adipokines in obesity-related diseases","volume":"25","author":"Ohashi","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"118","DOI":"10.12659\/MSM.892081","article-title":"Decreased levels of serum omentin-1 in patients with inflammatory bowel disease","volume":"21","author":"Yin","year":"2015","journal-title":"Med. Sci. Monit."},{"key":"ref_155","first-page":"162517","article-title":"Serum omentin-1 as a disease activity marker for Crohn\u2019s disease","volume":"2014","author":"Lu","year":"2014","journal-title":"Dis. Mark."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.cell.2014.03.065","article-title":"Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis","volume":"157","author":"Rao","year":"2014","journal-title":"Cell"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/aps.2016.9","article-title":"Metrnl: A secreted protein with new emerging functions","volume":"37","author":"Zheng","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/ecco-jcc\/jjz001","article-title":"The adipokine metrnl ameliorates chronic colitis in Il-10\u2013\/\u2013mice by attenuating mesenteric adipose tissue lesions during spontaneous colitis","volume":"13","author":"Zuo","year":"2019","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_159","first-page":"20","article-title":"Unraveling the link between leptin, ghrelin and different types of colitis","volume":"24","author":"Tiaka","year":"2011","journal-title":"Ann. Gastroenterol."},{"key":"ref_160","first-page":"41","article-title":"Ghrelin ameliorates colonic inflammation. Role of nitric oxide and sensory nerves","volume":"60","author":"Konturek","year":"2009","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1159\/000494920","article-title":"Gastroduodenal Symptoms in Inflammatory Bowel Disease Are Correlated with Gastric Emptying and Serum Levels of Active Ghrelin","volume":"37","author":"Sales","year":"2019","journal-title":"Dig. Dis."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1091\/mbc.e03-09-0657","article-title":"Inhibition of Adipogenesis by Ghrelin","volume":"15","author":"Zhang","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Bilski, J., Mazur-Bialy, A., Wojcik, D., Surmiak, M., Magierowski, M., Sliwowski, Z., Pajdo, R., Kwiecien, S., Danielak, A., and Ptak-Belowska, A. (2019). Role of Obesity, Mesenteric Adipose Tissue, and Adipokines in Inflammatory Bowel Diseases. Biomolecules, 9.","DOI":"10.3390\/biom9120780"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.nut.2011.09.009","article-title":"Visceral fat and gut inflammation","volume":"28","author":"Drouet","year":"2012","journal-title":"Nutrition"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"9210","DOI":"10.1016\/S0021-9258(19)50409-4","article-title":"Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue","volume":"267","author":"White","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","article-title":"Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance","volume":"259","author":"Hotamisligil","year":"1993","journal-title":"Science"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1001\/jama.1984.03340250053024","article-title":"Landmark article Oct 15, 1932. Regional ileitis. A pathological and clinical entity. By Burril B. Crohn, Leon Ginzburg, and Gordon D. Oppenheimer","volume":"251","author":"Crohn","year":"1984","journal-title":"JAMA"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Karaskova, E., Velganova-Veghova, M., Geryk, M., Foltenova, H., Kucerova, V., and Karasek, D. (2021). Role of Adipose Tissue in Inflammatory Bowel Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22084226"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/ibd\/izy331","article-title":"The Mesenteric Fat and Intestinal Muscle Interface: Creeping Fat Influencing Stricture Formation in Crohn\u2019s Disease","volume":"25","author":"Mao","year":"2019","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1136\/gutjnl-2020-323719","article-title":"Activated intestinal muscle cells promote preadipocyte migration: A novel mechanism for creeping fat formation in Crohn\u2019s disease","volume":"71","author":"Mao","year":"2022","journal-title":"Gut"},{"key":"ref_171","first-page":"424","article-title":"Adipokines and the role of visceral adipose tissue in inflammatory bowel disease","volume":"29","author":"Karrasch","year":"2016","journal-title":"Ann. Gastroenterol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.2353\/ajpath.2007.060699","article-title":"Leptin-dependent toll-like receptor expression and responsiveness in preadipocytes and adipocytes","volume":"170","author":"Batra","year":"2007","journal-title":"Am. J. Pathol."},{"key":"ref_173","first-page":"987","article-title":"Overexpression of leptin mRNA in mesenteric adipose tissue in inflammatory bowel diseases","volume":"1221","author":"Barbier","year":"2003","journal-title":"Gastroenterol. Clin. Biol."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Eder, P., Adler, M., Dobrowolska, A., Kamhieh-Milz, J., and Witowski, J. (2019). The Role of Adipose Tissue in the Pathogenesis and Therapeutic Outcomes of Inflammatory Bowel Disease. Cells, 8.","DOI":"10.3390\/cells8060628"},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Elhag, D.A., Kumar, M., Saadaoui, M., Akobeng, A.K., Al-Mudahka, F., Elawad, M., and Al Khodor, S. (2022). Inflammatory Bowel Disease Treatments and Predictive Biomarkers of Therapeutic Response. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23136966"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"367","DOI":"10.21037\/atm-22-1126","article-title":"Sarcopenia is associated with poor clinical outcomes in patients with inflammatory bowel disease: A prospective cohort study","volume":"10","author":"Liu","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1136\/flgastro-2022-102117","article-title":"Imaging in inflammatory bowel disease: Current and future perspectives","volume":"13","author":"Shaban","year":"2022","journal-title":"Frontline Gastroenterol."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Faye, A.S., Dodson, J.A., and Shaukat, A. (2022). Sarcopenia as a Risk Prediction Tool in Inflammatory Bowel Disease. Inflamm. Bowel Dis., Epub ahead of print.","DOI":"10.1093\/ibd\/izac069"},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Campbell, J.P., Teigen, L., Manski, S., Blumhof, B., Guglielmo, F.F., Shivashankar, R., and Shmidt, E. (2022). Sarcopenia Is More Prevalent Among Inflammatory Bowel Disease Patients Undergoing Surgery and Predicts Progression to Surgery Among Medically Treated Patients. Inflamm. Bowel Dis., Epub ahead of print.","DOI":"10.1093\/ibd\/izac013"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s12664-021-01223-2","article-title":"Nutritional screening and assessment in inflammatory bowel disease","volume":"41","author":"Singh","year":"2022","journal-title":"Indian J. Gastroenterol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"90","DOI":"10.4292\/wjgpt.v12.i5.90","article-title":"Influence of nutritional status in the postoperative period of patients with inflammatory bowel disease","volume":"12","author":"Rocha","year":"2021","journal-title":"World J. Gastrointest. Pharmacol. Ther."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/MOG.0000000000000445","article-title":"The role of adipose tissue in inflammatory bowel diseases","volume":"34","author":"Weidinger","year":"2018","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bbadis.2018.10.020","article-title":"The role of obesity in inflammatory bowel disease","volume":"1865","author":"Kreuter","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Tsai, Y.W., Fu, S.H., Dong, J.L., Chien, M.W., Liu, Y.W., Hsu, C.Y., and Sytwu, H.K. (2020). Adipokine-Modulated Immunological Homeostasis Shapes the Pathophysiology of Inflammatory Bowel Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249564"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1196\/annals.1326.021","article-title":"Toll-like receptor expression and response to specific stimulation in adipocytes and preadipocytes: On the role of fat in inflammation","volume":"1072","author":"Pietsch","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"24255","DOI":"10.1074\/jbc.M002137200","article-title":"The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes","volume":"11","author":"Lin","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1365-2567.2008.02892.x","article-title":"Fatty acid-induced induction of Toll-like receptor-4\/nuclear factor-B pathway in adipocytes links nutritional signalling with innate immunity","volume":"126","author":"Schaeer","year":"2009","journal-title":"Immunology"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"903688","DOI":"10.3389\/fimmu.2022.903688","article-title":"Helper-Like Type-1 Innate Lymphoid Cells in Inflammatory Bowel Disease","volume":"13","author":"Coman","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/oby.2008.607","article-title":"Innate immunity and adipocyte function: Ligand-specific activation of multiple Toll-like receptors modulates cytokine, adipokine, and chemokine secretion in adipocytes","volume":"17","author":"Kopp","year":"2009","journal-title":"Obesity"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/ecco-jcc\/jjy146","article-title":"T-cell Composition in Ileal and Colonic Creeping Fat. Separating Ileal from Colonic Crohn\u2019s Disease","volume":"13","author":"Kredel","year":"2019","journal-title":"J. Crohns Colitis"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/ame2.12255","article-title":"Association between intestinal microbiota and inflammatory bowel disease","volume":"5","author":"Zhang","year":"2022","journal-title":"Anim. Model Exp. Med."},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Andoh, A., and Nishida, A. (2022). Alteration of the Gut Microbiome in Inflammatory Bowel Disease. Digestion, 1\u20138.","DOI":"10.1159\/000525925"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/MIB.0000000000000209","article-title":"Metabolic inflammation in inflammatory bowel disease: Crosstalk between adipose tissue and bowel","volume":"21","author":"Magro","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"6702","DOI":"10.18632\/aging.202526","article-title":"The impact of visceral obesity on chronic constipation, inflammation, immune function and cognitive function in patients with inflammatory bowel disease","volume":"13","author":"Wan","year":"2021","journal-title":"Aging"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/bjs.1800790934","article-title":"Fat-wrapping in Crohn\u2019s disease: Pathological basis and relevance to surgical practice","volume":"79","author":"Sheehan","year":"1992","journal-title":"Br. J. Surg."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1097\/MIB.0000000000000200","article-title":"Impact of abdominal visceralmadipose tissue on disease outcome in pediatric Crohn\u2019s disease","volume":"20","author":"Uko","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.cgh.2011.05.005","article-title":"Ratio of visceral to subcutaneous fat area is a biomarker of complicated Crohn\u2019s disease","volume":"9","author":"Erhayiem","year":"2011","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/MIB.0000000000000978","article-title":"Visceral Adiposity, Genetic Susceptibility, and Risk of Complications Among Individuals with Crohn\u2019s Disease","volume":"23","author":"Joshi","year":"2017","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1097\/MPG.0000000000001593","article-title":"Increase of Intra-abdominal Adipose Tissue in Pediatric Crohn Disease","volume":"65","author":"Frivolt","year":"2017","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1159\/000365359","article-title":"Volumetric fat ratio and not body mass index is predictive of ileocolectomy outcomes in Crohn\u2019s disease patients","volume":"31","author":"Connelly","year":"2014","journal-title":"Dig. Surg."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1097\/MIB.0000000000000791","article-title":"The Role of the Mesentery in Crohn\u2019s Disease: The Contributions of Nerves, Vessels, Lymphatics, and Fat to the Pathogenesis and Disease Course","volume":"22","author":"Li","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1053\/j.gastro.2006.01.046","article-title":"Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: A meta-analysis","volume":"130","author":"Osterman","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"e199","DOI":"10.1038\/ctg.2016.56","article-title":"Weight and Body Composition Compartments do Not Predict Therapeutic Thiopurine Metabolite Levels in Inflammatory Bowel Disease","volume":"7","author":"Holt","year":"2016","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s40259-022-00522-0","article-title":"Impact of Obesity on Response to Biologic Therapies in Patients with Inflammatory Bowel Diseases","volume":"36","author":"Bassi","year":"2022","journal-title":"BioDrugs"},{"key":"ref_205","first-page":"275","article-title":"Effect of obesity on vedolizumab response in inflammatory bowel disease","volume":"35","author":"Levine","year":"2022","journal-title":"Ann. Gastroenterol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1111\/apt.14665","article-title":"High body mass index is associated with increased risk of treatment failure and surgery in biologic-treated patients with ulcerative colitis","volume":"47","author":"Kurnool","year":"2018","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/s41395-018-0104-x","article-title":"Obesity and Response to Infliximab in Patients with Inflammatory Bowel Diseases: Pooled Analysis of Individual Participant Data from Clinical Trials","volume":"113","author":"Singh","year":"2018","journal-title":"Am. J. Gastroenterol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/DCR.0000000000001074","article-title":"Visceral fat is Associated with Mucosal Healing of Infliximab Treatment in Crohn\u2019s Disease","volume":"61","author":"Shen","year":"2018","journal-title":"Dis. Colon Rectum"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.3748\/wjg.v28.i21.2282","article-title":"Updates in therapeutic drug monitoring in inflammatory bowel disease","volume":"28","author":"Lodhia","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1007\/s00384-021-03968-w","article-title":"Visceral adiposity and inflammatory bowel disease","volume":"36","author":"Rowan","year":"2021","journal-title":"Int. J. Colorectal Dis."},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Stromsnes, K., Correas, A.G., Lehmann, J., Gambini, J., and Olaso-Gonzalez, G. (2021). Anti-Inflammatory Properties of Diet: Role in Healthy Aging. Biomedicines, 9.","DOI":"10.3390\/biomedicines9080922"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s12328-019-01037-y","article-title":"Relationship(s) between obesity and inflammatory bowel diseases: Possible intertwined pathogenic mechanisms","volume":"13","author":"Szilagyi","year":"2020","journal-title":"Clin. J. Gastroenterol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.mayocp.2018.09.013","article-title":"Mechanisms of disease: Inflammatory bowel diseases","volume":"94","author":"Ramos","year":"2019","journal-title":"Mayo Clin.Clin. Proc."},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Pilarczyk-Zurek, M., Strus, M., Adamski, P., and Heczko, P.B. (2016). The dual role of Escherichia coli in the course of ulcerative colitis. BMC Gastroenterol., 16.","DOI":"10.1186\/s12876-016-0540-2"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13073-017-0490-5","article-title":"A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients","volume":"9","author":"Hall","year":"2017","journal-title":"Genome Med."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/ueg2.12280","article-title":"European guideline on obesity care in patients with gastrointestinal and liver diseases. Joint European Society for Clinical Nutrition and Metabolism\/United European Gastroenterology guideline","volume":"10","author":"Bischoff","year":"2022","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Bertani, L., Ribaldone, D.G., Bellini, M., Mumolo, M.G., and Costa, F. (2021). Inflammatory Bowel Diseases: Is There a Role for Nutritional Suggestions?. Nutrients, 13.","DOI":"10.3390\/nu13041387"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"110542","DOI":"10.1016\/j.nut.2019.06.023","article-title":"A randomized, 6-wk trial of a low FODMAP diet in patients with inflammatory bowel disease","volume":"67\u201368","author":"Bodini","year":"2019","journal-title":"Nutrition"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1093\/ecco-jcc\/jjx073","article-title":"Fermentable Carbohydrates [FODMAPs] Exacerbate Functional Gastrointestinal Symptoms in Patients with Inflammatory Bowel Disease: A Randomised, Double-blind, Placebo-controlled, Cross-over, Re-challenge Trial","volume":"11","author":"Cox","year":"2017","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1053\/j.gastro.2019.09.024","article-title":"Effects of Low FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients with Quiescent Inflammatory Bowel Disease in a Randomized Trial","volume":"158","author":"Cox","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_221","doi-asserted-by":"crossref","unstructured":"Peng, Z., Yi, J., and Liu, X. (2022). A Low-FODMAP Diet Provides Benefits for Functional Gastrointestinal Symptoms but Not for Improving Stool Consistency and Mucosal Inflammation in IBD: A Systematic Review and Meta-Analysis. Nutrients, 14.","DOI":"10.3390\/nu14102072"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s00394-021-02755-1","article-title":"FODMAPs, inflammatory bowel disease and gut microbiota: Updated overview on the current evidence","volume":"61","author":"Maganinho","year":"2022","journal-title":"Eur. J. Nutr."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1136\/gut.2005.082925","article-title":"Mesenteric fat in Crohn\u2019s disease. A pathogenetic hallmark or an innocent bystander?","volume":"56","author":"Chamaillard","year":"2007","journal-title":"Gut"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.tem.2014.04.001","article-title":"PPAR and the Global Map of Adipogenesis and Beyond","volume":"25","author":"Lefterova","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"8772","DOI":"10.1073\/pnas.0905745107","article-title":"Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon","volume":"107","author":"Beisner","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"620839","DOI":"10.1155\/2012\/620839","article-title":"PPAR in Inflammatory Bowel Disease","volume":"2012","author":"Annese","year":"2012","journal-title":"PPAR Res."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1136\/gutjnl-2012-303959","article-title":"New therapeutic avenues in ulcerative colitis: Thinking out of the box","volume":"62","author":"Torres","year":"2013","journal-title":"Gut"},{"key":"ref_228","first-page":"587","article-title":"Comparison of anti-inflammatory properties of peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone in prophylactic treatment of experimental colitis","volume":"64","author":"Celinski","year":"2013","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1053\/j.gastro.2007.12.012","article-title":"Rosiglitazone for active ulcerative colitis: A randomized placebo-controlled trial","volume":"134","author":"Lewis","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1056\/NEJMp1008233","article-title":"Revisiting the rosiglitazone story-lessons learned","volume":"363","author":"Rosen","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1021\/jm101360s","article-title":"Targeting peroxisome proliferator-activated receptors (PPARs): Development of modulators","volume":"55","author":"Pirat","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/MIB.0000000000000618","article-title":"Novel PPARgamma Modulator GED-0507-34 Levo Ameliorates Inflammation-driven Intestinal Fibrosis","volume":"22","author":"Speca","year":"2016","journal-title":"Inflamm. Bowel Dis."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/19\/3983\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:39:08Z","timestamp":1760143148000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/19\/3983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,25]]},"references-count":232,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["nu14193983"],"URL":"https:\/\/doi.org\/10.3390\/nu14193983","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,25]]}}}