{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:08:29Z","timestamp":1791889709735,"version":"4.3.4"},"reference-count":69,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010438","name":"Poznan University of Medical Sciences","doi-asserted-by":"publisher","award":["502-14-22193490-45055"],"award-info":[{"award-number":["502-14-22193490-45055"]}],"id":[{"id":"10.13039\/501100010438","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Anorexia nervosa (AN) is a widespread, metabo-psychiatric disorder with high relapse rates, comorbidity, and mortality. Many regulatory proteins and neurohormones studied to date play essential roles in the etiopathogenesis of eating disorders and the maintenance of psychopathological symptoms. Nevertheless, the regulatory and pathophysiological mechanisms of AN are still poorly understood. In the presented study, the plasma levels of apelin-13 (APE-13) and asprosin (ASP), as well as carbohydrate metabolism parameters and psychometric parameters, were evaluated in low-weight adolescent female patients with AN (AN1), after partial weight normalization (AN2) and in an age-matched healthy control group (CG) were evaluated. APE-13 levels were higher in the AN1 group than in the post-realimentation and the CG group. APE-13 levels were independent of insulin and glucose levels. Plasma ASP levels increased with increasing body weight in patients with AN, correlating with the severity of eating disorder symptoms in emaciation. The presented data suggest that APE-13 and ASP may be AN\u2019s biomarkers-regulation of eating behavior by APE-13 and ASP, the close relationship between them and emotional behavior, and changes in neurohormone levels in patients with eating and affective disorders seem to support these hypotheses. Moreover, their plasma levels seem to be related to the severity of psychopathological symptoms of eating disorders.<\/jats:p>","DOI":"10.3390\/nu14194022","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T22:53:19Z","timestamp":1664405599000},"page":"4022","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Apelin-13 and Asprosin in Adolescents with Anorexia Nervosa and Their Association with Psychometric and Metabolic Variables"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7027-5905","authenticated-orcid":false,"given":"Katarzyna","family":"Jowik","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, 61-701 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0493-8325","authenticated-orcid":false,"given":"Monika","family":"Dmitrzak-W\u0119glarz","sequence":"additional","affiliation":[{"name":"Department of Psychiatric Genetics, Poznan University of Medical Sciences, 61-701 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Pytli\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, 61-701 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Jasi\u0144ska-Miko\u0142ajczyk","sequence":"additional","affiliation":[{"name":"Department of Adult Psychiatry, Poznan University of Medical Sciences, 61-701 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"S\u0142opie\u0144","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, 61-701 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0141-4593","authenticated-orcid":false,"given":"Marta","family":"Tyszkiewicz-Nwafor","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, 61-701 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/s41588-019-0439-2","article-title":"Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa","volume":"51","author":"Watson","year":"2019","journal-title":"Nat. Genet."},{"key":"ref_2","first-page":"515","article-title":"Incidence, prevalence and mortality of anorexia nervosa and bulimia nervosa. Curr. Opin","volume":"34","author":"Hoek","year":"2021","journal-title":"Psychiatry"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Gonz\u00e1lez, L., Fern\u00e1ndez-Villa, T., Molina, A.J., Delgado-Rodr\u00edguez, M., and Mart\u00edn, V. (2020). Incidence of Anorexia Nervosa in Women: A Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17113824"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.psyneuen.2012.10.021","article-title":"Dysfunctions of leptin, ghrelin, BDNF and endocannabinoids in eating disorders: Beyond the homeostatic control of food intake","volume":"38","author":"Monteleone","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/pcn.12857","article-title":"Reconceptualizing anorexia nervosa","volume":"73","author":"Bulik","year":"2019","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.physbeh.2018.02.011","article-title":"Homeostatic and non-homeostatic controls of feeding behavior: Distinct vs. common neural systems","volume":"193","author":"Liu","year":"2018","journal-title":"Physiol. Behav."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.2147\/NDT.S199927","article-title":"Cognitive impairment in eating disorder patients of short and long-term duration: A case\u2013control study","volume":"15","author":"Grau","year":"2019","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"20888","DOI":"10.1002\/jcp.28694","article-title":"Asprosin attenuates insulin signaling pathway through PKC\u03b4-activated ER stress and inflammation in skeletal muscle","volume":"234","author":"Jung","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/nm.4432","article-title":"Asprosin is a centrally acting orexigenic hormone","volume":"23","author":"Duerrschmid","year":"2017","journal-title":"Nat. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.cell.2016.02.063","article-title":"Asprosin, a Fasting-Induced Glucogenic Protein Hormone","volume":"165","author":"Romere","year":"2016","journal-title":"Cell"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.cmet.2019.05.022","article-title":"OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin","volume":"30","author":"Li","year":"2019","journal-title":"Cell Metab."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.neuron.2018.01.050","article-title":"A Spotlight on Appetite","volume":"97","author":"Beutler","year":"2018","journal-title":"Neuron"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1749-6632.1955.tb36543.x","article-title":"Regulation of energy intake and the body weight: The glucostatic theory and the lipostatic hypothesis","volume":"63","author":"Mayer","year":"1955","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.appet.2006.08.002","article-title":"Appetite sensations and satiety quotient: Predictors of energy intake and weight loss","volume":"48","author":"Drapeau","year":"2007","journal-title":"Appetite"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1007\/s00520-020-05621-8","article-title":"Asprosin is associated with anorexia and body fat mass in cancer patients","volume":"29","author":"Du","year":"2021","journal-title":"Support. Care Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1111\/j.1572-0241.2004.30246.x","article-title":"Gastric emptying in patients with restricting and binge\/purging subtypes of anorexia nervosa","volume":"99","author":"Benini","year":"2004","journal-title":"Am. J. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"E565","DOI":"10.1152\/ajpendo.00149.2018","article-title":"Effects of starvation and short-term refeeding on gastric emptying and postprandial blood glucose regulation in adolescent girls with anorexia nervosa","volume":"315","author":"Heruc","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0167-4781(00)00072-5","article-title":"Distribution of mRNA encoding B78\/apj, the rat homologue of the human APJ receptor, and its endogenous ligand apelin in brain and peripheral tissues","volume":"1492","author":"Selby","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1055\/s-2006-948309","article-title":"Changes and relations of circulating visfatin, apelin, and resistin levels in normal, impaired glucose tolerance, and type 2 diabetic subjects","volume":"114","author":"Li","year":"2006","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.3889\/oamjms.2018.312","article-title":"Serum Apelin and Obesity-Related Complications in Egyptian Children","volume":"6","author":"Kamhawy","year":"2018","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1210\/en.2004-1427","article-title":"Apelin, a newly identified adipokine up-regulated by insulin and obesity","volume":"146","author":"Boucher","year":"2005","journal-title":"Endocrinology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.regpep.2005.05.003","article-title":"Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding","volume":"130","author":"Heinonen","year":"2005","journal-title":"Regul. Pept."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Ba, H.J., Chen, H.S., Su, Z., Du, M.L., Chen, Q.L., Li, Y.H., and Ma, H.M. (2014). Associations between Serum Apelin-12 Levels and Obesity-Related Markers in Chinese Children. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0086577"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Suriyaprom, K., Pheungruang, B., Tungtrongchitr, R., and Sroijit, O.U.Y. (2020). Relationships of apelin concentration and APLN T-1860C polymorphism with obesity in Thai children. BMC Pediatr., 20.","DOI":"10.1186\/s12887-020-02350-z"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/ijpo.251","article-title":"Apelin and G212A apelin receptor gene polymorphism in obese and diabese youth","volume":"10","author":"Kotanidou","year":"2015","journal-title":"Pediatr. Obes."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1515\/jpem.2010.165","article-title":"Decreased plasma apelin levels in pubertal obese children","volume":"23","author":"Tapan","year":"2010","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"243","DOI":"10.21037\/atm.2020.02.07","article-title":"Apelin\/Elabela-APJ: A novel therapeutic target in the cardiovascular system","volume":"8","author":"Liu","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.pharmthera.2018.05.013","article-title":"Vascular effects of apelin: Mechanisms and therapeutic potential","volume":"190","author":"Mughal","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"33","DOI":"10.5603\/EP.2014.0005","article-title":"Bone metabolism, osteoprotegerin, receptor activator of nuclear factor-kB ligand and selected adipose tissue hormones in girls with anorexia nervosa","volume":"65","author":"Ostrowska","year":"2014","journal-title":"Endokrynol. Pol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.pnpbp.2018.10.005","article-title":"Protective role of Apelin-13 on amyloid \u03b225-35-induced memory deficit; Involvement of autophagy and apoptosis process","volume":"89","author":"Aminyavari","year":"2019","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.bcp.2018.01.011","article-title":"Adipokine apelin ameliorates chronic colitis in Il-10 -\/- mice by promoting intestinal lymphatic functions","volume":"148","author":"Ge","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1080\/1028415X.2019.1692494","article-title":"Longitudinal study on novel neuropeptides phoenixin, spexin and kisspeptin in adolescent inpatients with anorexia nervosa - association with psychiatric symptoms","volume":"24","author":"Bacopoulou","year":"2021","journal-title":"Nutr. Neurosci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1080\/15622975.2018.1492735","article-title":"Adiponectin and resistin in acutely ill and weight-recovered adolescent anorexia nervosa: Association with psychiatric symptoms","volume":"20","author":"Slopien","year":"2019","journal-title":"World J. Biol. Psychiatry"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.3389\/fpsyt.2019.01032","article-title":"Brain-Derived Neurotrophic Factor and Oxytocin Signaling in Association With Clinical Symptoms in Adolescent Inpatients With Anorexia Nervosa\u2014A Longitudinal Study","volume":"10","author":"Rybakowski","year":"2020","journal-title":"Front. Psychiatry"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/s41598-020-79410-y","article-title":"Nutritional status and anxious and depressive symptoms in anorexia nervosa: A prospective study","volume":"11","author":"Lalanne","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Sj\u00f6gren, M., and St\u00f8ving, R.K. (2022). Anorexia Nervosa: Reduction in Depression during Inpatient Treatment Is Closely Related to Reduction in Eating Disorder Psychopathology. J. Pers. Med., 12.","DOI":"10.3390\/jpm12050682"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s40519-021-01252-y","article-title":"Obsessive-compulsive symptoms in young women affected with anorexia nervosa, and their relationship with personality, psychopathology, and attachment style","volume":"27","author":"Amianto","year":"2022","journal-title":"Eat. Weight Disord."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/erv.2635","article-title":"Associations between dimensions of anorexia nervosa and obsessive-compulsive disorder: An examination of personality and psychological factors in patients with anorexia nervosa","volume":"27","author":"Levinson","year":"2019","journal-title":"Eur. Eat. Disord. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Kucharska, K., Kulakowska, D., Starzomska, M., Rybakowski, F., and Biernacka, K. (2019). The improvement in neurocognitive functioning in anorexia nervosa adolescents throughout the integrative model of psychotherapy including cognitive remediation therapy. BMC Psychiatry, 19.","DOI":"10.1186\/s12888-018-1984-4"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/mp.2010.95","article-title":"Role of the evolutionarily conserved starvation response in anorexia nervosa","volume":"16","author":"Dwyer","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"ref_41","first-page":"1","article-title":"A 57-year follow-up investigation and review of the Minnesota study on human starvation and its relevance to eating disorders","volume":"2","author":"Eckert","year":"2018","journal-title":"Arch. Psychol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"157","DOI":"10.5214\/ans.0972.7531.200409","article-title":"A critique of the literature on etiology of eating disorders","volume":"20","author":"Rikani","year":"2013","journal-title":"Ann. Neurosci."},{"key":"ref_43","first-page":"1","article-title":"Growth factors in anorexia nervosa: A systematic review and meta-analysis of cross-sectional and longitudinal data","volume":"1","author":"Keeler","year":"2022","journal-title":"World J. Biol. Psychiatry"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/BF03354435","article-title":"GH\/IGF-I axis in anorexia nervosa","volume":"7","author":"Gianotti","year":"2002","journal-title":"Eat. Weight Disord."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000443735","article-title":"Anorexia Nervosa and Its Associated Endocrinopathy in Young People","volume":"85","author":"Misra","year":"2016","journal-title":"Horm. Res. Paediatr."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Mazur-Bialy, A.I. (2021). Asprosin-A Fasting-Induced, Glucogenic, and Orexigenic Adipokine as a New Promising Player. Will It Be a New Factor in the Treatment of Obesity, Diabetes, or Infertility? A Review of the Literature. Nutrients, 13.","DOI":"10.3390\/nu13020620"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s40519-020-00845-3","article-title":"Increased plasma asprosin levels in patients with drug-naive anorexia nervosa","volume":"26","author":"Hu","year":"2021","journal-title":"Eat. Weight Disord."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1080\/09513590.2018.1512967","article-title":"Asprosin: A novel peptide hormone related to insulin resistance in women with polycystic ovary syndrome","volume":"35","author":"Alan","year":"2019","journal-title":"Gynecol. Endocrinol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"7375294","DOI":"10.1155\/2018\/7375294","article-title":"Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases","volume":"2018","author":"Li","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.cca.2017.10.034","article-title":"Circulating asprosin concentrations are increased in type 2 diabetes mellitus and independently associated with fasting glucose and triglyceride","volume":"489","author":"Zhang","year":"2019","journal-title":"Clin. Chim. Acta"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1038\/s41366-018-0248-1","article-title":"Sen Serum asprosin levels and bariatric surgery outcomes in obese adults","volume":"43","author":"Wang","year":"2019","journal-title":"Int. J. Obes."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1159\/000500523","article-title":"Decreased Circulating Levels of Asprosin in Obese Children","volume":"91","author":"Long","year":"2019","journal-title":"Horm. Res. Paediatr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3389\/fphys.2018.00557","article-title":"The Role of Apelin in Cardiovascular Diseases, Obesity and Cancer","volume":"9","author":"Wysocka","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.peptides.2013.05.013","article-title":"The apelinergic system: Sexual dimorphism and tissue-specific modulations by obesity and insulin resistance in female mice","volume":"46","author":"Butruille","year":"2013","journal-title":"Peptides"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1530\/EJE-08-0039","article-title":"Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ","volume":"158","author":"Daviaud","year":"2008","journal-title":"Eur. J. Endocrinol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1210\/jc.2009-1958","article-title":"Assessment of Serum Apelin Levels in Girls with Anorexia Nervosa","volume":"95","author":"Ziora","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1515\/jpem-2014-0490","article-title":"Role of circulating adipocytokines vaspin, apelin, and visfatin in the loss of appetite in underweight children: A pilot trial","volume":"28","author":"Vehapoglu","year":"2015","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fnagi.2020.00058","article-title":"Endogenous Apelin Is Protective Against Age-Associated Loss of Retinal Ganglion Cells in Mice","volume":"12","author":"Ishimaru","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cca.2016.12.023","article-title":"Apelin\/APJ system: A novel promising therapy target for pathological angiogenesis","volume":"466","author":"Wu","year":"2017","journal-title":"Clin. Chim. Acta"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.cca.2018.05.012","article-title":"Review: Apelin in disease","volume":"483","author":"Antushevich","year":"2018","journal-title":"Clin. Chim. Acta"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1530\/JOE-13-0227","article-title":"The apelin receptor APJ: Journey from an orphan to a multifaceted regulator of homeostasis","volume":"219","author":"Lolait","year":"2013","journal-title":"J. Endocrinol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.pharmthera.2005.04.001","article-title":"Emerging roles of apelin in biology and medicine","volume":"107","author":"Kleinz","year":"2005","journal-title":"Pharmacol. Ther."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.peptides.2012.07.012","article-title":"Neuroprotection of apelin and its signaling pathway","volume":"37","author":"Cheng","year":"2012","journal-title":"Peptides"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3940(03)00351-3","article-title":"Intracerebroventricular injection of apelin-13 reduces food intake in the rat","volume":"353","author":"Sunter","year":"2003","journal-title":"Neurosci. Lett."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1054\/clnu.2001.0420","article-title":"The effect of food intake on mood","volume":"20","author":"Christensen","year":"2001","journal-title":"Clin. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0306-9877(89)90026-1","article-title":"Hyperinsulinemia; A mediator of decreased food intake and weight loss in anorexia nervosa and major depression","volume":"28","year":"1989","journal-title":"Med. Hypotheses"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"109","DOI":"10.9758\/cpn.2020.18.1.109","article-title":"Plasma Apelin, Visfatin and Resistin Levels in Patients with First Episode Psychosis and Chronic Schizophrenia","volume":"18","author":"Sahpolat","year":"2020","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"39","DOI":"10.5350\/DAJPN2017300105","article-title":"Serum Apelin And Nesfatin-1 Levels in Depression Patients and Their Relationship with Treatment","volume":"30","author":"Dede","year":"2017","journal-title":"Dusunen Adam J. Psychiatry Neurol. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.peptides.2011.11.011","article-title":"Central apelin-13 inhibits food intake via the CRF receptor in mice","volume":"33","author":"Lv","year":"2012","journal-title":"Peptides"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/19\/4022\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:40:57Z","timestamp":1760143257000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/19\/4022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,28]]},"references-count":69,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["nu14194022"],"URL":"https:\/\/doi.org\/10.3390\/nu14194022","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,28]]}}}