{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:00:04Z","timestamp":1787029204734,"version":"build-2736575974"},"reference-count":111,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fitoplancton Marino, S.L.","award":["FM_EURECAT"],"award-info":[{"award-number":["FM_EURECAT"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Increased oxidative stress has been linked to the pathogenic process of obesity and can trigger inflammation, which is often linked with the risk factors that make up metabolic syndrome (MetS), including obesity, insulin resistance, dyslipidaemia and hypertension. TetraSOD\u00ae, a natural marine vegan ingredient derived from the microalgae Tetraselmis chuii that is high in the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) has recently demonstrated in vitro increased activity of these key antioxidant enzymes. In the present study, the potential bioactive effects of three dietary dosages of TetraSOD\u00ae in enhancing antioxidant and anti-inflammatory mechanisms to combat the metabolic disturbances that compose MetS were assessed in rats given a cafeteria (CAF) diet. Chronic supplementation with 0.17, 1.7, and 17 mg kg\u22121 day\u22121 of TetraSOD\u00ae for 8 weeks ameliorated the abnormalities associated with MetS, including oxidative stress and inflammation, promoting endogenous antioxidant defence mechanisms in the liver (GPx and GSH), modulating oxidative stress and inflammatory markers in plasma (NOx, oxLDL and IL-10), and regulating genes involved in antioxidant, anti-inflammatory and immunomodulatory pathways in the liver, mesenteric white adipose tissue (MWAT), thymus, and spleen. Overall, TetraSOD\u00ae appears to be a potential therapeutic option for the management of MetS.<\/jats:p>","DOI":"10.3390\/nu14194028","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T22:53:19Z","timestamp":1664405599000},"page":"4028","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["TetraSOD\u00ae, a Unique Marine Microalgae Ingredient, Promotes an Antioxidant and Anti-Inflammatory Status in a Metabolic Syndrome-Induced Model in Rats"],"prefix":"10.3390","volume":"14","author":[{"given":"Katherine","family":"Gil-Cardoso","sequence":"first","affiliation":[{"name":"Eurecat, Centre Tecnol\u00f2gic de Catalunya, Technological Unit of Nutrition and Health, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0700-2004","authenticated-orcid":false,"given":"Josep M.","family":"Del Bas","sequence":"additional","affiliation":[{"name":"Eurecat, Centre Tecnol\u00f2gic de Catalunya, Technological Unit of Nutrition and Health, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6144-0294","authenticated-orcid":false,"given":"Antoni","family":"Caimari","sequence":"additional","affiliation":[{"name":"Eurecat, Centre Tecnol\u00f2gic de Catalunya, Biotechnology Area, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Lama","sequence":"additional","affiliation":[{"name":"Fitoplancton Marino S.L., D\u00e1rsena Comercial, S\/N (Muelle Pesquero), 11500 C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Torres","sequence":"additional","affiliation":[{"name":"Fitoplancton Marino S.L., D\u00e1rsena Comercial, S\/N (Muelle Pesquero), 11500 C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2669-5659","authenticated-orcid":false,"given":"Lalia","family":"Mantec\u00f3n","sequence":"additional","affiliation":[{"name":"Fitoplancton Marino S.L., D\u00e1rsena Comercial, S\/N (Muelle Pesquero), 11500 C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Infante","sequence":"additional","affiliation":[{"name":"Fitoplancton Marino S.L., D\u00e1rsena Comercial, S\/N (Muelle Pesquero), 11500 C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"943162","DOI":"10.1155\/2014\/943162","article-title":"A Comprehensive Review on Metabolic Syndrome","volume":"2014","author":"Kaur","year":"2014","journal-title":"Cardiol. 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