{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:35:53Z","timestamp":1782779753831,"version":"3.54.5"},"reference-count":203,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jane Wilson"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Knowledge that certain nutraceuticals can modulate the immune system is not new. These naturally occurring compounds are known as immunoceuticals, which is a novel term that refers to products and systems that naturally improve an individual\u2019s immuno-competence. Examples of immunoceuticals include vitamin D3, mushroom glycans, flavonols, quercetin, omega-3 fatty acids, carotenoids, and micronutrients (e.g., zinc and selenium), to name a few. The immune system is a complex and highly intricate system comprising molecules, cells, tissues, and organs that are regulated by many different genetic and environmental factors. There are instances, such as pathological conditions, in which a normal immune response is suboptimal or inappropriate and thus augmentation or tuning of the immune response by immunoceuticals may be desired. With infectious diseases, cancers, autoimmune disorders, inflammatory conditions, and allergies on the rise in both humans and animals, the importance of the use of immunoceuticals to prevent, treat, or augment the treatment of these conditions is becoming more evident as a natural and often economical approach to support wellness. The global nutraceuticals market, which includes immunoceuticals, is a multi-billion-dollar industry, with a market size value of USD 454.55 billion in 2021, which is expected to reach USD 991.09 billion by 2030. This review will provide an overview of the immune system, the importance of immunomodulation, and defining and testing for immunocompetence, followed by a discussion of several key immunoceuticals with clinically proven and evidence-based immunomodulatory properties.<\/jats:p>","DOI":"10.3390\/nu14194075","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T01:21:07Z","timestamp":1665364867000},"page":"4075","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Immunoceuticals: Harnessing Their Immunomodulatory Potential to Promote Health and Wellness"],"prefix":"10.3390","volume":"14","author":[{"given":"Sophie","family":"Tieu","sequence":"first","affiliation":[{"name":"Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armen","family":"Charchoglyan","sequence":"additional","affiliation":[{"name":"ImmunoCeutica Inc., Cambridge, ON N1T 1N6, Canada"},{"name":"Advanced Analysis Centre, University of Guelph, Guelph, ON N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauri","family":"Wagter-Lesperance","sequence":"additional","affiliation":[{"name":"ImmunoCeutica Inc., Cambridge, ON N1T 1N6, Canada"},{"name":"Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7245-5851","authenticated-orcid":false,"given":"Khalil","family":"Karimi","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8335-1118","authenticated-orcid":false,"given":"Byram W.","family":"Bridle","sequence":"additional","affiliation":[{"name":"ImmunoCeutica Inc., Cambridge, ON N1T 1N6, Canada"},{"name":"Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niel A.","family":"Karrow","sequence":"additional","affiliation":[{"name":"Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada"},{"name":"ImmunoCeutica Inc., Cambridge, ON N1T 1N6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie A.","family":"Mallard","sequence":"additional","affiliation":[{"name":"ImmunoCeutica Inc., Cambridge, ON N1T 1N6, Canada"},{"name":"Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1208\/ps050325","article-title":"Nutraceutical\u2014Definition and Introduction","volume":"5","author":"Kalra","year":"2003","journal-title":"AAPS PharmSci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/bcp.12935","article-title":"Defining \u2018nutraceuticals\u2019: Neither nutritious nor pharmaceutical","volume":"83","author":"Aronson","year":"2017","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_3","unstructured":"(2022, August 28). Nutraceuticals\/Functional Foods and Health Claims on Foods. Available online: https:\/\/www.canada.ca\/en\/health-canada\/services\/food-nutrition\/food-labelling\/health-claims\/nutraceuticals-functional-foods-health-claims-foods-policy-paper.html."},{"key":"ref_4","first-page":"262","article-title":"A Review on Human Immunity System and HIV Infection","volume":"6","author":"Sahoo","year":"2015","journal-title":"IJCPR"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Marshall, J.S., Warrington, R., Watson, W., and Kim, H.L. (2018). An introduction to immunology and immunopathology. Allergy Asthma Clin. Immunol., 14.","DOI":"10.1186\/s13223-018-0278-1"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Hunt, S.E., McLaren, W., Gil, L., Thormann, A., Schuilenburg, H., Sheppard, D., Parton, A., Armean, I.M., Trevanion, S.J., and Flicek, P. (2018). Ensembl variation resources. Database, 2018.","DOI":"10.1093\/database\/bay119"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nri.2016.125","article-title":"Human immune system variation","volume":"17","author":"Brodin","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.3168\/jds.2020-18405","article-title":"The bioactivity of colostrum and milk exosomes of high, average, and low immune responder cows on human intestinal epithelial cells","volume":"104","author":"Ross","year":"2021","journal-title":"J. Dairy Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.tim.2020.04.008","article-title":"Epigenetics: A New Frontier in Probiotic Research","volume":"29","author":"Morovic","year":"2021","journal-title":"Trends Microbiol."},{"key":"ref_10","first-page":"187","article-title":"Epigenetic Mechanisms of Quercetin and Other Flavonoids in Cancer Therapy and Prevention","volume":"Volume 8","author":"Bishayee","year":"2019","journal-title":"Epigenetics of Cancer Prevention"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Patel, V., and Preedy, V. (2017). Natural Polyphenol Kaempferol and Its Epigenetic Impact on Histone Deacetylases: Focus on Human Liver Cells. Handbook of Nutrition, Diet, and Epigenetics, Springer. [1st ed.].","DOI":"10.1007\/978-3-319-31143-2"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Hassan, F.U., Rehman, M.S., Khan, M.S., Ali, M.A., Javed, A., Nawaz, A., and Yang, C. (2019). Curcumin as an Alternative Epigenetic Modulator: Mechanism of Action and Potential Effects. Front. Genet., 10.","DOI":"10.3389\/fgene.2019.00514"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"De la Rocha, C., Rodr\u00edguez-R\u00edos, D., Ram\u00edrez-Ch\u00e1vez, E., Molina-Torres, J., de Jes\u00fas Flores-Sierra, J., Orozco-Castellanos, L.M., Galv\u00e1n-Ch\u00eda, J.P., S\u00e1nchez, A.V., Zaina, S., and Lund, G. (2022). Cumulative Metabolic and Epigenetic Effects of Paternal and\/or Maternal Supplementation with Arachidonic Acid across Three Consecutive Generations in Mice. Cells, 11.","DOI":"10.3390\/cells11061057"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.tig.2022.03.006","article-title":"Transgenerational epigenetic impacts of parental infection on offspring health and disease susceptibility","volume":"38","author":"Kleeman","year":"2022","journal-title":"Trends Genet."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s00262-011-1053-z","article-title":"Cooperativity of adaptive and innate immunity: Implications for cancer therapy","volume":"60","author":"Shanker","year":"2011","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/s41586-020-2886-4","article-title":"Gut-educated IgA plasma cells defend the meningeal venous sinuses","volume":"587","author":"Fitzpatrick","year":"2020","journal-title":"Nature"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Bellavance, M.A., and Rivest, S. (2014). The HPA\u2014Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain. Front. Immunol., 5.","DOI":"10.3389\/fimmu.2014.00136"},{"key":"ref_18","first-page":"365","article-title":"The inflammasomes: The key regulators of inflammation","volume":"102","author":"Fietta","year":"2009","journal-title":"Riv. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1515\/hsz-2014-0253","article-title":"Inflammatory caspases: Key regulators of inflammation and cell death","volume":"396","author":"Lamkanfi","year":"2015","journal-title":"Biol. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/s41581-021-00454-y","article-title":"Pro-resolving lipid mediators: Regulators of inflammation, metabolism and kidney function","volume":"17","author":"Brennan","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s11515-011-1123-9","article-title":"An overview of inflammation: Mechanism and consequences","volume":"6","author":"Ahmed","year":"2011","journal-title":"Front. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C.M., Ligotti, M.E., Zareian, N., and Accardi, G. (2019). Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.02247"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Runge, M.S., and Patterson, C. (2006). Immunomodulation. Principles of Molecular Medicine, Humana Press. [2nd ed.].","DOI":"10.1007\/978-1-59259-963-9"},{"key":"ref_24","first-page":"S37","article-title":"Genetic selection of cattle for improved immunity and health","volume":"63","author":"Mallard","year":"2015","journal-title":"Jpn. J. Vet. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1038\/s41590-021-01058-1","article-title":"Human immune diversity: From evolution to modernity","volume":"22","author":"Liston","year":"2021","journal-title":"Nat. Immunol."},{"key":"ref_26","unstructured":"Mallard, B.A., Atalla, H., Cartwright, S., Hine, B., Hussey, B., Paibomesai, M., Thompson-Crispi, K., and Wagter-Lesperance, L. (2011, January 23\u201326). Genetic and epigenetic regulation of the bovine immune system: Practical implications of the high immune response technology. Proceedings of the 50th Annual National Mastitis Council Meeting, Arlington, VA, USA."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1128\/CVI.00494-12","article-title":"Incidence rates of clinical mastitis among Canadian Holsteins classified as high, average, or low immune responders","volume":"20","author":"Miglior","year":"2013","journal-title":"Clin. Vaccine Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1039\/D0AY02098B","article-title":"A review of pharmaceutical occurrence and pathways in the aquatic environment in the context of a changing climate and the COVID-19 pandemic","volume":"13","author":"Lawler","year":"2021","journal-title":"Anal. Methods"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Huang, L.C., Wu, X., and Chen, J.Y. (2011). Predicting adverse side effects of drugs. BMC Genom., 12.","DOI":"10.1186\/1471-2164-12-S5-S11"},{"key":"ref_30","unstructured":"\u00dcst\u00fcn, N.\u015e., Bulam, S., and Pek\u015fen, A. (2018, January 27\u201329). The use of Mushrooms and Their Extracts and Compounds in Functional Foods and Nutraceuticals. Proceedings of the International Technology Sciences and Design Symposium, Giresun, Turkey."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Sabico, S., Enani, M.A., Sheshah, E., Aljohani, N.J., Aldisi, D.A., Alotaibi, N.H., Alshingetti, N., Alomar, S.Y., Alnaami, A.M., and Amer, O.E. (2021). Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate COVID-19: A Randomized Clinical Trial. Nutrients, 13.","DOI":"10.3390\/nu13072170"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Annweiler, C., Hanotte, B., Grandin de l\u2019Eprevier, C., Sabatier, J.M., Lafaie, L., and C\u00e9larier, T. (2020). Vitamin D and survival in COVID-19 patients: A quasi-experimental study. J. Steroid Biochem. Mol. Biol., 204.","DOI":"10.1016\/j.jsbmb.2020.105771"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Zuno, G.A., Gonz\u00e1lez-Estevez, G., Matuz-Flores, M.G., Macedo-Ojeda, G., Hern\u00e1ndez-Bello, J., Mora-Mora, J.C., P\u00e9rez-Guerrero, E.E., Garc\u00eda-Chagoll\u00e1n, M., Vega-Maga\u00f1a, N., and Turrubiates-Hern\u00e1ndez, F.J. (2021). Vitamin D Levels in COVID-19 Outpatients from Western Mexico: Clinical Correlation and Effect of Its Supplementation. J. Clin. Med., 10.","DOI":"10.3390\/jcm10112378"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.3945\/ajcn.2009.29094","article-title":"Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren","volume":"91","author":"Urashima","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF01740932","article-title":"Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) administration after curative surgical operation of colorectal cancer","volume":"31","author":"Torisu","year":"1990","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF02050666","article-title":"Randomized, controlled study on adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer","volume":"35","author":"Mitomi","year":"1992","journal-title":"Dis. Colon Rectum"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1053\/rmed.2003.1490","article-title":"Coriolus versicolor polysaccharide peptide slows progression of advanced non-small cell lung cancer","volume":"97","author":"Tsang","year":"2003","journal-title":"Respir. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.2147\/CIA.S141518","article-title":"Yogurt supplemented with probiotics can protect the healthy elderly from respiratory infections: A randomized controlled open-label trial","volume":"12","author":"Pu","year":"2017","journal-title":"Clin. Interv. Aging"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Sazawal, S., Dhingra, U., Hiremath, G., Sarkar, A., Dhingra, P., Dutta, A., Verma, P., Menon, V.P., and Black, R.E. (2010). Prebiotic and probiotic fortified milk in prevention of morbidities among children: Community-based, randomized, double-blind, controlled trial. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0012164"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.2147\/IJGM.S318720","article-title":"Possible Therapeutic Effects of Adjuvant Quercetin Supplementation Against Early-Stage COVID-19 Infection: A Prospective, Randomized, Controlled, and Open-Label Study","volume":"14","author":"Derosa","year":"2021","journal-title":"Int. J. Gen. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.2147\/IJGM.S318949","article-title":"Potential Clinical Benefits of Quercetin in the Early Stage of COVID-19: Results of a Second, Pilot, Randomized, Controlled and Open-Label Clinical Trial","volume":"14","author":"Iqtadar","year":"2021","journal-title":"Int. J. Gen. Med."},{"key":"ref_42","first-page":"19","article-title":"The effect of supplemental beta-carotene on immunologic indices in patients with AIDS: A pilot study","volume":"68","author":"Fryburg","year":"1995","journal-title":"Yale J. Biol. Med."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Sedighiyan, M., Abdollahi, H., Karimi, E., Badeli, M., Erfanian, R., Raeesi, S., Hashemi, R., Vahabi, Z., Asanjarani, B., and Mansouri, F. (2021). Omega-3 polyunsaturated fatty acids supplementation improve clinical symptoms in patients with COVID-19: A randomised clinical trial. Int. J. Clin. Pract., 75.","DOI":"10.1111\/ijcp.14854"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Doaei, S., Gholami, S., Rastgoo, S., Gholamalizadeh, M., Bourbour, F., Bagheri, S.E., Samipoor, F., Akbari, M.E., Shadnoush, M., and Ghorat, F. (2021). The effect of omega-3 fatty acid supplementation on clinical and biochemical parameters of critically ill patients with COVID-19: A randomized clinical trial. J. Transl. Med., 19.","DOI":"10.1186\/s12967-021-02795-5"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.arcmed.2021.06.006","article-title":"Efficacy of a Low Dose of Melatonin as an Adjunctive Therapy in Hospitalized Patients with COVID-19: A Randomized, Double-blind Clinical Trial","volume":"53","author":"Farnoosh","year":"2022","journal-title":"Arch. Med. Res."},{"key":"ref_46","unstructured":"(2022, August 27). Nutraceuticals Market Size, Share and Trends Analysis Report by Product (Dietary Supplements, Functional Food, Functional Beverages), By Region (North America, Europe, APAC, CSA, MEA), And Segment Forecasts, 2021\u20132030. Available online: https:\/\/www.grandviewresearch.com\/industry-analysis\/nutraceuticals-market."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Costagliola, G., Nuzzi, G., Spada, E., Comberiati, P., Verduci, E., and Peroni, D.G. (2021). Nutraceuticals in Viral Infections: An Overview of the Immunomodulating Properties. Nutrients, 13.","DOI":"10.3390\/nu13072410"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1037\/0033-2909.111.3.475","article-title":"Depression and immunocompetence: A review of the literature","volume":"111","author":"Weisse","year":"1992","journal-title":"Psychol. Bull."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1007\/s00204-016-1809-5","article-title":"Measuring the immune system: A comprehensive approach for the analysis of immune functions in humans","volume":"90","author":"Claus","year":"2016","journal-title":"Arch. Toxicol."},{"key":"ref_50","unstructured":"Glaser, R., and Gotlieb-Stematsky, T. (1982). Human Herpesvirus Infections: Clinical Aspects, Taylor & Francis Inc."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/09540105.2015.1079600","article-title":"Studying the impact of nutritional immunology underlying the modulation of immune responses by nutritional compounds\u2014A review","volume":"27","author":"Saeed","year":"2016","journal-title":"Food Agric. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1301\/00296640260130722","article-title":"Micronutrient malnutrition, infection, and immunity: An overview","volume":"60","author":"Bhaskaram","year":"2002","journal-title":"Nutr. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"495S","DOI":"10.1093\/jn\/132.3.495S","article-title":"Breeding strategies for biofortified staple plant foods to reduce micronutrient malnutrition globally","volume":"132","author":"Welch","year":"2002","journal-title":"J. Nutr."},{"key":"ref_54","unstructured":"(2022, August 26). Merriam-Webster. Available online: https:\/\/www.merriam-webster.com\/dictionary\/nutritional%20deficiency."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1128\/IAI.00602-13","article-title":"Sequestration and scavenging of iron in infection","volume":"81","author":"Parrow","year":"2013","journal-title":"Infect. Immun."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Musavi, H., Abazari, O., Barartabar, Z., Kalaki-Jouybari, F., Hemmati-Dinarvand, M., Esmaeili, P., and Mahjoub, S. (2020). The benefits of Vitamin D in the COVID-19 pandemic: Biochemical and immunological mechanisms. Arch. Physiol. Biochem., 1\u20139.","DOI":"10.1080\/13813455.2020.1826530"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1002\/eji.200324532","article-title":"The anti-inflammatory effects of 1,25-dihydroxyvitamin D3 on Th2 cells in vivo are due in part to the control of integrin-mediated T lymphocyte homing","volume":"34","author":"Topilski","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/jcb.240550404","article-title":"Regulation of TNF-alpha release from bone marrow-derived macrophages by vitamin D","volume":"55","year":"1994","journal-title":"J. Cell. Biochem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s40618-020-01327-0","article-title":"Possible role of vitamin D in COVID-19 infection in pediatric population","volume":"44","author":"Panfili","year":"2021","journal-title":"J. Endocrinol. Investig."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1678S","DOI":"10.1093\/ajcn\/80.6.1678S","article-title":"Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease","volume":"80","author":"Holick","year":"2004","journal-title":"Am. J. Clin. Nutri."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11154-016-9405-9","article-title":"Does vitamin D play a role in autoimmune endocrine disorders? A proof of concept","volume":"18","author":"Altieri","year":"2017","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Saleh, M.H., Rashedi, I., and Keating, A. (2017). Immunomodulatory Properties of Coriolus versicolor: The Role of Polysaccharopeptide. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.01087"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nri2691","article-title":"The IL-1 family: Regulators of immunity","volume":"10","author":"Sims","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1177\/009127000204200904","article-title":"Coriolus versicolor: A medicinal mushroom with promising immunotherapeutic values","volume":"42","author":"Chu","year":"2002","journal-title":"J. Clin. Pharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0024-3205(99)00027-2","article-title":"Analysis of immunomodulating cytokine mRNAs in the mouse induced by mushroom polysaccharides","volume":"64","author":"Liu","year":"1999","journal-title":"Life Sci."},{"key":"ref_66","unstructured":"Chang, S.T., Buswell, J.A., and Chiu, S.W. (1993). Diverse biological activity of PSK (Krestin), a protein-bound polysaccharide from Coriolus versicolor (Fr.) Quel. Mushroom Biology and Mushroom Products, Chinese University Press."},{"key":"ref_67","unstructured":"Yang, Q.Y. (1999). Effect of Coriolus versicolor polysaccharopeptide on production of IL-6 from human peripheral blood lymphocytes. Advanced Research in PSP, Hong Kong Association for Health Care."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Saakre, M., Mathew, D., and Ravisankar, V. (2021). Perspectives on plant flavonoid quercetin-based drugs for novel SARS-CoV-2. Beni Suef Univ. J. Basic. Appl. Sci., 10.","DOI":"10.1186\/s43088-021-00107-w"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Xu, D., Hu, M.J., Wang, Y.Q., and Cui, Y.L. (2019). Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application. Molecules, 24.","DOI":"10.3390\/molecules24061123"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Li, Y., Yao, J., Han, C., Yang, J., Chaudhry, M.T., Wang, S., Liu, H., and Yin, Y. (2016). Quercetin, Inflammation and Immunity. Nutrients, 8.","DOI":"10.3390\/nu8030167"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Mujwar, S., Sun, L., and Fidan, O. (2022). In silico evaluation of food-derived carotenoids against SARS-CoV-2 drug targets: Crocin is a promising dietary supplement candidate for COVID-19. J. Food Biochem., 46.","DOI":"10.1111\/jfbc.14219"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.arcmed.2021.03.002","article-title":"Probiotics in Prevention and Treatment of COVID-19: Current Perspective and Future Prospects","volume":"52","author":"Kurian","year":"2021","journal-title":"Arch. Med. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3947\/ic.2020.52.4.478","article-title":"Omega 3 Fatty Acids and COVID-19: A Comprehensive Review","volume":"52","author":"Hathaway","year":"2020","journal-title":"Infect. Chemother."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Guti\u00e9rrez, S., Svahn, S.L., and Johansson, M.E. (2019). Effects of Omega-3 Fatty Acids on Immune Cells. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20205028"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Tan, D.X., and Reiter, R.J. (2020). Mechanisms and clinical evidence to support melatonin\u2019s use in severe COVID-19 patients to lower mortality. Life Sci., 294.","DOI":"10.1016\/j.lfs.2022.120368"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.pbiomolbio.2006.02.017","article-title":"Vitamin D in foods and as supplements","volume":"92","year":"2006","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_77","unstructured":"(2022, August 28). Vitamin D\u2014Fact Sheet for Health Professionals, Available online: https:\/\/ods.od.nih.gov\/factsheets\/Vitamind-HealthProfessional\/#h3."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.3390\/nu5072502","article-title":"Vitamin D and immune function","volume":"5","author":"Prietl","year":"2013","journal-title":"Nutrients"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ecl.2010.02.002","article-title":"Vitamin D: Metabolism","volume":"39","author":"Christakos","year":"2010","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1056\/NEJMe1206858","article-title":"Vitamin D\u2014Baseline status and effective dose","volume":"367","author":"Heaney","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/281317a0","article-title":"1 alpha, 25-Dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 in vitro synthesis by human decidua and placenta","volume":"281","author":"Weisman","year":"1979","journal-title":"Nature"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1126\/science.451538","article-title":"Evidence for extra-renal 1 alpha-hydroxylation of 25-hydroxyvitamin D3 in pregnancy","volume":"204","author":"Gray","year":"1979","journal-title":"Science"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.jsbmb.2006.12.091","article-title":"Immune regulation of 1alpha-hydroxylase in murine peritoneal macrophages: Unravelling the IFNgamma pathway","volume":"103","author":"Stoffels","year":"2007","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jsbmb.2004.03.092","article-title":"1alpha-Hydroxylase transactivation by gamma-interferon in murine macrophages requires enhanced C\/EBPbeta expression and activation","volume":"89\u201390","author":"Esteban","year":"2004","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.coph.2010.04.001","article-title":"Vitamin D: Modulator of the immune system","volume":"10","author":"Baeke","year":"2010","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1006\/abbi.1999.1605","article-title":"Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system","volume":"374","author":"Veldman","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1096\/fj.01-0433rev","article-title":"Vitamin D: Its role and uses in immunology","volume":"15","author":"Deluca","year":"2001","journal-title":"FASEB J."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Martens, P.J., Gysemans, C., Verstuyf, A., and Mathieu, A.C. (2020). Vitamin D\u2019s Effect on Immune Function. Nutrients, 12.","DOI":"10.3390\/nu12051248"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"5382","DOI":"10.4049\/jimmunol.170.11.5382","article-title":"Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells","volume":"170","author":"Hewison","year":"2003","journal-title":"J. Immunol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1159\/000107673","article-title":"Contribution of selected vitamins and trace elements to immune function","volume":"51","author":"Wintergerst","year":"2007","journal-title":"Ann. Nutr. Metab."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1359\/JBMR.050908","article-title":"Immune regulation of 25-hydroxyvitamin-D3-1alpha-hydroxylase in human monocytes","volume":"21","author":"Stoffels","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jaut.2017.07.007","article-title":"Modulation of inflammatory and immune responses by vitamin D","volume":"85","author":"Colotta","year":"2017","journal-title":"J. Autoimmun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.4049\/jimmunol.1102412","article-title":"Vitamin D inhibits monocyte\/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1","volume":"188","author":"Zhang","year":"2012","journal-title":"J. Immunol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jsbmb.2014.02.004","article-title":"Regulation of the human cathelicidin antimicrobial peptide gene by 1\u03b1,25-dihydroxyvitamin D3 in primary immune cells","volume":"143","author":"Lowry","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.4049\/jimmunol.179.4.2060","article-title":"Cutting edge: Vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin","volume":"179","author":"Liu","year":"2007","journal-title":"J. Immunol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.4049\/jimmunol.173.5.2909","article-title":"Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression","volume":"173","author":"Wang","year":"2004","journal-title":"J. Immunol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.4049\/jimmunol.1302350","article-title":"1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice","volume":"192","author":"Ferreira","year":"2014","journal-title":"J. Immunol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.humimm.2009.01.016","article-title":"Dendritic cell tolerogenicity: A key mechanism in immunomodulation by vitamin D receptor agonists","volume":"70","author":"Adorini","year":"2009","journal-title":"Hum. Immunol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.2337\/diabetes.51.7.2119","article-title":"Redirection of human autoreactive T-cells Upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D(3)","volume":"51","author":"Bouillon","year":"2002","journal-title":"Diabetes"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jaut.2004.06.004","article-title":"1alpha,25-dihydroxyvitamin D3 or analogue treated dendritic cells modulate human autoreactive T cells via the selective induction of apoptosis","volume":"23","author":"Tysma","year":"2004","journal-title":"J. Autoimmun."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1182\/blood-2005-05-2044","article-title":"Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4+Foxp3+ regulatory T cells by 1,25-dihydroxyvitamin D3","volume":"106","author":"Penna","year":"2005","journal-title":"Blood"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1002\/eji.200839103","article-title":"Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: Differential role for PD-L1","volume":"39","author":"Unger","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S0046-8177(99)90202-2","article-title":"Progression-related expression of beta3 integrin in melanomas and nevi","volume":"30","author":"Elenitsas","year":"1999","journal-title":"Hum. Pathol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/5584_2018_246","article-title":"Immunomodulatory Role of Vitamin D: A Review","volume":"1108","author":"Skrobot","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.it.2008.12.003","article-title":"AMPed up immunity: How antimicrobial peptides have multiple roles in immune defense","volume":"30","author":"Lai","year":"2009","journal-title":"Trends Immunol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1159\/000455969","article-title":"Vitamin D Promotes Pneumococcal Killing and Modulates Inflammatory Responses in Primary Human Neutrophils","volume":"9","author":"Subramanian","year":"2017","journal-title":"J. Innate Immun."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1365-3083.1993.tb03237.x","article-title":"1,25-Dihydroxyvitamin D3 exerts opposing effects to IL-4 on MHC class-II antigen expression, accessory activity, and phagocytosis of human monocytes","volume":"38","author":"Xu","year":"1993","journal-title":"Scand. J. Immunol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1017\/S0954422407742713","article-title":"Vitamin D3 and the immune system: Maintaining the balance in health and disease","volume":"20","author":"Baeke","year":"2007","journal-title":"Nutr. Res. Rev."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1399-5448.2012.00923.x","article-title":"Effects of vitamin D on antigen-specific and non-antigen-specific immune modulation: Relevance for type 1 diabetes","volume":"14","author":"Takiishi","year":"2013","journal-title":"Pediatr. Diabetes"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jsbmb.2010.03.037","article-title":"Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system","volume":"121","author":"Baeke","year":"2010","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/jcb.10580","article-title":"The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells","volume":"89","author":"Mahon","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"5458","DOI":"10.4049\/jimmunol.0803217","article-title":"1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3","volume":"183","author":"Jeffery","year":"2009","journal-title":"J. Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.3390\/nu7043011","article-title":"Vitamin D and 1,25(OH)2D regulation of T cells","volume":"7","author":"Cantorna","year":"2015","journal-title":"Nutrients"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1172\/JCI111465","article-title":"1 alpha,25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells","volume":"74","author":"Lemire","year":"1984","journal-title":"J. Clin. Investig."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1002\/eji.200838216","article-title":"1,25-dihydroxyvitamin D(3) promotes IL-10 production in human B cells","volume":"38","author":"Heine","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/cei.12406","article-title":"Impaired T cell activation and cytokine production by calcitriol-primed human B cells","volume":"178","author":"Drozdenko","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/S0140-6736(01)06580-1","article-title":"Intake of vitamin D and risk of type 1 diabetes: A birth-cohort study","volume":"358","author":"Reunanen","year":"2001","journal-title":"Lancet"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/postgradmedj-2020-139065","article-title":"Short term, high-dose vitamin D supplementation for COVID-19 disease: A randomised, placebo-controlled, study (SHADE study)","volume":"98","author":"Rastogi","year":"2022","journal-title":"Postgrad. Med. J."},{"key":"ref_119","unstructured":"(2022, August 29). Vitamin D and Calcium: Updated Dietary Reference Intakes. Available online: https:\/\/www.canada.ca\/en\/health-canada\/services\/food-nutrition\/healthy-eating\/vitamins-minerals\/vitamin-calcium-updated-dietary-reference-intakes-nutrition.html#shr-pg0."},{"key":"ref_120","unstructured":"(2022, August 29). Vitamin D. Available online: https:\/\/www.canada.ca\/en\/health-canada\/services\/nutrients\/vitamin-d.html."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Grant, W.B., Lahore, H., McDonnell, S.L., Baggerly, C.A., French, C.B., Aliano, J.L., and Bhattoa, H.P. (2020). Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients, 12.","DOI":"10.20944\/preprints202003.0235.v2"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Grant, W.B., Karras, S.N., Bischoff-Ferrari, H.A., Annweiler, C., Boucher, B.J., Juzeniene, A., Garland, C.F., and Holick, M.F. (2016). Do studies reporting \u2018U\u2019-shaped serum 25-hydroxyvitamin D-health outcome relationships reflect adverse effects. Dermatoendocrinology, 8.","DOI":"10.1080\/19381980.2016.1187349"},{"key":"ref_123","first-page":"432","article-title":"Global epidemic of coronavirus- COVID-19: What can we do to minimize risks","volume":"7","author":"Wimalawansa","year":"2020","journal-title":"Eur. J. Biomed. Pharm. Sci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"e13748","DOI":"10.1111\/ijcp.13748","article-title":"Vitamin D and COVID-19: It is time to act","volume":"75","author":"Bleizgys","year":"2021","journal-title":"Int. J. Clin. Pract."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J. Clin Endocrinol. Metab."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Rusi\u0144ska, A., P\u0142udowski, P., Walczak, M., Borszewska-Kornacka, M.K., Bossowski, A., Chlebna-Sok\u00f3\u0142, D., Czech-Kowalska, J., Dobrza\u0144ska, A., Franek, E., and Helwich, E. (2018). Vitamin D Supplementation Guidelines for General Population and Groups at Risk of Vitamin D Deficiency in Poland-Recommendations of the Polish Society of Pediatric Endocrinology and Diabetes and the Expert Panel with Participation of National Specialist Consultants and Representatives of Scientific Societies-2018 Update. Front. Endocrinol., 9.","DOI":"10.3389\/fendo.2018.00246"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s11154-017-9424-1","article-title":"The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention","volume":"18","author":"Holick","year":"2017","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"R27","DOI":"10.1530\/EC-18-0432","article-title":"Vitamin D testing and treatment: A narrative review of current evidence","volume":"8","author":"Pilz","year":"2019","journal-title":"Endocr. Connect."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ando.2020.12.002","article-title":"Non-classical effects of vitamin D: Non-bone effects of vitamin D","volume":"82","author":"Lopez","year":"2021","journal-title":"Ann. Endocrinol."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"American Geriatrics Society Workgroup on Vitamin D Supplementation for Older Adults (2014). Recommendations abstracted from the American Geriatrics Society Consensus Statement on vitamin D for Prevention of Falls and Their Consequences. J. Am. Geriatr. Soc., 62, 147\u2013152.","DOI":"10.1111\/jgs.12631"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2147\/RMHP.S291584","article-title":"Effects of Vitamin D on COVID-19 Infection and Prognosis: A Systematic Review","volume":"14","author":"Yisak","year":"2021","journal-title":"Risk Manag. Healthc. Policy"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jsbmb.2017.01.021","article-title":"Vitamin D supplementation guidelines","volume":"175","author":"Pludowski","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1038\/s41430-020-00706-3","article-title":"Official recommendations for vitamin D through the life stages in developed countries","volume":"74","author":"Kimball","year":"2020","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/s41430-020-0661-0","article-title":"Perspective: Improving vitamin D status in the management of COVID-19","volume":"74","author":"Ebadi","year":"2020","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/s41430-020-0558-y","article-title":"Vitamin D deficiency 2.0: An update on the current status worldwide","volume":"74","author":"Amrein","year":"2020","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Charoenngam, N., and Holick, M.F. (2020). Immunologic Effects of Vitamin D on Human Health and Disease. Nutrients, 12.","DOI":"10.3390\/nu12072097"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1024\/0300-9831\/a000693","article-title":"The coronavirus disease (COVID-19)\u2014A supportive approach with selected micronutrients","volume":"92","author":"Holick","year":"2022","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.eprac.2021.03.006","article-title":"Vitamin D and Its Potential Benefit for the COVID-19 Pandemic","volume":"27","author":"Charoenngam","year":"2021","journal-title":"Endocr. Pract."},{"key":"ref_139","first-page":"328","article-title":"Mushrooms and cancer therapy","volume":"52","author":"Smith","year":"2005","journal-title":"Biologist"},{"key":"ref_140","unstructured":"(2022, August 29). Mushroom Market Size, Share & Trends Analysis Report by Product (Button, Shiitake, Oyster), by Form, by Distribution Channel, By Application (Food, Pharmaceuticals, Cosmetics), By Region, and Segment Forecasts, 2022\u20132030. Available online: https:\/\/www.grandviewresearch.com\/industry-analysis\/mushroom-market."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"681","DOI":"10.2174\/1871520611313050002","article-title":"The use of lentinan for treating gastric cancer","volume":"13","author":"Ina","year":"2013","journal-title":"Anticancer Agents Med. Chem."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.mycres.2007.02.011","article-title":"Medicinal importance of fungal beta-(1-->3), (1-->6)-glucans","volume":"111","author":"Chen","year":"2007","journal-title":"Mycol. Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1074-7613(03)00233-4","article-title":"Fungal beta-glucans and mammalian immunity","volume":"19","author":"Brown","year":"2003","journal-title":"Immunity"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1074\/jbc.M209715200","article-title":"Pneumocystis carinii cell wall beta-glucan induces release of macrophage inflammatory protein-2 from alveolar epithelial cells via a lactosylceramide-mediated mechanism","volume":"278","author":"Hahn","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1165\/rcmb.2004-0300OC","article-title":"Pneumocystis cell wall beta-glucans stimulate alveolar epithelial cell chemokine generation through nuclear factor-kappaB-dependent mechanisms","volume":"32","author":"Evans","year":"2005","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0162-3109(98)00059-9","article-title":"PGG-glucan, a soluble beta-(1,3)-glucan, enhances the oxidative burst response, microbicidal activity, and activates an NF-kappa B-like factor in human PMN: Evidence for a glycosphingolipid beta-(1,3)-glucan receptor","volume":"41","author":"Wakshull","year":"1999","journal-title":"Immunopharmacology"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1128\/CMR.13.4.523","article-title":"Polysaccharide immunomodulators as therapeutic agents: Structural aspects and biologic function","volume":"13","author":"Tzianabos","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1016\/j.lfs.2005.10.011","article-title":"Polysaccharide peptides from COV-1 strain of Coriolus versicolor induce hyperalgesia via inflammatory mediator release in the mouse","volume":"78","author":"Chan","year":"2006","journal-title":"Life Sci."},{"key":"ref_149","unstructured":"Yang, Q.-Y. (1999). Advances in immunomodulating studies of PSP. Advanced Research in PSP, Hong Kong Association for Health Care Ltd."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0192-0561(83)90069-3","article-title":"The effect of PS-K, a protein bound polysaccharide, on immune responses against allogeneic antigens","volume":"5","author":"Ehrke","year":"1983","journal-title":"Int. J. Immunopharmacol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0305-7372(84)90005-7","article-title":"Krestin (PSK)","volume":"11","author":"Tsukagoshi","year":"1984","journal-title":"Cancer Treat. Rev."},{"key":"ref_152","first-page":"140","article-title":"Antitumor effects of a refined polysaccharide peptide fraction isolated from Coriolus versicolor: In vitro and in vivo studies","volume":"92","author":"Dong","year":"1996","journal-title":"Res. Commun. Mol. Pathol. Pharmacol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"PL135","DOI":"10.1016\/S0024-3205(96)00695-9","article-title":"In vitro inhibition of proliferation of HL-60 cells by tetrandrine and coriolus versicolor peptide derived from Chinese medicinal herbs","volume":"60","author":"Dong","year":"1997","journal-title":"Life Sci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/(SICI)1097-0215(19970127)70:3<362::AID-IJC19>3.0.CO;2-H","article-title":"Oral administration of PSK can improve the impaired anti-tumor CD4+ T-cell response in gut-associated lymphoid tissue (GALT) of specific-pathogen-free mice","volume":"70","author":"Harada","year":"1997","journal-title":"Int. J. Cancer"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/BF01517346","article-title":"Induction of gene expression for immunomodulating cytokines in peripheral blood mononuclear cells in response to orally administered PSK, an immunomodulating protein-bound polysaccharide","volume":"40","author":"Kato","year":"1995","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/0024-3205(96)00163-4","article-title":"Induction in the mouse of gene expression of immunomodulating cytokines by mushroom polysaccharide-protein complexes","volume":"58","author":"Liu","year":"1996","journal-title":"Life Sci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/jns.2016.41","article-title":"Flavonoids: An overview","volume":"5","author":"Panche","year":"2016","journal-title":"J. Nutr. Sci."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jfca.2014.12.015","article-title":"Determination of antioxidant activity, rutin, quercetin, phenolic acids and trace elements in tea infusions: Influence of citric acid addition on extraction of metals","volume":"40","author":"Krawczyk","year":"2015","journal-title":"J. Food Compost. Anal."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.foodchem.2014.02.080","article-title":"Determination of polyphenolic compounds of red wines by UV-VIS-NIR spectroscopy and chemometrics tools","volume":"158","year":"2014","journal-title":"Food Chem."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Mlcek, J., Jurikova, T., Skrovankova, S., and Sochor, J. (2016). Quercetin and Its Anti-Allergic Immune Response. Molecules, 21.","DOI":"10.3390\/molecules21050623"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Dabeek, W.M., and Marra, M.V. (2019). Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans. Nutrients, 11.","DOI":"10.3390\/nu11102288"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jpha.2021.09.009","article-title":"Antiviral, immunomodulatory, and anticoagulant effects of quercetin and its derivatives: Potential role in prevention and management of COVID-19","volume":"12","author":"Manjunath","year":"2022","journal-title":"J. Pharm. Anal."},{"key":"ref_163","first-page":"1067","article-title":"Evidence for antiradical and antioxidant properties of four biologically active N,N-diethylaminoethyl ethers of flavanone oximes: A comparison with natural polyphenolic flavonoid (rutin) action","volume":"41","author":"Metodiewa","year":"1997","journal-title":"Biochem. Mol. Biol. Int."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1021\/np50056a030","article-title":"Inhibition of cow\u2019s milk xanthine oxidase by flavonoids","volume":"51","author":"Hayashi","year":"1988","journal-title":"J. Nat. Prod."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S1097-2765(05)00089-4","article-title":"Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine","volume":"6","author":"Walker","year":"2000","journal-title":"Mol. Cell"},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Shakoor, H., Feehan, J., Apostolopoulos, V., Platat, C., Al Dhaheri, A.S., Ali, H.I., Ismail, L.C., Bosevski, M., and Stojanovska, L. (2021). Immunomodulatory Effects of Dietary Polyphenols. Nutrients, 13.","DOI":"10.3390\/nu13030728"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Al-Khayri, J.M., Sahana, G.R., Nagella, P., Joseph, B.V., Alessa, F.M., and Al-Mssallem, M.Q. (2022). Flavonoids as Potential Anti-Inflammatory Molecules: A Review. Molecules, 27.","DOI":"10.3390\/molecules27092901"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1017\/S002966511000162X","article-title":"Flavonoids as anti-inflammatory agents","volume":"69","author":"Serafini","year":"2010","journal-title":"Proc. Nutr. Soc."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0952-3278(98)90125-9","article-title":"Effects of naturally-occurring flavonoids and biflavonoids on epidermal cyclooxygenase and lipoxygenase from guinea-pigs","volume":"58","author":"Kim","year":"1998","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"5815","DOI":"10.1021\/jf903698s","article-title":"Protective effect of quercetin against arsenite-induced COX-2 expression by targeting PI3K in rat liver epithelial cells","volume":"58","author":"Lee","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/jcp.20852","article-title":"Silibinin polarizes Th1\/Th2 immune responses through the inhibition of immunostimulatory function of dendritic cells","volume":"210","author":"Lee","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"6815","DOI":"10.4049\/jimmunol.0903991","article-title":"Immunosuppressive effect of quercetin on dendritic cell activation and function","volume":"184","author":"Huang","year":"2010","journal-title":"J. Immunol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1124\/mol.106.024547","article-title":"Apigenin inhibits immunostimulatory function of dendritic cells: Implication of immunotherapeutic adjuvant","volume":"70","author":"Yoon","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.abb.2014.06.006","article-title":"Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols","volume":"559","author":"Gupta","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2174\/187152810793358741","article-title":"The role of quercetin, flavonols and flavones in modulating inflammatory cell function","volume":"9","author":"Chirumbolo","year":"2010","journal-title":"Inflamm. Allergy Drug Targets"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/bph.12138","article-title":"Twenty-first century mast cell stabilizers","volume":"170","author":"Finn","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"ref_177","first-page":"448","article-title":"Natural treatment of perennial allergic rhinitis","volume":"5","author":"Thornhill","year":"2000","journal-title":"Altern. Med. Rev."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/sj.bjp.0706246","article-title":"Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells","volume":"145","author":"Kempuraj","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Weng, Z., Zhang, B., Asadi, S., Sismanopoulos, N., Butcher, A., Fu, X., Katsarou-Katsari, A., Antoniou, C., and Theoharides, T.C. (2012). Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0033805"},{"key":"ref_180","first-page":"139","article-title":"Quercetin as a potential anti-allergic drug: Which perspectives?","volume":"10","author":"Chirumbolo","year":"2011","journal-title":"Iran. J. Allergy Asthma Immunol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.biopha.2017.02.081","article-title":"Kaempferol ameliorates H9N2 swine influenza virus-induced acute lung injury by inactivation of TLR4\/MyD88-mediated NF-\u03baB and MAPK signaling pathways","volume":"89","author":"Zhang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s10753-014-0011-2","article-title":"Protective effect of kaempferol on LPS plus ATP-induced inflammatory response in cardiac fibroblasts","volume":"38","author":"Tang","year":"2015","journal-title":"Inflammation"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.fct.2014.07.038","article-title":"The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: Involvement of the Nrf2-ARE signaling pathway","volume":"72","author":"Saw","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cbi.2017.07.010","article-title":"Kaempferol impedes IL-32-induced monocyte-macrophage differentiation","volume":"274","author":"Nam","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.imbio.2011.05.002","article-title":"Kaempferol from Semen cuscutae attenuates the immune function of dendritic cells","volume":"216","author":"Lin","year":"2011","journal-title":"Immunobiology"},{"key":"ref_186","first-page":"1","article-title":"Anti-inflammatory effects of flavonoids: Genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages","volume":"2007","author":"Nieminen","year":"2007","journal-title":"Mediators Inflamm."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"265","DOI":"10.5483\/BMBRep.2009.42.5.265","article-title":"Inhibitory effects of flavonoids on TNF-alpha-induced IL-8 gene expression in HEK 293 cells","volume":"42","author":"Lee","year":"2009","journal-title":"BMB Rep."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00011-010-0196-2","article-title":"Quercetin and kaempferol suppress immunoglobulin E-mediated allergic inflammation in RBL-2H3 and Caco-2 cells","volume":"59","author":"Lee","year":"2010","journal-title":"Inflamm. Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/iub.94","article-title":"Kaempferol: A new immunosuppressant of calcineurin","volume":"60","author":"Wang","year":"2008","journal-title":"IUBMB Life"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0014-5793(01)02393-6","article-title":"Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-gamma by flavonoids in mouse macrophages","volume":"496","author":"Liang","year":"2001","journal-title":"FEBS Lett."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1089\/107555303321223035","article-title":"Safety and anti-inflammatory activity of curcumin: A component of tumeric (Curcuma longa)","volume":"9","year":"2003","journal-title":"J. Altern. Complement. Med."},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Shindikar, A., Singh, A., Nobre, M., and Kirolikar, S. (2016). Curcumin and Resveratrol as Promising Natural Remedies with Nanomedicine Approach for the Effective Treatment of Triple Negative Breast Cancer. J. Oncol., 2016.","DOI":"10.1155\/2016\/9750785"},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Salehi, B., Mishra, A.P., Nigam, M., Sener, B., Kilic, M., Sharifi-Rad, M., Fokou, P., Martins, N., and Sharifi-Rad, J. (2018). Resveratrol: A Double-Edged Sword in Health Benefits. Biomedicines, 6.","DOI":"10.3390\/biomedicines6030091"},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Zhou, X., Afzal, S., Zheng, Y.F., M\u00fcnch, G., and Li, C.G. (2021). Synergistic Protective Effect of Curcumin and Resveratrol against Oxidative Stress in Endothelial EAhy926 Cells. Evid. Based Complement. Alternat. Med., 2021.","DOI":"10.1155\/2021\/2661025"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Mazzanti, G., and Di Giacomo, S. (2016). Curcumin and Resveratrol in the Management of Cognitive Disorders: What is the Clinical Evidence?. Molecules, 21.","DOI":"10.3390\/molecules21091243"},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Teng, S., Joseph, M.J., Yu, H., Hu, C., Li, X., and Hu, C. (2022). A narrative review of the protective effects of curcumin in treating ischemia-reperfusion injury. Ann. Transl. Med., 10.","DOI":"10.21037\/atm-22-3178"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"9262","DOI":"10.3748\/wjg.v21.i31.9262","article-title":"Role of phytochemicals in colorectal cancer prevention","volume":"21","author":"Li","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-2249.2006.03257.x","article-title":"Resveratrol and curcumin suppress immune response through CD28\/CTLA-4 and CD80 co-stimulatory pathway","volume":"147","author":"Sharma","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/jn\/nxx072","article-title":"Supplementation with Resveratrol and Curcumin Does Not Affect the Inflammatory Response to a High-Fat Meal in Older Adults with Abdominal Obesity: A Randomized, Placebo-Controlled Crossover Trial","volume":"148","author":"Vors","year":"2018","journal-title":"J. Nutr."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Csaki, C., Mobasheri, A., and Shakibaei, M. (2009). Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: Inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis. Arthritis Res. Ther., 11.","DOI":"10.1186\/ar2850"},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Karimi, K., Sarir, H., Mortaz, E., Smit, J.J., Hosseini, H., De Kimpe, S.J., Nijkamp, F.P., and Folkerts, G. (2006). Toll-like receptor-4 mediates cigarette smoke-induced cytokine production by human macrophages. Respir. Res., 7.","DOI":"10.1186\/1465-9921-7-66"},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Bereswill, S., Mu\u00f1oz, M., Fischer, A., Plickert, R., Haag, L.M., Otto, B., K\u00fchl, A.A., Loddenkemper, C., G\u00f6bel, U.B., and Heimesaat, M.M. (2010). Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0015099"},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Gan, Z., Wei, W., Li, Y., Wu, J., Zhao, Y., Zhang, L., Wang, T., and Zhong, X. (2019). Curcumin and Resveratrol Regulate Intestinal Bacteria and Alleviate Intestinal Inflammation in Weaned Piglets. 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