{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:32:28Z","timestamp":1793039548453,"version":"4.5.0"},"reference-count":20,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Clermont-Ferrand University Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Systematic iron supplementation may be harmful in pregnant women with non-depleted iron. Our objectives were to estimate the prevalence of anemia at the third trimester of pregnancy (T3) and to identify the parameters at the first trimester (T1), which best predict anemia at T3. Methods: This prospective cohort study in France included pregnant women at T1 without non-iron deficiency anemia. Clinical and social characteristics, health-related quality of life, blood count, and a frozen blood sample were collected at T1 and\/or T3. Secondly, a matched nested case\u2013control study was built for women with anemia at T3 but not at T1. Multivariate analyses and ROC curves were used to identify the best predictive parameter(s) of anemia at T3. Results: The prevalence of anemia at T3 in the cohort (629 women) was 21.9% (95% CI 18.7\u201325.2%). In the matched nested case\u2013control study (256 women), hemoglobin (Hb), serum ferritin (SF) and the SF\/soluble transferrin receptor ratio at T1 were predictive of anemia at T3 (p &lt; 0.001); however, clinical and social characteristics, as serum hepcidin were not. In multivariate analyses, Hb at T1 was the best predictive biomarker of anemia at T3 with a cut-off value of 120 g\/L (specificity 87.5%). Conclusions: The prevalence of anemia at the end of pregnancy remained high in a High-Income Country. Clinical, social, and biochemical parameters did not seem useful to predict anemia at T3 and could not guide iron supplementation. We suggest systematically performing a simple blood count in the first trimester of pregnancy and offering oral iron supplementation for women with Hb &lt; 120 g\/L.<\/jats:p>","DOI":"10.3390\/nu14194091","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T01:21:07Z","timestamp":1665364867000},"page":"4091","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prediction of Iron Deficiency Anemia in Third Trimester of Pregnancy Based on Data in the First Trimester: A Prospective Cohort Study in a High-Income Country"],"prefix":"10.3390","volume":"14","author":[{"given":"Anne-Sophie","family":"Resseguier","sequence":"first","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne, CHU Clermont-Ferrand, CNRS, Institut Pascal, F-63000 Clermont-Ferrand, France"},{"name":"Internal Medicine Department, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0782-2889","authenticated-orcid":false,"given":"Candy","family":"Guiguet-Auclair","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne, CHU Clermont-Ferrand, CNRS, Institut Pascal, F-63000 Clermont-Ferrand, France"},{"name":"Public Health Department, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Debost-Legrand","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne, CHU Clermont-Ferrand, CNRS, Institut Pascal, F-63000 Clermont-Ferrand, France"},{"name":"R\u00e9seau de Sant\u00e9 P\u00e9rinatale d\u2019Auvergne, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Fran\u00e7oise","family":"Serre-Sapin","sequence":"additional","affiliation":[{"name":"Hematology Department, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Gerbaud","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne, CHU Clermont-Ferrand, CNRS, Institut Pascal, F-63000 Clermont-Ferrand, France"},{"name":"Public Health Department, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7183-7607","authenticated-orcid":false,"given":"Fran\u00e7oise","family":"Vendittelli","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne, CHU Clermont-Ferrand, CNRS, Institut Pascal, F-63000 Clermont-Ferrand, France"},{"name":"R\u00e9seau de Sant\u00e9 P\u00e9rinatale d\u2019Auvergne, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Ruivard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne, CHU Clermont-Ferrand, CNRS, Institut Pascal, F-63000 Clermont-Ferrand, France"},{"name":"Internal Medicine Department, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/bjh.16221","article-title":"UK guidelines on the management of iron deficiency in pregnancy","volume":"188","author":"Pavord","year":"2020","journal-title":"Br. J. Haematol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.ajog.2020.03.006","article-title":"Iron deficiency in pregnancy","volume":"223","author":"Georgieff","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1016\/S2214-109X(13)70001-9","article-title":"Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non- pregnant women for 1995\u20132011: A systematic analysis of population-representative data","volume":"1","author":"Stevens","year":"2013","journal-title":"Lancet Glob. Health"},{"key":"ref_4","first-page":"CD004736","article-title":"Daily oral iron supplementation during pregnancy","volume":"22","author":"Dowswell","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/nyas.14093","article-title":"Maternal hemoglobin concentrations across pregnancy and maternal and child health: A systematic review and meta-analysis","volume":"1450","author":"Young","year":"2019","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_6","first-page":"485","article-title":"Iron-Deficiency Anemia","volume":"373","author":"Camaschella","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1567S","DOI":"10.3945\/ajcn.117.155812","article-title":"Iron homeostasis during pregnancy","volume":"106","author":"Fisher","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0140-6736(15)60865-0","article-title":"Iron deficiency anaemia","volume":"387","author":"Lopez","year":"2016","journal-title":"Lancet"},{"key":"ref_9","unstructured":"(2022, September 15). Haute Autorit\u00e9 de Sant\u00e9\u2014Suivi et Orientation des Femmes Enceintes en Fonction des Situations \u00e0 Risque Identifi\u00e9es. Available online: https:\/\/www.has-sante.fr\/upload\/docs\/application\/pdf\/suivi_des_femmes_enceintes_-_recommandations_23-04-2008.pdf."},{"key":"ref_10","unstructured":"Lecorguill\u00e9, M., Camier, A., and Kadawathagedara, M. (2022, September 15). Recommandations Pour la Pratique Clinique: \u201cInterventions Pendant la P\u00e9riode P\u00e9rinatale\u201d. Chapitre 3: Variations de Poids, Apports Nutritionnels Essentiels et Contaminants, Suppl\u00e9mentation Chez les Femmes Enceintes et les Femmes en \u00c2ge de Procr\u00e9er. [Rapport de Recherche] Coll\u00e8ge National des Sages-Femmes de France. Available online: https:\/\/hal.uca.fr\/hal-03283264\/document."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0895-4356(98)00093-6","article-title":"The French SF-36 Health Survey: Translation, cultural adaptation and preliminary psychometric evaluation","volume":"51","author":"Ecosse","year":"1998","journal-title":"J. Clin. Epidemiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/eurpub\/cku231","article-title":"A new reliable index to measure individual deprivation: The EPICES score","volume":"25","author":"Labbe","year":"2015","journal-title":"Eur. J. Public Health"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/07315724.2008.10719709","article-title":"Prevalence of Iron Deficiency and Health-related Quality of Life among Female Students","volume":"27","author":"Grondin","year":"2008","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Noshiro, K., Umazume, T., Hattori, R., Kataoka, S., Yamada, T., and Watari, H. (2022). Hemoglobin Concentration during Early Pregnancy as an Accurate Predictor of Anemia during Late Pregnancy. Nutrients, 14.","DOI":"10.3390\/nu14040839"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Mayasari, N.R., Bai, C.H., Hu, T.Y., Chao, J.C.J., Chen, Y.C., Huang, Y.L., Wang, F.F., Tinkov, A.A., Skalny, A.V., and Chang, J.S. (2021). Associations of Food and Nutrient Intake with Serum Hepcidin and the Risk of Gestational Iron-Deficiency Anemia among Pregnant Women: A Population-Based Study. Nutrients, 13.","DOI":"10.3390\/nu13103501"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/sj.ejcn.1600561","article-title":"Determining factors in the iron status of adult women in the SU.VI.MAX study. SUpplementation en VItamines et Min\u00e9raux AntioXydants","volume":"52","author":"Galan","year":"1998","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1655S","DOI":"10.3945\/ajcn.117.156000","article-title":"Iron status in pregnant women and women of reproductive age in Europe","volume":"106","author":"Milman","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1182\/blood-2019-127602","article-title":"Prevalence of iron deficiency and iron deficiency anemia during pregnancy: A single centre Canadian study","volume":"134","author":"Tang","year":"2019","journal-title":"Blood"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Oh, C., Keats, E.C., and Bhutta, Z.A. (2020). Vitamin and Mineral Supplementation During Pregnancy on Maternal, Birth, Child Health and Development Outcomes in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis. Nutrients, 12.","DOI":"10.3390\/nu12020491"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1182\/blood-2016-08-672246","article-title":"How I treat anemia in pregnancy: Iron, cobalamin, and folate","volume":"129","author":"Achebe","year":"2017","journal-title":"Blood"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/19\/4091\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:45:23Z","timestamp":1760143523000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/19\/4091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,1]]},"references-count":20,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["nu14194091"],"URL":"https:\/\/doi.org\/10.3390\/nu14194091","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,1]]}}}