{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:10:41Z","timestamp":1787508641009,"version":"build-2736575974"},"reference-count":55,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82170451"],"award-info":[{"award-number":["82170451"]}]},{"name":"National Natural Science Foundation of China","award":["81500313"],"award-info":[{"award-number":["81500313"]}]},{"name":"National Natural Science Foundation of China","award":["82070440"],"award-info":[{"award-number":["82070440"]}]},{"name":"National Natural Science Foundation of China","award":["82070439"],"award-info":[{"award-number":["82070439"]}]},{"name":"National Natural Science Foundation of China","award":["2020A02"],"award-info":[{"award-number":["2020A02"]}]},{"name":"Research Program of Xi\u2019an Children\u2019s Hospital","award":["82170451"],"award-info":[{"award-number":["82170451"]}]},{"name":"Research Program of Xi\u2019an Children\u2019s Hospital","award":["81500313"],"award-info":[{"award-number":["81500313"]}]},{"name":"Research Program of Xi\u2019an Children\u2019s Hospital","award":["82070440"],"award-info":[{"award-number":["82070440"]}]},{"name":"Research Program of Xi\u2019an Children\u2019s Hospital","award":["82070439"],"award-info":[{"award-number":["82070439"]}]},{"name":"Research Program of Xi\u2019an Children\u2019s Hospital","award":["2020A02"],"award-info":[{"award-number":["2020A02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: The hypothalamic paraventricular nucleus (PVN) is an important nucleus in the brain that plays a key role in regulating sympathetic nerve activity (SNA) and blood pressure. Silent mating-type information regulation 2 homolog-1 (sirtuin1, SIRT1) not only protects cardiovascular function but also reduces inflammation and oxidative stress in the periphery. However, its role in the central regulation of hypertension remains unknown. It is hypothesized that SIRT1 activation by resveratrol may reduce SNA and lower blood pressure through the regulation of intracellular reactive oxygen species (ROS) and neurotransmitters in the PVN. Methods: The two-kidney one-clip (2K1C) method was used to induce renovascular hypertension in male Sprague-Dawley rats. Then, bilaterally injections of vehicle (artificial cerebrospinal fluid, aCSF, 0.4 \u03bcL) or resveratrol (a SIRT1 agonist, 160 \u03bcmol\/L, 0.4 \u03bcL) into rat PVN were performed for four weeks. Results: PVN SIRT1 expression was lower in the hypertension group than the sham surgery (SHAM) group. Activated SIRT1 within the PVN lowered systolic blood pressure and plasma norepinephrine (NE) levels. It was found that PVN of 2K1C animals injected with resveratrol exhibited increased expression of SIRT1, copper-zinc superoxide dismutase (SOD1), and glutamic acid decarboxylase (GAD67), as well as decreased activity of nuclear factor-kappa B (NF-\u03baB) p65 and NAD(P)H oxidase (NOX), particularly NOX4. Treatment with resveratrol also decreased expression of ROS and tyrosine hydroxylase (TH). Conclusion: Resveratrol within the PVN attenuates hypertension via the SIRT1\/NF-\u03baB pathway to decrease ROS and restore the balance of excitatory and inhibitory neurotransmitters.<\/jats:p>","DOI":"10.3390\/nu14194177","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T01:21:07Z","timestamp":1665364867000},"page":"4177","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Resveratrol in the Hypothalamic Paraventricular Nucleus Attenuates Hypertension by Regulation of ROS and Neurotransmitters"],"prefix":"10.3390","volume":"14","author":[{"given":"Jie","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"},{"name":"Institute of Cardiovascular Sciences, Translational Medicine Institute, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases, Xi\u2019an Jiaotong University, Ministry of Education, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Yan","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"},{"name":"Institute of Cardiovascular Sciences, Translational Medicine Institute, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases, Xi\u2019an Jiaotong University, Ministry of Education, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"},{"name":"Institute of Cardiovascular Sciences, Translational Medicine Institute, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases, Xi\u2019an Jiaotong University, Ministry of Education, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Juan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Second Affiliated Hospital, Air Force Military Medical University, Xi\u2019an 710038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-An","family":"Qiao","sequence":"additional","affiliation":[{"name":"Institute of Pediatric Diseases, Xi\u2019an Children\u2019s Hospital, Xi\u2019an 710002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"},{"name":"Institute of Cardiovascular Sciences, Translational Medicine Institute, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases, Xi\u2019an Jiaotong University, Ministry of Education, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yue","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"},{"name":"Institute of Cardiovascular Sciences, Translational Medicine Institute, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases, Xi\u2019an Jiaotong University, Ministry of Education, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"},{"name":"Institute of Cardiovascular Sciences, Translational Medicine Institute, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases, Xi\u2019an Jiaotong University, Ministry of Education, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Peng","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"},{"name":"Institute of Cardiovascular Sciences, Translational Medicine Institute, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases, Xi\u2019an Jiaotong University, Ministry of Education, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Yue","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"},{"name":"Institute of Cardiovascular Sciences, Translational Medicine Institute, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases, Xi\u2019an Jiaotong 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