{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:13:57Z","timestamp":1790799237896,"version":"4.1.0"},"reference-count":117,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004166","name":"Cardiology Clinic of Physiotherapy Division from the Second Faculty of Medicine, Medical University of Warsaw, Poland","doi-asserted-by":"publisher","award":["2F5\/PM2\/16"],"award-info":[{"award-number":["2F5\/PM2\/16"]}],"id":[{"id":"10.13039\/501100004166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Lazarski University in Warsaw","award":["2F5\/PM2\/16"],"award-info":[{"award-number":["2F5\/PM2\/16"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The incidence of ischemic heart disease (IHD) increases every year. This cardiovascular disease has an inflammatory factor in its etiology due to different immune cells that influence atherogenesis. New inflammatory biomarkers\u2014the Systemic Inflammatory Index (SII) and the Systemic Inflammatory Response (SIRI)\u2014attempt to describe the pro- and anti-inflammatory balance and quantify the complex impact of the immune system on atherosclerosis, while vitamin D has a multidirectional impact on the human body, including the cardiovascular and immune systems. Hence, the objective of this research was to analyze the association between SII and SIRI and serum vitamin D concentrations in patients with IHD. A significant correlation was observed between SIRI and 25(OH)D in the whole group and between both biomarkers (SII and SIRI) and 25(OH)D in the group of patients with ACS but not in the group of patients with stable IHD. The role of vitamin D in IHD complications and its association with new inflammatory biomarkers requires further well-designed, large-scale research.<\/jats:p>","DOI":"10.3390\/nu14194212","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:50:01Z","timestamp":1665449401000},"page":"4212","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["The Association between Serum Vitamin D Concentration and New Inflammatory Biomarkers\u2014Systemic Inflammatory Index (SII) and Systemic Inflammatory Response (SIRI)\u2014In Patients with Ischemic Heart Disease"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9912-3240","authenticated-orcid":false,"given":"Ewelina A.","family":"Dziedzic","sequence":"first","affiliation":[{"name":"Medical Faculty, Lazarski University in Warsaw, 02-662 Warsaw, Poland"},{"name":"Department of Internal Medicine and Geriatric Cardiology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2009-2200","authenticated-orcid":false,"given":"Jakub S.","family":"G\u0105sior","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7476-7023","authenticated-orcid":false,"given":"Agnieszka","family":"Tuzimek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Geriatric Cardiology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1692-8578","authenticated-orcid":false,"given":"Marek","family":"D\u0105browski","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bielanski Hospital, 01-809 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6223-8821","authenticated-orcid":false,"given":"Piotr","family":"Jankowski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Geriatric Cardiology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland"},{"name":"Department of Epidemiology and Health Promotion, School of Public Health, Center of Postgraduate Medical Education, 01-826 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022, September 16). 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