{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:22:10Z","timestamp":1788546130117,"version":"build-2803163510"},"reference-count":30,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T00:00:00Z","timestamp":1665792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of the Environment, Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The influence of family allergic history on food allergy in offspring in Japan is unknown. We analyzed data from a nationwide birth cohort study using logistic regression models to examine the associations of maternal, paternal, and both parental histories of allergic diseases (food allergy, atopic dermatitis, asthma, and rhinitis) with their child\u2019s food allergy at 1.5 and 3 years of age. This analysis included 69,379 singleton full-term mothers and 37,179 fathers and their children. All parental histories of allergic diseases showed significant positive associations with their child\u2019s food allergy. When both parents had a history of allergic diseases, the adjusted odds ratio (aOR) tended to be higher than when either parent had allergic diseases (p for trend &lt; 0.0001). The highest aOR was detected when both parents had food allergy (2.60; 95% confidential interval, 1.58\u20134.27), and the aOR was 1.71 when either parent had food allergy (95% confidential interval, 1.54\u20131.91). The aORs were attenuated but still had significant positive associations after adjusting for the child\u2019s atopic dermatitis, a risk factor for allergy development. In conclusion, all parental allergic diseases were significantly positively associated with their child\u2019s food allergy. The effect of family history showed a stepwise increase in risk from either parent to both parents, and the highest risk of allergic disease was a parental history of food allergy.<\/jats:p>","DOI":"10.3390\/nu14204323","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T03:43:58Z","timestamp":1665978238000},"page":"4323","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["How a Family History of Allergic Diseases Influences Food Allergy in Children: The Japan Environment and Children\u2019s Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8845-7034","authenticated-orcid":false,"given":"Mayako","family":"Saito-Abe","sequence":"first","affiliation":[{"name":"Medical Support Center for the Japan Environment and Children\u2019s Study, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1288-9620","authenticated-orcid":false,"given":"Kiwako","family":"Yamamoto-Hanada","sequence":"additional","affiliation":[{"name":"Medical Support Center for the Japan Environment and Children\u2019s Study, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyongsun","family":"Pak","sequence":"additional","affiliation":[{"name":"Department of Data Science, Clinical Research Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9266-7811","authenticated-orcid":false,"given":"Shintaro","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Department of Data Science, Clinical Research Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miori","family":"Sato","sequence":"additional","affiliation":[{"name":"Medical Support Center for the Japan Environment and Children\u2019s Study, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Miyaji","sequence":"additional","affiliation":[{"name":"Medical Support Center for the Japan Environment and Children\u2019s Study, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5151-164X","authenticated-orcid":false,"given":"Hidetoshi","family":"Mezawa","sequence":"additional","affiliation":[{"name":"Medical Support Center for the Japan Environment and Children\u2019s Study, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1248-2807","authenticated-orcid":false,"given":"Minaho","family":"Nishizato","sequence":"additional","affiliation":[{"name":"Medical Support Center for the Japan Environment and Children\u2019s Study, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3936-6371","authenticated-orcid":false,"given":"Limin","family":"Yang","sequence":"additional","affiliation":[{"name":"Medical Support Center for the Japan Environment and Children\u2019s Study, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuhiko","family":"Kumasaka","sequence":"additional","affiliation":[{"name":"Medical Support Center for the Japan Environment and Children\u2019s Study, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Data Science, Clinical Research Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1560-3942","authenticated-orcid":false,"given":"Yukihiro","family":"Ohya","sequence":"additional","affiliation":[{"name":"Medical Support Center for the Japan Environment and Children\u2019s Study, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Japan Environment and Children\u2019s Study (JECS) 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