{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:47:17Z","timestamp":1792806437537,"version":"4.5.0"},"reference-count":188,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Universities with European Union\u2019s NextGeneration EU funds","award":["AGL 2.013-48.244-R"],"award-info":[{"award-number":["AGL 2.013-48.244-R"]}],"id":[{"id":"https:\/\/ror.org\/03zcny908","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Spanish Ministry of Universities with European Union\u2019s NextGeneration EU funds","award":["IN607D 2017\/01"],"award-info":[{"award-number":["IN607D 2017\/01"]}],"id":[{"id":"https:\/\/ror.org\/03zcny908","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Xunta de Galicia and the European Union (European Social Fund\u2013ESF)","award":["AGL 2.013-48.244-R"],"award-info":[{"award-number":["AGL 2.013-48.244-R"]}],"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Xunta de Galicia and the European Union (European Social Fund\u2013ESF)","award":["IN607D 2017\/01"],"award-info":[{"award-number":["IN607D 2017\/01"]}],"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Spanish Ministry of Economy and Competitivity Project","award":["AGL 2.013-48.244-R"],"award-info":[{"award-number":["AGL 2.013-48.244-R"]}]},{"name":"Spanish Ministry of Economy and Competitivity Project","award":["IN607D 2017\/01"],"award-info":[{"award-number":["IN607D 2017\/01"]}]},{"name":"European Regional Development Fund (ERDF)","award":["AGL 2.013-48.244-R"],"award-info":[{"award-number":["AGL 2.013-48.244-R"]}]},{"name":"European Regional Development Fund (ERDF)","award":["IN607D 2017\/01"],"award-info":[{"award-number":["IN607D 2017\/01"]}]},{"name":"GAIN-Xunta de Galicia Project","award":["AGL 2.013-48.244-R"],"award-info":[{"award-number":["AGL 2.013-48.244-R"]}],"id":[{"id":"https:\/\/ror.org\/0181xnw06","id-type":"ROR","asserted-by":"crossref"}]},{"name":"GAIN-Xunta de Galicia Project","award":["IN607D 2017\/01"],"award-info":[{"award-number":["IN607D 2017\/01"]}],"id":[{"id":"https:\/\/ror.org\/0181xnw06","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the Spanish AEI\/EU-FEDER PID2019-103845RB-C21 project","award":["AGL 2.013-48.244-R"],"award-info":[{"award-number":["AGL 2.013-48.244-R"]}]},{"name":"the Spanish AEI\/EU-FEDER PID2019-103845RB-C21 project","award":["IN607D 2017\/01"],"award-info":[{"award-number":["IN607D 2017\/01"]}]},{"name":"Plan Complementario en Ciencias Marinas (PCCM)","award":["AGL 2.013-48.244-R"],"award-info":[{"award-number":["AGL 2.013-48.244-R"]}]},{"name":"Plan Complementario en Ciencias Marinas (PCCM)","award":["IN607D 2017\/01"],"award-info":[{"award-number":["IN607D 2017\/01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Bioactive peptides are found in foods and dietary supplements and are responsible for health benefits with applications in human and animal medicine. The health benefits include antihypertensive, antimicrobial, antithrombotic, immunomodulatory, opioid, antioxidant, anti-allergic and anti-inflammatory functions. Bioactive peptides can be obtained by microbial action, mainly by the gastrointestinal microbiota from proteins present in food, originating from either vegetable or animal matter or by the action of different gastrointestinal proteases. Proteomics can play an important role in the identification of bioactive peptides. High-resolution mass spectrometry is the principal technique used to detect and identify different types of analytes present in complex mixtures, even when available at low concentrations. Moreover, proteomics may provide the characterization of epitopes to develop new food allergy vaccines and the use of immunomodulating peptides to induce oral tolerance toward offending food allergens or even to prevent allergic sensitization. In addition, food-derived bioactive peptides have been investigated for their anti-inflammatory properties to provide safer alternatives to nonsteroidal anti-inflammatory drugs (NSAIDs). All these bioactive peptides can be a potential source of novel drugs and ingredients in food and pharmaceuticals. The following review is focused on food-derived bioactive peptides with antiallergic and anti-inflammatory properties and summarizes the new insights into the use of proteomics for their identification and quantification.<\/jats:p>","DOI":"10.3390\/nu14204400","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:34:30Z","timestamp":1666312470000},"page":"4400","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Proteomics Characterization of Food-Derived Bioactive Peptides with Anti-Allergic and Anti-Inflammatory Properties"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9214-3273","authenticated-orcid":false,"given":"Ana G.","family":"Abril","sequence":"first","affiliation":[{"name":"Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Santiago de Compostela, 15898 Santiago de Compostela, Spain"},{"name":"Department of Food Technology, Spanish National Research Council (CSIC), Marine Research Institute (IIM), 36208 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Pazos","sequence":"additional","affiliation":[{"name":"Department of Food Technology, Spanish National Research Council (CSIC), Marine Research Institute (IIM), 36208 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9282-6234","authenticated-orcid":false,"given":"Tom\u00e1s G.","family":"Villa","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Santiago de Compostela, 15898 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Calo-Mata","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Nutrition and Food Science, Food Technology Division, School of Veterinary Sciences, University of Santiago de Compostela, Campus Lugo, 27002 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4742-9384","authenticated-orcid":false,"given":"Jorge","family":"Barros-Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Nutrition and Food Science, Food Technology Division, School of Veterinary Sciences, University of Santiago de Compostela, Campus Lugo, 27002 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2973-449X","authenticated-orcid":false,"given":"M\u00f3nica","family":"Carrera","sequence":"additional","affiliation":[{"name":"Department of Food Technology, Spanish National Research Council (CSIC), Marine Research Institute (IIM), 36208 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.idairyj.2005.10.012","article-title":"Bioactive peptides: Production and functionality","volume":"16","author":"Korhonen","year":"2006","journal-title":"Int. Dairy J."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Daliri, E.B.M., Oh, D.H., and Lee, B.H. (2017). Bioactive Peptides. Foods, 6.","DOI":"10.3390\/foods6050032"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Nicoletti, R., and Trincone, A. (2016). Bioactive Compounds Produced by Strains of Penicillium and Talaromyces of Marine Origin. Mar. Drugs, 14.","DOI":"10.3390\/md14020037"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1016\/0031-9422(89)80245-6","article-title":"Bioactive polysaccharides from plants","volume":"28","author":"Srivastava","year":"1989","journal-title":"Phytochemistry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1208\/ps050325","article-title":"Nutraceutical-definition and introduction","volume":"5","author":"Kalra","year":"2013","journal-title":"AAPS PharmSci"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Hasler, C.M. (2005). Regulation of Functional Foods and Nutraceuticals: A Global Perspective, IFT Press.","DOI":"10.1002\/9780470277676"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.24926\/iip.v12i2.3694","article-title":"A Comparison of Current Regulatory Frameworks for Nutraceuticals in Australia, Canada, Japan, and the United States","volume":"12","author":"Blaze","year":"2021","journal-title":"Inov. Pharm."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.2174\/1381612033454883","article-title":"Bioactive Proteins and Peptides from Food Sources. Applications of Bioprocesses used in Isolation and Recovery","volume":"9","author":"Kitts","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.yrtph.2017.01.002","article-title":"Bioactive nutrients-Time for tolerable upper intake levels to address safety","volume":"84","author":"Yates","year":"2017","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Chakrabarti, S., Guha, S., and Majumder, K. (2018). Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities. Nutrients, 10.","DOI":"10.3390\/nu10111738"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.peptides.2014.01.022","article-title":"Functional significance of bioactive peptides derived from soybean","volume":"54","author":"Singh","year":"2014","journal-title":"Peptides"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/fqs\/fyx006","article-title":"Bioactive peptides: A review","volume":"1","year":"2017","journal-title":"Food Qual. Saf."},{"key":"ref_13","first-page":"1614","article-title":"Biofunctional and physicochemical properties of fish scales collagen-derived protein powders","volume":"23","author":"Manikkam","year":"2016","journal-title":"Int. Food Res. J."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Przybylski, R., Bazinet, L., Firdaous, L., Kouach, M., Goossens, J.F., Dhulster, P., and Nedjar-Arroume, N. (2020). Electroseparation of Slaughterhouse By-Product: Antimicrobial Peptide Enrichment by pH Modification. Membranes, 10.","DOI":"10.3390\/membranes10050090"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jprot.2015.06.016","article-title":"Bioactive peptides identified in thornback ray skin\u2019s gelatin hydrolysates by proteases from Bacillus subtilis and Bacillus amyloliquefaciens","volume":"128","author":"Lassoued","year":"2015","journal-title":"J. Proteom."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.foodchem.2016.01.107","article-title":"Influence of heat pre-treatment on BSA tryptic hydrolysis and peptide release","volume":"202","author":"Arrutia","year":"2016","journal-title":"Food Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1541-4337.2005.tb00075.x","article-title":"A New Frontier in Soy Bioactive Peptides that May Prevent Age-related Chronic Diseases","volume":"4","author":"Wang","year":"2005","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jnutbio.2006.02.006","article-title":"Purification and characterization of antioxidant peptide from hoki (Johnius belengerii) frame protein by gastrointestinal digestion","volume":"18","author":"Kim","year":"2007","journal-title":"J. Nutr. Biochem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"765","DOI":"10.3390\/nu3090765","article-title":"Bioactive Peptides from Muscle Sources: Meat and Fish","volume":"3","author":"Ryan","year":"2011","journal-title":"Nutrients"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.bcp.2016.09.018","article-title":"Antimicrobial peptides (AMPs): Ancient compounds that represent novel weapons in the fight against bacteria","volume":"133","author":"Ageitos","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Chakrabarti, S., Jahandideh, F., and Wu, J. (2014). Food-derived bioactive peptides on inflammation and oxidative stress. BioMed Res. Int., 2014.","DOI":"10.1155\/2014\/608979"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e12531","DOI":"10.1111\/jfbc.12531","article-title":"Structural-features of food-derived bioactive peptides with anti-inflammatory activity: A brief review","volume":"43","author":"Guha","year":"2019","journal-title":"J. Food Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"102051","DOI":"10.1016\/j.bcab.2021.102051","article-title":"An Updated review on production of food derived bioactive peptides; focus on the psychrotrophic bacterial proteases","volume":"35","author":"Ahangari","year":"2021","journal-title":"Biocatal. Agric. Biotechnol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Chelliah, R., Wei, S., Daliri, E.B.M., Elahi, F., Yeon, S.J., Tyagi, A., Liu, S., Madar, I.H., Sultan, G., and Oh, D.H. (2021). The Role of Bioactive Peptides in Diabetes and Obesity. Foods, 10.","DOI":"10.3390\/foods10092220"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.tifs.2020.12.019","article-title":"Bioactive peptides and gut microbiota: Candidates for a novel strategy for reduction and control of neurodegenerative diseases","volume":"108","author":"Wu","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Aloo, S.O., and Oh, D.H. (2022). The Functional Interplay between Gut Microbiota, Protein Hydrolysates\/Bioactive Peptides, and Obesity: A Critical Review on the Study Advances. Antioxidants, 11.","DOI":"10.3390\/antiox11020333"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00343-008-0307-x","article-title":"Antiviral active peptide from oyster","volume":"26","author":"Zeng","year":"2008","journal-title":"Chinese J. Oceanol. Limnol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1017\/S0007114500002336","article-title":"Immunoregulatory peptides in bovine milk","volume":"84","author":"Gill","year":"2000","journal-title":"Br. J. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/pmic.201400383","article-title":"Nutriproteomics: Facts, concepts, and perspectives","volume":"15","author":"Sauer","year":"2015","journal-title":"Proteomics"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.euprot.2014.02.014","article-title":"Historical perspective of peptidomics","volume":"3","author":"Schrader","year":"2014","journal-title":"EuPA Open Proteomics"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1007\/s00216-016-9303-8","article-title":"Recent trends in the analysis of bioactive peptides in milk and dairy products","volume":"408","author":"Capriotti","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1074\/mcp.M113.036194","article-title":"Mechanistic peptidomics: Factors that dictate specificity in the formation of endogenous peptides in human milk","volume":"13","author":"Guerrero","year":"2014","journal-title":"Mol. Cell. Proteom."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.tifs.2020.12.002","article-title":"Novel technologies for the production of bioactive peptides","volume":"108","author":"Ulug","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_34","first-page":"1","article-title":"Food allergy","volume":"4","author":"Renz","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.jaci.2008.04.023","article-title":"TH2 adjuvants: Implications for food allergy","volume":"121","author":"Berin","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/978-1-0716-1884-4_36","article-title":"Proteomics for Development of Food Allergy Vaccines","volume":"2410","author":"Carrera","year":"2022","journal-title":"Methods Mol. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Carrera, M., Ezquerra-Brauer, J.M., and Aubourg, S.P. (2019). Characterization of the Jumbo Squid (Dosidicus gigas) Skin By-Product by Shotgun Proteomics and Protein-Based Bioinformatics. Mar. Drugs, 18.","DOI":"10.3390\/md18010031"},{"key":"ref_38","first-page":"1629","article-title":"Immunomodulating peptides for food allergy prevention and treatment","volume":"58","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1021\/jf803372b","article-title":"Immunomodulatory effects of egg white enzymatic hydrolysates containing immunodominant epitopes in a BALB\/c mouse model of egg allergy","volume":"57","author":"Yang","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1398-9995.2011.02724.x","article-title":"Oral immunotherapy with immunodominant T-cell epitope peptides alleviates allergic reactions in a Balb\/c mouse model of egg allergy","volume":"67","author":"Rupa","year":"2012","journal-title":"Allergy"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.foodres.2015.03.011","article-title":"Effects of orally administered immunodominant T-cell epitope peptides on cow\u2019s milk protein allergy in a mouse model","volume":"71","author":"Thang","year":"2015","journal-title":"Food Res. Int."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1080\/09168451.2016.1243984","article-title":"Anti-allergic effects of His-Ala-Gln tripeptide in vitro and in vivo","volume":"81","author":"Tanaka","year":"2017","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.molimm.2007.04.020","article-title":"Anti-allergic properties of a new all-D synthetic immunoglobulin-binding peptide","volume":"45","author":"Rossi","year":"2008","journal-title":"Mol. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ejphar.2007.11.033","article-title":"Inhibitory mechanism of anti-allergic peptides in RBL2H3 cells","volume":"581","author":"Kim","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"ref_45","first-page":"252","article-title":"IgE-Mediated Disorders: Current Therapeutics and New Strategies Involving Synthetic Peptides","volume":"7","author":"Verdoliva","year":"2008","journal-title":"Anti Inflamm. Anti Allergy Agents Med. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/j.ijbiomac.2018.07.096","article-title":"Spirulina maxima peptides suppress mast cell degranulation via inactivating Akt and MAPKs phosphorylation in RBL-2H3 cells","volume":"118","author":"Vo","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1002\/mnfr.201400329","article-title":"The role of peptides derived from Spirulina maxima in downregulation of Fc\u03b5RI-mediated allergic responses","volume":"58","author":"Vo","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/all.12077","article-title":"Anti-allergic action of anti-malarial drug artesunate in experimental mast cell-mediated anaphylactic models","volume":"68","author":"Cheng","year":"2013","journal-title":"Allergy"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3892\/ijmm.2015.2420","article-title":"Anti-allergic effects of a nonameric peptide isolated from the intestine gastrointestinal digests of abalone (Haliotis discus hannai) in activated HMC-1 human mast cells","volume":"37","author":"Ko","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"104084","DOI":"10.1016\/j.jff.2020.104084","article-title":"Purification and identification of anti-allergic peptide from Atlantic Salmon (Salmo salar) byproduct enzymatic hydrolysates","volume":"72","author":"Wang","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1080\/10408398.2019.1650716","article-title":"An overview on marine anti-allergic active substances for alleviating food-induced allergy","volume":"60","author":"Wang","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S1567-5769(01)00025-X","article-title":"Anti-allergy properties of fermented foods: An important immunoregulatory mechanism of lactic acid bacteria?","volume":"1","author":"Cross","year":"2001","journal-title":"Int. Immunopharmacol."},{"key":"ref_53","first-page":"299","article-title":"Interferon induction by Lactobacillus bulgaricus and Streptococcus thermophilus in mice","volume":"2","author":"Pereyra","year":"1991","journal-title":"Eur. Cytokine Netw."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1046\/j.1365-3083.1996.d01-258.x","article-title":"Down-Regulation of Anti-CD3 Antibody-Induced IL-4 Production by Bovine Caseins Hydrolysed with Lactobacillus GG-Derived Enzymes","volume":"43","author":"Hurme","year":"1996","journal-title":"Scand. J. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1007\/s13197-020-04838-z","article-title":"Preparation and in vitro bioactive evaluation of cashew-nut proteins hydrolysate as a potential source of anti-allergy peptides","volume":"58","author":"Chen","year":"2021","journal-title":"J. Food Sci. Technol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.fsi.2020.09.019","article-title":"Gut immune functions and health in Atlantic salmon (Salmo salar) from late freshwater stage until one year in seawater and effects of functional ingredients: A case study from a commercial sized research site in the Arctic region","volume":"106","author":"Wang","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cell.2010.03.006","article-title":"Inflammation 2010: New Adventures of an Old Flame","volume":"140","author":"Medzhitov","year":"2010","journal-title":"Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"104044","DOI":"10.1016\/j.jff.2020.104044","article-title":"Sturgeon protein-derived peptides exert anti-inflammatory effects in LPS-stimulated RAW264.7 macrophages via the MAPK pathway","volume":"72","author":"Gao","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_60","first-page":"e14122","article-title":"Separation and identification of collagen peptides derived from enzymatic hydrolysate of Salmo salar skin and their anti-inflammatory activity in lipopolysaccharide (LPS)-induced RAW264.7 inflammatory model","volume":"46","author":"Liu","year":"2022","journal-title":"J. Food Biochem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.foodchem.2014.05.112","article-title":"Purification and anti-inflammatory action of tripeptide from salmon pectoral fin byproduct protein hydrolysate","volume":"168","author":"Ahn","year":"2015","journal-title":"Food Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1039\/D1FO03615G","article-title":"Green tea peptides ameliorate diabetic nephropathy by inhibiting the TGF-\u03b2\/Smad signaling pathway in mice","volume":"13","author":"Chen","year":"2022","journal-title":"Food Funct."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s00726-020-02899-0","article-title":"Anti-inflammatory potential of novel hexapeptide derived from Meretrix meretrix foot and its functional properties","volume":"52","author":"Joshi","year":"2020","journal-title":"Amino Acids"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/jn\/nxab350","article-title":"Peptides Derived from In Vitro and In Vivo Digestion of Human Milk Are Immunomodulatory in THP-1 Human Macrophages","volume":"152","author":"Liang","year":"2022","journal-title":"J. Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1039\/C3FO60657K","article-title":"Immunomodulating effects of casein-derived peptides QEPVL and QEPV on lymphocytes in vitro and in vivo","volume":"5","author":"Jiehui","year":"2014","journal-title":"Food Funct."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"8370","DOI":"10.1021\/acs.jafc.9b03079","article-title":"Anti-inflammatory effect and cellular uptake mechanism of peptides from common bean (Phaseolus vulga L.) milk and yogurts in caco-2 mono-A nd caco-2\/EA.hy926 co-culture models","volume":"67","author":"Chen","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"7028","DOI":"10.1021\/acs.jafc.1c01712","article-title":"Peptides Released from Extruded Adzuki Bean Protein through Simulated Gastrointestinal Digestion Exhibit Anti-inflammatory Activity","volume":"69","author":"Shi","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1089\/jmf.2012.2541","article-title":"Milk-Derived Peptides, Val-Pro-Pro and Ile-Pro-Pro, Attenuate Atherosclerosis Development in Apolipoprotein E\u2013Deficient Mice: A Preliminary Study","volume":"16","author":"Nakamura","year":"2013","journal-title":"J. Med. Food"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Chakrabarti, S., and Wu, J. (2015). Milk-Derived Tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) Promote Adipocyte Differentiation and Inhibit Inflammation in 3T3-F442A Cells. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0117492"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Kennedy, K., Keogh, B., Lopez, C., Adelfio, A., Molloy, B., Kerr, A., Wall, A.M., Jalowicki, G., Holton, T.A., and Khaldi, N. (2020). An Artificial Intelligence Characterised Functional Ingredient, Derived from Rice, Inhibits TNF-\u03b1 and Significantly Improves Physical Strength in an Inflammaging Population. Foods, 9.","DOI":"10.3390\/foods9091147"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.jff.2013.05.001","article-title":"Purification of novel anti-inflammatory peptides from enzymatic hydrolysate of the edible microalgal Spirulina maxima","volume":"5","author":"Vo","year":"2013","journal-title":"J. Funct. Foods"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1007\/s00726-014-1809-9","article-title":"Leucine stimulates ASCT2 amino acid transporter expression in porcine jejunal epithelial cell line (IPEC-J2) through PI3K\/Akt\/mTOR and ERK signaling pathways","volume":"46","author":"Zhang","year":"2015","journal-title":"Amino Acids"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/s41598-017-00188-7","article-title":"Tryptophan end-tagging for promoted lipopolysaccharide interactions and anti-inflammatory effects","volume":"7","author":"Singh","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jbiosc.2021.07.009","article-title":"Walnut peptide WEKPPVSH in alleviating oxidative stress and inflammation in lipopolysaccharide-activated BV-2 microglia via the Nrf2\/HO-1 and NF-\u03baB\/p38 MAPK pathways","volume":"132","author":"Gao","year":"2021","journal-title":"J. Biosci. Bioeng."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/00218839.2020.1745434","article-title":"Identification of novel anti-inflammatory peptides from bee pollen (Apis mellifera) hydrolysate in lipopolysaccharide-stimulated RAW264.7 macrophages","volume":"60","author":"Saisavoey","year":"2020","journal-title":"J. Apic. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"126563","DOI":"10.1016\/j.foodchem.2020.126563","article-title":"Enzymatically derived sunflower protein hydrolysate and peptides inhibit NF\u03baB and promote monocyte differentiation to a dendritic cell phenotype","volume":"319","author":"Velliquette","year":"2020","journal-title":"Food Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e14162","DOI":"10.1111\/jfbc.14162","article-title":"Corn oligopeptides inhibit Akt\/NF-\u03baB signaling pathway and inflammatory factors to ameliorate CCl4-induced hepatic fibrosis in mice","volume":"46","author":"Feng","year":"2022","journal-title":"J. Food Biochem."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Ga\u0142\u0105zka-Czarnecka, I., and Budryn, G. (2021). Bioactive Peptide Analysis. Analytical Methods in the Determination of Bioactive Compounds and Elements in Food, Springer.","DOI":"10.1007\/978-3-030-61879-7_10"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"697","DOI":"10.2144\/000112823","article-title":"Two-dimensional polyacrylamide gel electrophoresis (2D-PAGE): Advances and perspectives","volume":"44","author":"Issaq","year":"2008","journal-title":"Biotechniques"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.chroma.2008.04.075","article-title":"Validation of a new reversed-phase high-performance liquid chromatography method for separation and quantification of bovine milk protein genetic variants","volume":"1195","author":"Bonfatti","year":"2008","journal-title":"J. Chromatogr. A"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Agreg\u00e1n, R., Echegaray, N., L\u00f3pez-Pedrouso, M., Kharabsheh, R., Franco, D., and Lorenzo, J.M. (2021). Proteomic Advances in Milk and Dairy Products. Molecules, 26.","DOI":"10.3390\/molecules26133832"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.biotechadv.2011.01.001","article-title":"Industrial-scale manufacturing of pharmaceutical-grade bioactive peptides","volume":"29","author":"Agyei","year":"2011","journal-title":"Biotechnol. Adv."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s12393-012-9058-8","article-title":"Use of Proteomics and Peptidomics Methods in Food Bioactive Peptide Science and Engineering","volume":"4","year":"2012","journal-title":"Food Eng. Rev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1080\/10942912.2016.1270963","article-title":"Bioactive peptides with ACE-I and antioxidant activity produced from milk proteolysis","volume":"20","author":"Sakr","year":"2017","journal-title":"Int. J. Food Prop."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1080\/10408398.2018.1436038","article-title":"Exploration of collagen recovered from animal by-products as a precursor of bioactive peptides: Successes and challenges","volume":"59","author":"Fu","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Wang, X., Yu, H., Xing, R., and Li, P. (2017). Characterization, Preparation, and Purification of Marine Bioactive Peptides. BioMed Res. Int., 2017.","DOI":"10.1155\/2017\/9746720"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.idairyj.2005.10.006","article-title":"Identification of antibacterial peptides from ovine \u03b1s2-casein","volume":"16","author":"Amigo","year":"2006","journal-title":"Int. Dairy J."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1002\/elps.201500559","article-title":"Food peptidomics of in vitro gastrointestinal digestions of partially purified bovine hemoglobin: Low-resolution versus high-resolution LC-MS\/MS analyses","volume":"37","author":"Caron","year":"2016","journal-title":"Electrophoresis"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.foodchem.2008.06.081","article-title":"Structures and properties of antioxidative peptides derived from royal jelly protein","volume":"113","author":"Guo","year":"2009","journal-title":"Food Chem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1021\/jf021191n","article-title":"Antioxidative properties of tripeptide libraries prepared by the combinatorial chemistry","volume":"51","author":"Saito","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1021\/jf034997b","article-title":"Angiotensin Converting Enzyme Inhibitory Activity in Commercial Fermented Products. Formation of Peptides under Simulated Gastrointestinal Digestion","volume":"52","author":"Amigo","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1021\/jf052464s","article-title":"Development of a liquid chromatography-tandem mass spectrometry method using capillary liquid chromatography and nanoelectrospray ionization-quadrupole time-of-flight hybrid mass spectrometer for the detection of milk allergens","volume":"54","author":"Weber","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1021\/jf800865b","article-title":"Identification and quantification of inhibitors for angiotensin-converting enzyme in hypoallergenic infant milk formulas","volume":"56","author":"Martin","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.aca.2010.10.002","article-title":"Identification of bioactive peptides in hypoallergenic infant milk formulas by capillary electrophoresis\u2013mass spectrometry","volume":"683","author":"Benavente","year":"2010","journal-title":"Anal. Chim. Acta"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1002\/elps.200700404","article-title":"Capillary electrophoresis-electrospray-mass spectrometry in peptide analysis and peptidomics","volume":"29","author":"Herrero","year":"2008","journal-title":"Electrophoresis"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1002\/elps.200800782","article-title":"CE-TOF\/MS: Fundamental concepts, instrumental considerations and applications","volume":"30","author":"Staub","year":"2009","journal-title":"Electrophoresis"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/elps.201300331","article-title":"\u00b4; Ka\u0161i, K.; Ka\u0161i\u010dka, K. Recent developments in capillary and microchip electroseparations of peptides (2011\u20132013)","volume":"35","year":"2014","journal-title":"Electrophoresis"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/elps.200700721","article-title":"Trends in CE-MS 2005\u20132006","volume":"29","author":"Gaspar","year":"2008","journal-title":"Electrophoresis"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1002\/elps.200700794","article-title":"Capillary electrophoresis-mass spectrometry\u2014A fast and reliable tool for the monitoring of milk adulteration","volume":"29","author":"Muller","year":"2008","journal-title":"Electrophoresis"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/jssc.200500020","article-title":"Analysis of trace amounts of bovine \u03b2-lactoglobulin in infant formulas by capillary electrophoresis with on-capillary derivatization and laser-induced fluorescence detection","volume":"28","author":"Veledo","year":"2005","journal-title":"J. Sep. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2013.07.042","article-title":"Metabolomics, peptidomics and proteomics applications of capillary electrophoresis-mass spectrometry in Foodomics: A review","volume":"802","author":"Cifuentes","year":"2013","journal-title":"Anal. Chim. Acta"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"6962","DOI":"10.1021\/jf0710985","article-title":"In vitro antioxidant activity of coffee compounds and their metabolites","volume":"55","author":"Leake","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0021-9673(01)00617-3","article-title":"Improved method for the simultaneous determination of whey proteins, caseins and para-\u03ba-casein in milk and dairy products by capillary electrophoresis","volume":"915","author":"Miralles","year":"2001","journal-title":"J. Chromatogr. A"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"6094","DOI":"10.1021\/jf050352v","article-title":"Chemometrical analysis of capillary electrophoresis casein fractions for predicting ripening times of milk mixture cheese","volume":"53","author":"Albillos","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1017\/S0022029900004167","article-title":"Capillary electrophoresis characterization of the casein fraction of cheeses made from cows\u2019, ewes\u2019 and goats\u2019 milks","volume":"67","author":"Molina","year":"2000","journal-title":"J. Dairy Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3389\/fmicb.2016.00319","article-title":"Staphylococcus aureus Isolates from Goat and Sheep Milk Seem to Be Closely Related and Differ from Isolates Detected from Bovine Milk","volume":"7","author":"Merz","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1002\/1522-2683(200105)22:8<1510::AID-ELPS1510>3.0.CO;2-4","article-title":"Qualitative and quantitative analysis of proteins and peptides in milk products by capillary electrophoresis-Strickland-2001-ELECTROPHORESIS-Wiley Online Library","volume":"22","author":"Strickland","year":"2001","journal-title":"Electrophoresis"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/jssc.200600247","article-title":"High performance liquid chromatography and capillary electrophoresis in the analysis of soybean proteins and peptides in foodstuffs","volume":"30","author":"Saz","year":"2007","journal-title":"J. Sep. Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.trac.2010.03.008","article-title":"Greening analytical chromatography","volume":"29","author":"Welch","year":"2010","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_110","first-page":"477","article-title":"18 Coupling CE and microchip-based devices with mass spectrometry","volume":"9","author":"Schappler","year":"2008","journal-title":"Sep. Sci. Technol."},{"key":"ref_111","unstructured":"Chen, C.-H., Krupke, A., Carrera, M., Weisbrod, C.R., Huguet, R., Chen, S.-M., Karger, A., Williams, S., Wenz, M., and Huhmer, A.F. (2016, January 18\u201322). Ultra-Fast Analysis of Allergens Using Capillary Electrophoresis Coupled to Mass Spectrometry and Ultra Violet Photodissociation. Proceedings of the 15th Human Proteome Organization (HUPO) World Congress, Taipei, Taiwan."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.freeradbiomed.2013.08.184","article-title":"Post-translational Modifications and Mass Spectrometry Detection","volume":"65","author":"Silva","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1016\/j.jprot.2011.12.022","article-title":"Mass spectrometry for nutritional peptidomics: How to analyze food bioactives and their health effects","volume":"75","author":"Panchaud","year":"2012","journal-title":"J. Proteomics"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s00217-005-0238-0","article-title":"Identification of ACE-inhibitory peptides in different Spanish cheeses by tandem mass spectrometry","volume":"223","author":"Taborda","year":"2006","journal-title":"Eur. Food Res. Technol."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Leopold, J., Popkova, Y., Engel, K.M., and Schiller, J. (2018). Recent Developments of Useful MALDI Matrices for the Mass Spectrometric Characterization of Lipids. Biomolecules, 8.","DOI":"10.3390\/biom8040173"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Ayala-Ni\u00f1o, A., Rodr\u00edguez-Serrano, G.M., Gonz\u00e1lez-Olivares, L.G., Contreras-L\u00f3pez, E., Regal-L\u00f3pez, P., and Cepeda-Saez, A. (2019). Sequence Identification of Bioactive Peptides from Amaranth Seed Proteins (Amaranthus hypochondriacus spp.). Molecules, 24.","DOI":"10.3390\/molecules24173033"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1021\/jf072911z","article-title":"Bioactive peptides in amaranth (Amaranthus hypochondriacus) seed","volume":"56","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1093\/jaoac\/91.4.936","article-title":"Analysis of Soybean Protein-Derived Peptides and the Effect of Cultivar, Environmental Conditions, and Processing on Lunasin Concentration in Soybean and Soy Products","volume":"91","author":"Wang","year":"2008","journal-title":"J. AOAC Int."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"O111.014902","DOI":"10.1074\/mcp.O111.014902","article-title":"De Novo Sequencing and Homology Searching","volume":"11","author":"Ma","year":"2012","journal-title":"Mol. Cell. Proteom."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.trac.2013.08.001","article-title":"Protein digestomics: Integrated platforms to study food-protein digestion and derived functional and active peptides","volume":"52","author":"Picariello","year":"2013","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_121","unstructured":"Kastin, A. (2013). Handbook of Biologically Active Peptides, Elsevier. [2nd ed.]."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jpba.2012.03.024","article-title":"New trends in reversed-phase liquid chromatographic separations of therapeutic peptides and proteins: Theory and applications","volume":"69","author":"Fekete","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.3945\/ajcn.112.055202","article-title":"Sequential release of milk protein\u2013derived bioactive peptides in the jejunum in healthy humans","volume":"97","author":"Boutrou","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.foodchem.2017.04.071","article-title":"Fractionation and identification of novel antioxidant peptides from buffalo and bovine casein hydrolysates","volume":"232","author":"Shazly","year":"2017","journal-title":"Food Chem."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Peighambardoust, S.H., Karami, Z., Pateiro, M., and Lorenzo, J.M. (2021). A Review on Health-Promoting, Biological, and Functional Aspects of Bioactive Peptides in Food Applications. Biomolecules, 11.","DOI":"10.3390\/biom11050631"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.foodchem.2018.07.187","article-title":"Discovery and quantification of bioactive peptides in fermented cucumber by direct analysis IR-MALDESI mass spectrometry and LC-QQQ-MS","volume":"271","author":"Fideler","year":"2019","journal-title":"Food Chem."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"109389","DOI":"10.1016\/j.foodres.2020.109389","article-title":"Antioxidant activity and peptidomic analysis of porcine liver hydrolysates using alcalase, bromelain, flavourzyme and papain enzymes","volume":"137","author":"Borrajo","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"012014","DOI":"10.1088\/1757-899X\/299\/1\/012014","article-title":"Identification and Characterization of Bioactive Peptides of Fermented Goat Milk as a Sources of Antioxidant as a Therapeutic Natural Product","volume":"299","author":"Mahdi","year":"2018","journal-title":"IOP Conf. Ser. Mater. Sci. Eng."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"129399","DOI":"10.1016\/j.foodchem.2021.129399","article-title":"kui Preparation and identification of antioxidant peptides from cottonseed proteins","volume":"352","author":"Wang","year":"2021","journal-title":"Food Chem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"127876","DOI":"10.1016\/j.foodchem.2020.127876","article-title":"Identification of antioxidant peptides derived from tropical jackfruit seed and investigation of the stability profiles","volume":"340","author":"Chai","year":"2021","journal-title":"Food Chem."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"103978","DOI":"10.1016\/j.jff.2020.103978","article-title":"Structure-activity relationship and pathway of antioxidant shrimp peptides in a PC12 cell model","volume":"70","author":"Wu","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jprot.2012.11.016","article-title":"The sarcoplasmic fish proteome: Pathways, metabolic networks and potential bioactive peptides for nutritional inferences","volume":"78","author":"Carrera","year":"2013","journal-title":"J. Proteomics"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"128159","DOI":"10.1016\/j.foodchem.2020.128159","article-title":"Baijiu vinasse as a new source of bioactive peptides with antioxidant and anti-inflammatory activity","volume":"339","author":"Peng","year":"2021","journal-title":"Food Chem."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.fshw.2020.04.014","article-title":"Peptide fraction from sturgeon muscle by pepsin hydrolysis exerts anti-inflammatory effects in LPS-stimulated RAW264.7 macrophages via MAPK and NF-\u03baB pathways","volume":"10","author":"Gao","year":"2021","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"128394","DOI":"10.1016\/j.foodchem.2020.128394","article-title":"Anti-inflammatory and antioxidant effects of peptides released from germinated amaranth during in vitro simulated gastrointestinal digestion","volume":"343","year":"2021","journal-title":"Food Chem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"128917","DOI":"10.1016\/j.foodchem.2020.128917","article-title":"Generation of antimicrobial peptides Leg1 and Leg2 from chickpea storage protein, active against food spoilage bacteria and foodborne pathogens","volume":"347","author":"Heymich","year":"2021","journal-title":"Food Chem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.3389\/fmicb.2021.662462","article-title":"A Novel Antimicrobial Peptides From Pine Needles of Pinus densiflora Sieb. et Zucc. Against Foodborne Bacteria","volume":"12","author":"Lee","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.crfs.2021.08.008","article-title":"In silico analysis of novel dipeptidyl peptidase-IV inhibitory peptides released from Macadamia integrifolia antimicrobial protein 2 (MiAMP2) and the possible pathways involved in diabetes protection","volume":"4","author":"Zhao","year":"2021","journal-title":"Curr. Res. Food Sci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.phytochem.2019.05.011","article-title":"Isolation and functional characterization of an antifungal hydrophilic peptide, Skh-AMP1, derived from Satureja khuzistanica leaves","volume":"164","author":"Khani","year":"2019","journal-title":"Phytochemistry"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1111\/ijfs.14853","article-title":"In vitro antihypertensive activity of bioactive peptides derived from porcine blood corpuscle and plasma proteins","volume":"56","author":"Aiemratchanee","year":"2021","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"430","DOI":"10.5713\/ajas.18.0455","article-title":"Isolation and identification of angiotensin I-converting enzyme inhibitory peptides derived from thermolysin-injected beef M. longissimus","volume":"32","author":"Choe","year":"2019","journal-title":"Asian-Australas. J. Anim. Sci."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s13197-018-3549-4","article-title":"Bioactive food derived peptides: A review on correlation between structure of bioactive peptides and their functional properties","volume":"56","author":"Karami","year":"2019","journal-title":"J. Food Sci. Technol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.3390\/md12031390","article-title":"Identification of the Major ACE-Inhibitory Peptides Produced by Enzymatic Hydrolysis of a Protein Concentrate from Cuttlefish Wastewater","volume":"12","author":"Amado","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"129374","DOI":"10.1016\/j.foodchem.2021.129374","article-title":"Simulated gastrointestinal digestion of camel and bovine casein hydrolysates: Identification and characterization of novel anti-diabetic bioactive peptides","volume":"353","author":"Mudgil","year":"2021","journal-title":"Food Chem."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.3168\/jds.2020-19271","article-title":"Identification and characterization of novel \u03b1-amylase and \u03b1-glucosidase inhibitory peptides from camel whey proteins","volume":"104","author":"Baba","year":"2021","journal-title":"J. Dairy Sci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"103944","DOI":"10.1016\/j.jff.2020.103944","article-title":"Anti-diabetic effect by walnut (Juglans mandshurica Maxim.)-derived peptide LPLLR through inhibiting \u03b1-glucosidase and \u03b1-amylase, and alleviating insulin resistance of hepatic HepG2 cells","volume":"69","author":"Wang","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.foodchem.2016.07.069","article-title":"Development of a workflow for screening and identification of \u03b1-amylase inhibitory peptides from food source using an integrated Bioinformatics-phage display approach: Case study\u2013Cumin seed","volume":"214","author":"Siow","year":"2017","journal-title":"Food Chem."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1111\/1750-3841.15778","article-title":"Characterization of peptides with antioxidant activity and antidiabetic potential obtained from chickpea (Cicer arietinum L.) protein hydrolyzates","volume":"86","year":"2021","journal-title":"J. Food Sci."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"130690","DOI":"10.1016\/j.foodchem.2021.130690","article-title":"Identification of novel antihypertensive peptides from wine lees hydrolysate","volume":"366","author":"Bravo","year":"2022","journal-title":"Food Chem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s12257-019-0329-6","article-title":"Production of Functional Peptide with Anti-obesity Effect from Defatted Tenebrio molitor Larvae Using Proteolytic Enzyme","volume":"25","author":"Song","year":"2020","journal-title":"Biotechnol. Bioprocess Eng."},{"key":"ref_151","unstructured":"FAO (2022, September 08). The State of World Fisheries and Aquaculture. Available online: https:\/\/www.fao.org\/documents\/card\/en\/c\/ca9229en."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s10811-013-0066-8","article-title":"Proteomic profile analysis of Pyropia haitanensis in response to high-temperature stress","volume":"26","author":"Xu","year":"2014","journal-title":"J. Appl. Phycol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1002\/pmic.201400625","article-title":"Identification of proteins involved in desiccation tolerance in the red seaweed Pyropia orbicularis (Rhodophyta, Bangiales)","volume":"15","author":"Zapata","year":"2015","journal-title":"Proteomics"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.marpolbul.2018.07.030","article-title":"Proteome responses of Gracilaria lemaneiformis exposed to lead stress","volume":"135","author":"Du","year":"2018","journal-title":"Mar. Pollut. Bull."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Deng, Y., Yao, J., Wang, X., Guo, H., and Duan, D. (2012). Transcriptome Sequencing and Comparative Analysis of Saccharina japonica (Laminariales, Phaeophyceae) under Blue Light Induction. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0039704"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2229-14-116","article-title":"Transcriptomic and metabolomic analysis of copper stress acclimation in Ectocarpus siliculosus highlights signaling and tolerance mechanisms in brown algae","volume":"14","author":"Ritter","year":"2014","journal-title":"BMC Plant Biol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.gene.2015.09.077","article-title":"De novo transcriptome sequencing and discovery of genes related to copper tolerance in Paeonia ostii","volume":"576","author":"Wang","year":"2016","journal-title":"Gene"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.gene.2018.01.075","article-title":"Transcriptome analysis of starch and sucrose metabolism across bulb development in Sagittaria sagittifolia","volume":"649","author":"Gao","year":"2018","journal-title":"Gene"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"100671","DOI":"10.1016\/j.margen.2019.03.006","article-title":"Transcriptome profiling of the meristem tissue of Saccharina japonica (Phaeophyceae, Laminariales) under severe stress of copper","volume":"47","author":"Zhang","year":"2019","journal-title":"Mar. Genom."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1111\/jpy.13016","article-title":"Comparative Transcriptome Analysis Reveals Candidate Genes Related to Structural and Storage Carbohydrate Biosynthesis in Kelp Saccharina japonica (Laminariales, Phaeophyceae)","volume":"56","author":"Zhang","year":"2020","journal-title":"J. Phycol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/978-1-0716-1178-4_14","article-title":"Shotgun Proteomics and Protein-Based Bioinformatics for the Characterization of Food-Derived Bioactive Peptides","volume":"2259","author":"Carrera","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-3233(08)60017-0","article-title":"The Arrangement of Amino Acids in Proteins","volume":"7","author":"Sanger","year":"1952","journal-title":"Adv. Protein Chem."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1007\/s00216-018-0974-1","article-title":"Bioinformatics and peptidomics approaches to the discovery and analysis of food-derived bioactive peptides","volume":"410","author":"Agyei","year":"2018","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_164","first-page":"345","article-title":"Online Programs and Databases of Peptides and Proteolytic Enzymes\u2013A Brief Update for 2007\u20132008","volume":"47","author":"Minkiewicz","year":"2009","journal-title":"Food Technol. Biotechnol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/jaoac\/91.4.965","article-title":"BIOPEP Database and Other Programs for Processing Bioactive Peptide Sequences","volume":"91","author":"Minkiewicz","year":"2008","journal-title":"J. AOAC Int."},{"key":"ref_166","first-page":"1","article-title":"Food Peptidomics","volume":"46","author":"Minkiewicz","year":"2008","journal-title":"Food Technol. Biotechnol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13062-015-0103-4","article-title":"PEPstrMOD: Structure prediction of peptides containing natural, non-natural and modified residues","volume":"10","author":"Singh","year":"2015","journal-title":"Biol. Direct"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.foodres.2014.01.069","article-title":"Peptidomics for discovery, bioavailability and monitoring of dairy bioactive peptides","volume":"63","author":"Miralles","year":"2014","journal-title":"Food Res. Int."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1016\/j.foodres.2011.01.051","article-title":"QSAR-aided in silico approach in evaluation of food proteins as precursors of ACE inhibitory peptides","volume":"44","author":"Gu","year":"2011","journal-title":"Food Res. Int."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1021\/jf051263l","article-title":"Structural requirements of angiotensin I-converting enzyme inhibitory peptides: Quantitative structure-activity relationship study of Di- and tripeptides","volume":"54","author":"Wu","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1745-4514.2009.00331.x","article-title":"Antioxidant Activities of Sardinelle HEADS and\/or Viscera Protein Hydrolysates Prepared by Enzymatic Treatment","volume":"34","author":"Barkia","year":"2010","journal-title":"J. Food Biochem."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2174\/157340911795677602","article-title":"Molecular Docking: A Powerful Approach for Structure-Based Drug Discovery","volume":"7","author":"Meng","year":"2012","journal-title":"Curr. Comput. Aided-Drug Des."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Chamata, Y., Watson, K.A., and Jauregi, P. (2020). Whey-Derived Peptides Interactions with ACE by Molecular Docking as a Potential Predictive Tool of Natural ACE Inhibitors. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21030864"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.tifs.2017.09.001","article-title":"Ribulose-1,5-bisphosphate carboxylase as a sustainable and promising plant source of bioactive peptides for food applications","volume":"69","author":"Udenigwe","year":"2017","journal-title":"Trends Food Sci. Technol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1016\/j.procbio.2013.08.013","article-title":"In silico analysis of the large and small subunits of cereal RuBisCO as precursors of cryptic bioactive peptides","volume":"48","author":"Udenigwe","year":"2013","journal-title":"Process Biochem."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1016\/j.foodchem.2013.04.064","article-title":"LC\u2013MS\/MS coupled with QSAR modeling in characterising of angiotensin I-converting enzyme inhibitory peptides from soybean proteins","volume":"141","author":"Gu","year":"2013","journal-title":"Food Chem."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.foodres.2010.04.027","article-title":"A new approach for identification of novel antihypertensive peptides from egg proteins by QSAR and bioinformatics","volume":"43","author":"Majumder","year":"2010","journal-title":"Food Res. Int."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.peptides.2016.03.005","article-title":"Structure activity relationship modelling of milk protein-derived peptides with dipeptidyl peptidase IV (DPP-IV) inhibitory activity","volume":"79","author":"Nongonierma","year":"2016","journal-title":"Peptides"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.idairyj.2012.12.006","article-title":"Quantitative structure\u2013activity relationship based screening of bioactive peptides identified in ripened cheese","volume":"33","author":"Sagardia","year":"2013","journal-title":"Int. Dairy J."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2174\/0929866523666161220113230","article-title":"Antimicrobial Peptides of Meat Origin-An In silico and In vitro Analysis","volume":"24","author":"Keska","year":"2017","journal-title":"Protein Pept. Lett."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.peptides.2014.07.005","article-title":"Identification of novel dipeptidyl peptidase-IV and angiotensin-I-converting enzyme inhibitory peptides from meat proteins using in silico analysis","volume":"59","author":"Lafarga","year":"2014","journal-title":"Peptides"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.foodchem.2014.11.150","article-title":"In silico methods to identify meat-derived prolyl endopeptidase inhibitors","volume":"175","author":"Lafarga","year":"2015","journal-title":"Food Chem."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Villaluenga, C., and Hern\u00e1ndez-Ledesma, B. (2020). Peptides for Health Benefits 2019. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072543"},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Tejano, L.A., Peralta, J.P., Yap, E.E.S., Panjaitan, F.C.A., and Chang, Y.W. (2019). Prediction of Bioactive Peptides from Chlorella sorokiniana Proteins Using Proteomic Techniques in Combination with Bioinformatics Analyses. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20071786"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.jff.2015.09.065","article-title":"Analysis of proteins and potential bioactive peptides from tilapia (Oreochromis spp.) processing co-products using proteomic techniques coupled with BIOPEP database","volume":"19","author":"Huang","year":"2015","journal-title":"J. Funct. Foods"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"110502","DOI":"10.1016\/j.lwt.2020.110502","article-title":"Proteolysis of tilapia skin collagen: Identification and release behavior of ACE-inhibitory peptides","volume":"139","author":"Chen","year":"2021","journal-title":"LWT"},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Panjaitan, F.C.A., Gomez, H.L.R., and Chang, Y.W. (2018). In Silico Analysis of Bioactive Peptides Released from Giant Grouper (Epinephelus lanceolatus) Roe Proteins Identified by Proteomics Approach. Molecules, 23.","DOI":"10.3390\/molecules23112910"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1111\/1541-4337.12911","article-title":"An updated review on food-derived bioactive peptides: Focus on the regulatory requirements, safety, and bioavailability","volume":"21","author":"Patil","year":"2022","journal-title":"Compr. Rev. Food Sci. Food Saf."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/20\/4400\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:57:58Z","timestamp":1760144278000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/20\/4400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,20]]},"references-count":188,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["nu14204400"],"URL":"https:\/\/doi.org\/10.3390\/nu14204400","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,20]]}}}