{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T14:34:11Z","timestamp":1775486051734,"version":"3.50.1"},"reference-count":50,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science","award":["NRF-2019M3A9I3080265"],"award-info":[{"award-number":["NRF-2019M3A9I3080265"]}]},{"name":"Ministry of Science","award":["NRF-2019M3A9I3080266"],"award-info":[{"award-number":["NRF-2019M3A9I3080266"]}]},{"name":"Ministry of Science","award":["NRF-2022R1A2C1003088"],"award-info":[{"award-number":["NRF-2022R1A2C1003088"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The genus Daphnopsis has been traditionally used as a purgative, diuretic, stimulant, and psoriasis treatment. In this study, the anti-AD (atopic dermatitis) activities of the Daphnopsis costaricensis EtOH extract (DCE) were investigated in an oxazolone (OX)-induced mouse model of AD, and the anti-inflammatory effects of its active compounds were confirmed in PI-sensitized or IgE\/DNP-BSA-sensitized RBL-2H3 cells. DCE improved the symptoms of OX-induced inflammatory dermatitis (swelling, erythema, and increased ear thickening) in OX-induced BALB\/c mice ears and reduced epidermal thickness and mast cell infiltration. Eleven flavonoid compounds were isolated from DCE, and two compounds (7,8-dimethoxyflavone and 7,2\u2019-dimethoxyflavone) significantly inhibited IL-4 overexpression in PI-induced RBL-2H3 cells and mast cell degranulation in IgE + DNP-BSA-induced RBL-2H3 cells. Our study indicates that DCE and two compounds (7,8-dimethoxyflavone and 7,2\u2019-dimethoxyflavone) might effectively improve inflammatory and atopic skin symptoms.<\/jats:p>","DOI":"10.3390\/nu14214521","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T22:36:17Z","timestamp":1666910177000},"page":"4521","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ameliorative Effects of Daphnopsis costaricensis Extract against Oxazolone-Induced Atopic Dermatitis-like Lesions in BALB\/c Mice"],"prefix":"10.3390","volume":"14","author":[{"given":"Yunji","family":"Bae","sequence":"first","affiliation":[{"name":"College of Pharmacy, Pusan National University, Busan 46241, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taeyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Pusan National University, Busan 46241, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nojune","family":"Park","sequence":"additional","affiliation":[{"name":"Natural Products Research Center, Korea Institute of Science and Technology, Gangneung 25451, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangho","family":"Choi","sequence":"additional","affiliation":[{"name":"International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology, 111 Gwahak-ro, Yuseong-gu, Daejeon 34141, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongkeun","family":"Yi","sequence":"additional","affiliation":[{"name":"International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology, 111 Gwahak-ro, Yuseong-gu, Daejeon 34141, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Soto","sequence":"additional","affiliation":[{"name":"Bioprospecting Research Unit, National Biodiversity Institute, Heredia 22-3100, Costa Rica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson","family":"Zamora","sequence":"additional","affiliation":[{"name":"Bioprospecting Research Unit, National Biodiversity Institute, Heredia 22-3100, Costa Rica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunam","family":"Kim","sequence":"additional","affiliation":[{"name":"Natural Products Research Center, Korea Institute of Science and Technology, Gangneung 25451, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minhye","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Pusan National University, Busan 46241, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0091-6749(99)70051-5","article-title":"Pathogenesis of atopic dermatitis","volume":"104","author":"Leung","year":"1999","journal-title":"J. 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