{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:35:44Z","timestamp":1775176544038,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute for Health and Care Research (NIHR)","award":["PB-PG-0816-20050"],"award-info":[{"award-number":["PB-PG-0816-20050"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Bovine colostrum (BC) has anti-inflammatory, anti-infective, growth and intestinal repair factors that may be beneficial in Crohn\u2019s disease (CD). We assessed whether daily BC for up to 3 months was acceptable to children and young people (CYP) with CD in remission or of mild\/moderate severity. CYP were randomised to receive either BC or matching placebo milk daily for 6 weeks (blinded phase); all received BC for the following 6 weeks (open phase). In 23 CYP, median (inter-quartile range) age was 15.2 (13.9\u201316.1) years and 9 (39.1%) were girls. A similar proportion of CYP in the BC and placebo arms completed the blinded phase (8\/12, 75.0% and 9\/11, 81.8% respectively). Twelve (70.6%) CYP completed the open phase with 7 (58.3%) tolerating BC for 3 months. Diaries in weeks 2, 6 and 12 revealed that most CYP took BC every day (5\/7, 71.4%; 5\/8, 62.5% and 6\/11, 54.5% respectively). In interviews, opinions were divided as to preference of BC over the placebo milk and some preferred BC over other nutritional supplements. Symptoms, clinical and laboratory variables and quality of life were similar in the two arms. BC may be an acceptable nutritional supplement for daily, longer-term use in CYP with CD.<\/jats:p>","DOI":"10.3390\/nu14214598","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T03:36:44Z","timestamp":1667360204000},"page":"4598","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Dietary Therapy to Improve Nutrition and Gut Health in Paediatric Crohn\u2019s Disease; A Feasibility Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Stephen J.","family":"Allen","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK"},{"name":"Alder Hey Children\u2019s NHS Foundation Trust, Eaton Road, Liverpool L12 2AP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salma","family":"Belnour","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Liverpool, Foundation Building, Brownlow Hill, Liverpool L69 7ZX, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Renji","sequence":"additional","affiliation":[{"name":"Alder Hey Children\u2019s NHS Foundation Trust, Eaton Road, Liverpool L12 2AP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5226-9878","authenticated-orcid":false,"given":"Bernie","family":"Carter","sequence":"additional","affiliation":[{"name":"Faculty of Health, Social Care and Medicine, Edge Hill University, St Helens Road, Ormskirk L39 4QP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Bray","sequence":"additional","affiliation":[{"name":"Faculty of Health, Social Care and Medicine, Edge Hill University, St Helens Road, Ormskirk L39 4QP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Jones","sequence":"additional","affiliation":[{"name":"Alder Hey Children\u2019s NHS Foundation Trust, Eaton Road, Liverpool L12 2AP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta","family":"Urban","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Moule","sequence":"additional","affiliation":[{"name":"Independent Researcher, Hartlepool TS27 4RR, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2788-2464","authenticated-orcid":false,"given":"Duolao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1235-8504","authenticated-orcid":false,"given":"Raymond J.","family":"Playford","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, University of West London, St Mary\u2019s Road, Ealing, London W5 5RF, UK"},{"name":"School of Medicine, College of Medicine and Health, University College Cork, College Road, T12 K8AF Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","article-title":"Crohn\u2019s disease","volume":"389","author":"Torres","year":"2017","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/ibd.21349","article-title":"Epidemiology of pediatric inflammatory bowel disease: A systematic review of international trends","volume":"17","author":"Benchimol","year":"2011","journal-title":"Inflamm. 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(Lond.)"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/21\/4598\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:09:01Z","timestamp":1760144941000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/21\/4598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,1]]},"references-count":30,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["nu14214598"],"URL":"https:\/\/doi.org\/10.3390\/nu14214598","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,1]]}}}