{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:19:10Z","timestamp":1791933550963,"version":"4.3.4"},"reference-count":34,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"collaborative research agreement between the University of Tsukuba Faculty of Health and Sport Sciences and Link &amp; Communication Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Mobile applications are increasingly used in healthcare. We have developed a smartphone healthcare application, CALO mama Plus, that can register daily diet, exercise, mood, and sleep quality, calculate dietary intake, and provide advice using artificial intelligence technology. This 3-month randomized controlled trial tested the hypothesis that CALO mama Plus could promote body weight reduction in Japanese adults with overweight or obesity. We recruited office workers as participants. The key eligibility criteria were an age of 20\u201365 years and a body mass index of 23\u201340 kg\/m2. The primary outcome was body weight change over 3 months. We enrolled 141 participants and randomly assigned them to the intervention (n = 72) and control (n = 69) groups. The intervention group used CALO mama Plus, and the control group did not receive any intervention. The change in body weight was \u22122.4 \u00b1 4.0 kg and \u22120.7 \u00b1 3.3 kg in the intervention and control groups, respectively. An analysis of covariance adjusted for related variables showed a significant between-group difference in body weight change (\u22121.60 kg; 95% confidence interval \u22122.83 to \u22120.38; p = 0.011). The present study suggests that CALO mama Plus effectively promotes weight loss.<\/jats:p>","DOI":"10.3390\/nu14214608","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T03:36:44Z","timestamp":1667360204000},"page":"4608","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["A Smartphone Healthcare Application, CALO mama Plus, to Promote Weight Loss: A Randomized Controlled Trial"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0888-4440","authenticated-orcid":false,"given":"Yoshio","family":"Nakata","sequence":"first","affiliation":[{"name":"Faculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8577, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8120-6163","authenticated-orcid":false,"given":"Hiroyuki","family":"Sasai","sequence":"additional","affiliation":[{"name":"Research Team for Promoting Independence and Mental Health, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo 173-0015, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Gosho","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mito Kyodo General Hospital, University of Tsukuba, 3-2-7 Miyamachi, Mito 310-0015, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Shi","sequence":"additional","affiliation":[{"name":"Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8577, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9630-5882","authenticated-orcid":false,"given":"Tomohiro","family":"Ohigashi","sequence":"additional","affiliation":[{"name":"Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8577, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Link & Communication Inc., Chiyoda-ku, Tokyo 102-0094, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiaki","family":"Murayama","sequence":"additional","affiliation":[{"name":"Link & Communication Inc., Chiyoda-ku, Tokyo 102-0094, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Link & Communication Inc., Chiyoda-ku, Tokyo 102-0094, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Link & Communication Inc., Chiyoda-ku, Tokyo 102-0094, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"i5855","DOI":"10.1136\/bmj.i5855","article-title":"Combined associations of body weight and lifestyle factors with all cause and cause specific mortality in men and women: Prospective cohort study","volume":"355","author":"Veronese","year":"2016","journal-title":"BMJ"},{"key":"ref_2","unstructured":"WHO (2022, October 07). 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