{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:42:08Z","timestamp":1790192528786,"version":"4.1.0"},"reference-count":41,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination of Improvement of Higher Education Personnel\u2014Brazil","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Associations between vitamin D deficiency and metabolic syndrome (MS) have been reported; however, the underlying biological mechanisms remain controversial. The aim of this study was to investigate the associations of CYP2R1 and VDR variants with MS and MS components in non-diabetic Brazilian adolescents. This cross-sectional study included 174 adolescents who were classified as overweight\/obese. Three CYP2R1 variants and four VDR variants were identified by allelic discrimination. The CYP2R1 polymorphisms, rs12794714 (GG genotype) (odds ratio [OR] = 3.54, 95% confidence interval [CI] = 1.24\u201310.14, p = 0.023) and rs10741657 (recessive model\u2014GG genotype) (OR = 3.90, 95%CI = 1.18\u201312.92, p = 0.026) were significantly associated with an increased risk of MS and hyperglycemia, respectively. The AG + GG genotype (dominant model) of the rs2060793 CYP2R1 polymorphism was associated with hyperglycemia protection (OR = 0.28, 95%CI = 0.08\u20130.92, p = 0.037). Furthermore, the CC genotype (recessive model) of the rs7975232 VDR polymorphism was significantly associated with a risk of hypertension (OR = 5.91, 95%CI = 1.91\u201318.32, p = 0.002). In conclusion, the CYP2R1 rs12794714 polymorphism could be considered a possible new molecular marker for predicting the risk of MS; CYP2R1 rs10741657 polymorphism and VDR rs7975232 polymorphism are associated with an increased risk of diabetes and hypertension in adolescents with overweight\/obesity.<\/jats:p>","DOI":"10.3390\/nu14214612","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T03:53:07Z","timestamp":1667447587000},"page":"4612","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association of CYP2R1 and VDR Polymorphisms with Metabolic Syndrome Components in Non-Diabetic Brazilian Adolescents"],"prefix":"10.3390","volume":"14","author":[{"given":"Eduarda Pontes dos Santos","family":"Ara\u00fajo","sequence":"first","affiliation":[{"name":"Postgraduate Program in Health Sciences, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, RN, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Severina Carla Vieira da Cunha","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59056-000, RN, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5190-4638","authenticated-orcid":false,"given":"Ony Ara\u00fajo","family":"Galdino","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, RN, Brazil"},{"name":"Department of Clinical and Toxicological Analyses, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, RN, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Fernando","family":"Arrais","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, RN, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8541-1444","authenticated-orcid":false,"given":"Karla Simone Costa","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analyses, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, RN, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2452-4047","authenticated-orcid":false,"given":"Adriana Augusto","family":"de Rezende","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, RN, Brazil"},{"name":"Department of Clinical and Toxicological Analyses, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, RN, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.clindermatol.2017.09.004","article-title":"Pathophysiology of the metabolic syndrome","volume":"36","author":"McCracken","year":"2018","journal-title":"Clin. 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