{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:32:44Z","timestamp":1790706764788,"version":"4.1.0"},"reference-count":61,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Royal Golden Jubilee (RGJ) Ph.D. Program","award":["PHD\/0005\/2559"],"award-info":[{"award-number":["PHD\/0005\/2559"]}]},{"name":"National Research Council of Thailand (NRCT)","award":["PHD\/0005\/2559"],"award-info":[{"award-number":["PHD\/0005\/2559"]}]},{"name":"Faculty of Medicine, Exercise and Sport Sciences Development and Research Group (ESRG)","award":["PHD\/0005\/2559"],"award-info":[{"award-number":["PHD\/0005\/2559"]}]},{"name":"Graduate School, Khon Kaen University, Thailand","award":["PHD\/0005\/2559"],"award-info":[{"award-number":["PHD\/0005\/2559"]}]},{"name":"Blackmores Limited","award":["PHD\/0005\/2559"],"award-info":[{"award-number":["PHD\/0005\/2559"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>We investigated the effects of Irvingia gabonensis (IG) kernel extract on the metabolism, adiposity indices, redox status, inflammation, adipocytokines, blood leukocyte relative telomere length (RTL), and aerobic capacity of overweight\/obese individuals. All participants used the first 12-week phase to monitor body weight. They were then randomly divided into two groups: (1) 300 mg IG or (2) placebo (PLA). Both groups took one tablet per day for 12 weeks. The variables were measured before supplementation and after 3, 6, and 12 weeks of supplementation. RTL and aerobic capacity were measured before and after 12 weeks. Compared with the PLA, the IG increased plasma vitamin C after supplementation at 6 (p &lt; 0.01) and 12 weeks (p &lt; 0.05) and serum adiponectin after 3 weeks (p &lt; 0.05). Compared with before supplementation, plasma malondialdehyde in the IG and serum leptin in the PLA were decreased after 12-week supplementation, without any differences between the groups. There were no differences between groups with respect to metabolism, inflammation, RTL, and aerobic capacity after the supplementation. We suggest that 12-week daily IG supplementation improved plasma vitamin C and adiponectin. The findings show the possible mechanism contributing to the effect of IG supplementation on a reduction in obesity-related complications.<\/jats:p>","DOI":"10.3390\/nu14214646","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T04:00:51Z","timestamp":1667534451000},"page":"4646","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight\/Obese Individuals"],"prefix":"10.3390","volume":"14","author":[{"given":"Rujira","family":"Nonsa-ard","sequence":"first","affiliation":[{"name":"Biomedical Sciences Program, Graduate School, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ploypailin","family":"Aneknan","sequence":"additional","affiliation":[{"name":"Exercise and Sport Sciences Development and Research Group, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5286-0788","authenticated-orcid":false,"given":"Terdthai","family":"Tong-un","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3852-9092","authenticated-orcid":false,"given":"Sittisak","family":"Honsawek","sequence":"additional","affiliation":[{"name":"Center of Excellence in Osteoarthritis and Musculoskeleton, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naruemon","family":"Leelayuwat","sequence":"additional","affiliation":[{"name":"Graduate School, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization, and Regional Office for the Western Pacific (2000). 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