{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T07:54:06Z","timestamp":1793433246330,"version":"4.5.0"},"reference-count":26,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III, ISCIII","doi-asserted-by":"publisher","award":["PI19\/01638"],"award-info":[{"award-number":["PI19\/01638"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III, ISCIII","doi-asserted-by":"publisher","award":["CD20\/00025"],"award-info":[{"award-number":["CD20\/00025"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>(1) Background: The serum ferritin cut-off to define absolute iron deficiency is not well-established. The aim of the present study was to determine a clinically relevant ferritin threshold by using early serum biomarkers of iron deficiency such as hepcidin and the soluble transferrin receptor; (2) Methods: Two hundred and twenty-eight asymptomatic subjects attending a hospital as outpatients between 1st April 2020 and 27th February 2022 were selected. Iron metabolism parameters as part of the blood analysis were requested by their doctor and included in the study. Then, they were classified into groups according to their ferritin levels and iron-related biomarkers in serum were determined, quantified, and compared between ferritin score groups and anemic subjects. (3) Results: Serum ferritin levels below 50 ng\/mL establish the point from which the serum biomarker, the soluble transferrin receptor to hepcidin ratio (sTfR\/Hep ratio), begins to correlate significantly with ferritin levels. (4) Conclusion: Ferritin levels \u2264 50 ng\/mL are indicative of early iron deficiency; hence, this should be considered as a clinically relevant cut-off for iron deficiency.<\/jats:p>","DOI":"10.3390\/nu14224739","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T02:07:48Z","timestamp":1668046068000},"page":"4739","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Threshold Ferritin Concentrations Reflecting Early Iron Deficiency Based on Hepcidin and Soluble Transferrin Receptor Serum Levels in Patients with Absolute Iron Deficiency"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9528-4098","authenticated-orcid":false,"given":"Laura","family":"Tarancon-Diez","sequence":"first","affiliation":[{"name":"Immunology Section, Laboratorio Inmuno-Biolog\u00eda Molecular (LIBM), Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM), 28009 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Genebat","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital F\u00e1tima, 41012 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Roman-Enry","sequence":"additional","affiliation":[{"name":"AnAliza laboratorio, Hospital Jerez Puerta del Sur, 11408 C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3011-9611","authenticated-orcid":false,"given":"Elena","family":"V\u00e1zquez-Alejo","sequence":"additional","affiliation":[{"name":"Immunology Section, Laboratorio Inmuno-Biolog\u00eda Molecular (LIBM), Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM), 28009 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de la Sierra","family":"Espinar-Buitrago","sequence":"additional","affiliation":[{"name":"Immunology Section, Laboratorio Inmuno-Biolog\u00eda Molecular (LIBM), Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM), 28009 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Leal","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Viamed Santa \u00c1ngela de la Cruz, 41014 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0813-4500","authenticated-orcid":false,"given":"M\u00aa \u00c1ngeles","family":"Mu\u00f1oz-Fernandez","sequence":"additional","affiliation":[{"name":"Immunology Section, Laboratorio Inmuno-Biolog\u00eda Molecular (LIBM), Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM), 28009 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1182\/blood-2013-06-508325","article-title":"A Systematic Analysis of Global Anemia Burden from 1990 to 2010","volume":"123","author":"Kassebaum","year":"2014","journal-title":"Blood"},{"key":"ref_2","first-page":"422","article-title":"Current Misconceptions in Diagnosis and Management of Iron Deficiency","volume":"15","author":"Besser","year":"2017","journal-title":"Blood Transfus."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2147\/JBM.S342321","article-title":"Effects of Iron Deficiency and Its Indicators on Lymphocyte Subsets: A Study at King Fahd Hospital of the University, Saudi Arabia","volume":"13","author":"AlRajeh","year":"2022","journal-title":"JBM"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Weyh, C., Kr\u00fcger, K., Peeling, P., and Castell, L. 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