{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:34:15Z","timestamp":1782513255614,"version":"3.54.5"},"reference-count":41,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program","award":["2021YFA1301200"],"award-info":[{"award-number":["2021YFA1301200"]}]},{"name":"National Key Research and Development Program","award":["81974513"],"award-info":[{"award-number":["81974513"]}]},{"name":"National Key Research and Development Program","award":["2022JJ80097"],"award-info":[{"award-number":["2022JJ80097"]}]},{"name":"National Key Research and Development Program","award":["2022JJ80113"],"award-info":[{"award-number":["2022JJ80113"]}]},{"name":"National Scientific Foundation of China","award":["2021YFA1301200"],"award-info":[{"award-number":["2021YFA1301200"]}]},{"name":"National Scientific Foundation of China","award":["81974513"],"award-info":[{"award-number":["81974513"]}]},{"name":"National Scientific Foundation of China","award":["2022JJ80097"],"award-info":[{"award-number":["2022JJ80097"]}]},{"name":"National Scientific Foundation of China","award":["2022JJ80113"],"award-info":[{"award-number":["2022JJ80113"]}]},{"name":"Natural Science Foundation of Hunan Province","award":["2021YFA1301200"],"award-info":[{"award-number":["2021YFA1301200"]}]},{"name":"Natural Science Foundation of Hunan Province","award":["81974513"],"award-info":[{"award-number":["81974513"]}]},{"name":"Natural Science Foundation of Hunan Province","award":["2022JJ80097"],"award-info":[{"award-number":["2022JJ80097"]}]},{"name":"Natural Science Foundation of Hunan Province","award":["2022JJ80113"],"award-info":[{"award-number":["2022JJ80113"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>People in Eastern countries hold a tradition of soaking herbal medicine in wine; however, the efficacy and safety of herbal wine have not been rigorously assessed. By assessing the efficacy of resveratrol (RSV) in ethanol against alcoholic liver disease (ALD) in mice, we aimed to offer a perspective on the use of herbal wine. To simulate the behaviour of herbal wine users, RSV (15 mg\/kg) soaked in ethanol (RSV-alcohol) was administrated via gavage to the mice, here with alcohol consumption-induced ALD. RSV soaked in water (RSV-water) was the treatment control. The efficacy and safety of RSV on ALD were evaluated. Compared with the RSV-water group, a higher rate of mortality was found in the RSV-alcohol group (50.0% vs. 20.0%), which also exhibited more severe liver injury. RSV significantly increased the exposure of alcohol by 126.0%, which was accompanied by a significant inhibition of the ethanol metabolic pathway. In contrast, alcohol consumption significantly reduced exposure to RSV by 95.0%. Alcohol consumption had little effect on the expression of drug-metabolizing enzymes in RSV; however, alcohol seemed to reduce the absorption of RSV. RSV in liquor exacerbates alcoholic liver injury and has a reduced therapeutic effect, suggesting that the habit of herbal wine use without supervision is risky.<\/jats:p>","DOI":"10.3390\/nu14224752","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T21:33:02Z","timestamp":1668115982000},"page":"4752","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Resveratrol in Liquor Exacerbates Alcoholic Liver Injury with a Reduced Therapeutic Effect in Mice: An Unsupervised Herbal Wine Habit Is Risky"],"prefix":"10.3390","volume":"14","author":[{"given":"Songxia","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"Institute of Clinical Pharmacology, Central South University, Changsha 410078, China"},{"name":"Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha 410078, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"Institute of Clinical Pharmacology, Central South University, Changsha 410078, China"},{"name":"Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha 410078, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengling","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"Institute of Clinical Pharmacology, Central South University, Changsha 410078, China"},{"name":"Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha 410078, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"Institute of Clinical Pharmacology, Central South University, Changsha 410078, China"},{"name":"Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha 410078, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"Institute of Clinical Pharmacology, Central South University, Changsha 410078, China"},{"name":"Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha 410078, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6190-3129","authenticated-orcid":false,"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"Institute of Clinical Pharmacology, Central South 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Rev. Dis. Primers."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/S0140-6736(09)60746-7","article-title":"Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders","volume":"373","author":"Rehm","year":"2009","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1007\/s00204-019-02447-0","article-title":"The LRP6 functional mutation rs2302685 contributes to individual susceptibility to alcoholic liver injury related to the Wnt\/beta-catenin-TCF1-CYP2E1 signaling pathway","volume":"93","author":"Xu","year":"2019","journal-title":"Arch. Toxicol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1136\/gutjnl-2019-319720","article-title":"Recent advances in alcohol-related liver disease (ALD): Summary of a Gut round table meeting","volume":"69","author":"Avila","year":"2020","journal-title":"Gut"},{"key":"ref_5","unstructured":"GBD 2016 Alcohol Collaborators (2018). Alcohol use and burden for 195 countries and territories, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet, 392, 1015\u20131035."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/S1470-2045(21)00279-5","article-title":"Global burden of cancer in 2020 attributable to alcohol consumption: A population-based study","volume":"22","author":"Rumgay","year":"2021","journal-title":"Lancet Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Bao, X.Y., Xu, B.B., Fang, K., Li, Y., Hu, Y.H., and Yu, G.P. (2015). Changing trends of hospitalisation of liver cirrhosis in Beijing, China. BMJ Open Gastroenterol., 2.","DOI":"10.1136\/bmjgast-2015-000051"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/ajg.2017.469","article-title":"ACG Clinical Guideline: Alcoholic Liver Disease","volume":"113","author":"Singal","year":"2018","journal-title":"Am. J. Gastroenterol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Li, S., Xu, Y., Guo, W., Chen, F., Zhang, C., Tan, H.Y., Wang, N., and Feng, Y. (2020). The Impacts of Herbal Medicines and Natural Products on Regulating the Hepatic Lipid Metabolism. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.00351"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Liu, Y.S., Yuan, M.H., Zhang, C.Y., Liu, H.M., Liu, J.R., Wei, A.L., Ye, Q., Zeng, B., Li, M.F., and Guo, Y.P. (2021). Puerariae Lobatae radix flavonoids and puerarin alleviate alcoholic liver injury in zebrafish by regulating alcohol and lipid metabolism. Biomed. Pharmacother., 134.","DOI":"10.1016\/j.biopha.2020.111121"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Zhou, J., Zhang, N., Zhao, L., Wu, W., Zhang, L., Zhou, F., and Li, J. (2021). Astragalus Polysaccharides and Saponins Alleviate Liver Injury and Regulate Gut Microbiota in Alcohol Liver Disease Mice. Foods., 10.","DOI":"10.3390\/foods10112688"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1002\/ptr.6410","article-title":"Natural compounds in the chemoprevention of alcoholic liver disease","volume":"33","author":"Tu","year":"2019","journal-title":"Phytother. Res."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Mirhadi, E., Roufogalis, B.D., Banach, M., Barati, M., and Sahebkar, A. (2021). Resveratrol: Mechanistic and therapeutic perspectives in pulmonary arterial hypertension. Pharmacol. Res., 163.","DOI":"10.1016\/j.phrs.2020.105287"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Zhou, D.D., Luo, M., Huang, S.Y., Saimaiti, A., Shang, A., Gan, R.Y., and Li, H.B. (2021). Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases. Oxid. Med. Cell. Longev., 2021.","DOI":"10.1155\/2021\/9932218"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Izzo, C., Annunziata, M., Melara, G., Sciorio, R., Dallio, M., Masarone, M., Federico, A., and Persico, M. (2021). The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials. Nutrients, 13.","DOI":"10.3390\/nu13030933"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Chambers, K.F., Day, P.E., Aboufarrag, H.T., and Kroon, P.A. (2019). Polyphenol Effects on Cholesterol Metabolism via Bile Acid Biosynthesis, CYP7A1: A Review. Nutrients, 11.","DOI":"10.3390\/nu11112588"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Yu, B., Qin, S.Y., Hu, B.L., Qin, Q.Y., Jiang, H.X., and Luo, W. (2019). Resveratrol improves CCL4-induced liver fibrosis in mouse by upregulating endogenous IL-10 to reprogramme macrophages phenotype from M(LPS) to M(IL-4). Biomed. Pharmacother., 117.","DOI":"10.1016\/j.biopha.2019.109110"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Trepiana, J., Krisa, S., Renouf, E., and Portillo, M.P. (2020). Resveratrol Metabolites Are Able to Reduce Steatosis in Cultured Hepatocytes. Pharmaceuticals, 13.","DOI":"10.3390\/ph13100285"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/hep.26607","article-title":"M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease","volume":"59","author":"Wan","year":"2014","journal-title":"Hepatology"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Huang, K., Zhang, P., Zhang, Z., Youn, J.Y., Wang, C., Zhang, H., and Cai, H. (2021). Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: Efficacies and mechanisms. Pharmacol. Ther., 225.","DOI":"10.1016\/j.pharmthera.2021.107843"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Wang, W.Y., Zhou, H., Wang, Y.F., Sang, B.S., and Liu, L. (2021). Current Policies and Measures on the Development of Traditional Chinese Medicine in China. Pharmacol. Res., 163.","DOI":"10.1016\/j.phrs.2020.105187"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1016\/j.jfda.2018.02.004","article-title":"Effects of processing adjuvants on traditional Chinese herbs","volume":"26","author":"Chen","year":"2018","journal-title":"J. Food Drug Anal."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.joim.2020.12.003","article-title":"Processing methods and mechanisms for alkaloid-rich Chinese herbal medicines: A review","volume":"19","author":"Li","year":"2021","journal-title":"J. Integr. Med."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Song, Y., Shan, B., Zeng, S., Zhang, J., Jin, C., Liao, Z., Wang, T., Zeng, Q., He, H., and Wei, F. (2021). Raw and wine processed Schisandra chinensis attenuate anxiety like behavior via modulating gut microbiota and lipid metabolism pathway. J. Ethnopharmacol., 266.","DOI":"10.1016\/j.jep.2020.113426"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1111\/1556-4029.14766","article-title":"Reflections on the aconitine poisoning","volume":"66","author":"Ya","year":"2021","journal-title":"J. Forensic Sci."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Xu, Y., Zhang, S.X., Guo, J., Chen, L.J., Liou, Y.L., Rao, T., Peng, J.B., Guo, Y., Huang, W.H., and Tan, Z.R. (2022). A Joint Technology Combining the Advantages of Capillary Microsampling with Mass Spectrometry Applied to the Trans-Resveratrol Pharmacokinetic Study in Mice. J. Anal. Methods Chem., 2022.","DOI":"10.1155\/2022\/5952436"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jare.2021.10.004","article-title":"Gut microbiota and host Cyp450s co-contribute to pharmacokinetic variability in mice with non-alcoholic steatohepatitis: Effects vary from drug to drug","volume":"39","author":"Guo","year":"2022","journal-title":"J. Adv. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.7150\/ijbs.63732","article-title":"Lrp6 Genotype affects Individual Susceptibility to Nonalcoholic Fatty Liver Disease and Silibinin Therapeutic Response via Wnt\/beta-catenin-Cyp2e1 Signaling","volume":"17","author":"Chen","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Luo, G., Huang, B., Qiu, X., Xiao, L., Wang, N., Gao, Q., Yang, W., and Hao, L. (2017). Resveratrol attenuates excessive ethanol exposure induced insulin resistance in rats via improving NAD (+)\/NADH ratio. Mol. Nutr. Food Res., 61.","DOI":"10.1002\/mnfr.201700087"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Bujanda, L., Garc\u00eda-Barcina, M., Guti\u00e9rrez de Juan, V., Bidaurrazaga, J., de Luco, M.F., Guti\u00e9rrez-Stampa, M., Larzabal, M., Hijona, E., Sarasqueta, C., and Echenique-Elizondo, M. (2006). Effect of resveratrol on alcohol-induced mortality and liver lesions in mice. BMC Gastroenterol., 6.","DOI":"10.1186\/1471-230X-6-35"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Ma, Z., Zhang, Y., Li, Q., Xu, M., Bai, J., and Wu, S. (2017). Resveratrol improves alcoholic fatty liver disease by downregulating HIF-1\u03b1 expression and mitochondrial ROS production. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0183426"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"G833","DOI":"10.1152\/ajpgi.90358.2008","article-title":"Resveratrol alleviates alcoholic fatty liver in mice","volume":"295","author":"Ajmo","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.3892\/etm.2016.3077","article-title":"Hepatoprotective effect of resveratrol against ethanol-induced oxidative stress through induction of superoxide dismutase in vivo and in vitro","volume":"11","author":"Chen","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cld.2016.08.001","article-title":"Drug Metabolism in the Liver","volume":"21","author":"Almazroo","year":"2017","journal-title":"Clin. Liver Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","article-title":"Alcoholic liver disease: Pathogenesis and new therapeutic targets","volume":"141","author":"Gao","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jhep.2018.10.008","article-title":"Hepatocellular carcinoma in the setting of alcohol-related liver disease","volume":"70","author":"Nahon","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Harjumaki, R., Pridgeon, C.S., and Ingelman-Sundberg, M. (2021). CYP2E1 in Alcoholic and Non-Alcoholic Liver Injury. Roles of ROS, Reactive Intermediates and Lipid Overload. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22158221"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/ptr.5549","article-title":"Resveratrol Pretreatment Affects CYP2E1 Activity of Chlorzoxazone in Healthy Human Volunteers","volume":"30","author":"Bedada","year":"2016","journal-title":"Phytother. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.15585\/mmwr.mm6932e1","article-title":"Serious Adverse Health Events, Including Death, Associated with Ingesting Alcohol-Based Hand Sanitizers Containing Methanol\u2014Arizona and New Mexico, May\u2013June 2020","volume":"69","author":"Yip","year":"2020","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1080\/15563650.2019.1708091","article-title":"Fomepizole to treat disulfiram-ethanol reaction: A case series","volume":"58","author":"Schicchi","year":"2020","journal-title":"Clin. Toxicol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1080\/15563650.2019.1676899","article-title":"Analysis of fomepizole safety based on a 16-year post-marketing experience in France","volume":"58","author":"Rasamison","year":"2020","journal-title":"Clin. Toxicol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/22\/4752\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:13:53Z","timestamp":1760145233000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/22\/4752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,10]]},"references-count":41,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["nu14224752"],"URL":"https:\/\/doi.org\/10.3390\/nu14224752","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,10]]}}}