{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T04:25:15Z","timestamp":1765254315603,"version":"build-2065373602"},"reference-count":57,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2020R1A2C1009608","WISET-2022-496"],"award-info":[{"award-number":["NRF-2020R1A2C1009608","WISET-2022-496"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vitamin D status is essential for preventing bone disease. Young Korean women have the highest vitamin D deficiency prevalence compared with other demographic groups. This study aimed to establish the optimal vitamin D intake level for maintaining an adequate serum 25-hydroxyvitamin D (25[OH]D) level by season in young Korean women (mean age: 23.1 years). Each participant (wintertime, n = 101; summertime, n = 117) completed a lifestyle survey, dietary record, bone mineral density, and biochemical tests. Seasonal factors impacting 25(OH)D were identified, vitamin D intake for sufficient 25(OH)D levels was calculated, and the relationship between 25(OH)D and intact parathyroid hormone (iPTH) was analyzed. During summertime, 25(OH)D levels were higher than in wintertime (17.9 vs. 15.0 ng\/mL). A 1 \u00b5g\/1000 kcal increase in vitamin D intake increased 25(OH)D levels by 0.170 ng\/mL in wintertime and 0.149 ng\/mL in summertime. iPTH levels reached a theoretical plateau corresponding to an 18.4 ng\/mL 25(OH)D level. The vitamin D intake threshold for maintaining 25(OH)D levels at \u226520 and \u226518.4 ng\/mL was \u226510.97 \u03bcg\/day. For a sufficient level of 25(OH)D in young Korean women, increasing summertime UV irradiation time and increasing vitamin D supplements and vitamin D-containing foods throughout the year is beneficial.<\/jats:p>","DOI":"10.3390\/nu14224845","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T03:27:44Z","timestamp":1668655664000},"page":"4845","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Optimal Serum 25(OH)D Level and Vitamin D Intake in Young Korean Women"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9434-7379","authenticated-orcid":false,"given":"Hye Ran","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition, Chungnam National University, Daejeon 34134, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2277-7382","authenticated-orcid":false,"given":"Hyeon Ju","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Chungnam National University, Daejeon 34134, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6813-8573","authenticated-orcid":false,"given":"Sun Yung","family":"Ly","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Chungnam National University, Daejeon 34134, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.21037\/apm-19-610","article-title":"Association between vitamin D deficiency and fragility fractures in Chinese elderly patients: A cross-sectional study","volume":"9","author":"Wang","year":"2020","journal-title":"Ann. Palliat. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.bone.2007.10.026","article-title":"Severe vitamin D deficiency in Swiss hip fracture patients","volume":"42","author":"Can","year":"2008","journal-title":"Bone"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/jgs.15716","article-title":"Osteoporosis in Older Persons: Old and New Players","volume":"67","author":"Zanker","year":"2019","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.beem.2008.08.005","article-title":"Nutrition: Its role in bone health","volume":"22","author":"Rizzoli","year":"2008","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00132-017-3446-y","article-title":"The effect of vitamin D and calcium supplementation on falls in older adults","volume":"46","author":"Wu","year":"2017","journal-title":"Der Orthop\u00e4de"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/s41430-020-0558-y","article-title":"Vitamin D deficiency 2.0: An update on the current status worldwide","volume":"74","author":"Amrein","year":"2020","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_7","first-page":"e19","article-title":"Vitamin D intake and bone mineral density in Korean adults: Analysis of the 2009\u20132011 Korea National Health and Nutrition Examination Survey","volume":"16","author":"You","year":"2021","journal-title":"Nutr. Res. Pract."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.maturitas.2017.12.010","article-title":"Causes of low peak bone mass in women","volume":"111","author":"Chew","year":"2018","journal-title":"Maturitas"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1365-2796.1992.tb00518.x","article-title":"Calcium and peak bone mass","volume":"231","author":"Matkovic","year":"1992","journal-title":"J. Intern. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/BF01880417","article-title":"Interaction of genetic and environmental influences on peak bone density","volume":"1","author":"Kelly","year":"1990","journal-title":"Osteoporos. Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1056\/NEJM198411153112002","article-title":"Relative contributions of aging and estrogen deficiency to postmenopausal bone loss","volume":"311","author":"Richelson","year":"1984","journal-title":"New Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Qian, Y., Wang, L., Yu, L., and Huang, W. (2021). Pregnancy- and lactation-associated osteoporosis with vertebral fractures: A systematic review. BMC Musculoskelet. Disord., 22.","DOI":"10.1186\/s12891-021-04776-7"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Woo, J., Penckofer, S., Fagan, M., and Giurgescu, C. (2022). Associations between Pregnancy-Related Symptoms, Serum 25(OH)D, and Physical Quality of Life in Pregnant Women. Nutrients, 14.","DOI":"10.3390\/nu14030482"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Jukic, A.M.Z., Song, H., Zhang, L., Yang, F., Wu, S., Yin, D., and Jiang, H. (2022). Serum Vitamin D Concentrations, Time to Pregnancy, and Pregnancy Outcomes among Preconception Couples: A Cohort Study in Shanghai, China. Nutrients, 14.","DOI":"10.3390\/nu14153058"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"365","DOI":"10.22203\/eCM.v035a25","article-title":"Calcium and vitamin D in bone fracture healing and post-traumatic bone turnover","volume":"35","author":"Fischer","year":"2018","journal-title":"Eur. Cell. Mater."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11657-018-0483-z","article-title":"Vitamin D and parathyroid hormone in relation to bone health in Croatian women","volume":"13","author":"Keser","year":"2018","journal-title":"Arch. Osteoporos."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/ajcn\/84.3.602","article-title":"Optimal vitamin D status and serum parathyroid hormone concentrations in African American women","volume":"84","author":"Aloia","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s11657-019-0565-6","article-title":"Vitamin D cutoff point in relation to parathyroid hormone: A population based study in Riyadh city, Saudi Arabia","volume":"14","author":"AlQuaiz","year":"2019","journal-title":"Arch. Osteoporos."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.nutres.2022.06.002","article-title":"Dietary vitamin D intake in low ultraviolet irradiation seasons is associated with a better nutritional status of vitamin D in Korean adults according to the 2013\u20132014 National Health and Nutrition Examination Survey","volume":"105","author":"Shin","year":"2022","journal-title":"Nutr. Res."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Asakura, K., Etoh, N., Imamura, H., Michikawa, T., Nakamura, T., Takeda, Y., Mori, S., and Nishiwaki, Y. (2020). Vitamin D status in Japanese adults: Relationship of serum 25-hydroxyvitamin D with simultaneously measured dietary vitamin D intake and ultraviolet ray exposure. Nutrients, 12.","DOI":"10.3390\/nu12030743"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jsbmb.2019.02.017","article-title":"Determinants of vitamin D status of healthy office workers in Sydney, Australia","volume":"189","author":"Brock","year":"2019","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_22","unstructured":"The Korean Nutrition Society (2020). Dietary Reference Intakes for Koreans 2020, Ministry of Health and Welfare."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"115","DOI":"10.4162\/nrp.2019.13.2.115","article-title":"Association between vitamin D intake and bone mineral density in Koreans aged \u2265 50 years: Analysis of the 2009 Korea National Health and Nutrition Examination Survey using a newly established vitamin D database","volume":"13","author":"Yoo","year":"2019","journal-title":"Nutr. Res. Pract."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.11005\/jbm.2016.23.2.55","article-title":"Inadequate dietary calcium and vitamin D intake in patients with osteoporotic fracture","volume":"23","author":"Yoon","year":"2016","journal-title":"J. Bone Metab."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/s00774-016-0782-7","article-title":"Low calcium and vitamin D intake in Korean women over 50 years of age","volume":"35","author":"Lee","year":"2017","journal-title":"J. Bone Miner. Metab."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Yoo, K., Cho, J., and Ly, S. (2016). Vitamin D intake and serum 25-hydroxyvitamin D levels in korean adults: Analysis of the 2009 Korea national health and nutrition examination survey (KNHANES IV-3) using a newly established vitamin D database. Nutrients, 8.","DOI":"10.3390\/nu8100610"},{"key":"ref_27","first-page":"532","article-title":"Validity and Reliability of Korean Version of International Physical Activity Questionnaire (IPAQ) Short Form","volume":"28","author":"Oh","year":"2007","journal-title":"Korean J. Fam. Med."},{"key":"ref_28","unstructured":"The Korean Nutrition Society (2022, August 25). Computer Aided Nutritional Analysis Program; CAN-Pro 5.0 (Web Ver.). Available online: http:\/\/canpro5.kns.or.kr\/."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.clinbiochem.2012.06.002","article-title":"Performance Evaluation of Siemens ADVIA Centaur and Roche MODULAR Analytics E170 Total 25-OH Vitamin D Assays","volume":"45","author":"Chen","year":"2012","journal-title":"Clin. Biochem."},{"key":"ref_30","unstructured":"Del Valle, H.B., Yaktine, A.L., Taylor, C.L., and Ross, A.C. (2011). Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. Dietary Reference Intakes for Calcium and Vitamin D, National Academies Press."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: An endocrine society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s001980050219","article-title":"Vitamin D status during puberty in French healthy aale adolescents","volume":"10","author":"Guillemant","year":"1999","journal-title":"Osteoporos. Int."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s001980050030","article-title":"Prevalence of Vitamin D Insufficiency in an Adult Normal Population","volume":"7","author":"Chapuy","year":"1997","journal-title":"Osteoporos. Int."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"New Engl. J. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/cen.14012","article-title":"Absence of vitamin D deficiency among common outdoor workers in Delhi","volume":"91","author":"Dharmshaktu","year":"2019","journal-title":"Clin. Endocrinol."},{"key":"ref_36","first-page":"123","article-title":"The Radiative Characteristics of EUV-B over the Korean Peninsula and Exposure Time for Synthesizing Adequate Vitamin D","volume":"21","author":"Kwak","year":"2011","journal-title":"Atmosphere"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4328151","DOI":"10.1155\/2019\/4328151","article-title":"Simulation of threshold UV exposure time for vitamin D synthesis in South Korea","volume":"2019","author":"Park","year":"2019","journal-title":"Adv. Meteorol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Ekwaru, J.P., Zwicker, J.D., Holick, M.F., Giovannucci, E., and Veugelers, P.J. (2014). The importance of body weight for the dose response relationship of oral vitamin D supplementation and serum 25-hydroxyvitamin D in healthy volunteers. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0111265"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1017\/S0007114521002816","article-title":"The effects of vitamin D-fortified foods on circulating 25(OH)D concentrations in adults: A systematic review and meta-analysis","volume":"127","author":"Nikooyeh","year":"2022","journal-title":"Br. J. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00198-005-1867-7","article-title":"Estimates of optimal vitamin D status","volume":"16","author":"Heaney","year":"2005","journal-title":"Osteoporos. Int."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1007\/s00774-017-0879-7","article-title":"Optimal vitamin D intake for preventing serum 25-hydroxyvitamin D insufficiency in young Japanese women","volume":"36","author":"Ohta","year":"2018","journal-title":"J. Bone Miner. Metab."},{"key":"ref_42","first-page":"8570986","article-title":"Vitamin D Intake among Premenopausal Women Living in Jeddah: Food Sources and Relationship to Demographic Factors and Bone Health","volume":"2018","author":"Zareef","year":"2018","journal-title":"Nutr. Metab."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s11914-996-0028-z","article-title":"The role of vitamin D for bone health and fracture prevention","volume":"4","author":"Holick","year":"2006","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"437","DOI":"10.4163\/jnh.2016.49.6.437","article-title":"Vitamin D intake, serum 25OHD, and bone mineral density of Korean adults: Based on the Korea national health and nutrition examination survey (KNHANES, 2011)","volume":"49","author":"Kim","year":"2016","journal-title":"J. Nutr. Health"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1017\/S0007114510000437","article-title":"Effect of vitamin D, calcium and multiple micronutrient supplementation on vitamin D and bone status in Bangladeshi premenopausal garment factory workers with hypovitaminosis D: A double-blinded, randomised, placebo-controlled 1-year intervention","volume":"104","author":"Islam","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"624","DOI":"10.3945\/ajcn.113.067199","article-title":"Vitamin D supplementation increases calcium absorption without a threshold effect","volume":"99","author":"Aloia","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3945\/ajcn.112.044909","article-title":"Vitamin D supplementation and calcium absorption during caloric restriction: A randomized double-blind trial","volume":"97","author":"Shapses","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_48","unstructured":"Korea Health Industry Development Institute (2022, August 26). National Nutrition Statistics. Available online: https:\/\/www.khidi.or.kr\/kps\/dhraStat\/result5?menuId=MENU01656&gubun=age3&year=2020."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.clinbiochem.2009.04.001","article-title":"Bone turnover markers in the management of postmenopausal osteoporosis","volume":"42","author":"Brown","year":"2009","journal-title":"Clin. Biochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.bone.2008.01.011","article-title":"Vitamin D status in postmenopausal women living at higher latitudes in the UK in relation to bone health, overweight, sunlight exposure and dietary vitamin D","volume":"42","author":"Macdonald","year":"2008","journal-title":"Bone"},{"key":"ref_51","first-page":"6794837","article-title":"The effect of clothing on vitamin D status, bone turnover markers, and bone mineral density in young Kuwaiti females","volume":"2019","author":"AlOtaibi","year":"2019","journal-title":"Int. J. Endocrinol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1007\/s00774-009-0094-2","article-title":"Age-related distribution of bone and skeletal parameters in 1,322 Japanese young women","volume":"27","author":"Orito","year":"2009","journal-title":"J. Bone Miner. Metab."},{"key":"ref_53","unstructured":"Williams, C., and Sapra, A. (2022, October 19). Osteoporosis Markers, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559306\/."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00198-010-1501-1","article-title":"Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: A need for international reference standards","volume":"22","author":"Vasikaran","year":"2011","journal-title":"Osteoporos. Int."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"R19","DOI":"10.1530\/EJE-17-0585","article-title":"DIAGNOSIS OF ENDOCRINE DISEASE: Bone turnover markers: Are they clinically useful?","volume":"178","author":"Eastell","year":"2018","journal-title":"Eur. J. Endocrinol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650090802","article-title":"The diagnosis of osteoporosis","volume":"9","author":"Kanis","year":"1994","journal-title":"J. Bone Miner. Res."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Whiting, S.J., and Calvo, M.S. (2018). Vitamin D fortification and supplementation policies to correct vitamin D insufficiency\/deficiency globally. Vitamin D, Elsevier Academic Press.","DOI":"10.1016\/B978-0-12-809963-6.00062-6"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/22\/4845\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:19:28Z","timestamp":1760145568000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/22\/4845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,16]]},"references-count":57,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["nu14224845"],"URL":"https:\/\/doi.org\/10.3390\/nu14224845","relation":{},"ISSN":["2072-6643"],"issn-type":[{"type":"electronic","value":"2072-6643"}],"subject":[],"published":{"date-parts":[[2022,11,16]]}}}