{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:25:14Z","timestamp":1782732314428,"version":"3.54.5"},"reference-count":25,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation (NRF)","doi-asserted-by":"publisher","award":["NRF-2020R1A2C212660"],"award-info":[{"award-number":["NRF-2020R1A2C212660"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation (NRF)","doi-asserted-by":"publisher","award":["NRF-2020R1A2C4002594"],"award-info":[{"award-number":["NRF-2020R1A2C4002594"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>A high rate of Meniere\u2019s disease (MD) in patients with osteoporosis has been suggested. This research intended to estimate the bidirectional association of MD with osteoporosis. The \u226540-year-old population in the Korean National Health Insurance Service-Health Screening Cohort 2002\u20132019 was examined. In study I, 9529 patients with MD and 38,116 control I participants were analyzed for a previous history of osteoporosis. In study II, 65,858 patients with osteoporosis and 65,858 control II participants were analyzed for a previous history of MD. Stratified Cox proportional hazard models were applied to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) of MD for osteoporosis in study I and of osteoporosis for MD in study II. The rate of a prior history of osteoporosis was 13.3% for the MD group and 11.3% for the control I group. The patients with MD had a 1.12 times higher HR for previous osteoporosis (95% CI = 1.04\u20131.20). In study II, the rate or a prior history of MD was 3.7% for patients with osteoporosis and 2.0% for the control II group. The patients with osteoporosis had a 1.50 times higher HR for previous MD (95% CI = 1.40\u20131.61). Most subgroups according to age, sex, and comorbid conditions demonstrated consistent bidirectional associations between MD and osteoporosis. Adult patients with MD had a greater risk of osteoporosis. In addition, adult patients with osteoporosis also showed a higher risk of MD.<\/jats:p>","DOI":"10.3390\/nu14224885","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T04:13:36Z","timestamp":1669004016000},"page":"4885","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between Osteoporosis and Meniere\u2019s Disease: Two Longitudinal Follow-Up Cohort Studies"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1655-9549","authenticated-orcid":false,"given":"Hyo Geun","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Anyang 14068, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juyong","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head & Neck Surgery, Wonkwang University School of Medicine, Iksan 54538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2511-5536","authenticated-orcid":false,"given":"Dae Myoung","family":"Yoo","sequence":"additional","affiliation":[{"name":"Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam 13496, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7361-4930","authenticated-orcid":false,"given":"So Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam 13496, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"ref_1","first-page":"S1","article-title":"Clinical Practice Guideline: Meniere\u2019s Disease","volume":"162","author":"Basura","year":"2020","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3109\/00016489509121906","article-title":"Epidemiological and clinical characteristics of Meniere\u2019s disease in Japan","volume":"519","author":"Watanabe","year":"1995","journal-title":"Acta Otolaryngol. Suppl."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000189783","article-title":"Meniere\u2019s disease is a viral neuropathy","volume":"71","author":"Gacek","year":"2009","journal-title":"ORL J. Otorhinolaryngol. Relat. Spec."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.autrev.2012.01.004","article-title":"Meniere\u2019s disease might be an autoimmune condition?","volume":"11","author":"Greco","year":"2012","journal-title":"Autoimmun. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"107872","DOI":"10.1016\/j.heares.2019.107872","article-title":"Genetic architecture of Meniere\u2019s disease","volume":"397","year":"2020","journal-title":"Hear. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1007\/s00415-015-7930-1","article-title":"What is Meniere\u2019s disease? A contemporary re-evaluation of endolymphatic hydrops","volume":"263","author":"Gurkov","year":"2016","journal-title":"J. Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1177\/0194599816675843","article-title":"A New Theory for Meniere\u2019s Disease: Detached Saccular Otoconia","volume":"156","author":"Hornibrook","year":"2017","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1159\/000124277","article-title":"Ultrastructural changes in otoconia of osteoporotic rats","volume":"13","author":"Vibert","year":"2008","journal-title":"Audiol. Neurotol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s11657-021-01006-4","article-title":"Relationship between osteoporosis and benign paroxysmal positional vertigo based on evidence-based medicine and bioinformatics","volume":"16","author":"Guo","year":"2021","journal-title":"Arch. Osteoporos."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/AUD.0000000000000320","article-title":"Association between Osteoporosis\/Osteopenia and Vestibular Dysfunction in South Korean Adults","volume":"37","author":"Park","year":"2016","journal-title":"Ear Hear."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s11914-015-0271-2","article-title":"The Vestibular System: A Newly Identified Regulator of Bone Homeostasis Acting Through the Sympathetic Nervous System","volume":"13","author":"Vignaux","year":"2015","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.bjorl.2016.08.012","article-title":"Significant association between osteoporosis and hearing loss: A systematic review and meta-analysis","volume":"83","author":"Upala","year":"2017","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Kim, S.Y., Yoo, D.M., Min, C., and Choi, H.G. (2021). Association between Osteoporosis and Low Hemoglobin Levels: A Nested Case-Control Study Using a National Health Screening Cohort. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18168598"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1001\/jamaoto.2022.0331","article-title":"Association Between Meniere Disease and Migraine","volume":"148","author":"Kim","year":"2022","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"278","DOI":"10.21053\/ceo.2021.00325","article-title":"Hearing Impairment Increases Economic Inequality","volume":"14","author":"Kim","year":"2021","journal-title":"Clin. Exp. Otorhinolaryngol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000506039","article-title":"Bone Mineral Density in Patients Suffering from Meniere\u2019s Disease","volume":"25","author":"Shupak","year":"2020","journal-title":"Audiol. Neurotol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.annepidem.2013.10.012","article-title":"Low bone mineral density is associated with balance and hearing impairments","volume":"24","author":"Mendy","year":"2014","journal-title":"Ann. Epidemiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00405-017-4768-4","article-title":"Altered auditory and vestibular functioning in individuals with low bone mineral density: A systematic review","volume":"275","author":"Singh","year":"2018","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/jbmr.2426","article-title":"Inner Ear Vestibular Signals Regulate Bone Remodeling via the Sympathetic Nervous System","volume":"30","author":"Vignaux","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3233\/VES-2004-14501","article-title":"Labyrinthectomy decreases bone mineral density in the femoral metaphysis in rats","volume":"14","author":"Levasseur","year":"2004","journal-title":"J. Vestib. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e12979","DOI":"10.14814\/phy2.12979","article-title":"The vestibular system is critical for the changes in muscle and bone induced by hypergravity in mice","volume":"4","author":"Kawao","year":"2016","journal-title":"Physiol. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1017\/S0022215118001366","article-title":"Saccular otoconia as a cause of Meniere\u2019s disease: Hypothesis based on two theories","volume":"132","author":"Hornibrook","year":"2018","journal-title":"J. Laryngol. Otol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1007\/s00415-020-10175-0","article-title":"Risk factors for benign paroxysmal positional vertigo recurrence: A systematic review and meta-analysis","volume":"268","author":"Chen","year":"2021","journal-title":"J. Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1177\/000348940311201010","article-title":"Benign paroxysmal positional vertigo in older women may be related to osteoporosis and osteopenia","volume":"112","author":"Vibert","year":"2003","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s12603-013-0357-4","article-title":"A path model of sarcopenia on bone mass loss in elderly subjects","volume":"18","author":"Rondanelli","year":"2014","journal-title":"J. Nutr. Health Aging"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/22\/4885\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:21:28Z","timestamp":1760145688000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/22\/4885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,18]]},"references-count":25,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["nu14224885"],"URL":"https:\/\/doi.org\/10.3390\/nu14224885","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,18]]}}}