{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:00:49Z","timestamp":1787029249975,"version":"build-2736575974"},"reference-count":53,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T00:00:00Z","timestamp":1668902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Medical Research Development (NIMAD)","award":["IR.NIMAD.REC.1394.027"],"award-info":[{"award-number":["IR.NIMAD.REC.1394.027"]}]},{"name":"National Institute of Medical Research Development (NIMAD)","award":["24706"],"award-info":[{"award-number":["24706"]}]},{"DOI":"10.13039\/501100007076","name":"Fondazione AIRC","doi-asserted-by":"publisher","award":["IR.NIMAD.REC.1394.027"],"award-info":[{"award-number":["IR.NIMAD.REC.1394.027"]}],"id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007076","name":"Fondazione AIRC","doi-asserted-by":"publisher","award":["24706"],"award-info":[{"award-number":["24706"]}],"id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>As colorectal cancer (CRC) is largely due to modifiable lifestyle habits, the awareness on its risk factors is highly important. Dietary fatty acids have been linked to CRC risk. We explored the association between dietary trans fatty acids (TFAs) intake and CRC risk. We analyzed 865 CRC cases (434 in colon and 404 in rectum) and 3206 controls of the IROPICAN study, with data collected by trained interviewers using validated questionnaires. TFAs intake (industrial and ruminant types) was categorized into quartiles. Multivariate logistic regression models were built to calculate the odds ratios (OR) for the association between CRC and TFAs. We observed a positive association between industrial TFAs and colon cancer (OR for highest vs lowest quartile [ORQ4vsQ1] = 1.28, 95% confidence interval 1.07\u20131.54). A higher association was observed between industrial TFAs and CRC, occurring after 50 years of age. In addition, elaidic acid was associated with an increased risk of colon (ORQ4vsQ1 = 1.58, 1.24\u20132.02) and specifically of proximal colon cancer (OR Q4vsQ1 = 2.12, 1.40\u20133.20), as well as of rectum cancer (ORQ4vsQ1 = 1.40, 1.07\u20131.83). An inverse association was observed between ruminant TFAs intake and colon cancer risk (ORQ4vsQ1 = 0.80, 0.67\u20130.97). Industrial TFAs, such as semisolid\/solid hydrogenated oils, may increase the risk of CRC, especially colon and proximal colon cancer. In contrast, ruminant TFAs do not appear to be associated with CRC. Awareness programs and regulatory actions regarding hydrogenated oils are warranted, given their high consumption through ultra-processed foods in more developed and less developed countries.<\/jats:p>","DOI":"10.3390\/nu14224912","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T04:13:36Z","timestamp":1669004016000},"page":"4912","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dietary Ruminant and Industrial Trans-Fatty Acids Intake and Colorectal Cancer Risk"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9063-9128","authenticated-orcid":false,"given":"Monireh Sadat","family":"Seyyedsalehi","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy"},{"name":"Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran 1419733141, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2309-7365","authenticated-orcid":false,"given":"Giulia","family":"Collatuzzo","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamideh","family":"Rashidian","sequence":"additional","affiliation":[{"name":"Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran 1419733141, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5486-7513","authenticated-orcid":false,"given":"Maryam","family":"Hadji","sequence":"additional","affiliation":[{"name":"Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran 1419733141, Iran"},{"name":"Health Sciences Unit, Faculty of Social Sciences, Tampere University, 33014 Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1551-9254","authenticated-orcid":false,"given":"Mahin","family":"Gholipour","sequence":"additional","affiliation":[{"name":"Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan 4934174515, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0868-4067","authenticated-orcid":false,"given":"Elham","family":"Mohebbi","sequence":"additional","affiliation":[{"name":"Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran 1419733141, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farin","family":"Kamangar","sequence":"additional","affiliation":[{"name":"Department of Biology, School of Computer, Mathematical, and Natural Sciences, Morgan State University, Baltimore, MD 21251, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9536-6440","authenticated-orcid":false,"given":"Eero","family":"Pukkala","sequence":"additional","affiliation":[{"name":"Health Sciences Unit, Faculty of Social Sciences, Tampere University, 33014 Tampere, Finland"},{"name":"Finnish Cancer Registry-Institute for Statistical and Epidemiological Cancer Research, 00130 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3838-855X","authenticated-orcid":false,"given":"Inge","family":"Huybrechts","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer, 69372 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc J.","family":"Gunter","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer, 69372 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1297-3064","authenticated-orcid":false,"given":"Veronique","family":"Chajes","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer, 69372 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3811-2791","authenticated-orcid":false,"given":"Paolo","family":"Boffetta","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy"},{"name":"Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazem","family":"Zendehdel","sequence":"additional","affiliation":[{"name":"Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran 1419733141, Iran"},{"name":"Cancer Biology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran 1419733141, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"A Cancer J. 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