{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:08:57Z","timestamp":1789142937583,"version":"build-2803163510"},"reference-count":41,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"national medical reform major program: Chinese adults chronic diseases and nutrition surveillance","award":["131031107000210003"],"award-info":[{"award-number":["131031107000210003"]}]},{"name":"national medical reform major program: Chinese adults chronic diseases and nutrition surveillance","award":["2016ZX08011-005"],"award-info":[{"award-number":["2016ZX08011-005"]}]},{"name":"national financial projects: assessment and application of nutrients requirement and food environment for Chinese residents","award":["131031107000210003"],"award-info":[{"award-number":["131031107000210003"]}]},{"name":"national financial projects: assessment and application of nutrients requirement and food environment for Chinese residents","award":["2016ZX08011-005"],"award-info":[{"award-number":["2016ZX08011-005"]}]},{"name":"major national science and technology projects","award":["131031107000210003"],"award-info":[{"award-number":["131031107000210003"]}]},{"name":"major national science and technology projects","award":["2016ZX08011-005"],"award-info":[{"award-number":["2016ZX08011-005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vitamin D is very important in maintaining children\u2019s bone health because of its regulatory role in calcium and phosphate metabolism. To better understand vitamin D status and related risk factors of children and adolescents in China, this study analyzed the 25-hydroxyvitamin-D (25(OH)D) concentration of children and adolescents aged 6\u201317 years in China and assessed the risk factors of vitamin D deficiency and insufficiency. We analyzed the data of 25(OH)D concentration collected from the China National Nutrition and Health Survey of Children and Lactating Mothers in 2016\u20132017 (CNNHS 2016\u20132017). The age, sex, region type, ethnicities, season, weight and height were recorded, measured by unified questionnaire, equipment and standards. The concentration of 25(OH)D was detected by LC-MS\/MS. A total of 64,391 participants from the cross-sectional study of CNNHS in 2016\u20132017 were included in this study. The median serum 25(OH)D concentration was 17.70 (13.20\u201322.68) ng\/mL, 18.70 (14.10\u201323.80) ng\/mL in boys and 16.60 (12.40\u201321.40) ng\/mL in girls. The total prevalence rate of vitamin D deficiency and insufficiency was 65.98% when the cut-off was 20 ng\/mL, 60.42% for boys and 71.99% for girls. According to the results of logistic regression analysis, girls aged above 12 y, living in midlands and northern regions, in spring and winter seasons and with abdominal obesity will have a significantly increased risk of vitamin D deficiency and insufficiency among Chinese children and adolescents. The results showed that vitamin D deficiency and insufficiency are very common among children and adolescents aged 6\u201317 y in China. They should be encouraged to have more effective sunlight exposure, increased intake of vitamin D from food or supplements in their diet, especially for those aged above 12 y, living in the northern or midlands areas, in spring and winter, and abdominally obese.<\/jats:p>","DOI":"10.3390\/nu14224928","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T03:08:37Z","timestamp":1669086517000},"page":"4928","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Vitamin D Status for Chinese Children and Adolescents in CNNHS 2016\u20132017"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0423-9169","authenticated-orcid":false,"given":"Yichun","family":"Hu","sequence":"first","affiliation":[{"name":"Key Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, China CDC, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, China CDC, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1939-5906","authenticated-orcid":false,"given":"Jiaxi","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, China CDC, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, China CDC, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, China CDC, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichen","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, China CDC, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jsbmb.2013.11.003","article-title":"Is vitamin D deficiency a major global public health problem?","volume":"144","author":"Palacios","year":"2014","journal-title":"J. Steroid. Biochem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11906-012-0262-y","article-title":"Vitamin D and Cardiovascular Risk","volume":"14","author":"Motiwala","year":"2012","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nrc3691","article-title":"The role of vitamin D in reducing cancer risk and progression","volume":"14","author":"Feldman","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2310\/JIM.0b013e31821b8755","article-title":"Vitamin D and the Immune System","volume":"59","author":"Aranow","year":"2011","journal-title":"J. Investig. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/nyas.13968","article-title":"Global prevalence and disease burden of vitamin D deficiency: A roadmap for action in low- and middle-income countries","volume":"1430","author":"Roth","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.ecl.2017.07.002","article-title":"Global Overview of Vitamin D Status","volume":"46","author":"Schoor","year":"2017","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jsbmb.2016.12.002","article-title":"Vitamin D measurement standardization: The way out of the chaos","volume":"173","author":"Binkley","year":"2016","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_8","unstructured":"Ross, A.C., Taylor, C.L., Yaktine, A.L., and Del Valle, H.B. (2011). Dietary Reference Intakes for Calcium and Vitamin D, National Academies Press."},{"key":"ref_9","first-page":"692","article-title":"Vitamin D in the Healthy European Paediatric Population","volume":"56","author":"Braegger","year":"2013","journal-title":"J. Craniofacial Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"179","DOI":"10.46234\/ccdcw2021.054","article-title":"Tracking New Challenges of Nutrition Transition and Developing Specific Strategies to Promote Healthy China","volume":"3","author":"Ding","year":"2021","journal-title":"China CDC Wkly."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Shi, J., He, L., Yu, D., Ju, L., Guo, Q., Piao, W., Xu, X., Zhao, L., Yuan, X., and Cao, Q. (2022). Prevalence and Correlates of Metabolic Syndrome and Its Components in Chinese Children and Adolescents Aged 7\u201317: The China National Nutrition and Health Survey of Children and Lactating Mothers from 2016\u20132017. Nutrients, 14.","DOI":"10.3390\/nu14163348"},{"key":"ref_12","unstructured":"Ma, X.W. (2018). China Health Statistics Yearbook in 2018, China Union Medical University Press."},{"key":"ref_13","unstructured":"China CDC (2016). Workbook of China National Nutrition and Health Survey of Children and Lactating Mothers (2016\u20132017), Unpublished Work."},{"key":"ref_14","unstructured":"(2014). Screening Standard for Malnutrition of School-Age Children and Adolescents (Standard No. WS\/T456-2014)."},{"key":"ref_15","unstructured":"(2018). High Waist Circumference Screening Threshold among Children and Adolescents Aged 7\u201317 Years (Standard No. WS\/T611-2018)."},{"key":"ref_16","unstructured":"(2018). Method for Vitamin D Deficiency Screening (Standard No. WS\/T677-2020)."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Hu, Y., Chen, J., Wang, R., Li, M., Yun, C., Li, W., Yang, Y., Piao, J., Yang, X., and Yang, L. (2017). Vitamin D Nutritional Status and Its Related Factors for Chinese Children and Adolescents in 2010\u20132012. Nutrients, 9.","DOI":"10.3390\/nu9091024"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.jchromb.2010.03.035","article-title":"Measurement of 25-OH-vitamin D in human serum using liquid chromatography tandem-mass spectrometry with comparison to radioimmunoassay and automated immunoassay","volume":"878","author":"Ouweland","year":"2010","journal-title":"J. Chromatogr. B"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cca.2015.06.007","article-title":"Comparison of two 25-hydroxyvitamin D immunoassays to liquid chromatography\u2013tandem mass spectrometry in assessing samples from the Chinese population","volume":"448","author":"Yun","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Hu, Y., Wang, R., Mao, D., Chen, J., Li, M., Li, W., Yang, Y., Zhao, L., Zhang, J., and Piao, J. (2021). Vitamin D Nutritional Status of Chinese Pregnant Women, Comparing the Chinese National Nutrition Surveillance (CNHS) 2015\u20132017 with CNHS 2010\u20132012. Nutrients, 13.","DOI":"10.3390\/nu13072237"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e11032","DOI":"10.1097\/MD.0000000000011032","article-title":"Vitamin D status in South Korean population: Seven-year trend from the KNHANES","volume":"97","author":"Park","year":"2018","journal-title":"Medicine"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"729","DOI":"10.3390\/nu6020729","article-title":"Vitamin D Deficiency in India: Prevalence, Causalities and Interventions","volume":"6","author":"Ritu","year":"2014","journal-title":"Nutrients"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"16790","DOI":"10.1038\/s41598-022-21279-0","article-title":"Vitamin D status and determinants in Indian children and adolescents: A multicentre study","volume":"12","author":"Khadilkar","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3945\/ajcn.115.127985","article-title":"The vitamin D status of the US population from 1988 to 2010 using standardized serum concentrations of 25-hydroxyvitamin D shows recent modest increases","volume":"104","author":"Schleicher","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/ajcn\/nqz037","article-title":"Vitamin D status in the United States, 2011\u20132014","volume":"110","author":"Herrick","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/jbmr.1587","article-title":"Temporal trends and determinants of longitudinal change in 25-hydroxyvitamin D and parathyroid hormone levels","volume":"27","author":"Berger","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.mayocp.2015.02.012","article-title":"Changing Incidence of Serum 25-Hydroxyvitamin D Values Above 50 ng\/mL: A 10-Year Population-Based Study","volume":"90","author":"Dudenkov","year":"2015","journal-title":"Mayo Clin. Proc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jsbmb.2012.09.034","article-title":"Survey of current vitamin D food fortification practices in the United States and Canada","volume":"136","author":"Calvo","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.3945\/jn.111.142257","article-title":"Foods, fortificants, and supplements: Where do Americans get their nutrients?","volume":"141","author":"Fulgoni","year":"2011","journal-title":"J. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"260","DOI":"10.26719\/emhj.19.084","article-title":"Vitamin D deficiency in healthy children in Bahrain: Do gender and age matter?","volume":"26","author":"Isa","year":"2020","journal-title":"East. Mediterr. Health J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.3945\/jn.115.227728","article-title":"National Estimates of Serum Total 25-Hydroxyvitamin D and Metabolite Concentrations Measured by Liquid Chromatography\u2013Tandem Mass Spectrometry in the US Population during 2007\u20132010","volume":"146","author":"Schleicher","year":"2016","journal-title":"J. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1136\/adc.87.2.111","article-title":"The impact of atmospheric pollution on vitamin D status of infants and toddlers in Delhi, India","volume":"87","author":"Agarwal","year":"2002","journal-title":"Arch. Dis. Child."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1007\/s00431-013-2119-z","article-title":"Vitamin D status and predictors of hypovitaminosis D in Italian children and adolescents: A cross-sectional study","volume":"172","author":"Vierucci","year":"2013","journal-title":"Eur. J. Pediatr."},{"key":"ref_34","first-page":"183","article-title":"Relationship between quantity of illumination and human vitamin D concentration and bone mineral density in different region","volume":"18","author":"Lian","year":"2012","journal-title":"Chin. J. Osteoporos."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"306","DOI":"10.21101\/cejph.a5947","article-title":"Serum vitamin D levels in healthy urban population at reproductive age: Effects of age, gender and season","volume":"28","author":"Karacan","year":"2020","journal-title":"Cent. Eur. J. Public Health"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1631\/jzus.B1500285","article-title":"Vitamin D status among infants, children, and adolescents in southeastern China","volume":"17","author":"Wang","year":"2016","journal-title":"J. Zhejiang Univ.-Sci. B (Biomed. Biotechnol.)"},{"key":"ref_37","first-page":"1","article-title":"Seasonal variation in vitamin D status of Japanese infants starts to emerge at 2 months of age: A retrospective cohort study","volume":"26","author":"Takahashi","year":"2022","journal-title":"Br. J. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jsbmb.2012.12.003","article-title":"The effect of vitamin D supplementation on serum 25(OH)D in thin and obese women","volume":"136","author":"Gallagher","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1017\/jns.2020.47","article-title":"Prevalence of vitamin D status and its association with overweight or obesity in a population of Colombian children and adolescents","volume":"9","author":"Rojas","year":"2020","journal-title":"J. Nutr. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1515\/jpem-2017-0246","article-title":"Obesity is associated with vitamin D deficiency in Danish children and adolescents","volume":"31","author":"Plesner","year":"2017","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"806459","DOI":"10.3389\/fnut.2022.806459","article-title":"Serum Vitamin D Levels in Relation to Abdominal Obesity in Children and Adolescents: A Systematic Review and Dose-Response Meta-Analysis","volume":"9","author":"Hajhashemy","year":"2022","journal-title":"Front. Nutr."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/22\/4928\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:22:52Z","timestamp":1760145772000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/22\/4928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,21]]},"references-count":41,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["nu14224928"],"URL":"https:\/\/doi.org\/10.3390\/nu14224928","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,21]]}}}