{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:35:17Z","timestamp":1767839717217,"version":"3.49.0"},"reference-count":42,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000199","name":"USDA NIFA Seed","doi-asserted-by":"publisher","award":["2020-67018-30852"],"award-info":[{"award-number":["2020-67018-30852"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Connecticut Foundation Esperance Funds","award":["2020-67018-30852"],"award-info":[{"award-number":["2020-67018-30852"]}]},{"name":"Berries Ltd.","award":["2020-67018-30852"],"award-info":[{"award-number":["2020-67018-30852"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Beneficial effects of blackcurrant supplementation on bone metabolism in mice has recently been demonstrated, but no studies are available in humans. The current study aimed to examine the dose-dependent effects of blackcurrant in preventing bone loss and the underlying mechanisms of action in adult women. Forty peri- and early postmenopausal women were randomly assigned into one of three treatment groups for 6 months: (1) a placebo (control group, n = 13); (2) 392 mg\/day of blackcurrant powder (low blackcurrant, BC, group, n = 16); and (3) 784 mg\/day of blackcurrant powder (high BC group, n = 11). The significance of differences in outcome variables was tested by repeated-measures ANOVA with treatment and time as between- and within-subject factors, respectively. Overall, blackcurrant supplementation decreased the loss of whole-body bone mineral density (BMD) compared to the control group (p &lt; 0.05), though the improvement of whole-body BMD remained significant only in the high BC group (p &lt; 0.05). Blackcurrant supplementation also led to a significant increase in serum amino-terminal propeptide of type 1 procollagen (P1NP), a marker of bone formation (p &lt; 0.05). These findings suggest that daily consumption of 784 mg of blackcurrant powder for six months mitigates the risk of postmenopausal bone loss, potentially through enhancing bone formation. Further studies of larger samples with various skeletal conditions are warranted to confirm these findings.<\/jats:p>","DOI":"10.3390\/nu14234971","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T02:54:05Z","timestamp":1669258445000},"page":"4971","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Blackcurrants Reduce the Risk of Postmenopausal Osteoporosis: A Pilot Double-Blind, Randomized, Placebo-Controlled Clinical Trial"],"prefix":"10.3390","volume":"14","author":[{"given":"Briana M.","family":"Nosal","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi R.","family":"Sakaki","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Macdonald","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle","family":"Mahoney","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2689-8376","authenticated-orcid":false,"given":"Kijoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA"},{"name":"Department of Food and Nutrition, Sookmyung Women\u2019s University, Seoul 04310, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Madore","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1449-4860","authenticated-orcid":false,"given":"Staci","family":"Thornton","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi Dong Binh","family":"Tran","sequence":"additional","affiliation":[{"name":"Jackson Laboratory Center for Aging Research, Farmington, CT 06032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2997-4592","authenticated-orcid":false,"given":"George","family":"Weinstock","sequence":"additional","affiliation":[{"name":"Jackson Laboratory Center for Aging Research, Farmington, CT 06032, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine Choung-Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7391-2380","authenticated-orcid":false,"given":"Ock K.","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1172\/JCI27071","article-title":"Pathogenesis of osteoporosis: Concepts, conflicts, and prospects","volume":"115","author":"Raisz","year":"2005","journal-title":"J. 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