{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:42:17Z","timestamp":1788190937351,"version":"build-2803163510"},"reference-count":68,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hyproca Nutrition Co., Ltd. (Changsha, China)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>This study aimed to investigate the relationship between anxiety, depression, and gut microbiota in elderly patients with FC. Methods: in this cross-sectional study, a total of 198 elderly participants (85 male and 113 female) aged over 60 years were recruited. The study was conducted in Changsha city, China. The participants completed an online questionnaire, including The Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), The Patient Assessment of Symptoms (PAC-SYM), and The Patient Assessment of Quality of Life (PAC-QoL). We selected the 16S rDNA V3 + V4 region as the amplification region and sequenced the gut microbiota using the Illumina Novaseq PE250 high-throughput sequencing platform. Results: in total, 30.3% of patients with constipation had depression, while 21.3% had anxiety. The relative abundance of intestinal microbiota in the normal group was higher than that in the anxiety and depression group. According to LEfSe analysis, the relative abundance of g_Peptoniphilus and g_Geobacter in the people without depression and anxiety was higher. The relative abundance of g_Pseudoramibacter-Eubacterium and g_Candidatus-Solibacter in the depression group was lower, and the relative abundance of g_Bacteroides and g_Paraprevotella, g_Cc_115 in the anxiety group was higher. In addition, according to the correlation analysis, g_Aquicella and g_Limnohabitans were negatively correlated with constipation symptoms, anxiety, and depression. Conclusions: this study found that gut microbiota composition may be associated with a higher incidence of anxiety and depression in patients with FC, thus providing insight into the mechanisms that ameliorate mood disorders in patients with FC.<\/jats:p>","DOI":"10.3390\/nu14235013","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T04:05:39Z","timestamp":1669349139000},"page":"5013","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Association between Depression, Anxiety Symptoms and Gut Microbiota in Chinese Elderly with Functional Constipation"],"prefix":"10.3390","volume":"14","author":[{"given":"Jiajing","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, 110 Xiangya Rd, Changsha 410078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Hyproca Nutrition Co., Ltd., Changsha 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, 110 Xiangya Rd, Changsha 410078, China"},{"name":"Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510275, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, 110 Xiangya Rd, Changsha 410078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiting","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, 110 Xiangya Rd, Changsha 410078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, 110 Xiangya Rd, Changsha 410078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanshuang","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, 110 Xiangya Rd, Changsha 410078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Hou","sequence":"additional","affiliation":[{"name":"Hyproca Nutrition Co., Ltd., Changsha 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, 110 Xiangya Rd, Changsha 410078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minchan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, 110 Xiangya Rd, Changsha 410078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, 110 Xiangya Rd, Changsha 410078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4287-1018","authenticated-orcid":false,"given":"Qian","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, 110 Xiangya Rd, Changsha 410078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1053\/j.gastro.2019.12.034","article-title":"Mechanisms, Evaluation, and Management of Chronic Constipation","volume":"158","author":"Bharucha","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_2","first-page":"337","article-title":"Individuals with persistent constipation tend to self-medicate and abuse drugs, which could affect the optimal timing of treatment and exacerbate the disease; all of these would impact the quality of life and lead to other chronic diseases","volume":"25","author":"Ji","year":"2022","journal-title":"Chin. 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