{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:28:59Z","timestamp":1790389739146,"version":"4.1.0"},"reference-count":251,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Oxidative stress represents one of the main factors driving the pathophysiology of multiple ophthalmic conditions including presbyopia, cataracts, dry eye disease (DED), glaucoma, age-related macular degeneration (AMD) and diabetic retinopathy (DR). Currently, different studies have demonstrated the role of orally administered nutraceuticals in these diseases. For instance, they have demonstrated to improve lens accommodation in presbyopia, reduce protein aggregation in cataracts, ameliorate tear film stability, break up time, and tear production in dry eye, and participate in the avoidance of retinal neuronal damage and a decrease in intraocular pressure in glaucoma, contribute to the delayed progression of AMD, or in the prevention or treatment of neuronal death in diabetic retinopathy. In this review, we summarized the nutraceuticals which have presented a positive impact in ocular disorders, emphasizing the clinical assays. The characteristics of the different types of nutraceuticals are specified along with the nutraceutical concentration used to achieve a therapeutic outcome in ocular diseases.<\/jats:p>","DOI":"10.3390\/nu14235014","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T04:05:39Z","timestamp":1669349139000},"page":"5014","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Nutraceuticals: A Promising Therapeutic Approach in Ophthalmology"],"prefix":"10.3390","volume":"14","author":[{"given":"Carlos Rodrigo","family":"Castro-Castaneda","sequence":"first","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Campus Guadalajara, Zapopan 45138, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4587-6201","authenticated-orcid":false,"given":"Francisco","family":"Altamirano-Lamarque","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Campus Guadalajara, Zapopan 45138, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1030-920X","authenticated-orcid":false,"given":"Alan Gabriel","family":"Ortega-Mac\u00edas","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Campus Guadalajara, Zapopan 45138, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1648-388X","authenticated-orcid":false,"given":"Francisco J.","family":"Santa Cruz-Pavlovich","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Campus Guadalajara, Zapopan 45138, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5283-6000","authenticated-orcid":false,"given":"Alejandro","family":"Gonzalez-De la Rosa","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Campus Guadalajara, Zapopan 45138, Mexico"},{"name":"Centro de Retina Medica y Quirurgica, S.C., Hospital Puerta de Hierro, Zapopan 45116, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7101-9943","authenticated-orcid":false,"given":"Juan","family":"Armendariz-Borunda","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Campus Guadalajara, Zapopan 45138, Mexico"},{"name":"Department of Molecular Biology and Genomics, Institute for Molecular Biology and Gene Therapy, University of Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4640-7263","authenticated-orcid":false,"given":"Arturo","family":"Santos","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Campus Guadalajara, Zapopan 45138, Mexico"},{"name":"Centro de Retina Medica y Quirurgica, S.C., Hospital Puerta de Hierro, Zapopan 45116, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3895-821X","authenticated-orcid":false,"given":"Jose","family":"Navarro-Partida","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Campus Guadalajara, Zapopan 45138, Mexico"},{"name":"Centro de Retina Medica y Quirurgica, S.C., Hospital Puerta de Hierro, Zapopan 45116, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.31989\/ffhd.v7i1.297","article-title":"Topical applied nutraceutical antioxidant formulation reduces ocular oxidative stress","volume":"7","author":"Kador","year":"2017","journal-title":"Funct. Foods Health Dis."},{"key":"ref_2","first-page":"571","article-title":"Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: Results of a prospective study","volume":"11","year":"2016","journal-title":"Clin. Interv. Aging"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3389\/fphar.2015.00280","article-title":"Effects of topical fucosyl-lactose, a milk oligosaccharide, on dry eye model: An example of nutraceutical candidate","volume":"6","author":"Bucolo","year":"2015","journal-title":"Front. Pharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/bs.pbr.2020.07.014","article-title":"Impact of nutraceuticals on glaucoma: A systematic review","volume":"257","author":"Scuteri","year":"2020","journal-title":"Prog. Brain Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1038\/sj.ejcn.1601481","article-title":"Functional foods and the immune system: A review","volume":"56","author":"Marcos","year":"2002","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1080\/07315724.2017.1410867","article-title":"Functional Food and Cardiovascular Disease Prevention and Treatment: A Review","volume":"37","author":"Asgary","year":"2018","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.maturitas.2013.05.006","article-title":"Nutraceuticals for older people: Facts, fictions and gaps in knowledge","volume":"75","author":"Larrosa","year":"2013","journal-title":"Maturitas"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1146\/annurev-pharmtox-010617-052844","article-title":"Adverse Effects of Nutraceuticals and Dietary Supplements","volume":"58","author":"Ronis","year":"2018","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1038\/s41598-021-81748-w","article-title":"Oral administration of resveratrol or lactic acid bacterium improves lens elasticity","volume":"11","author":"Nagashima","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6819","DOI":"10.1038\/s41598-017-07208-6","article-title":"Suppression of presbyopia progression with pirenoxine eye drops: Experiments on rats and non-blinded, randomized clinical trial of efficacy","volume":"7","author":"Tsuneyoshi","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.exer.2011.11.010","article-title":"Effect of vitamin C depletion on UVR-B induced cataract in SMP30\/GNL knockout mice","volume":"94","author":"Ishikawa","year":"2012","journal-title":"Exp. Eye Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0748-5514(86)80010-1","article-title":"Delay of UV-induced eye lens protein damage in guinea pigs by dietary ascorbate","volume":"2","author":"Blondin","year":"1986","journal-title":"J. Free Radic. Biol. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/cbf.1749","article-title":"Dietary vitamin C and E modulates oxidative stress induced-kidney and lens injury in diabetic aged male rats through modulating glucose homeostasis and antioxidant systems","volume":"29","author":"Ozkaya","year":"2011","journal-title":"Cell Biochem. Funct."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.exer.2009.12.004","article-title":"Curcumin protects against hyperosmoticity-induced IL-1\u03b2 elevation in human corneal epithelial cell via MAPK pathways","volume":"90","author":"Chen","year":"2010","journal-title":"Exp. Eye Res."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Park, B., Lee, I.S., Hyun, S.W., Jo, K., Lee, T.G., Kim, J.S., and Kim, C.S. (2018). The Protective Effect of Polygonum cuspidatum (PCE) Aqueous Extract in a Dry Eye Model. Nutrients, 10.","DOI":"10.3390\/nu10101550"},{"key":"ref_16","first-page":"809","article-title":"Effects of Lycium barbarum (goji berry) on dry eye disease in rats","volume":"17","author":"Chien","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1080\/15569527.2021.1973022","article-title":"Effects of eye drops containing a mixture of 3% diquafosol sodium and tocopherol acetate (vitamin E) on the ocular surface of murine dry eye","volume":"40","author":"Li","year":"2021","journal-title":"Cutan. Ocul. Toxicol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000313985","article-title":"Genistein blunts the negative effect of ischaemia to the retina caused by an elevation of intraocular pressure","volume":"45","author":"Kamalden","year":"2011","journal-title":"Ophthalmic Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"11066","DOI":"10.1038\/s41598-018-29393-8","article-title":"Topical Curcumin Nanocarriers are Neuroprotective in Eye Disease","volume":"8","author":"Davis","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_20","first-page":"643","article-title":"Protective effects of tomato extract with elevated \u0392-carotene levels on oxidative stress in ARPE-19 cells","volume":"96","author":"Chichili","year":"2006","journal-title":"Br. J. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1208\/s12249-020-01836-4","article-title":"Nanodelivery of Resveratrol-Loaded PLGA Nanoparticles for Age-Related Macular Degeneration","volume":"21","author":"Bhatt","year":"2020","journal-title":"AAPS PharmSciTech 2020"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00125-009-1655-6","article-title":"Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetes","volume":"53","author":"Sasaki","year":"2010","journal-title":"Diabetologia"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1743-7075-11-8","article-title":"Beneficial effects of the nutritional supplements on the development of diabetic retinopathy","volume":"11","author":"Kowluru","year":"2014","journal-title":"Nutr. Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s11130-020-00861-9","article-title":"Potential Inhibitors for SARS-CoV-2 and Functional Food Components as Nutritional Supplement for COVID-19: A Review","volume":"75","author":"Singh","year":"2020","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.amjcard.2009.05.037","article-title":"Effects of Consumption of Pomegranate Juice on Carotid Intima-Media Thickness in Men and Women at Moderate Risk for Coronary Heart Disease","volume":"104","author":"Davidson","year":"2009","journal-title":"Am. J. Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/eurheartj\/ehy597","article-title":"Importance of functional food compounds in cardioprotection through action on the epigenome","volume":"40","author":"Lionetti","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Alkhatib, A., Tsang, C., Tiss, A., Bahorun, T., Arefanian, H., Barake, R., Khadir, A., and Tuomilehto, J. (2017). Functional Foods and Lifestyle Approaches for Diabetes Prevention and Management. Nutrients, 9.","DOI":"10.3390\/nu9121310"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"109522","DOI":"10.1016\/j.biopha.2019.109522","article-title":"Antifibrotic and tumor microenvironment modulating effect of date palm fruit (Phoenix dactylifera L.) extracts in pancreatic cancer","volume":"121","author":"Alhamdani","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nrc1189","article-title":"Cancer chemoprevention with dietary phytochemicals","volume":"3","author":"Surh","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.ajo.2008.01.022","article-title":"Glaucoma Risk and the Consumption of Fruits and Vegetables Among Older Women in the Study of Osteoporotic Fractures","volume":"145","author":"Coleman","year":"2008","journal-title":"Am. J. Ophthalmol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s40123-018-0120-3","article-title":"The Role of Diet in Glaucoma: A Review of the Current Evidence","volume":"7","year":"2018","journal-title":"Ophthalmol. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1710-1492-6-33","article-title":"Anaphylaxis to hyperallergenic functional foods","volume":"6","author":"Ameratunga","year":"2010","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1080\/10408398.2012.751895","article-title":"Health Risks and Adverse Reactions to Functional Foods","volume":"56","author":"Ameratunga","year":"2015","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_34","first-page":"bcr0220091602","article-title":"Salicylate intolerance: A masquerader of multiple adverse drug reactions","volume":"2009","author":"Fernando","year":"2009","journal-title":"Case Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00045391-200305000-00003","article-title":"Drug-herb interaction among commonly used conventional medicines: A compendium for health care professionals","volume":"10","author":"Brazier","year":"2003","journal-title":"Am. J. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Low Dog, T., and Markham, M.J. (2013). Dietary Supplements and Hemostasis. Consult. Hemost. Thromb., 561\u2013566.","DOI":"10.1016\/B978-141602401-9.10033-1"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/bcp.13496","article-title":"Nutraceuticals: Opening the debate for a regulatory framework","volume":"84","author":"Santini","year":"2018","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/bcp.12935","article-title":"Defining \u2018nutraceuticals\u2019: Neither nutritious nor pharmaceutical","volume":"83","author":"Aronson","year":"2017","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.17151\/biosa.2015.14.2.9","article-title":"Consumo de nutrac\u00e9uticos, una alternativa en la prevenci\u00f3n de las enfermedades cr\u00f3nicas no transmisibles","volume":"14","author":"Valle","year":"2015","journal-title":"Biosalud"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Nwosu, O.K., and Ubaoji, K.I. (2020). Nutraceuticals: History, Classification and Market Demand. Functional Foods and Nutraceuticals, Springer.","DOI":"10.1007\/978-3-030-42319-3_2"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/978-3-319-92387-1_5","article-title":"Vitamins, Nutraceuticals, Food Additives, Enzymes, Anesthetic Aids, and Cosmetics","volume":"Volume 74","author":"Alamgir","year":"2018","journal-title":"Progress in Drug Research"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.2174\/1389557519666190617150051","article-title":"The Roles of Flavonols\/Flavonoids in Neurodegeneration and Neuroinflammation|Bentham Science","volume":"20","author":"Calis","year":"2020","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-3-319-63862-1_5","article-title":"Classification of Drugs, Nutraceuticals, Functional Food, and Cosmeceuticals; Proteins, Peptides, and Enzymes as Drugs","volume":"Volume 73","author":"Alamgir","year":"2017","journal-title":"Progress in Drug Research"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.5740\/jaoacint.19-0133","article-title":"Natural polyphenols: Chemical classification, definition of classes, subcategories, and structures","volume":"102","author":"Singla","year":"2019","journal-title":"J. AOAC Int."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Devi, S., Kumar, V., Singh, S.K., Dubey, A.K., and Kim, J.-J. (2021). Flavonoids: Potential Candidates for the Treatment of Neurodegenerative Disorders. Biomedicines, 9.","DOI":"10.3390\/biomedicines9020099"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Abotaleb, M., Samuel, S.M., Varghese, E., Varghese, S., Kubatka, P., Liskova, A., and Busselberg, D. (2018). Flavonoids in Cancer and Apoptosis. Cancers, 11.","DOI":"10.3390\/cancers11010028"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"11255","DOI":"10.1038\/s41598-018-29308-7","article-title":"Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kgamma mediated PI3K\/AKT\/mTOR\/p70S6K\/ULK signaling pathway in human breast cancer cells","volume":"8","author":"Zhang","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ejmech.2016.05.026","article-title":"Antidepressant-like effects and mechanisms of flavonoids and related analogues","volume":"121","author":"Guan","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1080\/1028415X.2015.1103461","article-title":"Natural products, micronutrients, and nutraceuticals for the treatment of depression: A short review","volume":"20","author":"Nabavi","year":"2017","journal-title":"Nutr. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.etap.2013.02.011","article-title":"Gallic acid: Molecular rival of cancer","volume":"35","author":"Verma","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.bbrc.2020.07.047","article-title":"Syringic acid mitigates myocardial ischemia reperfusion injury by activating the PI3K\/Akt\/GSK-3\u03b2 signaling pathway","volume":"531","author":"Liu","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1007\/s12011-020-02227-3","article-title":"Caffeic Acid Protects against Iron-Induced Cardiotoxicity by Suppressing Angiotensin-Converting Enzyme Activity and Modulating Lipid Spectrum, Gluconeogenesis and Nucleotide Hydrolyzing Enzyme Activities","volume":"199","author":"Salau","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"112770","DOI":"10.1016\/j.fct.2021.112770","article-title":"Caffeic acid phenethyl ester protects against doxorubicin-induced cardiotoxicity and increases chemotherapeutic efficacy by regulating the unfolded protein response","volume":"159","author":"Zhang","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.2174\/1389557521666210105122841","article-title":"Ferulic Acid and Cardiovascular Health: Therapeutic and Preventive Potential","volume":"21","author":"Dejani","year":"2021","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"119921","DOI":"10.1016\/j.lfs.2021.119921","article-title":"Ferulic acid: A review of its pharmacology, pharmacokinetics and derivatives","volume":"284","author":"Li","year":"2021","journal-title":"Life Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2019.03.027","article-title":"Effect of CAPE-pNO2 against type 2 diabetes mellitus via the AMPK\/GLUT4\/ GSK3\u03b2\/PPAR\u03b1 pathway in HFD\/STZ-induced diabetic mice","volume":"853","author":"Li","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1159\/000491755","article-title":"Antioxidant properties of ferulic acid and its possible application","volume":"31","author":"Dana","year":"2018","journal-title":"Ski. Pharmacol. Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.etp.2011.10.001","article-title":"Mechanism of acute lung injury due to phosgene exposition and its protection by cafeic acid phenethyl ester in the rat","volume":"65","author":"Wang","year":"2013","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.2147\/DDDT.S186726","article-title":"Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF- \u03b2\/Smad signaling pathway","volume":"12","author":"Mu","year":"2018","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Ellison, S.L. (2016). Carotenoids: Physiology. Encycl. Food Health, 670\u2013675.","DOI":"10.1016\/B978-0-12-384947-2.00120-3"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Papas, A.M. (2021). Vitamin E TPGS and its applications in nutraceuticals. Nutraceuticals, Academic Press. [2nd ed.].","DOI":"10.1016\/B978-0-12-821038-3.00059-8"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-94-024-0945-1_1","article-title":"Carotenoids and Retinoids: Nomenclature, Chemistry, and Analysis","volume":"81","author":"Harrison","year":"2016","journal-title":"Subcell. Biochem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"4637861","DOI":"10.1155\/2018\/4637861","article-title":"Non-Provitamin A and Provitamin A Carotenoids as Immunomodulators: Recommended Dietary Allowance, Therapeutic Index, or Personalized Nutrition?","volume":"2018","author":"Toti","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_64","first-page":"1139","article-title":"Nephroprotective effects of b-carotene on ACE gene expression, oxidative stress and antioxidant status in thioacetamide induced renal toxicity in rats","volume":"29","author":"Fazal","year":"2016","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1002\/jcp.29961","article-title":"Lutein inhibits breast cancer cell growth by suppressing antioxidant and cell survival signals and induces apoptosis","volume":"236","author":"Kavalappa","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"357357","DOI":"10.1155\/2015\/357357","article-title":"Naturally Occurring Anthraquinones: Chemistry and Therapeutic Potential in Autoimmune Diabetes","volume":"2015","author":"Chien","year":"2015","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/med.21391","article-title":"Anthraquinones As Pharmacological Tools and Drugs","volume":"36","author":"Malik","year":"2016","journal-title":"Med. Res. Rev."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"6063","DOI":"10.1039\/C8FO01569D","article-title":"Health functions and structure\u2013activity relationships of natural anthraquinones from plants","volume":"9","author":"Li","year":"2018","journal-title":"Food Funct."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"639","DOI":"10.2174\/157340611797928424","article-title":"Free radical scanvenging and antioxidant effects of some anthraquinone derivatives","volume":"7","author":"Abderrahmane","year":"2011","journal-title":"Med. Chem."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Goncharov, N.V., Belinskaia, D.A., Ukolov, A.I., Jenkins, R.O., and Avdonin, P.V. (2021). Organosulfur compounds as nutraceuticals. Nutraceuticals, Academic Press. [2nd ed.].","DOI":"10.1016\/B978-0-12-821038-3.00054-9"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3389\/fnut.2020.00064","article-title":"Organosulfur Compounds: A Review of Their Anti-inflammatory Effects in Human Health","volume":"7","author":"Ruhee","year":"2020","journal-title":"Front. Nutr."},{"key":"ref_72","unstructured":"Chukwuebuka, E., and Genevieve, T. (2020). Functional Foods and Nutraceuticals, Springer."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.2174\/1381612823666170111100531","article-title":"Vegetable Organosulfur Compounds and their Health Promoting Effects","volume":"23","author":"Petropoulos","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12937-020-00643-8","article-title":"Garlic (Allium sativum L.): A potential unique therapeutic food rich in organosulfur and flavonoid compounds to fight with COVID-19","volume":"19","author":"Khubber","year":"2020","journal-title":"Nutr. J."},{"key":"ref_75","first-page":"924","article-title":"Anti-obesity effects of pectinase and cellulase enzyme-treated Ecklonia cava extract in high-fat diet-fed C57BL\/6N mice","volume":"41","author":"Kim","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"827","DOI":"10.2174\/138955707781387939","article-title":"Organosulfur compounds in cancer chemoprevention","volume":"7","author":"Moriarty","year":"2007","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"433S","DOI":"10.3945\/jn.115.210427","article-title":"Aged Garlic Extract Modifies Human Immunity","volume":"146","author":"Percival","year":"2016","journal-title":"J. Nutr."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.clnu.2011.11.019","article-title":"Supplementation with aged garlic extract improves both NK and \u03b3\u03b4-T cell function and reduces the severity of cold and flu symptoms: A randomized, double-blind, placebo-controlled nutrition intervention","volume":"31","author":"Nantz","year":"2012","journal-title":"Clin. Nutr."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4103\/ijhas.IJHAS_55_20","article-title":"Activity of phytochemical constituents of black pepper, ginger, and garlic against coronavirus (COVID-19): An in silico approach","volume":"9","author":"Rajagopal","year":"2022","journal-title":"Int. J. Health Allied Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"7981","DOI":"10.33263\/BRIAC111.79817993","article-title":"Screening of potent inhibitors against 2019 novel coronavirus (COVID-19) from alliumsativum and allium cepa: An in silico approach","volume":"11","author":"Pandey","year":"2020","journal-title":"Biointerface Res. Appl. Chem."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Marrelli, M., Conforti, F., Araniti, F., and Statti, G.A. (2016). Effects of Saponins on Lipid Metabolism: A Review of Potential Health Benefits in the Treatment of Obesity. Molecules, 21.","DOI":"10.3390\/molecules21101404"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1089\/109662004322984734","article-title":"Saponins from Edible Legumes: Chemistry, Processing, and Health Benefits","volume":"7","author":"Shi","year":"2004","journal-title":"J. Med. Food"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00394-011-0236-x","article-title":"Platyconic acid, a saponin from Platycodi radix, improves glucose homeostasis by enhancing insulin sensitivity in vitro and in vivo","volume":"51","author":"Kwon","year":"2012","journal-title":"Eur. J. Nutr."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Casciaro, B., Mangiardi, L., Cappiello, F., Romeo, I., Loffredo, M.R., Iazzetti, A., Calcaterra, A., Goggiamani, A., Ghirga, F., and Mangoni, M.L. (2020). Naturally-Occurring Alkaloids of Plant Origin as Potential Antimicrobials against Antibiotic-Resistant Infections. Molecules, 25.","DOI":"10.3390\/molecules25163619"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"884","DOI":"10.2174\/1389201021666200130113441","article-title":"Current Prospects of Nutraceuticals: A Review","volume":"21","author":"Sachdeva","year":"2020","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/ja.2012.65","article-title":"Isohericenone, a new cytotoxic isoindolinone alkaloid from Hericium erinaceum","volume":"65","author":"Kim","year":"2012","journal-title":"J. Antibiot."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"9834","DOI":"10.1021\/jf302433r","article-title":"Astraodoric acids A-D: New lanostane triterpenes from edible mushroom astraeus odoratus and their anti-mycobacterium tuberculosis H37Ra and cytotoxic activity","volume":"60","author":"Arpha","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Chakrabarti, S., Guha, S., and Majumder, K. (2018). Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities. Nutrients, 10.","DOI":"10.3390\/nu10111738"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/fqs\/fyx006","article-title":"Bioactive peptides: A review","volume":"1","year":"2017","journal-title":"Food Qual. Saf."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.sjbs.2015.06.005","article-title":"Milk derived bioactive peptides and their impact on human health\u2014A review","volume":"23","author":"Mohanty","year":"2016","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"831","DOI":"10.5851\/kosfa.2015.35.6.831","article-title":"Bioactive Peptides in Milk and Dairy Products: A Review","volume":"35","author":"Park","year":"2015","journal-title":"Food Sci. Anim. Resour."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1089\/wound.2016.0713","article-title":"Bioactive Antimicrobial Peptides as Therapeutics for Corneal Wounds and Infections","volume":"6","author":"Griffith","year":"2017","journal-title":"Adv. Wound Care"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"4886","DOI":"10.1167\/iovs.14-14461","article-title":"Corneal Wound Healing, a Newly Identified Function of CAP37, Is Mediated by Protein Kinase C Delta (PKC\u03b4)","volume":"55","author":"Griffith","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0002-9440(10)64907-3","article-title":"CAP37, a novel inflammatory mediator: Its expression in endothelial cells and localization to atherosclerotic lesions","volume":"160","author":"Lee","year":"2002","journal-title":"Am. J. Pathol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.bcdf.2014.12.001","article-title":"A review of bioactive plant polysaccharides: Biological activities, functionalization, and biomedical applications","volume":"5","author":"Liu","year":"2015","journal-title":"Bioact. Carbohydr. Diet. Fibre"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.carbpol.2010.10.062","article-title":"Biological activities and potential health benefits of sulfated polysaccharides derived from marine algae","volume":"84","author":"Wijesekara","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Wang, Y., Xing, M., Cao, Q., Ji, A., Liang, H., and Song, S. (2019). Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies. Mar. Drugs, 17.","DOI":"10.3390\/md17030183"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1177\/1534735417692097","article-title":"An Exploratory Study on the Anti-inflammatory Effects of Fucoidan in Relation to Quality of Life in Advanced Cancer Patients","volume":"17","author":"Takahashi","year":"2018","journal-title":"Integr. Cancer Ther."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1080\/14756366.2016.1252759","article-title":"The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): A promising natural source of antiradical and AChE inhibitory agents","volume":"32","author":"Karaman","year":"2017","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.ijbiomac.2018.12.212","article-title":"Polysaccharopeptide from Trametes versicolor blocks inflammatory osteoarthritis pain-morphine tolerance effects via activating cannabinoid type 2 receptor","volume":"126","author":"Wang","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_101","unstructured":"Khan, M., Rahman, M., Zaman, S., Jahangir, T.A., and Razu, M.H. (2015). Omega-3 Polyunsaturated Fatty Acids from Algae. Recent Adv. Microalgal Biotechnol., 43-5."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Zhang, A.C., Singh, S., Craig, J.P., and Downie, L.E. (2020). Omega-3 fatty acids and eye health: Opinions and self-reported practice behaviors of optometrists in Australia and New Zealand. Nutrients, 12.","DOI":"10.3390\/nu12041179"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Pellegrini, M., Senni, C., Bernabei, F., Cicero, A.F.G., Vagge, A., Maestri, A., Scorcia, V., and Giannaccare, G. (2020). The Role of Nutrition and Nutritional Supplements in Ocular Surface Diseases. Nutrients, 12.","DOI":"10.3390\/nu12040952"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0753-3322(02)00253-6","article-title":"The importance of the ratio of omega-6\/omega-3 essential fatty acids","volume":"56","author":"Simopoulos","year":"2002","journal-title":"Biomed. Pharmacother."},{"key":"ref_105","first-page":"CD011016","article-title":"Omega-3 and omega-6 polyunsaturated fatty acids for dry eye disease","volume":"12","author":"Downie","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/ncp.10376","article-title":"The Role of Vitamin A in Wound Healing","volume":"34","author":"Polcz","year":"2019","journal-title":"Nutr. Clin. Pract."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"392","DOI":"10.5114\/ada.2019.87443","article-title":"Retinoids: Active molecules influencing skin structure formation in cosmetic and dermatological treatments","volume":"36","author":"Zasada","year":"2019","journal-title":"Adv. Dermatol. Allergol. Post\u0119py Dermatol. I Alergol."},{"key":"ref_108","unstructured":"Marriott, B.P., Birt, D.F., Stallings, V.A., and Yates, A.A. (2020). Chapter 5\u2014Vitamin A and provitamin A carotenoids. Present Knowledge in Nutrition, Academic Press. [11th ed.]."},{"key":"ref_109","unstructured":"Information, N.C.F.B. (2020, April 28). PubChem Compound Summary for CID 638015, Retinal, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Retinal."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"6605","DOI":"10.1039\/c3cs60062a","article-title":"Vitamin B12: Chemical modifications","volume":"42","author":"Proinsias","year":"2013","journal-title":"Chemical Society Reviews"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1177\/0310057X1604400410","article-title":"The role of Vitamin B12 in the critically ill\u2014A review","volume":"44","author":"Romain","year":"2016","journal-title":"Anaesth. Intensive Care"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Alonso, E.R., Le\u00f3n, I., and Alonso, J.L. (2021). The role of the intramolecular interactions in the structural behavior of biomolecules: Insights from rotational spectroscopy. Intra- and Intermolecular Interactions between Non-Covalently Bonded Species, Elsevier.","DOI":"10.1016\/B978-0-12-817586-6.00004-9"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Macan, A.M., Kraljevi\u0107, T.G., and Rai\u0107-Mali\u0107, S. (2019). Therapeutic Perspective of Vitamin C and Its Derivatives. Antioxidants, 8.","DOI":"10.3390\/antiox8080247"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Carr, A.C., and Maggini, S. (2017). Vitamin C and Immune Function. Nutrients, 9.","DOI":"10.3390\/nu9111211"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Holford, P., Carr, A.C., Jovic, T.H., Ali, S.R., Whitaker, I.S., Marik, P.E., and Smith, A.D. (2020). Vitamin C\u2014An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19. Nutrients, 12.","DOI":"10.20944\/preprints202010.0407.v2"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1136\/bjo.86.12.1369","article-title":"Protective role of oral antioxidant supplementation in ocular surface of diabetic patients","volume":"86","author":"Peponis","year":"2002","journal-title":"Br. J. Ophthalmol."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Charoenngam, N., and Holick, M.F. (2020). Immunologic Effects of Vitamin D on Human Health and Disease. Nutrients, 12.","DOI":"10.3390\/nu12072097"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0960-0760(95)00107-B","article-title":"Chemistry and conformation of vitamin D molecules","volume":"53","author":"Okamura","year":"1995","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Preedy, V.R. (2015). Selenium: Chemistry, Analysis, Function and Effects, Royal Society of Chemistry.","DOI":"10.1039\/9781782622215"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"7478523","DOI":"10.1155\/2017\/7478523","article-title":"Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant","volume":"2017","author":"Wang","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10787-017-0309-4","article-title":"Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-\u03baB signaling","volume":"25","author":"Jarosz","year":"2017","journal-title":"Inflammopharmacology"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Barak, P., and Helmke, P.A. (1993). The Chemistry of Zinc. Zinc in Soils and Plants, Springer.","DOI":"10.1007\/978-94-011-0878-2_1"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Sanna, A., Firinu, D., Zavattari, P., and Valera, P. (2018). Zinc Status and Autoimmunity: A Systematic Review and Meta-Analysis. Nutrients, 10.","DOI":"10.3390\/nu10010068"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1080\/07315724.2001.10719022","article-title":"Zinc and the Eye","volume":"20","author":"Grahn","year":"2001","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Skrajnowska, D., and Bobrowska-Korczak, B. (2019). Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms. Nutrients, 11.","DOI":"10.3390\/nu11102273"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Lin, P.H., Sermersheim, M., Li, H., Lee, P.H.U., Steinberg, S.M., and Ma, J. (2017). Zinc in Wound Healing Modulation. Nutrients, 10.","DOI":"10.3390\/nu10010016"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.3389\/fphar.2020.581840","article-title":"COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?","volume":"11","author":"Silveira","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"102979","DOI":"10.1016\/j.jddst.2021.102979","article-title":"Herbal medicine for ocular diseases: An age old therapy and its future perspective","volume":"68","author":"Pokkalath","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1039\/C9FO00375D","article-title":"Cranberries\u2014potential benefits in patients with chronic kidney disease","volume":"10","author":"Borges","year":"2019","journal-title":"Food Funct."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Gbinigie, O.A., Spencer, E.A., Heneghan, C.J., Lee, J.J., and Butler, C.C. (2020). Cranberry Extract for Symptoms of Acute, Uncomplicated Urinary Tract Infection: A Systematic Review. Antibiotics, 10.","DOI":"10.3390\/antibiotics10010012"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"4385","DOI":"10.1007\/s00216-013-6750-3","article-title":"Quantifying and characterizing proanthocyanidins in cranberries in relation to urinary tract health","volume":"405","author":"Krueger","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Jepson, R.G., Williams, G., and Craig, J.C. (2012). Cranberries for preventing urinary tract infections. Cochrane Database Syst. Rev.","DOI":"10.1002\/14651858.CD001321.pub5"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.1002\/jsfa.8882","article-title":"American cranberries and health benefits\u2014An evolving story of 25 years","volume":"100","author":"Zhao","year":"2020","journal-title":"J. Sci. Food Agric."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1002\/jsfa.4621","article-title":"Cranberries: Ripe for more cancer research?","volume":"91","author":"Neto","year":"2011","journal-title":"J. Sci. Food Agric."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1016\/j.fct.2011.08.013","article-title":"Amelioration of collagen-induced arthritis by Salix nigra bark extract via suppression of pro-inflammatory cytokines and oxidative stress","volume":"49","author":"Sharma","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1590\/0001-3765201520150056","article-title":"Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil","volume":"87","author":"Luft","year":"2015","journal-title":"An. Acad. Bras. Ci\u00eancias"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jphs.2021.05.003","article-title":"Linalyl acetate as a potential preventive agent against muscle wasting in rheumatoid arthritis rats chronically exposed to nicotine","volume":"147","author":"Seo","year":"2021","journal-title":"J. Pharmacol. Sci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.biopha.2018.11.045","article-title":"Lavender oil (Lavandula angustifolia) attenuates renal ischemia\/reperfusion injury in rats through suppression of inflammation, oxidative stress and apoptosis","volume":"110","author":"Aboutaleb","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"153099","DOI":"10.1016\/j.phymed.2019.153099","article-title":"Effects of lavender on anxiety: A systematic review and meta-analysis","volume":"65","author":"Donelli","year":"2019","journal-title":"Phytomedicine"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"634","DOI":"10.2174\/1568026615666150819105716","article-title":"A New Insight of Herbal Promises Against Ocular Disorders: An Occuloinformatics Approach","volume":"16","author":"Srivastava","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bse0590001","article-title":"Enzymes: Principles and biotechnological applications","volume":"59","author":"Robinson","year":"2015","journal-title":"Essays Biochem."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1080\/10408398.2017.1308312","article-title":"Plant proteases for bioactive peptides release: A review","volume":"58","author":"Yada","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1111\/1750-3841.14824","article-title":"Inhibitory Effects of Pectinase-Treated Prunus Mume Fruit Concentrate on Colorectal Cancer Proliferation and Angiogenesis of Endothelial Cells","volume":"84","author":"Cho","year":"2019","journal-title":"J. Food Sci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"8873","DOI":"10.1016\/j.biortech.2008.04.056","article-title":"Enzymatic preparation of immunomodulating hydrolysates from soy proteins","volume":"99","author":"Kong","year":"2008","journal-title":"Bioresour. Technol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"6563","DOI":"10.1007\/s00253-015-6776-x","article-title":"Probiotic Saccharomyces cerevisiae strains as biotherapeutic tools: Is there room for improvement?","volume":"99","author":"Palma","year":"2015","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1002\/jsfa.8147","article-title":"Antioxidant properties and global metabolite screening of the probiotic yeast Saccharomyces cerevisiae var. boulardii","volume":"97","author":"Datta","year":"2017","journal-title":"J. Sci. Food Agric."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/MCG.0b013e31827759ac","article-title":"Exploratory, Randomized, Double-blind, Placebo-controlled Study on the Effects of Bifidobacterium infantis Natren Life Start Strain Super Strain in Active Celiac Disease","volume":"47","author":"Smecuol","year":"2013","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1017\/S0007114514000609","article-title":"Double-blind, randomised, placebo-controlled intervention trial to evaluate the effects of Bifidobacterium longum CECT 7347 in children with newly diagnosed coeliac disease","volume":"112","author":"Olivares","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Quagliariello, A., Aloisio, I., Bozzi Cionci, N., Luiselli, D., D\u2019Auria, G., Martinez-Priego, L., P\u00e9rez-Villarroya, D., Langerholc, T., Primec, M., and Mi\u010deti\u0107-Turk, D. (2016). Effect of Bifidobacterium breve on the Intestinal Microbiota of Coeliac Children on a Gluten Free Diet: A Pilot Study. Nutrients, 8.","DOI":"10.3390\/nu8100660"},{"key":"ref_150","first-page":"16","article-title":"Pathophysiology of non-celiac gluten sensitivity: Where are we now?","volume":"63","author":"Caio","year":"2017","journal-title":"Minerva Gastroenterol. E Dietol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1365-3083.2011.02582.x","article-title":"Immunomodulatory Effects of Lactobacillus casei Administration in a Mouse Model of Gliadin-Sensitive Enteropathy","volume":"74","author":"Stefanile","year":"2011","journal-title":"Scand. J. Immunol."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Sergeev, I.N., Aljutaily, T., Walton, G., and Huarte, E. (2020). Effects of Synbiotic Supplement on Human Gut Microbiota, Body Composition and Weight Loss in Obesity. Nutrients, 12.","DOI":"10.3390\/nu12010222"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/j.foodchem.2011.02.048","article-title":"Influence of starter cultures on the antioxidant activity of kombucha beverage","volume":"127","author":"Vitas","year":"2011","journal-title":"Food Chem."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Yang, B., Wang, J., Tang, B., Liu, Y., Guo, C., Yang, P., Yu, T., Li, R., Zhao, J., and Zhang, L. (2011). Characterization of Bioactive Recombinant Human Lysozyme Expressed in Milk of Cloned Transgenic Cattle. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0017593"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Cormick, G., Betran, A.P., Romero, I.B., Cormick, M.S., Beliz\u00e1n, J.M., Bardach, A., and Ciapponi, A. (2021). Effect of Calcium Fortified Foods on Health Outcomes: A Systematic Review and Meta-Analysis. Nutrients, 13.","DOI":"10.3390\/nu13020316"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/odi.12515","article-title":"Nutrition and bone health","volume":"23","author":"Weaver","year":"2017","journal-title":"Oral Dis."},{"key":"ref_157","first-page":"31257574","article-title":"Fortification of wheat and maize flour with folic acid for population health outcomes","volume":"2019","author":"Tablante","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_158","unstructured":"Assessment, S.C.o.H.T. (2007). Benefits and Risks of Fortifying Flour with Folic Acid to Reduce the Risk of Neural Tube Defects: A Systematic Review, Swedish Council on Technology Assessment in Health Care (SBU)."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1017\/S0029665118001192","article-title":"Multiple nutritional factors and thyroid disease, with particular reference to autoimmune thyroid disease","volume":"78","author":"Rayman","year":"2018","journal-title":"Proc. Nutr. Soc."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1006\/exer.2000.0900","article-title":"Treatment of Corneal Neovascularization with Dietary Isoflavonoids and Flavonoids","volume":"71","author":"Joussen","year":"2000","journal-title":"Exp. Eye Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1089\/jop.2005.21.107","article-title":"Genistein Inhibited Retinal Neovascularization and Expression of Vascular Endothelial Growth Factor and Hypoxia Inducible Factor 1\u03b1 in a Mouse Model of Oxygen-Induced Retinopathy","volume":"21","author":"Wang","year":"2005","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"ref_162","first-page":"118","article-title":"Effect of the Isoflavone Genistein Against Galactose-Induced Cataracts in Rats","volume":"232","author":"Huang","year":"2007","journal-title":"Exp. Biol. Med."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1080\/02713680590967962","article-title":"Effects of Caffeic Acid Phenethyl Ester on Endotoxin-Induced Uveitis in Rats","volume":"30","author":"Yilmaz","year":"2005","journal-title":"Curr. Eye Res."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ejphar.2015.02.012","article-title":"Effects of novel hybrids of caffeic acid phenethyl ester and NSAIDs on experimental ocular inflammation","volume":"752","author":"Salerno","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3109\/15569527.2012.759958","article-title":"The protective effects of caffeic acid phenethyl ester in isoniazid and ethambutol-induced ocular toxicity of rats","volume":"32","author":"Kaya","year":"2013","journal-title":"Cutan. Ocul. Toxicol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"105214","DOI":"10.1016\/j.neuint.2021.105214","article-title":"Neuroprotection of retinal cells by Caffeic Acid Phenylethyl Ester (CAPE) is mediated by mitochondrial uncoupling protein UCP2","volume":"151","author":"Zhang","year":"2021","journal-title":"Neurochem. Int."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.2147\/OPTH.S259011","article-title":"Presbyopia\u2014A Review of Current Treatment Options and Emerging Therapies","volume":"15","author":"Katz","year":"2021","journal-title":"Clin. Ophthalmol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"e000453","DOI":"10.1136\/bmjophth-2020-000453","article-title":"Patient-reported outcome measures in presbyopia: A literature review","volume":"5","author":"Sharma","year":"2020","journal-title":"BMJ Open Ophthalmol"},{"key":"ref_169","first-page":"114","article-title":"Effect of Multiple Dietary Supplement Containing Lutein, \u2028Astaxanthin, Cyanidin-3-Glucoside, and DHA on Accommodative Ability","volume":"14","author":"Kono","year":"2014","journal-title":"Curr. Med. Chem."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"9902211","DOI":"10.1155\/2021\/9902211","article-title":"Improvement of Presbyopia Using a Mixture of Traditional Chinese Herbal Medicines, Including Cassiae Semen, Wolfberry, and Dendrobium huoshanense","volume":"2021","author":"Horng","year":"2021","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/APO.0000000000000297","article-title":"A Review of Pharmacological Presbyopia Treatment","volume":"9","author":"Grzybowski","year":"2020","journal-title":"Asia Pac. J. Ophthalmol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.sjopt.2016.12.001","article-title":"Nutraceuticals in prevention of cataract\u2014An evidence based approach","volume":"31","author":"Kaur","year":"2017","journal-title":"Saudi J. Ophthalmol."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Braakhuis, A.J., Donaldson, C.I., Lim, J.C., and Donaldson, P.J. (2019). Nutritional Strategies to Prevent Lens Cataract: Current Status and Future Strategies. Nutrients, 11.","DOI":"10.3390\/nu11051186"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/ICU.0000000000000340","article-title":"The global state of cataract blindness","volume":"28","author":"Lee","year":"2017","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/bs.pmbts.2015.04.007","article-title":"Overview of the Lens","volume":"134","author":"Hejtmancik","year":"2015","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"e170","DOI":"10.1111\/aos.12688","article-title":"Association of vitamin C with the risk of age-related cataract: A meta-analysis","volume":"94","author":"Wei","year":"2016","journal-title":"Acta Ophthalmol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1001\/archopht.118.11.1556","article-title":"Vitamin supplement use and incident cataracts in a population-based study","volume":"118","author":"Lyle","year":"2000","journal-title":"Arch. Ophthalmol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"346S","DOI":"10.1093\/ajcn\/53.1.346S","article-title":"A possible role for vitamins C and E in cataract prevention","volume":"53","author":"Robertson","year":"1991","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00001648-199305000-00003","article-title":"Plasma antioxidants and risk of cortical and nuclear cataract","volume":"4","author":"Vitale","year":"1993","journal-title":"Epidemiology"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/nure.12077","article-title":"Nutritional modulation of cataract","volume":"72","author":"Weikel","year":"2014","journal-title":"Nutr. Rev."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1001\/archopht.119.7.1009","article-title":"Long-term nutrient intake and early age-related nuclear lens opacities","volume":"119","author":"Jacques","year":"2001","journal-title":"Arch. Ophthalmol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1001\/archopht.1991.01080020090051","article-title":"The Lens Opacities Case-Control Study. Risk factors for cataract","volume":"109","author":"Leske","year":"1991","journal-title":"Arch. Ophthalmol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1093\/jn\/132.6.1299","article-title":"Vitamin C is associated with reduced risk of cataract in a Mediterranean population","volume":"132","author":"Valero","year":"2002","journal-title":"J. Nutr."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1016\/j.ophtha.2011.03.016","article-title":"Inverse association of vitamin C with cataract in older people in India","volume":"118","author":"Ravindran","year":"2011","journal-title":"Ophthalmology"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.ophtha.2007.09.011","article-title":"Supplements and age-related eye conditions the beaver dam eye study","volume":"115","author":"Klein","year":"2008","journal-title":"Ophthalmology"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1167\/iovs.07-1202","article-title":"Blood levels of vitamin C, carotenoids and retinol are inversely associated with cataract in a North Indian population","volume":"49","author":"Dherani","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1001\/archopht.120.12.1732","article-title":"Lens aging in relation to nutritional determinants and possible risk factors for age-related cataract","volume":"120","author":"Berendschot","year":"2002","journal-title":"Arch. Ophthalmol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1024\/0300-9831.76.6.359","article-title":"The relationship between antioxidant nutrient intake and cataracts in older people","volume":"76","author":"Ortega","year":"2006","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1017\/S0007114511005332","article-title":"Plasma lutein and zeaxanthin and the risk of age-related nuclear cataract among the elderly Finnish population","volume":"108","author":"Karppi","year":"2012","journal-title":"Br. J. Nutr."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1001\/archopht.126.1.102","article-title":"Dietary carotenoids, vitamins C and E, and risk of cataract in women: A prospective study","volume":"126","author":"Christen","year":"2008","journal-title":"Arch. Ophthalmol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1001\/archopht.126.3.354","article-title":"Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an Ancillary Study of the Women\u2019s Health Initiative","volume":"126","author":"Moeller","year":"2008","journal-title":"Arch. Ophthalmol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1076\/opep.9.1.49.1717","article-title":"The Roche European American Cataract Trial (REACT): A randomized clinical trial to investigate the efficacy of an oral antioxidant micronutrient mixture to slow progression of age-related cataract","volume":"9","author":"Chylack","year":"2002","journal-title":"Ophthalmic Epidemiol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/NHH.0000000000000652","article-title":"Dry eye disease: Prevalence, assessment, and management","volume":"36","author":"Rouen","year":"2018","journal-title":"Home Healthc. Now"},{"key":"ref_194","first-page":"107","article-title":"Dry eye disease. A review","volume":"Volume 77","year":"2021","journal-title":"Ceska a Slovenska Oftalmologie: Casopis Ceske Oftalmologicke Spolecnosti a Slovenske Oftalmologicke Spolecnosti"},{"key":"ref_195","first-page":"71","article-title":"The Pathophysiology, Diagnosis, and Treatment of Dry Eye Disease","volume":"112","author":"Messmer","year":"2015","journal-title":"Dtsch. \u00c4rzteblatt Int."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/bs.pmbts.2015.04.001","article-title":"Overview of the Cornea: Structure, Function, and Development","volume":"134","author":"Eghrari","year":"2015","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.ophtha.2017.05.031","article-title":"Meibomian Gland Disease: The Role of Gland Dysfunction in Dry Eye Disease","volume":"124","author":"Chhadva","year":"2017","journal-title":"Ophthalmology"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1167\/iovs.07-0770","article-title":"The Ocular Surface: The Challenge to Enable and Protect Vision: The Friedenwald Lecture","volume":"48","author":"Gipson","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Navarro-Partida, J., Rodrigo Castro-Castaneda, C., Santa Cruz-Pavlovich, F.J., Abraham Aceves-Franco, L., Ori Guy, T., Santos, A., Cruz-Pavlovich, S., Lipid-Based Nanocarriers, A., Lopes, C.M., and Lucio, M. (2021). Lipid-Based Nanocarriers as Topical Drug Delivery Systems for Intraocular Diseases. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13050678"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.exer.2003.09.003","article-title":"The role of the lacrimal functional unit in the pathophysiology of dry eye","volume":"78","author":"Stern","year":"2004","journal-title":"Exp. Eye Res."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jtos.2013.07.003","article-title":"Role of Hyperosmolarity in the Pathogenesis and Management of Dry Eye Disease: Proceedings of the OCEAN Group Meeting","volume":"11","author":"Baudouin","year":"2013","journal-title":"Ocul. Surf."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.4103\/ijo.IJO_3345_20","article-title":"Ocular Surface Disease Index\u00a9and the five-item dry eye questionnaire: A comparison in Indian patients with dry eye disease","volume":"69","author":"Chatterjee","year":"2021","journal-title":"Indian J. Ophthalmol."},{"key":"ref_203","first-page":"191","article-title":"Tear Film Break-up Time in Bipolar Disorder","volume":"7","author":"Dibajnia","year":"2012","journal-title":"Iran. J. Psychiatry"},{"key":"ref_204","unstructured":"Brott, N.R., and Ronquillo, Y. (2021). Schirmer Test. Encyclopedia of Ophthalmology, StatPearls Publishing."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Chi, S.C., Tuan, H.I., and Kang, Y.N. (2019). Effects of Polyunsaturated Fatty Acids on Nonspecific Typical Dry Eye Disease: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Nutrients, 11.","DOI":"10.3390\/nu11050942"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/ICO.0000000000001884","article-title":"Efficacy of Omega-3 Fatty Acid Supplementation for Treatment of Dry Eye Disease: A Meta-Analysis of Randomized Clinical Trials","volume":"38","author":"Giannaccare","year":"2019","journal-title":"Cornea"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.3109\/02713683.2015.1122810","article-title":"A Randomized Controlled Trial of Omega 3 Fatty Acids in Rosacea Patients with Dry Eye Symptoms","volume":"41","author":"Bhargava","year":"2016","journal-title":"Curr. Eye Res."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/ICO.0000000000000386","article-title":"Oral omega-3 fatty acid treatment for dry eye in contact lens wearers","volume":"34","author":"Bhargava","year":"2015","journal-title":"Cornea"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/ICL.0000000000000179","article-title":"Short-Term Omega 3 Fatty Acids Treatment for Dry Eye in Young and Middle-Aged Visual Display Terminal Users","volume":"42","author":"Bhargava","year":"2016","journal-title":"Eye Contact Lens Sci. Clin. Pract."},{"key":"ref_210","first-page":"811","article-title":"A randomized controlled trial of omega-3 fatty acids in dry eye syndrome","volume":"6","author":"Bhargava","year":"2013","journal-title":"Int. J. Ophthalmol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.clae.2015.01.007","article-title":"Oral omega-3 fatty acids treatment in computer vision syndrome related dry eye","volume":"38","author":"Bhargava","year":"2015","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1097\/ICO.0000000000000940","article-title":"Effect of oral re-esterified Omega-3 nutritional supplementation on dry eyes","volume":"35","author":"Epitropoulos","year":"2016","journal-title":"Cornea"},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"The Dry Eye Assessment and Management Study Research Group (2018). n\u22123 Fatty Acid Supplementation for the Treatment of Dry Eye Disease. N. Engl. J. Med., 378, 1681\u20131690.","DOI":"10.1056\/NEJMoa1709691"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2220\/biomedres.34.215","article-title":"Effects of dietary supplementation with fish oil on dry eye syndrome subjects: Randomized controlled trial","volume":"34","author":"Kawakita","year":"2013","journal-title":"Biomed. Res."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ophtha.2016.09.023","article-title":"A Randomized, Double-Masked, Placebo-Controlled Clinical Trial of Two Forms of Omega-3 Supplements for Treating Dry Eye Disease","volume":"124","author":"Deinema","year":"2017","journal-title":"Ophthalmology"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/opo.12365","article-title":"Omega-3 supplementation is neuroprotective to corneal nerves in dry eye disease: A pilot study","volume":"37","author":"Chinnery","year":"2017","journal-title":"Ophthalmic Physiol. Opt."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/ICU.0b013e3283477d23","article-title":"Nutritional supplements for dry eye syndrome","volume":"22","author":"Rand","year":"2011","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2147\/OPTH.S198349","article-title":"Effects of short-term oral vitamin A supplementation on the ocular tear film in patients with dry eye","volume":"13","author":"Alanazi","year":"2019","journal-title":"Clin. Ophthalmol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1097\/ICO.0b013e318299549c","article-title":"Long-term Supplementation With n-6 and n-3 PUFAs Improves Moderate-to-Severe Keratoconjunctivitis Sicca: A Randomized Double-Blind Clinical Trial","volume":"32","author":"Sheppard","year":"2013","journal-title":"Cornea"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jtcme.2018.11.001","article-title":"Effects of MaquiBright((R)) on improving eye dryness and fatigue in humans: A randomized, double-blind, placebo-controlled trial","volume":"9","author":"Yamashita","year":"2019","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_221","doi-asserted-by":"crossref","unstructured":"Hyon, J.Y., and Han, S.B. (2022). Dry Eye Disease and Vitamins: A Narrative Literature Review. Appl. Sci., 12.","DOI":"10.3390\/app12094567"},{"key":"ref_222","unstructured":"Kador, P.F. (2015). Antioxidant Eye Drops. (US 9,173,915 B1)."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.2147\/OPTH.S258081","article-title":"Efficacy and Safety of VisuEvo((R)) and Cationorm((R)) for the Treatment of Evaporative and Non-Evaporative Dry Eye Disease: A Multicenter, Double-Blind, Cross-Over, Randomized Clinical Trial","volume":"14","author":"Fogagnolo","year":"2020","journal-title":"Clin. Ophthalmol."},{"key":"ref_224","first-page":"e11686","article-title":"Epidemiology of Glaucoma: The Past, Present, and Predictions for the Future","volume":"12","author":"Allison","year":"2020","journal-title":"Cureus"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The Pathophysiology and Treatment of Glaucoma: A Review","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1089\/jop.2012.0021","article-title":"Oral Administration of Forskolin and Rutin Contributes to Intraocular Pressure Control in Primary Open Angle Glaucoma Patients Under Maximum Tolerated Medical Therapy","volume":"28","author":"Vetrugno","year":"2012","journal-title":"J. Ocular Pharmacol. Ther."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1089\/jop.2015.0121","article-title":"Oral Administration of Forskolin, Homotaurine, Carnosine, and Folic Acid in Patients with Primary Open Angle Glaucoma: Changes in Intraocular Pressure, Pattern Electroretinogram Amplitude, and Foveal Sensitivity","volume":"32","author":"Mutolo","year":"2016","journal-title":"J. Ocular Pharmacol. Ther."},{"key":"ref_228","first-page":"8259371","article-title":"Effects of Oral Supplementation with Docosahexaenoic Acid (DHA) plus Antioxidants in Pseudoexfoliative Glaucoma: A 6-Month Open-Label Randomized Trial","volume":"2018","year":"2018","journal-title":"J. Ophthalmol."},{"key":"ref_229","first-page":"711","article-title":"Patients undergoing long-term treatment with antihypertensive eye drops responded positively with respect to their ocular surface disorder to oral supplementation with antioxidants and essential fatty acids","volume":"8","year":"2013","journal-title":"Clin. Interv. Aging"},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Bonyadi, M.H.J., Yazdani, S., and Saadat, S. (2014). The ocular hypotensive effect of saffron extract in primary open angle glaucoma: A pilot study. BMC Complement. Altern. Med., 14.","DOI":"10.1186\/1472-6882-14-399"},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Sim, R.H., Sirasanagandla, S.R., Das, S., and Teoh, S.L. (2022). Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update. Nutrients, 14.","DOI":"10.3390\/nu14030534"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000335961","article-title":"Two-year randomized, placebo-controlled study of black currant anthocyanins on visual field in glaucoma","volume":"228","author":"Ohguro","year":"2012","journal-title":"Ophthalmologica"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s00417-015-3044-9","article-title":"Treatment with citicoline eye drops enhances retinal function and neural conduction along the visual pathways in open angle glaucoma","volume":"253","author":"Parisi","year":"2015","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1097\/IJG.0b013e318279b836","article-title":"Effects of coenzyme Q10 in conjunction with vitamin e on retinal-evoked and cortical-evoked responses in patients with open-angle glaucoma","volume":"23","author":"Parisi","year":"2014","journal-title":"J. Glaucoma"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1001\/archopht.119.10.1417","article-title":"A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss: AREDS Report No. 8","volume":"119","author":"Kassoff","year":"2001","journal-title":"Arch. Ophthalmol."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1001\/jamaophthalmol.2013.7376","article-title":"Secondary Analyses of the Effects of Lutein\/Zeaxanthin on Age-Related Macular Degeneration Progression: AREDS2 Report No. 3","volume":"132","author":"Chew","year":"2014","journal-title":"JAMA Ophthalmol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.ophtha.2012.08.040","article-title":"Secondary outcomes in a clinical trial of carotenoids with coantioxidants versus placebo in early age-related macular degeneration","volume":"120","author":"Beatty","year":"2013","journal-title":"Ophthalmology"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1017\/S0007114512004187","article-title":"The effects of a lutein-based supplement on objective and subjective measures of retinal and visual function in eyes with age-related maculopathy\u2014A randomised controlled trial","volume":"109","author":"Berrow","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Ma, L., Liu, R., Du, J.H., Liu, T., Wu, S.S., and Liu, X.H. (2016). Lutein, Zeaxanthin and Meso-zeaxanthin Supplementation Associated with Macular Pigment Optical Density. Nutrients, 8.","DOI":"10.3390\/nu8070426"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"8174","DOI":"10.1167\/iovs.11-7522","article-title":"Effects of Lutein Supplementation on Macular Pigment Optical Density and Visual Acuity in Patients with Age-Related Macular Degeneration","volume":"52","author":"Weigert","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.abb.2014.11.012","article-title":"A randomized placebo-controlled study on the effects of lutein and zeaxanthin on visual processing speed in young healthy subjects","volume":"572","author":"Bovier","year":"2015","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"543","DOI":"10.3390\/nu5020543","article-title":"Effects of Lutein and Docosahexaenoic Acid Supplementation on Macular Pigment Optical Density in a Randomized Controlled Trial","volume":"5","author":"Recalde","year":"2013","journal-title":"Nutrients"},{"key":"ref_243","first-page":"1191","article-title":"Curcuma-Based Nutritional Supplement in Patients with Neovascular Age-Related Macular Degeneration","volume":"24","author":"Allegrini","year":"2021","journal-title":"J. Med. Food"},{"key":"ref_244","doi-asserted-by":"crossref","unstructured":"Matos, A.L., Bruno, D.F., Ambr\u00f3sio, A.F., and Santos, P.F. (2020). The Benefits of Flavonoids in Diabetic Retinopathy. Nutrients, 12.","DOI":"10.3390\/nu12103169"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40662-017-0088-4","article-title":"Effect of carotenoids dietary supplementation on macular function in diabetic patients","volume":"4","author":"Moschos","year":"2017","journal-title":"Eye Vis."},{"key":"ref_246","first-page":"406","article-title":"Effect of lutein supplementation on visual function in nonproliferative diabetic retinopathy","volume":"26","author":"Zhang","year":"2017","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_247","first-page":"303","article-title":"Application of Lutein and Zeaxanthin in nonproliferative diabetic retinopathy","volume":"4","author":"Hu","year":"2011","journal-title":"Int. J. Ophthalmol."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4103\/0301-4738.151455","article-title":"Circulating levels of reactive oxygen species in patients with nonproliferative diabetic retinopathy and the influence of antioxidant supplementation: 6-month follow-up","volume":"63","author":"Domanico","year":"2015","journal-title":"Indian J. Ophthalmol."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1038\/s41433-020-01391-z","article-title":"Topical lipoic acid choline ester eye drop for improvement of near visual acuity in subjects with presbyopia: A safety and preliminary efficacy trial","volume":"35","author":"Korenfeld","year":"2021","journal-title":"Eye"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1016\/j.ophtha.2013.04.006","article-title":"Short-term Consumption of Oral Omega-3 and Dry Eye Syndrome","volume":"120","author":"Kangari","year":"2013","journal-title":"Ophthalmology"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.vhri.2020.09.003","article-title":"Consumer Preferences and Willingness to Pay for Nutraceuticals: A Discrete Choice Experiment","volume":"24","author":"Teoh","year":"2021","journal-title":"Value Health Reg. 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