{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T04:40:15Z","timestamp":1784954415605,"version":"3.55.0"},"reference-count":33,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Research","award":["PON-MIUR 03PE000_78_1"],"award-info":[{"award-number":["PON-MIUR 03PE000_78_1"]}]},{"name":"Italian Ministry of Research","award":["PONMIUR 03PE000_78_2"],"award-info":[{"award-number":["PONMIUR 03PE000_78_2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Both clinical and experimental evidence shows that iron deficiency (ID) correlates with an increased incidence of heart failure (HF). Moreover, data on iron supplementation demonstrating a beneficial effect in subjects with HF have mostly been collected in patients undergoing HF with reduced ejection fraction (HFrEF). Relatively poor data, however, exist on the potential of iron supplementation in patients with HF with preserved ejection fraction (HFpEF). Here, we report on data emerging from a multicentric, double-blind, randomized, placebo-controlled study investigating the effect of IV supplementation with a placebo or ferric carboxymaltose (FCM) on 64 subjects with HFpEF. ID was detected by the measurement of ferritin levels. These data were correlated with cardiac performance measurements derived from a 6 min walking test (6MWT) and with echocardiographic determinations of diastolic function. Moreover, an EndoPAT analysis was performed to correlate cardiac functionality with endothelial dysfunction. Finally, the determination of serum malondialdehyde (MDA) was performed to study oxidative stress biomarkers. These measurements were carried out before and 8 weeks after starting treatment with a placebo (100 mL of saline given i.v. in 10 min; n = 32) or FCM at a dose of 500 mg IV infusion (n = 32), which was given at time 0 and repeated after 4 weeks. Our data showed that a condition of ID was more frequently associated with impaired diastolic function, worse 6MWT and endothelial dysfunction, an effect that was accompanied by elevated MDA serum levels. Treatment with FCM, compared to the placebo, improved ferritin levels being associated with an improved 6MWT, enhanced cardiac diastolic function and endothelial reactivity associated with a significant reduction in MDA levels. In conclusion, this study confirmed that ID is a frequent comorbidity in patients with HFpEF and is associated with reduced exercise capacity and oxidative stress-related endothelial dysfunction. Supplementation with FCM determines a significant improvement in diastolic function and the exercise capacity of patients with HFpEF and is associated with an enhanced endothelial function and a reduced production of oxygen radical species.<\/jats:p>","DOI":"10.3390\/nu14235057","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T07:01:30Z","timestamp":1669618890000},"page":"5057","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Effect of Ferric Carboxymaltose Supplementation in Patients with Heart Failure with Preserved Ejection Fraction: Role of Attenuated Oxidative Stress and Improved Endothelial Function"],"prefix":"10.3390","volume":"14","author":[{"given":"Annachiara","family":"Mollace","sequence":"first","affiliation":[{"name":"Institute of Research for Food Safety & Health (IRC-FSH), Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2345-6751","authenticated-orcid":false,"given":"Roberta","family":"Macr\u00ec","sequence":"additional","affiliation":[{"name":"Institute of Research for Food Safety & Health (IRC-FSH), Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7106-5595","authenticated-orcid":false,"given":"Rocco","family":"Mollace","sequence":"additional","affiliation":[{"name":"Institute of Research for Food Safety & Health (IRC-FSH), Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy"},{"name":"IRCCS San Raffaele Pisana, 88163 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Tavernese","sequence":"additional","affiliation":[{"name":"Institute of Research for Food Safety & Health (IRC-FSH), Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micaela","family":"Gliozzi","sequence":"additional","affiliation":[{"name":"Institute of Research for Food Safety & Health (IRC-FSH), Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Musolino","sequence":"additional","affiliation":[{"name":"Laboratoy of Pharmaceutical Biology, IRC-FSH Department of Health Sciences, University \u201cMagna Gr\u00e6cia\u201d of Catanzaro, Campus Universitario di Germaneto, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3509-5930","authenticated-orcid":false,"given":"Cristina","family":"Carresi","sequence":"additional","affiliation":[{"name":"Institute of Research for Food Safety & Health (IRC-FSH), Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Maiuolo","sequence":"additional","affiliation":[{"name":"Laboratoy of Pharmaceutical Biology, IRC-FSH Department of Health Sciences, University \u201cMagna Gr\u00e6cia\u201d of Catanzaro, Campus Universitario di Germaneto, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Nicita","sequence":"additional","affiliation":[{"name":"Institute of Research for Food Safety & Health (IRC-FSH), Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosamaria","family":"Caminiti","sequence":"additional","affiliation":[{"name":"Institute of Research for Food Safety & Health (IRC-FSH), Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Paone","sequence":"additional","affiliation":[{"name":"Institute of Research for Food Safety & Health (IRC-FSH), Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Barill\u00e0","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, Tor Vergata University, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2624-9213","authenticated-orcid":false,"given":"Maurizio","family":"Volterrani","sequence":"additional","affiliation":[{"name":"IRCCS San Raffaele Pisana, 88163 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0392-7173","authenticated-orcid":false,"given":"Vincenzo","family":"Mollace","sequence":"additional","affiliation":[{"name":"Institute of Research for Food Safety & Health (IRC-FSH), Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy"},{"name":"IRCCS San Raffaele Pisana, 88163 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Alnuwaysir, R.I.S., Hoes, M.F., van Veldhuisen, D.J., van der Meer, P., and Beverborg, N.G. 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