{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:44:53Z","timestamp":1772768693217,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Area R&amp;D Program of Guangdong Province","award":["2019B020227005"],"award-info":[{"award-number":["2019B020227005"]}]},{"name":"Key Area R&amp;D Program of Guangdong Province","award":["DFJH2020022"],"award-info":[{"award-number":["DFJH2020022"]}]},{"name":"Key Area R&amp;D Program of Guangdong Province","award":["2020B111117011"],"award-info":[{"award-number":["2020B111117011"]}]},{"name":"Key Area R&amp;D Program of Guangdong Province","award":["Y0120220151"],"award-info":[{"award-number":["Y0120220151"]}]},{"name":"Climbing Plan of Guangdong Provincial People\u2019s Hospital","award":["2019B020227005"],"award-info":[{"award-number":["2019B020227005"]}]},{"name":"Climbing Plan of Guangdong Provincial People\u2019s Hospital","award":["DFJH2020022"],"award-info":[{"award-number":["DFJH2020022"]}]},{"name":"Climbing Plan of Guangdong Provincial People\u2019s Hospital","award":["2020B111117011"],"award-info":[{"award-number":["2020B111117011"]}]},{"name":"Climbing Plan of Guangdong Provincial People\u2019s Hospital","award":["Y0120220151"],"award-info":[{"award-number":["Y0120220151"]}]},{"name":"Guangdong Provincial Clinical Research Center for Cardiovascular disease","award":["2019B020227005"],"award-info":[{"award-number":["2019B020227005"]}]},{"name":"Guangdong Provincial Clinical Research Center for Cardiovascular disease","award":["DFJH2020022"],"award-info":[{"award-number":["DFJH2020022"]}]},{"name":"Guangdong Provincial Clinical Research Center for Cardiovascular disease","award":["2020B111117011"],"award-info":[{"award-number":["2020B111117011"]}]},{"name":"Guangdong Provincial Clinical Research Center for Cardiovascular disease","award":["Y0120220151"],"award-info":[{"award-number":["Y0120220151"]}]},{"name":"Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention","award":["2019B020227005"],"award-info":[{"award-number":["2019B020227005"]}]},{"name":"Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention","award":["DFJH2020022"],"award-info":[{"award-number":["DFJH2020022"]}]},{"name":"Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention","award":["2020B111117011"],"award-info":[{"award-number":["2020B111117011"]}]},{"name":"Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention","award":["Y0120220151"],"award-info":[{"award-number":["Y0120220151"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Previous studies have demonstrated a J-shaped association of alcohol consumption with all-cause mortality and hypertension, but the majority of these studies focus on a single measurement of alcohol intake and were conducted in a Western population. Whether long-term trajectories of alcohol consumption are associated with all-cause mortality, hypertension, and a change in blood pressure remains to be elucidated. Methods: In the large, population-based China Health and Nutrition Survey cohort from between 1993 and 2015, group-based trajectory modeling was conducted to identify distinct alcohol-consumption trajectory classes. We investigated their association with all-cause mortality and hypertension using Cox regression and binary logistics regression models. A restricted cubic spline was performed to determine the nonlinear relationships of mean alcohol intake with mortality and hypertension. Multivariate-adjusted generalized linear mixed-effects models were conducted to assess the change in blood pressure among alcohol-consumption trajectory classes. Results: Among the 5298 participants, 48.4% were women and the mean age was 62.6 years. After 22 years of follow-up, 568 (10.7%) of the participants died and 1284 (24.2%) developed hypertension. Long-term light and moderate drinkers had a lower risk of death than the non-drinkers, and a restricted cubic spline showed a J-shaped relationship between mean alcohol intake and mortality. Although blood pressure increased slower in light and moderate drinkers, a reduced risk of hypertension was only observed in the former. The long-term heavy drinkers had the highest blood pressure and death rate. Conclusions: Light alcohol intake might be protective even in the long run, while heavy drinking reversed the beneficial effect. The causality of such a connection needs to be further investigated.<\/jats:p>","DOI":"10.3390\/nu14235073","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T02:09:58Z","timestamp":1669687798000},"page":"5073","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Longitudinal Trajectories of Alcohol Consumption with All-Cause Mortality, Hypertension, and Blood Pressure Change: Results from CHNS Cohort, 1993\u20132015"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2206-8439","authenticated-orcid":false,"given":"Weida","family":"Qiu","sequence":"first","affiliation":[{"name":"The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China"},{"name":"Department of Cardiology, Hypertension Research Laboratory, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anping","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hypertension Research Laboratory, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hypertension Research Laboratory, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingqing","family":"Feng","sequence":"additional","affiliation":[{"name":"The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China"},{"name":"Department of Cardiology, Hypertension Research Laboratory, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/add.13757","article-title":"The relationship between different dimensions of alcohol use and the burden of disease-an update","volume":"112","author":"Rehm","year":"2017","journal-title":"Addiction"},{"key":"ref_2","unstructured":"GBD 2020 Alcohol Collaborators (2022). 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