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Proyectos cofinanciados en un 80% por fondos del Programa Operativo FEDER de Andaluc\u00eda 2014\u20132020","award":["CD21\/00148"],"award-info":[{"award-number":["CD21\/00148"]}]},{"name":"Consejer\u00eda de Transformaci\u00f3n Econ\u00f3mica, Industria, Conocimiento y Universidades (CTEICU) y 80% cofinanciados por la UE, PO FEDER Andaluc\u00eda 2014-2020","award":["PE-0527-2019"],"award-info":[{"award-number":["PE-0527-2019"]}]},{"name":"Consejer\u00eda de Transformaci\u00f3n Econ\u00f3mica, Industria, Conocimiento y Universidades (CTEICU) y 80% cofinanciados por la UE, PO FEDER Andaluc\u00eda 2014-2020","award":["PY20_01351"],"award-info":[{"award-number":["PY20_01351"]}]},{"name":"Consejer\u00eda de Transformaci\u00f3n Econ\u00f3mica, Industria, Conocimiento y Universidades (CTEICU) y 80% cofinanciados por la UE, PO FEDER Andaluc\u00eda 2014-2020","award":["CD21\/00148"],"award-info":[{"award-number":["CD21\/00148"]}]},{"DOI":"10.13039\/501100004587","name":"Sara Borrell program funded by ISCIII","doi-asserted-by":"publisher","award":["PE-0527-2019"],"award-info":[{"award-number":["PE-0527-2019"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Sara Borrell program funded by ISCIII","doi-asserted-by":"publisher","award":["PY20_01351"],"award-info":[{"award-number":["PY20_01351"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Sara Borrell program funded by ISCIII","doi-asserted-by":"publisher","award":["CD21\/00148"],"award-info":[{"award-number":["CD21\/00148"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Strokes are the second most common cause of death worldwide and a leading cause of disability. Regular consumption of polyphenols has been shown to reduce the risk of suffering a cardiovascular event. For this reason, we have investigated the protective effect of Salicornia ramosissima, a seasonal halophyte that synthetizes high amounts of bioactive compounds, including polyphenols, in response to environmental stress. Aqueous, hydroalcoholic, and ethanolic extracts were prepared to investigate if dietary supplementation prior to ischemic challenge can prevent subsequent damage using two animal models. First, we screened the protective effect against hypoxia\u2013reoxygenation in Drosophila melanogaster and observed that both ethanolic and hydroalcoholic extracts protected flies from the deleterious effects of hypoxia. Second, we confirmed the protective effect of S. ramosissima ethanolic extract against brain ischemia using the transient middle cerebral artery occlusion mice model. Four weeks of oral supplementation with the ethanolic extract before artery occlusion reduced infarct volume and lowered the plasma levels of the DNA peroxidant product 8-hydroxydeoxyguanosine. Phytochemical profiling of S. ramosissima ethanolic extract revealed 50 compounds. Thus, it represents a valuable source of bioactive compounds that show promising disease-modifying activities and could be further developed as an effective food supplement for the prevention or treatment of neurovascular disorders.<\/jats:p>","DOI":"10.3390\/nu14235077","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T04:32:53Z","timestamp":1669782773000},"page":"5077","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Diet Supplementation with Polyphenol-Rich Salicornia ramosissima Extracts Protects against Tissue Damage in Experimental Models of Cerebral Ischemia"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6596-8002","authenticated-orcid":false,"given":"Paula","family":"Garc\u00eda-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Neurovascular Research Laboratory, Vall d\u2019Hebron Institute of Research (VHIR), Universitat Aut\u00f2noma de Barcelona, Hospital Universitari Vall d\u2019Hebron, Pg. Vall d\u2019Hebron 119-129, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1321-5564","authenticated-orcid":false,"given":"Feifei","family":"Ma","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Vall d\u2019Hebron Institute of Research (VHIR), Universitat Aut\u00f2noma de Barcelona, Hospital Universitari Vall d\u2019Hebron, Pg. Vall d\u2019Hebron 119-129, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2332-2216","authenticated-orcid":false,"given":"Carmen del","family":"R\u00edo","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Roc\u00edo, CSIC, Universidad de Sevilla, 41013 Seville, Spain"},{"name":"Department of Neurology, Hospital Universitario Virgen Macarena, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Romero-Bernal","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Roc\u00edo, CSIC, Universidad de Sevilla, 41013 Seville, Spain"},{"name":"Department of Neurology, Hospital Universitario Virgen Macarena, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Najar","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Roc\u00edo, CSIC, Universidad de Sevilla, 41013 Seville, Spain"},{"name":"Department of Neurology, Hospital Universitario Virgen Macarena, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2613-4889","authenticated-orcid":false,"given":"Mar\u00eda de la Luz","family":"C\u00e1diz-Gurrea","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, University of Granada; Av. Fuentenueva s\/n, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9589-7388","authenticated-orcid":false,"given":"Francisco Javier","family":"Leyva-Jimenez","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry and Food Science and Technology, University of Castilla-La Mancha, Ronda de Calatrava, 7, 13071 Ciudad Real, Spain"},{"name":"Regional Institute for Applied Scientific Research (IRICA), Area of Food Science, University of Castilla-La Mancha, Avenida Camilo Jose Cela, 10, 13071 Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4121-4609","authenticated-orcid":false,"given":"Laura","family":"Ramiro","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory, Vall d\u2019Hebron Institute of Research (VHIR), Universitat Aut\u00f2noma de Barcelona, Hospital Universitari Vall d\u2019Hebron, Pg. Vall d\u2019Hebron 119-129, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8313-8720","authenticated-orcid":false,"given":"Paloma","family":"Men\u00e9ndez-Valladares","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Roc\u00edo, CSIC, Universidad de Sevilla, 41013 Seville, Spain"},{"name":"Department of Neurology, Hospital Universitario Virgen Macarena, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8940-9763","authenticated-orcid":false,"given":"Soledad","family":"P\u00e9rez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Roc\u00edo, CSIC, Universidad de Sevilla, 41013 Seville, Spain"},{"name":"Department of Neurology, Hospital Universitario Virgen Macarena, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5564-5338","authenticated-orcid":false,"given":"Antonio","family":"Segura-Carretero","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, University of Granada; Av. Fuentenueva s\/n, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4845-2279","authenticated-orcid":false,"given":"Joan","family":"Montaner","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Roc\u00edo, CSIC, Universidad de Sevilla, 41013 Seville, Spain"},{"name":"Department of Neurology, Hospital Universitario Virgen Macarena, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e391","DOI":"10.1016\/j.lpm.2016.10.003","article-title":"Epidemiology of stroke in Europe and trends for the 21st century","volume":"45","author":"Bejot","year":"2016","journal-title":"Presse Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1161\/01.STR.0000196957.55928.ab","article-title":"Time is brain\u2014Quantified","volume":"37","author":"Saver","year":"2006","journal-title":"Stroke"},{"key":"ref_3","first-page":"467","article-title":"1026 experimental treatments in acute stroke","volume":"59","author":"Macleod","year":"2006","journal-title":"Ann. 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