{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:19:11Z","timestamp":1790533151870,"version":"4.1.0"},"reference-count":65,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Agricultural Sciences, Rural Development Administration","award":["PJ01514401"],"award-info":[{"award-number":["PJ01514401"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Alcohol and drug overdoses cause liver diseases such as cirrhosis, hepatitis, and liver cancer globally. In particular, an overdose of acetaminophen (APAP), which is generally used as an analgesic and antipyretic agent, is a major cause of acute hepatitis, and cases of APAP-induced liver damage are steadily increasing. Potential antioxidants may inhibit the generation of free radicals and prevent drug-induced liver damage. Among plant-derived natural materials, radishes (RJ) and turnips (RG) have anti-inflammatory, anticancer, and antioxidant properties due to the presence of functional ingredients, such as glucosinolate and isothiocyanate. Although various functions have been reported, in vivo studies on the antioxidant activity of radishes are insufficient. Therefore, we aim to evaluate the hepatoprotective effects of RG and RJ in APAP-induced liver-damaged mice. RG and RJ extracts markedly improved the histological status, such as inflammation and infiltration, of mice liver tissue, significantly decreased the levels of alanine transaminase, aspartate aminotransferase, and malondialdehyde, and significantly increased the levels of glutathione, superoxide dismutase and catalase in the APAP-induced liver-damaged mice. In addition, RG and RJ extracts significantly increased the expression of Nrf-2 and HO-1, which are antioxidative-related factors, and regulated the BAX and BCL-2, thereby showing anti-apoptosis activity. These results indicated that RG and RJ extracts protected mice against acute liver injury, attributed to a reduction in both oxidative stress and apoptosis. These findings have clinical implications for the use of RG and RJ extracts as potential natural candidates for developing hepatoprotective agents.<\/jats:p>","DOI":"10.3390\/nu14235082","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T04:32:53Z","timestamp":1669782773000},"page":"5082","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Hepatoprotective Effects of Radish (Raphanus sativus L.) on Acetaminophen-Induced Liver Damage via Inhibiting Oxidative Stress and Apoptosis"],"prefix":"10.3390","volume":"14","author":[{"given":"Kyung-A","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Agrofood Resources, National Institute of Agricultural Sciences, Rural Development Administration, Wanju-gun 55365, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YuJin","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Agrofood Resources, National Institute of Agricultural Sciences, Rural Development Administration, Wanju-gun 55365, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1948-4442","authenticated-orcid":false,"given":"Hye-Jeong","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Agrofood Resources, National Institute of Agricultural Sciences, Rural Development Administration, Wanju-gun 55365, Republic of Korea"},{"name":"Department of Food and Biotechnology, Korea University, Sejong 30019, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NaYeong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Agrofood Resources, National Institute of Agricultural Sciences, Rural Development Administration, Wanju-gun 55365, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"ref_1","first-page":"295","article-title":"Acute-on-chronic liver failure: A review","volume":"10","author":"Torre","year":"2014","journal-title":"Ther. Clin. Risk. Manag."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jhep.2010.08.011","article-title":"The protective role of hydrogen-rich saline in experimental liver injury in mice","volume":"54","author":"Sun","year":"2011","journal-title":"J. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1080\/14740338.2018.1491547","article-title":"The economic burden of preventable adverse drug reactions: A systematic review of observational studies","volume":"17","author":"Formica","year":"2018","journal-title":"Expert. Opin. Drug. Saf."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1053\/gast.1996.v110.pm8964414","article-title":"Uncoupling of rat and human mitochondria: A possible explanation for tacrine-induced liver dysfunction","volume":"110","author":"Berson","year":"1996","journal-title":"Gastroenterology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0163-7258(95)00012-6","article-title":"Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity","volume":"67","author":"Fromenty","year":"1995","journal-title":"Pharmacol. Ther."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1007\/s10620-008-0239-5","article-title":"Green-tea polyphenols downregulate cyclooxygenase and Bcl-2 activity in acetaminophen-induced hepatotoxicity","volume":"53","author":"Helieh","year":"2008","journal-title":"Dig. Dis. Sci."},{"key":"ref_7","first-page":"73","article-title":"Drug-induced Liver Injury","volume":"6","author":"Stefan","year":"2010","journal-title":"US Gastroenterol. Hepatol. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1080\/14786419.2018.1503261","article-title":"Protective Effect of epicatechin on APAP-induced Acute Liver injury of mice through anti-inflammation and apoptosis inhibition","volume":"34","author":"Wu","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nrgastro.2011.22","article-title":"Mechanisms of drug-induced liver injury: From bedside to bench","volume":"8","author":"Tujios","year":"2011","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s11356-018-3553-2","article-title":"Protective effect of cinnamon against acetaminophen-mediated cellular damage and apoptosis in renal tissue","volume":"26","author":"Abdeen","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/brb3.208","article-title":"N-acetylcysteine (NAC) in neurological disorders: Mechanisms of action and therapeutic opportunities","volume":"4","author":"Shahripour","year":"2014","journal-title":"Brain Behav."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3109\/15563650.2010.486381","article-title":"A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose","volume":"48","author":"Bebarta","year":"2010","journal-title":"Clin. Toxicol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s13181-018-0653-9","article-title":"Anaphylactoid reactions to intravenous n-acetylcysteine during treatment for acetaminophen poisoning","volume":"14","author":"Yarema","year":"2018","journal-title":"J. Med. Toxicol."},{"key":"ref_14","unstructured":"Han, E.S., Kim, D.J., Han, B.H., Park, S.E., and Paek, H.S. (2021). Supply and Demand Trend and Outlook of root vegetables. Agriculture Outlook; 2021: Changes and Future of Agriculture and Rural Communities after COVID-19, Korea Rural Economic Institute."},{"key":"ref_15","first-page":"167","article-title":"Photosynthesis, productivity, and mineral content of winter radishes by soil type on Jeju Island","volume":"37","author":"Oh","year":"2019","journal-title":"Korean. J. Hortic. Sci. Technol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1021\/acs.jafc.5b04575","article-title":"Root glucosinolate profiles for screening of radish (Raphanus sativus L.) genetic resources","volume":"64","author":"Yi","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"104368","DOI":"10.1016\/j.jff.2021.104368","article-title":"Extract of radish (R. sativus Linn) promotes anti-atherosclerotic effect using urine metabolomics in ApoE\u2212\/\u2212 mice","volume":"78","author":"Na","year":"2021","journal-title":"J. Funct. Foods"},{"key":"ref_18","first-page":"333","article-title":"Physicochemical and functional properties of turnip","volume":"28","author":"Park","year":"1999","journal-title":"J. Korean Soc. Food Sci. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Tena, N., Martin, J., and Asuero, A.G. (2020). State of the art of anthocyanins: Antioxidant activity, sources, bioavailability, and therapeutic effect in human health. Antioxidants, 9.","DOI":"10.3390\/antiox9050451"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3109\/13880209.2014.950675","article-title":"Phytoextract of Indian mustard seeds acts by suppressing the generation of ROS against acetaminophen-induced hepatotoxicity in HepG2 cells","volume":"53","author":"Parikh","year":"2015","journal-title":"Pharm. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"211","DOI":"10.15616\/BSL.2019.25.3.211","article-title":"Comparison of the Antioxidant Activities of Various Processed Fruits and Vegetables in APAP-induced Oxidative Stress in BALB\/c Mice","volume":"25","author":"Saba","year":"2019","journal-title":"Biomed. Sci. Lett."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1021\/acs.jafc.5b00494","article-title":"Structural, thermal, and anti-inflammatory properties of a novel pectic polysaccharide from alfalfa (Medicago sativa L.) stem","volume":"63","author":"Chen","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"26087","DOI":"10.3390\/ijms161125942","article-title":"The role of oxidative stress and antioxidants in liver diseases","volume":"16","author":"Li","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0047-6374(90)90078-T","article-title":"Glutathione peroxidase, superoxide dismutase, and catalase inactivation by peroxides and oxygen derived free radicals","volume":"51","author":"Pigeolet","year":"1990","journal-title":"Mech. Ageing. Dev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1095\/biolreprod.104.028373","article-title":"Effect of Glutathione Depletion on Antioxidant Enzymes in the Epididymis, Seminal Vesicles, and Liver and on Spermatozoa Motility in the Aging Brown Norway Rat","volume":"71","author":"Zubkova","year":"2004","journal-title":"Biol. Reprod."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/10520295.2019.1566569","article-title":"Hepatoprotective and antioxidant effects of Hedera helix extract on acetaminophen induced oxidative stress and hepatotoxicity in mice","volume":"94","author":"Hosseini","year":"2019","journal-title":"Biotech. Histochem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1159\/000374074","article-title":"Cinnamaldehyde Prevents Endothelial DysFunction Induced by High Glucose by Activating Nrf2","volume":"36","author":"Wang","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.biopha.2018.04.175","article-title":"Hepatoprotective effects of berberine on acetaminophen-induced hepatotoxicity in mice","volume":"103","author":"Zhao","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"7416","DOI":"10.1093\/nar\/gks409","article-title":"Identification of Novel NRF2-regulated Genes by ChIP-Seq: Influence on Retinoid X Receptor Alpha","volume":"40","author":"Chorley","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.1128\/MCB.02193-05","article-title":"MafG Sumoylation Is Required for Active Transcriptional Repression","volume":"26","author":"Motohashi","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.immunol.16.1.395","article-title":"BCL-2 FAMILY: Regulators of cell death","volume":"16","author":"Chao","year":"1998","journal-title":"Annu. Rev. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Ahn, D.S., Lee, H.J., Hwang, J., Han, H., Kim, B., Shim, B., and Kim, S.H. (2018). Lambertianic acid sensitizes non-small cell lung cancers to trail-induced apoptosis via inhibition of xiap\/nf-\u03bab and activation of caspases and death receptor 4. Int. J. Mol. Sci., 19.","DOI":"10.20944\/preprints201804.0242.v1"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.3389\/fmicb.2018.01327","article-title":"Endoplasmic reticulum stress mediated mdrv p10.8 protein-induced cell cycle arrest and apoptosis through the perk\/eIF2\u03b1 pathway","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cbi.2016.03.008","article-title":"Protective effect of allyl methyl disulfide on acetaminophen-induced hepatotoxicity in mice","volume":"249","author":"Zhang","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1001\/jama.2014.716","article-title":"FDA asks physicians to stop prescribing high-dose acetaminophen products","volume":"311","author":"Mitka","year":"2014","journal-title":"JAMA"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.jhep.2016.11.017","article-title":"Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure","volume":"66","author":"Woolbright","year":"2016","journal-title":"J. Hepatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.taap.2012.08.015","article-title":"Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity","volume":"264","author":"McGill","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1016\/j.taap.2011.03.001","article-title":"Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury","volume":"252","author":"Williams","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1111\/liv.13866","article-title":"Role and mechanisms of autophagy in acetaminophen-induced liver injury","volume":"38","author":"Chao","year":"2018","journal-title":"Liver Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s00204-020-02689-3","article-title":"Antioxidants and antioxidant methods: An updated overview","volume":"94","author":"Gulcin","year":"2020","journal-title":"Arch. Toxicol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2008.08.006","article-title":"Glutathione: Overview of its protective roles, measurement, and biosynthesis","volume":"30","author":"Forman","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1039\/D1MA01235E","article-title":"Heterogeneous catalytic decomposition of hydrogen peroxide utilizing a Fe(iii)-based metal\u2013organic framework as an efficient and persistent nanozyme","volume":"3","author":"Abuzalat","year":"2022","journal-title":"Mater. Adv."},{"key":"ref_43","first-page":"407","article-title":"Levels of acetaminophen and its metabolites in mouse tissues after a toxic does","volume":"221","author":"Fisher","year":"1982","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_44","first-page":"723","article-title":"Effect of polysaccharide peptide on glutathione and protection against paracetamol-induced hepatotoxity in the rat","volume":"16","author":"Yung","year":"1994","journal-title":"Clin. Pharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jep.2006.11.003","article-title":"Hepatoprotective and antioxidant effects of Cuscuta chinensis against acetaminophen-induced hepatotoxicity in rats","volume":"111","author":"Yen","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.devcel.2011.06.017","article-title":"Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics","volume":"21","author":"Martinou","year":"2011","journal-title":"Dev. Cell."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1742-4658.2010.07975.x","article-title":"Regulation of DNA fragmentation: The role of caspases and phosphorylation","volume":"278","author":"Kitazumi","year":"2011","journal-title":"FEBS J."},{"key":"ref_48","first-page":"552","article-title":"Remote limb ischemic postconditioning protects mouse brain against cerebral ischemia\/reperfusion injury via upregulating expression of Nrf2, HO-1 and NQO-1 in mice","volume":"126","author":"Li","year":"2016","journal-title":"Int. J. Neurosci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1101\/gad.13.1.76","article-title":"Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain","volume":"13","author":"Itoh","year":"1999","journal-title":"Genes Dev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1128\/MCB.25.1.162-171.2005","article-title":"BTB Protein Keap1 Targets Antioxidant Transcription Factor Nrf2 for Ubiquitination by the Cullin 3-Roc1 Ligase","volume":"25","author":"Furukawa","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/aps.2015.120","article-title":"Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2\/ARE signaling pathway","volume":"37","author":"Jiang","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2016.10.003","article-title":"Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms","volume":"101","author":"Palliyaguru","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1523\/JNEUROSCI.4043-13.2014","article-title":"Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1","volume":"34","author":"Zhang","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1167\/iovs.16-19097","article-title":"UV-A irradiation activates Nrf2-regulated antioxidant defense and induces p53\/Caspase3-dependent apoptosis in corneal endothelial Cells UV-A activates Nrf2 and induces p53 in corneal endothelial cells","volume":"57","author":"Liu","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.freeradbiomed.2017.02.016","article-title":"Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death","volume":"106","author":"Lv","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3389\/fphar.2018.00147","article-title":"Licochalcone A Upregulates Nrf2 Antioxidant Pathway and Thereby Alleviates Acetaminophen-Induced Hepatotoxicity","volume":"9","author":"Lv","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"13565","DOI":"10.1074\/jbc.M708916200","article-title":"Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury","volume":"283","author":"Hanawa","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Pezzuto, M.J., and Suh, N. (2013). Chemoprotection against cancer by isothiocyanates: A focus on the animal models and the protective mechanisms. Natural Products in Cancer Prevention and Therapy, Springer.","DOI":"10.1007\/978-3-642-34575-3"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fgene.2012.00007","article-title":"Induction of Phase 2 antioxidant enzymes by broccoli sulforaphane: Perspectives in maintaining the antioxidant activity of vitamins A, C, and E","volume":"3","author":"Boddupalli","year":"2012","journal-title":"Front. Genet."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1007\/s00425-007-0627-7","article-title":"Regulation of plant glucosinolate metabolism","volume":"226","author":"Yan","year":"2007","journal-title":"Planta"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00023913","article-title":"Leaf glucosinolate profiles and their relationship to pest and disease resistance in oilseed rape","volume":"63","author":"Mithen","year":"1992","journal-title":"Euphytica"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1093\/carcin\/21.12.2287","article-title":"Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate","volume":"21","author":"Chung","year":"2000","journal-title":"Carcinogenesis"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/carcin\/bgg092","article-title":"The roles of JNK and apoptosis signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells","volume":"24","author":"Hu","year":"2003","journal-title":"Carcinogenesis"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.7314\/APJCP.2013.14.3.1565","article-title":"Cruciferous vegetables: Dietary phytochemicals for cancer prevention","volume":"14","author":"Noor","year":"2013","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1093\/carcin\/22.12.1987","article-title":"Total intracellular accumulation levels of dietary isothiocyanates determine their activity in elevation of cellular glutathione and induction of Phase 2 detoxyfication enzymes","volume":"22","author":"Ye","year":"2001","journal-title":"Carcinogenesis"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/23\/5082\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:29:19Z","timestamp":1760146159000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/23\/5082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,29]]},"references-count":65,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["nu14235082"],"URL":"https:\/\/doi.org\/10.3390\/nu14235082","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,29]]}}}