{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:58:12Z","timestamp":1791197892559,"version":"4.1.0"},"reference-count":103,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:00:00Z","timestamp":1670025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vitamin D (VD) is a pro-hormone that has long been known as a key regulator of calcium homeostasis and bone health in both children and adults. In recent years, studies have shown that VD may exert many extra-skeletal functions, mainly through a relevant modulation of the innate and adaptive immune system. This has suggested that VD could play a fundamental role in conditioning development, clinical course, and treatment of several autoimmune disorders, including celiac disease (CD) and inflammatory bowel diseases (IBDs). The main aim of this review is to evaluate the relationships between VD, CD, and IBDs. Literature analysis showed a potential impact of VD on CD and IBDs can be reasonably assumed based on the well-documented in vitro and in vivo VD activities on the gastrointestinal tract and the immune system. The evidence that VD can preserve intestinal mucosa from chemical and immunological damage and that VD modulation of the immune system functions can contrast the mechanisms that lead to the intestinal modifications characteristic of gastrointestinal autoimmune diseases has suggested that VD could play a role in controlling both the development and the course of CD and IBDs. Administration of VD in already diagnosed CD and IBD cases has not always significantly modified disease course. However, despite these relevant problems, most of the experts recommend monitoring of VD levels in patients with CD and IBDs and administration of supplements in patients with hypovitaminosis.<\/jats:p>","DOI":"10.3390\/nu14235154","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T04:40:09Z","timestamp":1670215209000},"page":"5154","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Role of Vitamin D in Celiac Disease and Inflammatory Bowel Diseases"],"prefix":"10.3390","volume":"14","author":[{"given":"Claudia","family":"Infantino","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery, Pediatric Clinic, University of Parma, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Francavilla","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Pediatric Clinic, University of Parma, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Vella","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Pediatric Clinic, University of Parma, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Cenni","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialized Surgery, Second University of Naples, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3468-5568","authenticated-orcid":false,"given":"Nicola","family":"Principi","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Milano, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Strisciuglio","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialized Surgery, Second University of Naples, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Pediatric Clinic, University of Parma, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.3390\/nu2070693","article-title":"Vitamin D and bone health: Potential mechanisms","volume":"2","author":"Laird","year":"2010","journal-title":"Nutrients"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1210\/er.2018-00126","article-title":"Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions","volume":"40","author":"Bouillon","year":"2019","journal-title":"Endocr. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Charoenngam, N., and Holick, M.F. (2020). Immunologic Effects of Vitamin D on Human Health and Disease. Nutrients, 12.","DOI":"10.3390\/nu12072097"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e10405","DOI":"10.1002\/jbm4.10405","article-title":"Vitamin D and Immune Regulation: Antibacterial, Antiviral, Anti-Inflammatory","volume":"5","author":"Bishop","year":"2020","journal-title":"JBMR Plus"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Mailhot, G., and White, J.H. (2020). Vitamin D and Immunity in Infants and Children. Nutrients, 12.","DOI":"10.3390\/nu12051233"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1267\/ahc.20011","article-title":"Vitamin D and the Host-Gut Microbiome: A Brief Overview","volume":"53","author":"Akimbekov","year":"2020","journal-title":"Acta Histochem. Cytochem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S2213-8587(21)00051-6","article-title":"Vitamin D supplementation to prevent acute respiratory infections: A systematic review and meta-analysis of aggregate data from randomised controlled trials","volume":"9","author":"Jolliffe","year":"2021","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_8","first-page":"136","article-title":"Vitamin D in plants: A review of occurrence, analysis, and biosynthesis","volume":"4","author":"Jakobsen","year":"2013","journal-title":"Front. Plant Sci."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Saponaro, F., Saba, A., and Zucchi, R. (2020). An Update on Vitamin D Metabolism. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186573"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1039\/c2pp05403e","article-title":"Serum 25-hydroxyvitamin-D responses to multiple UV exposures from solaria: Inferences for exposure to sunlight","volume":"11","author":"McKenzie","year":"2012","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3389\/fendo.2018.00246","article-title":"Vitamin D Supplementation Guidelines for General Population and Groups at Risk of Vitamin D Deficiency in Poland-Recommendations of the Polish Society of Pediatric Endocrinology and Diabetes and the Expert Panel With Participation of National Specialist Consultants and Representatives of Scientific Societies-2018 Update","volume":"9","author":"Walczak","year":"2018","journal-title":"Front Endocrinol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"15650","DOI":"10.1073\/pnas.1315006110","article-title":"CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo","volume":"110","author":"Zhu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/physrev.00014.2015","article-title":"Vitamin D: Metabolism, molecular mechanism of action, and pleiotropic effects","volume":"96","author":"Christakos","year":"2016","journal-title":"Physiol. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3389\/fimmu.2013.00148","article-title":"The vitamin d receptor and T cell function","volume":"4","author":"Kongsbak","year":"2013","journal-title":"Front Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.abb.2012.04.001","article-title":"Where is the vitamin D receptor?","volume":"523","author":"Wang","year":"2012","journal-title":"Arch Biochem. Biophys."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"35390","DOI":"10.18632\/oncotarget.15697","article-title":"Fine tuning of vitamin D receptor (VDR) activity by post-transcriptional and post-translational modifications","volume":"8","author":"Zenata","year":"2017","journal-title":"Oncotarget"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1111\/bcp.13652","article-title":"Vitamin D assays and the definition of hypovitaminosis D. Results from the First International onference on Controversies in Vitamin D","volume":"84","author":"Sempos","year":"2018","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"133","DOI":"10.7326\/M14-2450","article-title":"Screening for vitamin deficiency in adults: U.S. Preventive Services Task Force recommendation statement","volume":"162","author":"LeFevre","year":"2015","journal-title":"Ann. Intern. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3389\/fendo.2019.00317","article-title":"Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions","volume":"10","author":"Bikle","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1373\/clinchem.2014.234955","article-title":"Significance of serum 24,25-dihydroxyvitamin D in the assessment of vitamin D status: A double-edged sword?","volume":"61","author":"Cashman","year":"2015","journal-title":"Clin. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jsbmb.2016.12.002","article-title":"Vitamin D measurement standardization: The way out of the chaos","volume":"173","author":"Binkley","year":"2017","journal-title":"J. Steroid. Biochem. Mol. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1021\/ac9026862","article-title":"Development of a candidate reference measurement procedure for the determination of 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 in human serum using isotope-dilution liquid chromatography-tandem mass spectrometry","volume":"82","author":"Tai","year":"2010","journal-title":"Anal. Chem."},{"key":"ref_23","unstructured":"Institute of Medicine, Food and Nutrition Board (2010). Dietary Reference Intakes for Calcium and Vitamin D, National Academy Press."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society Clinical Practice Guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2012). Scientific Opinion on the Tolerable Upper Intake Level of vitamin D. EFSA J., 10, 2813.","DOI":"10.2903\/j.efsa.2012.2813"},{"key":"ref_26","first-page":"1","article-title":"Vitamin D and calcium: A systematic review of health outcomes","volume":"183","author":"Chung","year":"2009","journal-title":"Evid. Rep. Technol. Assess (Full Rep)."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00394-012-0476-4","article-title":"Implications of maternal vitamin D deficiency for the fetus, the neonate and the young infant","volume":"52","author":"Principi","year":"2013","journal-title":"Eur. J. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1080\/07853890.2022.2111602","article-title":"Vitamin D intakes and health outcomes in infants and preschool children: Summary of an evidence report","volume":"54","author":"Beauchesne","year":"2022","journal-title":"Ann. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/ncpgasthep0259","article-title":"Mechanisms of disease: The role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases","volume":"2","author":"Fasano","year":"2005","journal-title":"Nat. Clin. Pract. Gastroenterol. Hepatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13099-019-0291-z","article-title":"1,25(OH)2D3 deficiency-induced gut microbial dysbiosis degrades the colonic mucus barrier in Cyp27b1 knockout mouse model","volume":"11","author":"Zhu","year":"2019","journal-title":"Gut Pathog."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.nutres.2015.10.005","article-title":"Vitamin D receptor knockout mice exhibit elongated intestinal microvilli and increased ezrin expression","volume":"36","author":"Hause","year":"2016","journal-title":"Nutr. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/1751-2980.12591","article-title":"Vitamin D administration leads to a shift of the intestinal bacterial composition in Crohn\u2019s disease patients, but not in healthy controls","volume":"19","author":"Herlemann","year":"2018","journal-title":"J. Dig. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1749-6632.2012.06538.x","article-title":"Zonulin, regulation of tight junctions, and autoimmune diseases","volume":"1258","author":"Fasano","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Chibbar, R., and Dieleman, L.A. (2019). The Gut Microbiota in Celiac Disease and probiotics. Nutrients, 11.","DOI":"10.3390\/nu11102375"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Mentella, M.C., Scaldaferri, F., Pizzoferrato, M., Gasbarrini, A., and Miggiano, G.A.D. (2019). The Association of Disease Activity, BMI and Phase Angle with Vitamin D Deficiency in Patients with IBD. Nutrients, 11.","DOI":"10.3390\/nu11112583"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Zhao, H., Zhang, H., Wu, H., Li, H., Liu, L., Guo, J., Li, C., Shih, D.Q., and Zhang, X. (2012). Protective role of 1, 25 (OH) 2 vitamin D 3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice. BMC Gastroenterol., 12.","DOI":"10.1186\/1471-230X-12-57"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.toxlet.2015.06.006","article-title":"Protective effect of 1, 25-dihydroxyvitamin D3 on ethanol-induced intestinal barrier injury both in vitro and in vivo","volume":"237","author":"Chen","year":"2015","journal-title":"Toxicol. Lett."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.bbrc.2015.03.125","article-title":"1,25-Dihydroxyvitamin D3 preserves intestinal epithelial barrier function from TNF-\u03b1 induced injury via suppression of NF-kB p65 mediated MLCK-P-MLC signaling pathway","volume":"460","author":"Chen","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"10642","DOI":"10.1038\/srep10642","article-title":"Tight junction CLDN2 gene is a direct target of the vitamin D receptor","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1093\/ecco-jcc\/jjab044","article-title":"Overexpression of Vitamin D Receptor in Intestinal Epithelia Protects Against Colitis via Upregulating Tight Junction Protein Claudin 15","volume":"15","author":"Chatterjee","year":"2021","journal-title":"J. Crohns. Colitis."},{"key":"ref_41","first-page":"97","article-title":"Lack of Vitamin D Receptor Leads to Hyperfunction of Claudin-2 in Intestinal Inflammatory Responses","volume":"25","author":"Zhang","year":"2019","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1111\/j.0022-202X.2005.23687.x","article-title":"Vitamin D induces the antimicrobial protein hCAP18 in human skin","volume":"124","author":"Weber","year":"2005","journal-title":"J. Investig. Dermatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"9541","DOI":"10.1073\/pnas.95.16.9541","article-title":"The peptide antibiotic LL37\/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface","volume":"95","author":"Bals","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"13088","DOI":"10.1074\/jbc.272.20.13088","article-title":"Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse","volume":"272","author":"Gallo","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fphys.2014.00151","article-title":"Impact of vitamin D on immune function: Lessons learned from genome-wide analysis","volume":"5","author":"Chun","year":"2014","journal-title":"Front Physiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1681\/ASN.2013040355","article-title":"Suppression of iron-regulatory hepcidin by vitamin D","volume":"25","author":"Bacchetta","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s11914-022-00732-z","article-title":"Vitamin D Regulation of Immune Function","volume":"20","author":"Bikle","year":"2022","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0140-6736(17)31796-8","article-title":"Coeliac disease","volume":"391","author":"Lebwohl","year":"2018","journal-title":"Lancet"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00281-012-0305-0","article-title":"Role of transglutaminase 2 in celiac disease pathogenesis","volume":"34","author":"Diraimondo","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.cgh.2007.03.019","article-title":"Comparison of the interobserver reproducibility with different histologic criteria used in celiac disease","volume":"5","author":"Corazza","year":"2007","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S0022-3476(47)80050-2","article-title":"Celiac syndrome: The relationship of celiac disease, starch intolerance, and steatorrhea","volume":"30","author":"Andersen","year":"1947","journal-title":"J. Pediatr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fped.2019.00056","article-title":"Extra-Intestinal Manifestations of Coeliac Disease in Children: Clinical Features and Mechanisms","volume":"7","author":"Nardecchia","year":"2019","journal-title":"Front. Pediatr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/gutjnl-2011-301346","article-title":"The Oslo definitions for coeliac disease and related terms","volume":"62","author":"Ludvigsson","year":"2013","journal-title":"Gut"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"127589","DOI":"10.1155\/2013\/127589","article-title":"Celiac disease and autoimmune-associated conditions","volume":"2013","author":"Lauret","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"957","DOI":"10.3389\/fimmu.2020.00957","article-title":"Gut Microbiota in Celiac Disease: Is There Any Role for Probiotics?","volume":"11","author":"Pecora","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.bbamcr.2011.09.012","article-title":"Transglutaminase 2: A molecular Swiss army knife","volume":"1823","author":"Gundemir","year":"2012","journal-title":"Biochim. Biophys. Acta."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cgh.2017.06.037","article-title":"Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis","volume":"16","author":"Singh","year":"2018","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1080\/00365520903030795","article-title":"Incidence and prevalence of diagnosed coeliac disease in Finland: Results of effective case finding in adults","volume":"44","author":"Virta","year":"2009","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1053\/j.gastro.2017.02.002","article-title":"High incidence of celiac disease in a long-term study of adolescents with susceptibility genotypes","volume":"152","author":"Liu","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"507","DOI":"10.14309\/ajg.0000000000000523","article-title":"Incidence of Celiac Disease Is Increasing Over Time: A Systematic Review and Meta-analysis","volume":"115","author":"King","year":"2020","journal-title":"Am. J. Gastroenterol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/ajg.2008.8","article-title":"A report on the International Transglutaminase Autoantibody Workshop for Celiac Disease","volume":"104","author":"Li","year":"2009","journal-title":"Am. J. Gastroenterol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.jaci.2015.01.044","article-title":"Celiac disease","volume":"135","author":"Green","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1053\/j.gastro.2021.08.016","article-title":"Co-factors, Microbes, and Immunogenetics in Celiac Disease to Guide Novel Approaches for Diagnosis and Treatment","volume":"161","author":"Verdu","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Pecora, F., Persico, F., Argentiero, A., Neglia, C., and Esposito, S. (2020). The Role of Micronutrients in Support of the Immune Response against Viral Infections. Nutrients, 12.","DOI":"10.3390\/nu12103198"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1053\/j.gastro.2017.02.012","article-title":"Lower Prevalence of Celiac Disease and Gluten-Related Disorders in Persons Living in Southern vs Northern Latitudes of the United States","volume":"152","author":"Ruhl","year":"2017","journal-title":"Gastroenterol"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/jech.57.1.36","article-title":"Children born in the summer have increased risk for coeliac disease","volume":"57","author":"Ivarsson","year":"2003","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.nut.2013.05.027","article-title":"Pathologic bone alterations in celiac disease: Etiology, epidemiology, and treatment","volume":"30","year":"2014","journal-title":"Nutrition"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Delbue, D., Cardoso-Silva, D., Branchi, F., Itzlinger, A., Letizia, M., Siegmund, B., and Schumann, M. (2019). Celiac Disease Monocytes Induce a Barrier Defect in Intestinal Epithelial Cells. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20225597"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1016\/j.febslet.2005.07.066","article-title":"Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteins","volume":"579","author":"Sander","year":"2005","journal-title":"FEBS Lett."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s10620-017-4738-0","article-title":"Protective Effect of 1,25-Dihydroxy Vitamin D3 on Pepsin-Trypsin-Resistant Gliadin-Induced Tight Junction Injuries","volume":"63","author":"Dong","year":"2018","journal-title":"Dig. Dis. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3109\/08830185.2011.602443","article-title":"New clues in celiac disease epidemiology, pathogenesis, clinical manifestations, and treatment","volume":"30","author":"Lionetti","year":"2011","journal-title":"Int. Rev. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1357-2725(03)00239-5","article-title":"The pathogenesis of coeliac disease","volume":"36","author":"Dewar","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3390\/nu4040243","article-title":"Celiac disease, inflammation and oxidative damage: A nutrigenetic approach","volume":"4","author":"Ferretti","year":"2012","journal-title":"Nutrients"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1515\/jpem-2012-0048","article-title":"Is vitamin D deficiency a feature of pediatric celiac disease?","volume":"25","author":"Villanueva","year":"2012","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s12016-010-8237-8","article-title":"The clinical significance of 25OH-Vitamin D status in celiac disease","volume":"42","author":"Lerner","year":"2012","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1080\/10408398.2020.1772716","article-title":"Vitamin D status and vitamin D receptor genotypes in celiac disease: A meta-analysis","volume":"61","author":"Lu","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jpeds.2020.08.089","article-title":"Lower Level of Plasma 25-Hydroxyvitamin D in Children at Diagnosis of Celiac Disease Compared with Healthy Subjects: A Case-Control Study","volume":"228","author":"Lionetti","year":"2021","journal-title":"J. Pediatr."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/20469047.2021.1996089","article-title":"Prevalence and management of vitamin D deficiency in children with newly diagnosed coeliac disease: Cohort study","volume":"41","author":"Akhshayaa","year":"2021","journal-title":"Paediatr. Int. Child Health"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1309\/EVXT-851X-WHLC-RLX9","article-title":"Histologic follow-up of people with celiac disease on a gluten-free diet: Slow and incomplete recovery","volume":"118","author":"Wahab","year":"2002","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1055\/s-2006-925178","article-title":"Endoscopic and histological findings in the duodenum of adults with celiac disease before and after changing to a gluten-free diet: A 2-year prospective study","volume":"38","author":"Tursi","year":"2006","journal-title":"Endoscopy"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"603","DOI":"10.4103\/jfmpc.jfmpc_1190_21","article-title":"Study of effect of gluten-free diet on vitamin D levels and bone mineral density in celiac disease patients","volume":"11","author":"Verma","year":"2022","journal-title":"J. Family Med. Prim. Care"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/ajg.2013.79","article-title":"American College of Gastroenterology clinical guideline: Diagnosis and management of celiac disease","volume":"108","author":"Hill","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1136\/gutjnl-2013-306578","article-title":"Diagnosis and management of adult coeliac disease: Guidelines from the British Society of Gastroenterology","volume":"63","author":"Ludvigsson","year":"2014","journal-title":"Gut"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/MPG.0000000000001216","article-title":"NASPGHAN clinical report on the diagnosis and treatment of gluten-related disorders","volume":"63","author":"Hill","year":"2016","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13052-018-0488-7","article-title":"Vitamin D in pediatric age: Consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians","volume":"44","author":"Saggese","year":"2018","journal-title":"Ital. J. Pediatr."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"11525","DOI":"10.3748\/wjg.v20.i33.11525","article-title":"Clinical characteristics and treatment of inflammatory bowel disease: A comparison of Eastern and Western perspectives","volume":"20","author":"Park","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_87","unstructured":"Centers for Disease Control and Prevention (2022, September 12). Inflammatory Bowel Disease (IBD), Available online: http:\/\/www.cdc.gov\/ibd\/#epidIBD."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"991346","DOI":"10.3389\/fimmu.2022.991346","article-title":"Global alteration of colonic microRNAome landscape associated with inflammatory bowel disease","volume":"13","author":"Boros","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jinf.2018.10.005","article-title":"Gut dysbiosis and paediatric Crohn\u2019s disease","volume":"78","author":"Brusaferro","year":"2019","journal-title":"J. Infect."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1177\/1753425917722206","article-title":"Immunopathophysiology of inflammatory bowel disease: How genetics link barrier dysfunction and innate immunity to inflammation","volume":"23","author":"Mehta","year":"2017","journal-title":"Innate Immun."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"5848","DOI":"10.3748\/wjg.v18.i41.5848","article-title":"Changes of the cytokine profile in inflammatory bowel diseases","volume":"18","author":"Muzes","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"493012","DOI":"10.1155\/2015\/493012","article-title":"Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments","volume":"2015","author":"Garcia","year":"2015","journal-title":"Mediators Inflamm."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"26","DOI":"10.5217\/ir.2018.16.1.26","article-title":"Immunological pathogenesis of inflammatory bowel disease","volume":"16","author":"Lee","year":"2018","journal-title":"Intest. Res."},{"key":"ref_94","first-page":"140","article-title":"Can vitamin D induce remission in patients with inflammatory bowel disease?","volume":"35","author":"Goulart","year":"2022","journal-title":"Ann. Gastroenterol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.2147\/JIR.S363840","article-title":"The Role of Vitamin D in Immune System and Inflammatory Bowel Disease","volume":"15","author":"Wu","year":"2022","journal-title":"J. Inflam. Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s10620-020-06207-4","article-title":"Influence of Severe Vitamin D Deficiency on the Clinical Course of Inflammatory Bowel Disease","volume":"66","author":"Ham","year":"2021","journal-title":"Dig. Dis. Sci."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Mu\u00f1oz, P., Beltr\u00e1n, B., S\u00e1ez-Gonz\u00e1lez, E., Alba, A., Nos, P., and Iborra, M. (2019). Influence of Vitamin D Deficiency on Inflammatory Markers and Clinical Disease Activity in IBD Patients. Nutrients, 11.","DOI":"10.3390\/nu11051059"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/apm.12982","article-title":"Effect of single-dose injection of vitamin D on immune cytokines in ulcerative colitis patients: A randomized placebo-controlled trial","volume":"127","author":"Sharifi","year":"2019","journal-title":"APMIS"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Bendix, M., Dige, A., J\u00f8rgensen, S.P., Dahlerup, J.F., Bibby, B.M., Deleuran, B., and Agnholt, J. (2020). Decrease in Mucosal IL17A, IFN\u03b3 and IL10 Expressions in Active Crohn\u2019s Disease Patients Treated with High-Dose Vitamin Alone or Combined with Infliximab. Nutrients, 12.","DOI":"10.3390\/nu12123699"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s00011-014-0768-7","article-title":"Elevated levels of Th17 cells and Th17-related cytokines are associated with disease activity in patients with inflammatory bowel disease","volume":"63","author":"Jiang","year":"2014","journal-title":"Inflamm. Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"e12662","DOI":"10.1097\/MD.0000000000012662","article-title":"Efficacy of vitamin D in treatment of inflammatory bowel disease: A meta-analysis","volume":"97","author":"Li","year":"2018","journal-title":"Medicine"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"7588","DOI":"10.1039\/D1FO00613D","article-title":"Effects of oral vitamin D supplementation on inflammatory bowel disease: A systematic review and meta-analysis","volume":"12","author":"Guo","year":"2021","journal-title":"Food Funct."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Fletcher, J., Swift, A., Hewison, M., and Cooper, S.C. (2020). Screening and Treatment of Vitamin D Deficiency in UK Patients with Crohn\u2019s Disease: Self-Reported Practice among Gastroenterologists. 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