{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:36:18Z","timestamp":1760232978060,"version":"build-2065373602"},"reference-count":45,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2011\/23460-1","2012\/16778-8","2014\/20186-4","2017\/00657-0","23001.000422\/98\u201330"],"award-info":[{"award-number":["2011\/23460-1","2012\/16778-8","2014\/20186-4","2017\/00657-0","23001.000422\/98\u201330"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Brazilian Federal Agency for Support and Evaluation of Graduate Education (CAPES)","doi-asserted-by":"publisher","award":["2011\/23460-1","2012\/16778-8","2014\/20186-4","2017\/00657-0","23001.000422\/98\u201330"],"award-info":[{"award-number":["2011\/23460-1","2012\/16778-8","2014\/20186-4","2017\/00657-0","23001.000422\/98\u201330"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>This study aimed to compare phase angle (PhA) and bioelectrical impedance vector analysis (BIVA) values between adult patients with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency (CAH21OHD) and a control group. A total of 22 patients (15 women, 22.9 \u00b1 3.7 years) were compared with 17 controls (11 women, 27.0 \u00b1 2.5 years). Body composition was determined by dual-energy X-ray absorptiometry. Bioelectrical impedance was used to calculate PhA, and BIVA was performed using specific software. Student\u2019s t-test and analysis of covariance were used to compare groups. Hedges\u2019 G and partial n2 were calculated for the effect estimates. Hotelling\u2019s t2 test was used to compare the mean impedance vectors between the groups. The Mahalanobis test was used to determine the distance between confidence ellipses. Patients with CAH21OHD had a higher fat mass percentage than that of the control group (both sexes). There was no significant difference in PhA values between groups (CAH21OHD vs. control) in females (6.9\u00b0 vs. 6.3\u00b0, p = 0.092) and males (8.2\u00b0 vs. 8.1\u00b0, p = 0.849), after adjusting for covariates (age and height). BIVA analysis showed a significant difference in the mean impedance vectors between the female groups (T2 = 15.9, D = 1.58, p = 0.003) owing to the higher reactance\/height (\u0394 = 8.5; p &lt; 0.001) of the patients. The PhA did not significantly differ between the groups. Female patients had significantly higher reactance values. However, further studies are needed to determine the usefulness of bioimpedance parameters in evaluating the hydration status and cellular integrity of patients with CAH21OHD.<\/jats:p>","DOI":"10.3390\/nu14235184","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T02:55:39Z","timestamp":1670295339000},"page":"5184","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Higher Body Fat but Similar Phase Angle Values in Patients with the Classical Form of Congenital Adrenal Hyperplasia in Comparison to a Control Group"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7174-6905","authenticated-orcid":false,"given":"N\u00fabia Maria","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Laboratory of Growth and Development (LabCreD), Center for Investigation in Pediatrics (CIPED), School of Medical Sciences (FCM), State University of Campinas (UNICAMP), Campinas, Sao Paulo 13083-887, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9098-1863","authenticated-orcid":false,"given":"Raquel David","family":"Langer","sequence":"additional","affiliation":[{"name":"Laboratory of Growth and Development (LabCreD), Center for Investigation in Pediatrics (CIPED), School of Medical Sciences (FCM), State University of Campinas (UNICAMP), Campinas, Sao Paulo 13083-887, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia Helena","family":"Valente Lemos-Marini","sequence":"additional","affiliation":[{"name":"Laboratory of Growth and Development (LabCreD), Center for Investigation in Pediatrics (CIPED), School of Medical Sciences (FCM), State University of Campinas (UNICAMP), Campinas, Sao Paulo 13083-887, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Minutti","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Investigation of Metabolism and Diabetes (LIMED), School of Medical Sciences (FCM), State University of Campinas (UNICAMP), Campinas, Sao Paulo 13083-878, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Geloneze","sequence":"additional","affiliation":[{"name":"Laboratory of Investigation of Metabolism and Diabetes (LIMED), School of Medical Sciences (FCM), State University of Campinas (UNICAMP), Campinas, Sao Paulo 13083-878, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2991-7678","authenticated-orcid":false,"given":"Gil","family":"Guerra-J\u00fanior","sequence":"additional","affiliation":[{"name":"Laboratory of Growth and Development (LabCreD), Center for Investigation in Pediatrics (CIPED), School of Medical Sciences (FCM), State University of Campinas (UNICAMP), Campinas, Sao Paulo 13083-887, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8470-9479","authenticated-orcid":false,"given":"Ezequiel Moreira","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Laboratory of Growth and Development (LabCreD), Center for Investigation in Pediatrics (CIPED), School of Medical Sciences (FCM), State University of Campinas (UNICAMP), Campinas, Sao Paulo 13083-887, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0889-8529(08)70018-5","article-title":"Congenital adrenal hyperplasia owing to 21-hydroxylase deficiency","volume":"30","author":"Speiser","year":"2001","journal-title":"Endocrinol. 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