{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:19:48Z","timestamp":1790191188459,"version":"4.1.0"},"reference-count":47,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of University","award":["Microliver-PC131-132"],"award-info":[{"award-number":["Microliver-PC131-132"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease, reaching epidemic proportions worldwide. Targeting the gut\u2013adipose tissue\u2013liver axis by modulating the gut microbiota can be a promising therapeutic approach in NAFLD. Lactiplantibacillus plantarum, a potent lactic-acid-producing bacterium, has been shown to attenuate NAFLD. However, to our knowledge, the possible effect of the Lactiplantibacillus plantarum strain DSM20174 (L.p. DSM20174) on the gut\u2013adipose tissue axis, diminishing inflammatory mediators as fuel for NAFLD progression, is still unknown. Using a NAFLD mouse model fed a high-fat, high-fructose (HFHF) diet for 10 weeks, we show that L.p DSM20174 supplementation of HFHF mice prevented weight gain, improved glucose and lipid homeostasis, and reduced white adipose inflammation and NAFLD progression. Furthermore, 16S rRNA gene sequencing of the faecal microbiota suggested that treatment of HFHF-fed mice with L.p DSM20174 changed the diversity and altered specific bacterial taxa at the levels of family, genus, and species in the gut microbiota. In conclusion, the beneficial effects of L.p DSM20174 in preventing fatty liver progression may be related to modulations in the composition and potential function of gut microbiota associated with lower metabolic risk factors and a reduced M1-like\/M2-like ratio of macrophages and proinflammatory cytokine expression in white adipose tissue and liver.<\/jats:p>","DOI":"10.3390\/nu14245212","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T06:55:51Z","timestamp":1670396151000},"page":"5212","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Lactiplantibacillus plantarum DSM20174 Attenuates the Progression of Non-Alcoholic Fatty Liver Disease by Modulating Gut Microbiota, Improving Metabolic Risk Factors, and Attenuating Adipose Inflammation"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1885-8457","authenticated-orcid":false,"given":"Jos\u00e9 I.","family":"Riezu-Boj","sequence":"first","affiliation":[{"name":"Department of Nutrition, Food Sciences, and Physiology, University of Navarra, 31008 Pamplona, Spain"},{"name":"Center for Nutrition Research, University of Navarra, 31008 Pamplona, Spain"},{"name":"Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4004-1432","authenticated-orcid":false,"given":"Miguel","family":"Barajas","sequence":"additional","affiliation":[{"name":"Biochemistry Area, Department of Health Science, Public University of Navarre, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2125-6016","authenticated-orcid":false,"given":"Tania","family":"P\u00e9rez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Biochemistry Area, Department of Health Science, Public University of Navarre, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda J.","family":"Pajares","sequence":"additional","affiliation":[{"name":"Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain"},{"name":"Biochemistry Area, Department of Health Science, Public University of Navarre, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5363-896X","authenticated-orcid":false,"given":"Miriam","family":"Ara\u00f1a","sequence":"additional","affiliation":[{"name":"Biochemistry Area, Department of Health Science, Public University of Navarre, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3228-9916","authenticated-orcid":false,"given":"Ferm\u00edn I.","family":"Milagro","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Food Sciences, and Physiology, University of Navarra, 31008 Pamplona, Spain"},{"name":"Center for Nutrition Research, University of Navarra, 31008 Pamplona, Spain"},{"name":"Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2332-5361","authenticated-orcid":false,"given":"Raquel","family":"Urtasun","sequence":"additional","affiliation":[{"name":"Biochemistry Area, Department of Health Science, Public University of Navarre, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00423-020-01965-1","article-title":"Mechanisms of nonalcoholic fatty liver disease and implications for surgery","volume":"406","author":"Kaufmann","year":"2021","journal-title":"Langenbeck\u2019s Arch. 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