{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:45:51Z","timestamp":1791927951160,"version":"4.3.4"},"reference-count":88,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Estonian Ministry of Education and Research","award":["IUT 20-58"],"award-info":[{"award-number":["IUT 20-58"]}]},{"name":"Estonian Ministry of Education and Research","award":["PRG 435"],"award-info":[{"award-number":["PRG 435"]}]},{"name":"Institute of Sport Sciences and Physiotherapy of the University of Tartu","award":["IUT 20-58"],"award-info":[{"award-number":["IUT 20-58"]}]},{"name":"Institute of Sport Sciences and Physiotherapy of the University of Tartu","award":["PRG 435"],"award-info":[{"award-number":["PRG 435"]}]},{"name":"Institute of Clinical Medicine of the University of Tartu","award":["IUT 20-58"],"award-info":[{"award-number":["IUT 20-58"]}]},{"name":"Institute of Clinical Medicine of the University of Tartu","award":["PRG 435"],"award-info":[{"award-number":["PRG 435"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Data on the effect of vitamin D (Vit-D) supplementation on cardiorespiratory fitness (VO2max) are conflicting. A possible source of discrepancies in the literature is the heterogeneity in baseline Vit-D status among participants in previous studies. The main objectives of the present study were to assess the impact of Vit-D supplementation on VO2max and inflammatory status in Vit-D deficient young healthy men. Participants (n = 39, baseline serum Vit-D level &lt; 50 nmol\/L) were quasi-randomly assigned to one of the two groups, which, in a double-blind manner, supplemented their diet daily with either Vit-D (8000 IU; VD) or placebo (PLC) and concomitantly performed a 12-week supervised resistance training program. During the 12-week intervention, serum Vit-D concentrations increased 3.9-fold (p &lt; 0.001) in the VD group while no changes occurred in the PLC group. Baseline VO2max did not differ in the two groups and remained unchanged during the intervention. Serum interleukin-10\/tumour necrosis factor alpha ratio increased significantly (30%, p = 0.007; effect size 0.399) in VD but not in PLC group. In conclusion, 12-week Vit-D supplementation increases serum 25(OH)D levels and improves inflammatory status, but has no impact on VO2max in Vit-D deficient young men engaged in resistance training.<\/jats:p>","DOI":"10.3390\/nu14245302","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T02:54:21Z","timestamp":1670986461000},"page":"5302","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Vitamin D Supplementation Has No Impact on Cardiorespiratory Fitness, but Improves Inflammatory Status in Vitamin D Deficient Young Men Engaged in Resistance Training"],"prefix":"10.3390","volume":"14","author":[{"given":"Lauri","family":"Savolainen","sequence":"first","affiliation":[{"name":"Institute of Sport Sciences and Physiotherapy, University of Tartu, 18 \u00dclikooli St., 50090 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Timpmann","sequence":"additional","affiliation":[{"name":"Institute of Sport Sciences and Physiotherapy, University of Tartu, 18 \u00dclikooli St., 50090 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Mooses","sequence":"additional","affiliation":[{"name":"Institute of Sport Sciences and Physiotherapy, University of Tartu, 18 \u00dclikooli St., 50090 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luule","family":"Medijainen","sequence":"additional","affiliation":[{"name":"Institute of Sport Sciences and Physiotherapy, University of Tartu, 18 \u00dclikooli St., 50090 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette","family":"T\u00f5nutare","sequence":"additional","affiliation":[{"name":"Institute of Sport Sciences and Physiotherapy, University of Tartu, 18 \u00dclikooli St., 50090 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Ross","sequence":"additional","affiliation":[{"name":"Institute of Sport Sciences and Physiotherapy, University of Tartu, 18 \u00dclikooli St., 50090 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e4rt","family":"Lellsaar","sequence":"additional","affiliation":[{"name":"Institute of Sport Sciences and Physiotherapy, University of Tartu, 18 \u00dclikooli St., 50090 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneli","family":"Piir","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Institute of Biomedicine and Translational Medicine, University of Tartu, 50090 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihkel","family":"Zilmer","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Institute of Biomedicine and Translational Medicine, University of Tartu, 50090 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Unt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Institute of Clinical Medicine, University of Tartu, 50090 Tartu, Estonia"},{"name":"Department of Sport Medicine and Rehabilitation, Institute of Clinical Medicine, University of Tartu, 50090 Tartu, Estonia"},{"name":"Sport Medicine and Rehabilitation Clinic, Tartu University Hospital, 1a Puusepa St., 50406 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahur","family":"\u00d6\u00f6pik","sequence":"additional","affiliation":[{"name":"Institute of Sport Sciences and Physiotherapy, University of Tartu, 18 \u00dclikooli St., 50090 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1689S","DOI":"10.1093\/ajcn\/80.6.1689S","article-title":"Overview of general physiologic features and functions of vitamin D","volume":"80","author":"DeLuca","year":"2004","journal-title":"Am. 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