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However, results remain conflicting. This study investigated the influence of dietary factors on the risk of incident non-alcoholic fatty liver disease (NAFLD), cirrhosis, and liver cancer. Methods: Data from the UK Biobank database were analyzed (n = 372,492). According to baseline data from the food frequency questionnaire, two main dietary patterns (Western and prudent) were identified using principal component analysis. We used cox proportional hazards models to explore the associations of individual food groups and dietary patterns with NAFLD, cirrhosis, and liver cancer. Results: During a median follow-up of 12 years, 3527 hospitalized NAFLD, 1643 cirrhosis, and 669 liver cancer cases were recorded among 372,492 participants without prior history of cancer or chronic liver diseases at baseline. In multivariable adjusted analysis, participants in the high tertile of Western dietary pattern score had an 18% (95%CI = 1.09\u20131.29), 21% (95%CI = 1.07\u20131.37), and 24% (95%CI = 1.02\u20131.50) higher risk of incident NAFLD, liver cirrhosis, and liver cancer, respectively, compared with the low tertile. Participants in the high tertile of prudent scores had a 15% (95%CI = 0.75\u20130.96) lower risk of cirrhosis, as compared with those in the low tertile. In addition, the higher consumption of red meat and the lower consumption of fruit, cereal, tea, and dietary fiber were significantly associated with a higher risk of NAFLD, cirrhosis, and liver cancer (ptrend &lt; 0.05). Conclusions: This large prospective cohort study showed that an increased intake of food from the Western dietary pattern could be correlated with an increased risk of chronic liver diseases, while the prudent pattern was only correlated with a reduced liver cirrhosis risk. These data may provide new insights into lifestyle interventions for the prevention of chronical liver diseases.<\/jats:p>","DOI":"10.3390\/nu14245335","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T02:54:02Z","timestamp":1671159242000},"page":"5335","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Diet and Risk of Non-Alcoholic Fatty Liver Disease, Cirrhosis, and Liver Cancer: A Large Prospective Cohort Study in UK Biobank"],"prefix":"10.3390","volume":"14","author":[{"given":"Wen","family":"Guo","sequence":"first","affiliation":[{"name":"Health Management Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, China International Cooperation Center on Environment and Human Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lu","sequence":"additional","affiliation":[{"name":"Health Management Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China"},{"name":"Department of Epidemiology, China International Cooperation Center on Environment and Human Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, China International Cooperation Center on Environment and Human Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, China International Cooperation Center on Environment and Human Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanrongzi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ci","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, China International Cooperation Center on Environment and Human Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China"},{"name":"Research Units of Cohort Study on Cardiovascular Diseases and Cancers, Chinese Academy of Medical Sciences, Beijing 100000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Health Management Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6735-0027","authenticated-orcid":false,"given":"Chengxiao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, China International Cooperation Center on Environment and Human Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China"},{"name":"The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/hep.31173","article-title":"Changes in the Global Burden of Chronic Liver Diseases From 2012 to 2017: The Growing Impact of NAFLD","volume":"72","author":"Paik","year":"2020","journal-title":"Hepatology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jhep.2019.03.004","article-title":"Global liver disease burdens and research trends: Analysis from a Chinese perspective","volume":"71","author":"Xiao","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jhep.2018.03.011","article-title":"A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer","volume":"69","author":"Tsuchida","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.7150\/ijbs.26086","article-title":"Polydatin attenuates diet-induced nonalcoholic steatohepatitis and fibrosis in mice","volume":"14","author":"Li","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jhep.2018.01.019","article-title":"Fructose and sugar: A major mediator of non-alcoholic fatty liver disease","volume":"68","author":"Jensen","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1136\/gutjnl-2019-319664","article-title":"Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites","volume":"70","author":"Zhang","year":"2021","journal-title":"Gut"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Vancells Lujan, P., Vi\u00f1as Esmel, E., and Sacanella Meseguer, E. (2021). Overview of Non-Alcoholic Fatty Liver Disease (NAFLD) and the Role of Sugary Food Consumption and Other Dietary Components in Its Development. Nutrients, 13.","DOI":"10.3390\/nu13051442"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s12020-020-02268-7","article-title":"Insulin resistance is related with liver fibrosis in type 2 diabetic patients with non-alcoholic fatty liver disease proven biopsy and Mediterranean diet pattern as a protective factor","volume":"68","author":"Aller","year":"2020","journal-title":"Endocrine"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/hep.30362","article-title":"Dietary Patterns and Risk of Hepatocellular Carcinoma Among U.S. Men and Women","volume":"70","author":"Ma","year":"2019","journal-title":"Hepatology"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"George, E.S., Sood, S., Broughton, A., Cogan, G., Hickey, M., Chan, W.S., Sudan, S., and Nicoll, A.J. (2021). The Association between Diet and Hepatocellular Carcinoma: A Systematic Review. Nutrients, 13.","DOI":"10.3390\/nu13010172"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.nutres.2018.06.002","article-title":"The importance of healthy dietary patterns in chronic disease prevention","volume":"70","author":"Neuhouser","year":"2019","journal-title":"Nutr. Res."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Sudlow, C., Gallacher, J., Allen, N., Beral, V., Burton, P., Danesh, J., Downey, P., Elliott, P., Green, J., and Landray, M. (2015). UK biobank: An open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med., 12.","DOI":"10.1371\/journal.pmed.1001779"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Bradbury, K.E., Young, H.J., Guo, W., and Key, T.J. (2018). Dietary assessment in UK Biobank: An evaluation of the performance of the touchscreen dietary questionnaire. J. Nutr. Sci., 7.","DOI":"10.1017\/jns.2017.66"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1017\/S0007114512003868","article-title":"Dietary patterns obtained through principal components analysis: The effect of input variable quantification","volume":"109","author":"Smith","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"5834","DOI":"10.3390\/nu7075253","article-title":"Major Dietary Patterns in Relation to General and Central Obesity among Chinese Adults","volume":"7","author":"Yu","year":"2015","journal-title":"Nutrients"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Previdelli, \u00c1.N., de Andrade, S.C., Fisberg, R.M., and Marchioni, D.M. (2016). Using Two Different Approaches to Assess Dietary Patterns: Hypothesis-Driven and Data-Driven Analysis. Nutrients, 8.","DOI":"10.3390\/nu8100593"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1053\/j.gastro.2016.12.038","article-title":"Western Dietary Pattern Increases, and Prudent Dietary Pattern Decreases, Risk of Incident Diverticulitis in a Prospective Cohort Study","volume":"152","author":"Strate","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1053\/j.gastro.2020.12.011","article-title":"Association of Genetic Variation With Cirrhosis: A Multi-Trait Genome-Wide Association and Gene-Environment Interaction Study","volume":"160","author":"Emdin","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/hep.30702","article-title":"Unexpected Rapid Increase in the Burden of NAFLD in China From 2008 to 2018: A Systematic Review and Meta-Analysis","volume":"70","author":"Zhou","year":"2019","journal-title":"Hepatology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.jhep.2018.01.015","article-title":"High red and processed meat consumption is associated with non-alcoholic fatty liver disease and insulin resistance","volume":"68","author":"Webb","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"42","DOI":"10.7762\/cnr.2022.11.1.42","article-title":"Red and Processed Meat Intake in Relation to Non-Alcoholic Fatty Liver Disease Risk: Results from a Case-Control Study","volume":"11","author":"Maroofi","year":"2022","journal-title":"Clin. Nutr. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5252","DOI":"10.1016\/j.clnu.2021.08.012","article-title":"Dairy protein intake is inversely related to development of non-alcoholic fatty liver disease","volume":"40","author":"Lee","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1136\/jech-2020-214568","article-title":"Fruit and vegetable consumption and non-alcoholic fatty liver disease among Korean adults: A prospective cohort study","volume":"74","author":"Kim","year":"2020","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/j.numecd.2021.01.009","article-title":"Does a high intake of green leafy vegetables protect from NAFLD? Evidence from a large population study","volume":"31","author":"Li","year":"2021","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00394-012-0380-y","article-title":"Critical review: Vegetables and fruit in the prevention of chronic diseases","volume":"51","author":"Boeing","year":"2012","journal-title":"Eur. J. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1093\/ajcn\/nqab298","article-title":"Diet and Risk of Incident Lung Cancer: A Large Prospective Cohort Study in UK Biobank","volume":"114","author":"Wei","year":"2021","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Salehi-Sahlabadi, A., Sadat, S., Beigrezaei, S., Pourmasomi, M., Feizi, A., Ghiasvand, R., Hadi, A., Clark, C.C.T., and Miraghajani, M. (2021). Dietary patterns and risk of non-alcoholic fatty liver disease. BMC Gastroenterol., 21.","DOI":"10.1186\/s12876-021-01612-z"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1111\/jgh.15363","article-title":"Relationship between dietary patterns and non-alcoholic fatty liver disease: A systematic review and meta-analysis","volume":"36","author":"Mansoori","year":"2021","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0140-6736(21)01374-X","article-title":"Liver cirrhosis","volume":"398","author":"Krag","year":"2021","journal-title":"Lancet"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.jcmgh.2021.05.010","article-title":"Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet","volume":"12","author":"Ganguly","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/hep.26370","article-title":"The nutritional management of hepatic encephalopathy in patients with cirrhosis: International Society for Hepatic Encephalopathy and Nitrogen Metabolism Consensus","volume":"58","author":"Amodio","year":"2013","journal-title":"Hepatology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/apt.12678","article-title":"Systematic review with meta-analysis: Meat consumption and the risk of hepatocellular carcinoma","volume":"39","author":"Luo","year":"2014","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4478","DOI":"10.1039\/C9FO00804G","article-title":"Fruit and vegetable intake and liver cancer risk: A meta-analysis of prospective cohort studies","volume":"10","author":"Guo","year":"2019","journal-title":"Food Funct."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/jjco\/hyz097","article-title":"Coffee, green tea and liver cancer risk: An evaluation based on a systematic review of epidemiologic evidence among the Japanese population","volume":"49","author":"Tanaka","year":"2019","journal-title":"Jpn. J. Clin. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1001\/jamaoncol.2018.7159","article-title":"Association of Intake of Whole Grains and Dietary Fiber With Risk of Hepatocellular Carcinoma in US Adults","volume":"5","author":"Yang","year":"2019","journal-title":"JAMA Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Quesada-V\u00e1zquez, S., Aragon\u00e8s, G., Del Bas, J.M., and Escot\u00e9, X. (2020). Diet, Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Three Parts of the Same Axis. Cells, 9.","DOI":"10.3390\/cells9010176"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/24\/5335\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:42:04Z","timestamp":1760146924000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/24\/5335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,15]]},"references-count":38,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["nu14245335"],"URL":"https:\/\/doi.org\/10.3390\/nu14245335","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,15]]}}}