{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T15:39:55Z","timestamp":1781624395933,"version":"3.54.5"},"reference-count":37,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Asahimatsu Foods Company Limited, Nagano, Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Kori-tofu is a frozen soy tofu, and soy consumption is associated with positive effects on cardiometabolic health markers. We aimed to assess the potential of Kori-tofu to improve cardiometabolic health outcomes in humans by repetitive daily consumption. In a double-blind randomized controlled cross-over trial, 45 subjects aged 40\u201370 years with (mildly) elevated cholesterol levels, received a four week Kori-tofu intervention or whey protein control intervention with a four week wash-out period in between. Cardiometabolic biomarkers were measured before and after both interventions. A significant decrease in total, low-density lipids (LDL), and high-density lipids (HDL) cholesterol, Hemoglobin A1c (HbA1c), fructosamine and systolic blood pressure was observed within the Kori-tofu intervention. However, many of these findings were also observed in the control intervention. Only adiponectin changes were different between treatments but did not change significantly within interventions. Improvements in cardiometabolic markers within the Kori-tofu intervention point toward potential beneficial health effects. Due to the lack of significant effects as compared to control, there is, however, currently no substantiating evidence to claim that Kori-tofu has beneficial effects on cardiometabolic health.<\/jats:p>","DOI":"10.3390\/nu15010049","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T03:02:15Z","timestamp":1671764535000},"page":"49","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of 4-Week Consumption of Soy Kori-tofu on Cardiometabolic Health Markers: A Double-Blind Randomized Controlled Cross-Over Trial in Adults with Mildly Elevated Cholesterol Levels"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9679-6925","authenticated-orcid":false,"given":"Maartje","family":"van den Belt","sequence":"first","affiliation":[{"name":"Wageningen Food and Biobased Research, Wageningen University & Research, 6708 WG Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"van der Haar","sequence":"additional","affiliation":[{"name":"Wageningen Food and Biobased Research, Wageningen University & Research, 6708 WG Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Els","family":"Oosterink","sequence":"additional","affiliation":[{"name":"Wageningen Food and Biobased Research, Wageningen University & Research, 6708 WG Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"van Loenhout","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ziekenhuis Gelderse Vallei, 6710 HN Ede, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Ishiguro","sequence":"additional","affiliation":[{"name":"Food Research Laboratory, Asahimatsu Foods Company Limited, Nagano 399-2561, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diederik","family":"Esser","sequence":"additional","affiliation":[{"name":"Wageningen Food and Biobased Research, Wageningen University & Research, 6708 WG Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e360","DOI":"10.1161\/CIRCULATIONAHA.105.539106","article-title":"Treatment of elevated cholesterol","volume":"111","author":"Scirica","year":"2005","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1161\/HYPERTENSIONAHA.119.14240","article-title":"High blood pressure and cardiovascular disease","volume":"75","author":"Fuchs","year":"2020","journal-title":"Hypertension"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"i5953","DOI":"10.1136\/bmj.i5953","article-title":"Association between prediabetes and risk of cardiovascular disease and all cause mortality: Systematic review and meta-analysis","volume":"355","author":"Huang","year":"2016","journal-title":"BMJ"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3132\/dvdr.2005.007","article-title":"Impaired glucose tolerance and impaired fasting glucose\u2014A review of diagnosis, clinical implications and management","volume":"2","author":"Petersen","year":"2005","journal-title":"Diabetes Vasc. 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