{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:04:21Z","timestamp":1785427461323,"version":"3.56.0"},"reference-count":238,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM104320"],"award-info":[{"award-number":["P20GM104320"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["U54 GM115458"],"award-info":[{"award-number":["U54 GM115458"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pilot Award from Child Health Research Institute","award":["P20GM104320"],"award-info":[{"award-number":["P20GM104320"]}]},{"name":"Pilot Award from Child Health Research Institute","award":["U54 GM115458"],"award-info":[{"award-number":["U54 GM115458"]}]},{"name":"University of Nebraska Medical Center","award":["P20GM104320"],"award-info":[{"award-number":["P20GM104320"]}]},{"name":"University of Nebraska Medical Center","award":["U54 GM115458"],"award-info":[{"award-number":["U54 GM115458"]}]},{"name":"University of Nebraska Collaborative Research Seed grant Funding","award":["P20GM104320"],"award-info":[{"award-number":["P20GM104320"]}]},{"name":"University of Nebraska Collaborative Research Seed grant Funding","award":["U54 GM115458"],"award-info":[{"award-number":["U54 GM115458"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Zika virus (ZIKV) is a Flavivirus from the Flaviviridae family and a positive-sense single strand RNA virus. ZIKV infection can cause a mild infection to the mother but can be vertically transmitted to the developing fetus, causing congenital anomalies. The prevalence of ZIKV infections was relatively insignificant with sporadic outbreaks in the Asian and African continents until 2006. However, recent epidemic in the Caribbean showed significant increased incidence of Congenital Zika Syndrome. ZIKV infection results in placental pathology which plays a crucial role in disease transmission from mother to fetus. Currently, there is no Food and Drug Administration (FDA) approved vaccine or therapeutic drug against ZIKV. This review article summarizes the recent advances on ZIKV transmission and diagnosis and reviews nutraceuticals which can protect against the ZIKV infection. Further, we have reviewed recent advances related to the novel therapeutic nutrient molecules that have been shown to possess activity against Zika virus infected cells. We also review the mechanism of ZIKV-induced endoplasmic reticulum and apoptosis and the protective role of palmitoleate (nutrient molecule) against ZIKV-induced ER stress and apoptosis in the placental trophoblasts.<\/jats:p>","DOI":"10.3390\/nu15010124","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T05:28:24Z","timestamp":1672205304000},"page":"124","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Novel Therapeutic Nutrients Molecules That Protect against Zika Virus Infection with a Special Note on Palmitoleate"],"prefix":"10.3390","volume":"15","author":[{"given":"Philma Glora","family":"Muthuraj","sequence":"first","affiliation":[{"name":"Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5909-3107","authenticated-orcid":false,"given":"Chandan","family":"Krishnamoorthy","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8496-2543","authenticated-orcid":false,"given":"Ann","family":"Anderson-Berry","sequence":"additional","affiliation":[{"name":"Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA"},{"name":"Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrine","family":"Hanson","sequence":"additional","affiliation":[{"name":"Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA"},{"name":"Medical Nutrition Education, College of Allied Health Profession, University of Nebraska Medical Center, Omaha, NE 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7491-8592","authenticated-orcid":false,"given":"Sathish Kumar","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA"},{"name":"Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA"},{"name":"Medical Nutrition Education, College of Allied Health Profession, University of Nebraska Medical Center, Omaha, NE 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0035-9203(52)90042-4","article-title":"Zika virus. 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