{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:20:01Z","timestamp":1790619601990,"version":"4.1.0"},"reference-count":37,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Military activities often involve high-intensity exercise that can disrupt antioxidant capacity. We investigated the effects of oregano supplementation on muscle damage, oxidative stress, and plasma antioxidant markers of soldiers performing the army combat readiness test (ACRT). Twenty-four healthy male soldiers (age: 24 \u00b1 3 years, height: 167 \u00b1 14 cm, mass: 66 \u00b1 3 kg) were randomized into a placebo group (n = 12) or an oregano supplementation group (n = 12). The participants consumed a capsule containing 500 mg Origanum vulgare immediately after completing the ACRT. Blood sampling was taken before exercise, immediately after exercise, and 60 and 120 min after oregano consumption. Plasma levels of creatine kinase (CK), lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant capacity (TAC), and glutathione peroxidase (GPX) were measured at the four time points. The time \u00d7 group interactions were found for CK (p &lt; 0.0001, d = 3.64), LDH (p &lt; 0.0001, d = 1.64), MDA (p &lt; 0.0001, d = 9.94), SOD (p &lt; 0.0001, d = 1.88), TAC (p &lt; 0.0001, d = 5.68) and GPX (p &lt; 0.0001, d = 2.38). In all variables, the difference between placebo and oregano groups were significant at 60 (p &lt; 0.0001) and 120 (p &lt; 0.0001) minutes after ACRT test. The main effect of time was also significant for all the variables (p &lt; 0.0001). Our results suggest that oregano supplementation has the potential to reduce muscle damage and increase oxidative capacity following ACRT. Supplementation with oregano may serve as a dietary strategy to increase preparedness and promote recovery in military recruits.<\/jats:p>","DOI":"10.3390\/nu15010137","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T05:28:24Z","timestamp":1672205304000},"page":"137","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Oregano (Origanum vulgare) Consumption Reduces Oxidative Stress and Markers of Muscle Damage after Combat Readiness Tests in Soldiers"],"prefix":"10.3390","volume":"15","author":[{"given":"Hossein","family":"Shirvani","sequence":"first","affiliation":[{"name":"Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behzad","family":"Bazgir","sequence":"additional","affiliation":[{"name":"Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Shamsoddini","sequence":"additional","affiliation":[{"name":"Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2458-6256","authenticated-orcid":false,"given":"Ayoub","family":"Saeidi","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, University of Kurdistan, Kurdistan, Sanandaj 6617715175, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8031-3792","authenticated-orcid":false,"given":"Seyed Morteza","family":"Tayebi","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, Faculty of Physical Education and Sport Science, Allameh Tabataba\u2019i University, Tehran 1489684511, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5094-6895","authenticated-orcid":false,"given":"Kurt A.","family":"Escobar","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, California State University, Long Beach, CA 90840, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3917-4417","authenticated-orcid":false,"given":"Ismail","family":"Laher","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trisha A.","family":"VanDusseldorp","sequence":"additional","affiliation":[{"name":"Bonafide Health, LLC p\/b JDS Therapeutics, 500 Mamaroneck Ave, Harrison, NY 10528, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1247-6754","authenticated-orcid":false,"given":"Katja","family":"Weiss","sequence":"additional","affiliation":[{"name":"Institute of Primary Care, University of Zurich, 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-9103","authenticated-orcid":false,"given":"Beat","family":"Knechtle","sequence":"additional","affiliation":[{"name":"Institute of Primary Care, University of Zurich, 8091 Zurich, Switzerland"},{"name":"Medbase St. Gallen Am Vadianplatz, 9000 St. Gallen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6743-6464","authenticated-orcid":false,"given":"Hassane","family":"Zouhal","sequence":"additional","affiliation":[{"name":"Laboratoire Mouvement, Sport, Sant\u00e9, University of Rennes, M2S\u2014EA 1274, 35000 Rennes, France"},{"name":"Institut International des Sciences du Sport (2I2S), 35850 Irodouer, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,28]]},"reference":[{"key":"ref_1","unstructured":"Brown, M.J. 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