{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:21:50Z","timestamp":1792790510671,"version":"4.5.0"},"reference-count":159,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Chronic Kidney Disease\u2013Mineral and Bone Disorder (CKD-MBD) comprises alterations in calcium, phosphorus, parathyroid hormone (PTH), Vitamin D, and fibroblast growth factor-23 (FGF-23) metabolism, abnormalities in bone turnover, mineralization, volume, linear growth or strength, and vascular calcification leading to an increase in bone fractures and vascular disease, which ultimately result in high morbidity and mortality. The bone component of CKD-MBD, referred to as renal osteodystrophy, starts early during the course of CKD as a result of the effects of progressive reduction in kidney function which modify the tight interaction between mineral, hormonal, and other biochemical mediators of cell function that ultimately lead to bone disease. In addition, other factors, such as osteoporosis not apparently dependent on the typical pathophysiologic abnormalities resulting from altered kidney function, may accompany the different varieties of renal osteodystrophy leading to an increment in the risk of bone fracture. After kidney transplantation, these bone alterations and others directly associated or not with changes in kidney function may persist, progress or transform into a different entity due to new pathogenetic mechanisms. With time, these alterations may improve or worsen depending to a large extent on the restoration of kidney function and correction of the metabolic abnormalities developed during the course of CKD. In this paper, we review the bone lesions that occur during both CKD progression and after kidney transplant and analyze the factors involved in their pathogenesis as a means to raise awareness of their complexity and interrelationship.<\/jats:p>","DOI":"10.3390\/nu15010167","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T03:18:18Z","timestamp":1672370298000},"page":"167","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Bone Disease in Chronic Kidney Disease and Kidney Transplant"],"prefix":"10.3390","volume":"15","author":[{"given":"Ezequiel","family":"Bellorin-Font","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, Saint Louis University, Saint Louis, MO 63103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eudocia","family":"Rojas","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Transplantation, University Hospital of Caracas, Caracas 1053, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Martin","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Saint Louis University, Saint Louis, MO 63103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"ref_1","unstructured":"Kidney Disease: Improving Global Outcomes CKDMBDWG (2009). 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