{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:43:21Z","timestamp":1760147001405,"version":"build-2065373602"},"reference-count":67,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian law","award":["018-04"],"award-info":[{"award-number":["018-04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Recently, the impact of patients\u2019 eating habits on both breast cancer (BC) management and inflammation have been proven. Here, we investigated whether inflammatory habits could correlate with baseline bowel [18]F-fluorodeoxyglucose (FDG) uptake and the latter, in turn, with pathological Complete Response (pCR) to neoadjuvant chemotherapy (NAC). We included stage I\u2013III BC undergoing standard NAC at IRCCS Humanitas Research Hospital, Italy. Patients fulfilled a survey concerning eating\/lifestyle behaviors and performed a staging [18]F-FDG positrone emission tomography\/computed tomography (PET\/CT). In the absence of data on the effects of individual foods, we aggregated drink and food intake for their known inflammatory properties. Data were recorded for 82 women (median age, 48). We found positive correlations between colon mean standardized uptake value (SUVmean) and pro-inflammatory drinks (alcohol and spirits; r = +0.33, p &lt; 0.01) and foods (red and cured meats; r = +0.25, p = 0.04), and a significant negative correlation between rectum SUVmean and anti-inflammatory foods (fruits and vegetables; r = \u22120.23, p = 0.04). Furthermore, colon SUVmean was significantly lower in patients with pCR compared to non pCR (p = 0.02). Our study showed, for the first time, that patients\u2019 eating habits affected bowel [18]F-FDG uptake and that colon SUVmean correlated with pCR, suggesting that PET scan could be an instrument for identifying patients presenting unhealthy behaviors.<\/jats:p>","DOI":"10.3390\/nu15010211","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T02:44:03Z","timestamp":1672627443000},"page":"211","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Relationship among Bowel [18]F-FDG PET Uptake, Pathological Complete Response, and Eating Habits in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy"],"prefix":"10.3390","volume":"15","author":[{"given":"Paola","family":"Tiberio","sequence":"first","affiliation":[{"name":"Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidija","family":"Antunovic","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1004-2063","authenticated-orcid":false,"given":"Mariangela","family":"Gaudio","sequence":"additional","affiliation":[{"name":"Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Vigan\u00f2","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione Don Carlo Gnocchi, 20148 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Pastore","sequence":"additional","affiliation":[{"name":"Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6580-673X","authenticated-orcid":false,"given":"Chiara","family":"Miggiano","sequence":"additional","affiliation":[{"name":"Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9126-8325","authenticated-orcid":false,"given":"Flavia","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Benvenuti","sequence":"additional","affiliation":[{"name":"Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Farina","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione Don Carlo Gnocchi, 20148 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5806-1856","authenticated-orcid":false,"given":"Arturo","family":"Chiti","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1709-9492","authenticated-orcid":false,"given":"Armando","family":"Santoro","sequence":"additional","affiliation":[{"name":"Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3202-1933","authenticated-orcid":false,"given":"Rita","family":"De Sanctis","sequence":"additional","affiliation":[{"name":"Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"705927","DOI":"10.3389\/fonc.2021.705927","article-title":"Results of the ECHO (Eating habits CHanges in Oncologic patients) Survey: An Italian Cross-Sectional Multicentric Study to Explore Dietary Changes and Dietary Supplement Use; in Breast Cancer Survivors","volume":"11","author":"Caprara","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1200\/JCO.19.00435","article-title":"Dietary Modification and Breast Cancer Mortality: Long-Term Follow-Up of the Women\u2019s Health Initiative Randomized Trial","volume":"38","author":"Chlebowski","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_4","first-page":"JCO2200687","article-title":"Exercise; Diet; and Weight Management During Cancer Treatment: ASCO Guideline","volume":"18","author":"Ligibel","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/s12020-021-02884-x","article-title":"Obesity; metabolic syndrome; and cancer: Pathophysiological and therapeutic associations","volume":"74","author":"Mili","year":"2021","journal-title":"Endocrine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"12975","DOI":"10.1038\/s41598-021-92138-7","article-title":"Changes in eating habits and food preferences in breast cancer patients undergoing adjuvant chemotherapy","volume":"11","author":"Pedersini","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s41568-019-0227-4","article-title":"Dietary patterns and cancer risk","volume":"20","author":"Steck","year":"2020","journal-title":"Nat. Rev. Cancer."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1001\/jamainternmed.2015.4838","article-title":"Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial","volume":"175","author":"Toledo","year":"2015","journal-title":"JAMA Intern. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3322\/caac.21591","article-title":"American Cancer Society guideline for diet and physical activity for cancer prevention","volume":"70","author":"Rock","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1177\/0884533612454302","article-title":"Diet and breast cancer: Understanding risks and benefits","volume":"27","author":"Thomson","year":"2012","journal-title":"Nutr. Clin. Pract."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.clnu.2016.07.015","article-title":"ESPEN guidelines on nutrition in cancer patients","volume":"36","author":"Arends","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1186\/s12885-019-5896-6","article-title":"Short- and long-term impact of adapted physical activity and diet counseling during adjuvant breast cancer therapy: The \u201cAPAD1\u201d randomized controlled trial","volume":"19","author":"Carayol","year":"2019","journal-title":"BMC Cancer."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"De Cicco, P., Catani, M.V., Gasperi, V., Sibilano, M., Quaglietta, M., and Savini, I. (2019). Nutrition and Breast Cancer: A Literature Review on Prevention; Treatment and Recurrence. Nutrients., 11.","DOI":"10.3390\/nu11071514"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1200\/JCO.2008.19.4035","article-title":"Dietary patterns and breast cancer recurrence and survival among women with early-stage breast cancer","volume":"27","author":"Kwan","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1158\/1055-9965.EPI-20-1506","article-title":"Diet and Prognosis in Women with Breast Cancer","volume":"30","author":"McTiernan","year":"2021","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_16","first-page":"620","article-title":"(18)F-FDG-PET\/CT in evaluating response to therapy in solid tumors: Where we are and where we can go","volume":"55","author":"Herrmann","year":"2011","journal-title":"Q. J. Nucl. Med. Mol. Imaging."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/BF02988499","article-title":"From tumor biology to clinical Pet: A review of positron emission tomography (PET) in oncology","volume":"15","author":"Kubota","year":"2001","journal-title":"Ann. Nucl. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11307-018-1181-3","article-title":"The Evolving Role of FDG-PET\/CT in the Diagnosis; Staging; and Treatment of Breast Cancer","volume":"21","author":"Paydary","year":"2019","journal-title":"Mol. Imaging Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1007\/s10620-012-2190-8","article-title":"18F-Fluorodeoxyglucose positron-emission tomography (PET) can be used to assess inflammation non-invasively in Crohn\u2019s disease","volume":"57","author":"Holtmann","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/ibd.20819","article-title":"Positron emission tomography (PET) used to image subclinical inflammation associated with ulcerative colitis (UC) in remission","volume":"15","author":"Rubin","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s12149-020-01480-9","article-title":"Physiological 18F-FDG uptake in the normal adult anal canal: Evaluation by PET\/CT","volume":"34","author":"Sena","year":"2020","journal-title":"Ann. Nucl. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s00259-014-2961-x","article-title":"FDG PET\/CT: EANM procedure guidelines for tumour imaging: Version 2.0","volume":"42","author":"Boellaard","year":"2015","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_23","unstructured":"CREA Centro di Ricerca Alimenti e Nutrizione (2022, September 01). Linee Guida Per Una Sana Alimentazione, Available online: https:\/\/www.crea.gov.it\/web\/alimenti-e-nutrizione\/-\/linee-guidaper-una-sana-alimentazione-2018."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000489065","article-title":"Predictive Factors of Eribulin Activity in Metastatic Breast Cancer Patients","volume":"94","author":"Agostinetto","year":"2018","journal-title":"Oncology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000505915","article-title":"A Study of Clinical Features and Risk Factors of Self-Referring Emergency Department Headache Patients: A Comparison with Headache Center Outpatients","volume":"83","author":"Savastano","year":"2020","journal-title":"Eur. Neurol."},{"key":"ref_26","first-page":"2786163","article-title":"Unsupervised versus Supervised Identification of Prognostic Factors in Patients with Localized Retroperitoneal Sarcoma: A Data Clustering and Mahalanobis Distance Approach","volume":"2018","author":"Giuliani","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1159\/000525152","article-title":"A Propensity Score Matching Study on the Effect of OnabotulinumtoxinA Alone versus Short-Term Psychodynamic Psychotherapy Plus Drug-of-Choice as Preventive Therapy in Chronic Migraine: Effects and Predictive Factors","volume":"85","author":"Alessiani","year":"2022","journal-title":"Eur. Neurol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1007\/s10552-021-01483-5","article-title":"Dietary changes and food habits: Social and clinical determinants in a cohort of women diagnosed with breast cancer in Barcelona (DAMA cohort)","volume":"32","author":"Clotas","year":"2021","journal-title":"Cancer Causes Control"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ding, S., Chi, M.M., Scull, B.P., Rigby, R., Schwerbrock, N.M., Magness, S., Jobin, C., and Lund, P.K. (2010). High-fat diet: Bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0012191"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Malesza, I.J., Malesza, M., Walkowiak, J., Mussin, N., Walkowiak, D., Aringazina, R., Bartkowiak-Wieczorek, J., and M\u0105dry, E. (2021). High-Fat; Western-Style Diet; Systemic Inflammation; and Gut Microbiota: A Narrative Review. Cells, 10.","DOI":"10.3390\/cells10113164"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Beam, A., Clinger, E., and Hao, L. (2021). Effect of Diet and Dietary Components on the Composition of the Gut Microbiota. Nutrients., 13.","DOI":"10.3390\/nu13082795"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1093\/jn\/137.4.992","article-title":"Dietary patterns and markers of systemic inflammation among Iranian women","volume":"137","author":"Esmaillzadeh","year":"2007","journal-title":"J. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jada.2008.11.036","article-title":"Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents","volume":"109","author":"Holt","year":"2009","journal-title":"J. Am. Diet Assoc."},{"key":"ref_34","first-page":"167","article-title":"Impact of C-reactive protein on disease risk and its relation to dietary factors","volume":"8","author":"Nanri","year":"2007","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1093\/ajcn\/82.5.1052","article-title":"A 4-wk intervention with high intake of carotenoid-rich vegetables and fruit reduces plasma C-reactive protein in healthy; nonsmoking men","volume":"82","author":"Watzl","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1177\/0884533610385703","article-title":"Diet and inflammation","volume":"25","author":"Galland","year":"2010","journal-title":"Nutr. Clin. Pract."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1093\/ajcn\/83.6.1369","article-title":"Dietary patterns are associated with biochemical markers of inflammation and endothelial activation in the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"83","author":"Nettleton","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2967\/jnmt.120.257857","article-title":"Effect of Diet on Physiologic Bowel 18F-FDG Uptake","volume":"49","author":"Fallahi","year":"2021","journal-title":"J. Nucl. Med. Technol."},{"key":"ref_39","first-page":"52","article-title":"Factors influencing the pattern and intensity of myocardial 18F-FDG uptake in oncologic PET-CT imaging","volume":"25","author":"Fallahi","year":"2017","journal-title":"Iran J. Nucl. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0140-6736(13)62422-8","article-title":"Pathological complete response and long-term clinical benefit in breast cancer: The CTNeoBC pooled analysis","volume":"384","author":"Cortazar","year":"2014","journal-title":"Lancet"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s41575-018-0022-9","article-title":"The role of diet in the aetiopathogenesis of inflammatory bowel disease","volume":"15","author":"Khalili","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/1747-0080.12715","article-title":"Dietary intake of patients with inflammatory bowel disease aligns poorly with traditional Mediterranean diet principles","volume":"79","author":"Marsh","year":"2022","journal-title":"Nutr. Diet."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Ioni\u021b\u0103-M\u00eendrican, C.B., Ziani, K., Mititelu, M., Oprea, E., Neac\u0219u, S.M., Moro\u0219an, E., Dumitrescu, D.E., Ro\u0219ca, A.C., Dr\u0103g\u0103nescu, D., and Negrei, C. (2022). Therapeutic Benefits and Dietary Restrictions of Fiber Intake: A State of the Art Review. Nutrients, 14.","DOI":"10.3390\/nu14132641"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Illescas, O., Rodr\u00edguez-Sosa, M., and Gariboldi, M. (2021). Mediterranean Diet to Prevent the Development of Colon Diseases: A Meta-Analysis of Gut Microbiota Studies. Nutrients, 13.","DOI":"10.3390\/nu13072234"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Vernia, F., Longo, S., Stefanelli, G., Viscido, A., and Latella, G. (2021). Dietary Factors Modulating Colorectal Carcinogenesis. Nutrients, 13.","DOI":"10.3390\/nu13010143"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Campaniello, D., Corbo, M.R., Sinigaglia, M., Speranza, B., Racioppo, A., Altieri, C., and Bevilacqua, A. (2022). How Diet and Physical Activity Modulate Gut Microbiota: Evidence, and Perspectives. Nutrients, 14.","DOI":"10.3390\/nu14122456"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature11550","article-title":"Diversity; stability and resilience of the human gut microbiota","volume":"489","author":"Lozupone","year":"2012","journal-title":"Nature"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"151844","DOI":"10.1016\/j.acthis.2022.151844","article-title":"Physical activity ameliorates the function of organs via adipose tissue in metabolic diseases","volume":"124","author":"Abedpoor","year":"2022","journal-title":"Acta Histochem."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Hajibabaie, F., Abedpoor, N., Assareh, N., Tabatabaiefar, M.A., Shariati, L., and Zarrabi, A. (2022). The Importance of SNPs at miRNA Binding Sites as Biomarkers of Gastric and Colorectal Cancers: A Systematic Review. J. Pers. Med., 12.","DOI":"10.3390\/jpm12030456"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1007\/s12035-022-02835-1","article-title":"Cross Brain-Gut Analysis Highlighted Hub Genes and LncRNA Networks Differentially Modified During Leucine Consumption and Endurance Exercise in Mice with Depression-Like Behaviors","volume":"59","author":"Abedpoor","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13550-017-0318-8","article-title":"Gut microbiota and physiologic bowel 18F-FDG uptake","volume":"7","author":"Kang","year":"2017","journal-title":"EJNMMI Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"18273","DOI":"10.1038\/s41598-019-54680-3","article-title":"Physiologic intestinal 18F-FDG uptake is associated with alteration of gut microbiota and proinflammatory cytokine levels in breast cancer","volume":"9","author":"Yoon","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1007\/s10620-018-5259-1","article-title":"Gut Movements: A Review of the Physiology of Gastrointestinal Transit","volume":"63","author":"Kumral","year":"2018","journal-title":"Dig. Dis. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/biof.1835","article-title":"Gut microbiome-micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?","volume":"48","author":"Barone","year":"2022","journal-title":"Biofactors"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.suc.2009.09.001","article-title":"Anorectal anatomy and physiology","volume":"90","author":"Barleben","year":"2010","journal-title":"Surg. Clin. N. Am."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"101513","DOI":"10.1016\/j.redox.2020.101513","article-title":"Physical activity and exercise: Strategies to manage frailty","volume":"35","author":"Angulo","year":"2020","journal-title":"Redox Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/cncr.23226","article-title":"Comparison of triple-negative and estrogen receptor-positive\/progesterone receptor-positive\/HER2-negative breast carcinoma using quantitative fluorine-18 fluorodeoxyglucose\/positron emission tomography imaging parameters: A potentially useful method for disease characterization","volume":"112","author":"Basu","year":"2008","journal-title":"Cancer"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1118\/1.4921363","article-title":"Comparison of prone versus supine 18F-FDG-PET of locally advanced breast cancer: Phantom and preliminary clinical studies","volume":"42","author":"Williams","year":"2015","journal-title":"Med. Phys."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"20160239","DOI":"10.1259\/bjr.20160239","article-title":"Lymph node standardized uptake values at pre-treatment 18F-fluorodeoxyglucose positron emission tomography as a valuable prognostic factor for distant metastasis in nasopharyngeal carcinoma","volume":"90","author":"Jeong","year":"2017","journal-title":"Br. J. Radiol."},{"key":"ref_60","first-page":"125","article-title":"Combined prognostic role of TARC and interim 18F-FDG PET\/CT in patients with Hodgkin lymphoma-real world observational study","volume":"25","author":"Husi","year":"2022","journal-title":"Hell. J. Nucl. Med."},{"key":"ref_61","first-page":"215","article-title":"Evaluation of the prognostic value of the metabolic volumetric parameters calculated with 18F-FDG PET\/CT and its value added to the molecular characteristics in patients with diffuse large B-cell lymphoma","volume":"41","author":"Royuela","year":"2022","journal-title":"Rev. Esp. Med. Nucl. Imagen. Mol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"924223","DOI":"10.3389\/fonc.2022.924223","article-title":"Comparison of 68Ga-FAPI and 18F-FDG PET\/CT in the Evaluation of Patients With Newly Diagnosed Non-Small Cell Lung Cancer","volume":"12","author":"Wu","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"576409","DOI":"10.3389\/fonc.2020.576409","article-title":"Comparison of Nasopharyngeal MR; 18 F-FDG PET\/CT; and 18 F-FDG PET\/MR for Local Detection of Natural Killer\/T-Cell Lymphoma; Nasal Type","volume":"10","author":"Guo","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fneur.2017.00033","article-title":"Diagnostic Value of Positron Emission Tomography Combined with Computed Tomography for Evaluating Critically Ill Neurological Patients","volume":"8","author":"Kampe","year":"2017","journal-title":"Front. Neurol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fmed.2014.00054","article-title":"Prognostic Value and Clinical Impact of (18)FDG-PET in the Management of Children with Burkitt Lymphoma after Induction Chemotherapy","volume":"1","author":"Bailly","year":"2014","journal-title":"Front. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.21037\/apm-20-2555","article-title":"Diagnostic role of 18F-FDG PET\/MRI in the TNM staging of breast cancer: A systematic review and meta-analysis","volume":"10","author":"Lu","year":"2021","journal-title":"Ann. Palliat. Med."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Yoon, H.J., Kim, H.N., Yun, Y., Kim, Y., Ha, A.N., Kim, H.L., and Kim, B.S. (2015). Background Intestinal 18F-FDG Uptake Is Related to Serum Lipid Profile and Obesity in Breast Cancer Patients. 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