{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:58:06Z","timestamp":1791550686038,"version":"4.3.4"},"reference-count":47,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Taiwan National Science and Technology Council","award":["109-2314-B-038-007"],"award-info":[{"award-number":["109-2314-B-038-007"]}]},{"name":"the Taiwan National Science and Technology Council","award":["109-2320-B-038-057-MY3"],"award-info":[{"award-number":["109-2320-B-038-057-MY3"]}]},{"name":"the Taiwan National Science and Technology Council","award":["110-2314-B-038-154"],"award-info":[{"award-number":["110-2314-B-038-154"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Eccentric contraction can easily cause muscle damage and an inflammatory response, which reduces the efficiency of muscle contraction. Resveratrol causes anti-inflammatory effects in muscles, accelerates muscle repair, and promotes exercise performance after contusion recovery. However, whether resveratrol provides the same benefits for sports injuries caused by eccentric contraction is unknown. Thus, we explored the effects of resveratrol on inflammation and energy metabolism. In this study, mice were divided into four groups: a control group, an exercise group (EX), an exercise with low-dose resveratrol group (EX + RES25), and an exercise with high-dose resveratrol group (EX + RES150). The results of an exhaustion test showed that the time before exhaustion of the EX + RES150 group was greater than that of the EX group. Tumour necrosis factor-\u03b1 (Tnf\u03b1) mRNA expression was lower in the EX + RES150 group than in the EX group. The energy utilisation of the EX + RES150 group was greater than that of the EX + RES25 group in different muscles. High-dose resveratrol intervention decreased Tnf\u03b1 mRNA expression and enhanced the mRNA expressions of sirtuin 1, glucose transporter 4, AMP-activated protein kinase \u03b11, and AMP-activated protein kinase \u03b12 in muscles. These results revealed that high-dose resveratrol supplementation can reduce inflammation and oxidation and improve energy utilisation during short-duration high-intensity exercise.<\/jats:p>","DOI":"10.3390\/nu15010249","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T02:15:42Z","timestamp":1672798542000},"page":"249","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of Resveratrol on Muscle Inflammation, Energy Utilisation, and Exercise Performance in an Eccentric Contraction Exercise Mouse Model"],"prefix":"10.3390","volume":"15","author":[{"given":"Liang-Yu","family":"Su","sequence":"first","affiliation":[{"name":"Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei 110301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Ching","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Exercise and Health Science, National Taipei University of Nursing and Health Sciences, Taipei 112303, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2786-5878","authenticated-orcid":false,"given":"Nai-Wen","family":"Kan","sequence":"additional","affiliation":[{"name":"Office of Physical Education Affairs, Taipei Medical University Hospital, Taipei 110301, Taiwan"},{"name":"School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0712-4861","authenticated-orcid":false,"given":"Te-Hsuan","family":"Tung","sequence":"additional","affiliation":[{"name":"School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linh Ba Phuong","family":"Huynh","sequence":"additional","affiliation":[{"name":"School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110301, Taiwan"},{"name":"Department of Public Health, Nutrition and Food Safety, Lien Chieu Hospital, Danang 551000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2914-5513","authenticated-orcid":false,"given":"Shih-Yi","family":"Huang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei 110301, Taiwan"},{"name":"School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110301, Taiwan"},{"name":"Nutrition Research Center, Taipei Medical University Hospital, Taipei 110301, Taiwan"},{"name":"TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei 110301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1123\/ijspp.2015-0405","article-title":"Effects of Increased Muscle Strength and Muscle Mass on Endurance-Cycling Performance","volume":"11","author":"Mujika","year":"2016","journal-title":"Int. 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