{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:51:11Z","timestamp":1793029871649,"version":"4.5.0"},"reference-count":106,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Targeting calcitonin gene-related peptide (CGRP) and its receptor by antibodies and antagonists was a breakthrough in migraine prevention and treatment. However, not all migraine patients respond to CGRP-based therapy and a fraction of those who respond complain of aliments mainly in the gastrointestinal tract. In addition, CGRP and migraine are associated with obesity and metabolic diseases, including diabetes. Therefore, CGRP may play an important role in the functioning of the gut-brain-microflora axis. CGRP secretion may be modulated by dietary compounds associated with the disruption of calcium signaling and upregulation of mitogen-activated kinase phosphatases 1 and 3. CGRP may display anorexigenic properties through induction of anorexigenic neuropeptides, such as cholecystokinin and\/or inhibit orexigenic neuropeptides, such as neuropeptide Y and melanin-concentrating hormone CH, resulting in the suppression of food intake, functionally coupled to the activation of the hypothalamic 3\u2032,5\u2032-cyclic adenosine monophosphate. The anorexigenic action of CGRP observed in animal studies may reflect its general potential to control appetite\/satiety or general food intake. Therefore, dietary nutrients may modulate CGRP, and CGRP may modulate their intake. Therefore, anti-CGRP therapy should consider this mutual dependence to increase the efficacy of the therapy and reduce its unwanted side effects. This narrative review presents information on molecular aspects of the interaction between dietary nutrients and CGRP and their reported and prospective use to improve anti-CGRP therapy in migraine.<\/jats:p>","DOI":"10.3390\/nu15020289","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T03:54:49Z","timestamp":1672977289000},"page":"289","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Nutrition and Calcitonin Gene Related Peptide (CGRP) in Migraine"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0748-7080","authenticated-orcid":false,"given":"Michal","family":"Fila","sequence":"first","affiliation":[{"name":"Department of Developmental Neurology and Epileptology, Polish Mother\u2019s Memorial Hospital Research Institute, 93-338 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8766-7868","authenticated-orcid":false,"given":"Jan","family":"Chojnacki","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition and Gastroenterological Diagnostics, Medical University of Lodz, 90-647 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Sobczuk","sequence":"additional","affiliation":[{"name":"Emergency Medicine and Disaster Medicine Department, Medical University of Lodz, 92-209 Lodz, Poland"},{"name":"Department of Orthopaedics and Traumatology, Polish Mothers\u2019 Memorial Hospital Research Institute, Rzgowska 281, 93-338 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1620-4775","authenticated-orcid":false,"given":"Cezary","family":"Chojnacki","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition and Gastroenterological Diagnostics, Medical University of Lodz, 90-647 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9539-9584","authenticated-orcid":false,"given":"Janusz","family":"Blasiak","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/ana.410230214","article-title":"Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system","volume":"23","author":"Goadsby","year":"1988","journal-title":"Ann. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1021\/acsptsci.8b00036","article-title":"CGRP-based Migraine Therapeutics: How Might They Work, Why So Safe, and What Next?","volume":"2","author":"Russo","year":"2019","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Milliron, B.J., Packel, L., Dychtwald, D., Klobodu, C., Pontiggia, L., Ogbogu, O., Barksdale, B., and Deutsch, J. (2022). When Eating Becomes Torturous: Understanding Nutrition-Related Cancer Treatment Side Effects among Individuals with Cancer and Their Caregivers. Nutrients, 14.","DOI":"10.3390\/nu14020356"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1111\/bcp.14096","article-title":"Population pharmacokinetic modelling and simulation of fremanezumab in healthy subjects and patients with migraine","volume":"85","author":"Morris","year":"2019","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/0196-9781(84)90107-4","article-title":"Effects of calcitonin gene-related peptide on food intake","volume":"5","author":"Krahn","year":"1984","journal-title":"Peptides"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1210\/edrv-17-5-533","article-title":"Calcitonin gene-related peptide and its receptors: Molecular genetics, physiology, pathophysiology, and therapeutic potentials","volume":"17","author":"Wimalawansa","year":"1996","journal-title":"Endocr. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.cmet.2016.04.006","article-title":"Parabrachial CGRP Neurons Control Meal Termination","volume":"23","author":"Campos","year":"2016","journal-title":"Cell Metab."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1152\/physrev.00034.2015","article-title":"Pathophysiology of Migraine: A Disorder of Sensory Processing","volume":"97","author":"Goadsby","year":"2017","journal-title":"Physiol. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Spekker, E., Tanaka, M., Szab\u00f3, \u00c1., and V\u00e9csei, L. (2021). Neurogenic Inflammation: The Participant in Migraine and Recent Advancements in Translational Research. Biomedicines, 10.","DOI":"10.3390\/biomedicines10010076"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.neuroscience.2016.06.012","article-title":"Neurovascular contributions to migraine: Moving beyond vasodilation","volume":"338","author":"Jacobs","year":"2016","journal-title":"Neuroscience"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"111557","DOI":"10.1016\/j.biopha.2021.111557","article-title":"Genetics, pathophysiology, diagnosis, treatment, management, and prevention of migraine","volume":"139","author":"Khan","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s10194-019-1057-1","article-title":"Association of diet and headache","volume":"20","author":"Jahromi","year":"2019","journal-title":"J. Headache Pain"},{"key":"ref_13","first-page":"117","article-title":"Usefulness of nutraceuticals in migraine prophylaxis","volume":"38","author":"Raimo","year":"2017","journal-title":"Neurol. Sci. Off. J. Ital. Neurol. Soc. Ital. Soc. Clin. Neurophysiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.pediatrneurol.2020.09.009","article-title":"Retrospective Observational Study on Riboflavin Prophylaxis in Child and Adolescent Migraine","volume":"114","author":"Das","year":"2021","journal-title":"Pediatr. Neurol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"107282","DOI":"10.1016\/j.clineuro.2022.107282","article-title":"Palmitoylethanolamide-based nutraceutical Calmux\u00ae in preventive treatment of migraine","volume":"218","year":"2022","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_16","first-page":"6565","article-title":"Nutraceuticals and migraine: Further strategy for the treatment of specific conditions","volume":"43","author":"Quintana","year":"2022","journal-title":"Neurol. Sci. Off. J. Ital. Neurol. Soc. Ital. Soc. Clin. Neurophysiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s11910-022-01195-6","article-title":"Migraine and Diet: Updates in Understanding","volume":"22","author":"Moskatel","year":"2022","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/1747-0080.12761","article-title":"The comparison of the main dietary and non-dietary trigger factors in women with chronic and episodic migraine","volume":"79","author":"Hajjarzadeh","year":"2022","journal-title":"Nutr. Diet."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"748419","DOI":"10.3389\/fneur.2021.748419","article-title":"Old Habits Die Hard: Dietary Habits of Migraine Patients Challenge our Understanding of Dietary Triggers","volume":"12","author":"Lisicki","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"147629","DOI":"10.1016\/j.brainres.2021.147629","article-title":"Was it something I ate? Understanding the bidirectional interaction of migraine and appetite neural circuits","volume":"1770","author":"Tavares","year":"2021","journal-title":"Brain Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1111\/head.12952","article-title":"Diet and Headache: Part 2","volume":"56","author":"Martin","year":"2016","journal-title":"Headache"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1111\/head.12792","article-title":"Severe Headache or Migraine History is Inversely Correlated with Dietary Sodium Intake: NHANES 1999\u20132004","volume":"56","author":"Pogoda","year":"2016","journal-title":"Headache"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1111\/head.13623","article-title":"Comparison of Diet Quality Between Women with Chronic and Episodic Migraine","volume":"59","author":"Hajjarzadeh","year":"2019","journal-title":"Headache"},{"key":"ref_24","first-page":"155","article-title":"Promoting healthy eating can help preventing migraine: A real-life preliminary study","volume":"39","author":"Altamura","year":"2018","journal-title":"Neurol. Sci. Off. J. Ital. Neurol. Soc. Ital. Soc. Clin. Neurophysiol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Altamura, C., Cecchi, G., Bravo, M., Brunelli, N., Laudisio, A., Caprio, P.D., Botti, G., Paolucci, M., Khazrai, Y.M., and Vernieri, F. (2020). The Healthy Eating Plate Advice for Migraine Prevention: An Interventional Study. Nutrients, 12.","DOI":"10.21203\/rs.2.24183\/v1"},{"key":"ref_26","first-page":"111","article-title":"Ketogenic diet in migraine: Rationale, findings and perspectives","volume":"38","author":"Barbanti","year":"2017","journal-title":"Neurol. Sci. Off. J. Ital. Neurol. Soc. Ital. Soc. Clin. Neurophysiol."},{"key":"ref_27","first-page":"3865","article-title":"Effectiveness of ketogenic diet in treatment of patients with refractory chronic migraine","volume":"42","author":"Bongiovanni","year":"2021","journal-title":"Neurol. Sci. Off. J. Ital. Neurol. Soc. Ital. Soc. Clin. Neurophysiol."},{"key":"ref_28","first-page":"6479","article-title":"Ketogenic diet in refractory migraine: Possible efficacy and role of ketone bodies\u2014A pilot experience","volume":"43","author":"Lovati","year":"2022","journal-title":"Neurol. Sci. Off. J. Ital. Neurol. Soc. Ital. Soc. Clin. Neurophysiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"294","DOI":"10.11607\/ofph.2079","article-title":"Headache in Patients with Celiac Disease and Its Response to the Gluten-Free Diet","volume":"33","author":"Ameghino","year":"2019","journal-title":"J. Oral Facial Pain Headache"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s10194-020-1078-9","article-title":"Gut-brain Axis and migraine headache: A comprehensive review","volume":"21","author":"Arzani","year":"2020","journal-title":"J. Headache Pain"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1111\/head.13993","article-title":"Gluten-Free Diet and Migraine","volume":"60","author":"Beuthin","year":"2020","journal-title":"Headache"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Di Lorenzo, C., Pinto, A., Ienca, R., Coppola, G., Sirianni, G., Di Lorenzo, G., Parisi, V., Serrao, M., Spagnoli, A., and Vestri, A. (2019). A Randomized Double-Blind, Cross-Over Trial of very Low-Calorie Diet in Overweight Migraine Patients: A Possible Role for Ketones?. Nutrients, 11.","DOI":"10.3390\/nu11081742"},{"key":"ref_33","first-page":"8","article-title":"Early and long period follow-up results of low glycemic index diet for migraine prophylaxis","volume":"30","author":"Evcili","year":"2018","journal-title":"Agri"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1055\/s-0039-1698034","article-title":"Low-Glycemic-Index Diet Relieving Migraine but Inducing Muscle Cramps","volume":"10","author":"Finsterer","year":"2019","journal-title":"J. Neurosci. Rural Pract."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Arab, A., Khorvash, F., Karimi, E., Hadi, A., and Askari, G. (2021). Associations between adherence to Mediterranean dietary pattern and frequency, duration, and severity of migraine headache: A cross-sectional study. Nutr. Neurosci., 1\u201310.","DOI":"10.1080\/1028415X.2021.2009162"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1080\/1028415X.2021.1963065","article-title":"Associations between diet quality, DASH and Mediterranean dietary patterns and migraine characteristics","volume":"25","author":"Cankay","year":"2022","journal-title":"Nutr. Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"987958","DOI":"10.3389\/fneur.2022.987958","article-title":"Dietary \u03c9-3 intake for the treatment of morning headache: A randomized controlled trial","volume":"13","author":"Marchetti","year":"2022","journal-title":"Front. Neurol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1016\/j.pain.2013.07.028","article-title":"Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: A randomized trial","volume":"154","author":"Ramsden","year":"2013","journal-title":"Pain"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"n1448","DOI":"10.1136\/bmj.n1448","article-title":"Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: Randomized controlled trial","volume":"374","author":"Ramsden","year":"2021","journal-title":"BMJ"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1212\/WNL.0000000000003919","article-title":"Body composition status and the risk of migraine: A meta-analysis","volume":"88","author":"Gelaye","year":"2017","journal-title":"Neurology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s10194-015-0510-z","article-title":"Migraine and body mass index categories: A systematic review and meta-analysis of observational studies","volume":"16","author":"Ornello","year":"2015","journal-title":"J. Headache Pain"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Silva, M.L., Martins, L.B., Dos Santos, L.C., Henriques, G.S., Teixeira, A.L., Dos Santos Rodrigues, A.M., and Matos Ferreira, A.V. (2022). Decreased plasma levels and dietary intake of minerals in women with migraine. Nutr. Neurosci., 1\u20138.","DOI":"10.1080\/1028415X.2022.2075308"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1126\/science.2994212","article-title":"Expression in brain of a messenger RNA encoding a novel neuropeptide homologous to calcitonin gene-related peptide","volume":"229","author":"Amara","year":"1985","journal-title":"Science"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/298240a0","article-title":"Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products","volume":"298","author":"Amara","year":"1982","journal-title":"Nature"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.npep.2013.10.010","article-title":"CGRP and migraine: Could PACAP play a role too?","volume":"47","author":"Kaiser","year":"2013","journal-title":"Neuropeptides"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"12309","DOI":"10.1073\/pnas.1706656114","article-title":"Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission","volume":"114","author":"Yarwood","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/head.13064","article-title":"CGRP and its receptors","volume":"57","author":"Hay","year":"2017","journal-title":"Headache"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/cne.20669","article-title":"Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat","volume":"490","author":"Cottrell","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1177\/0333102418786261","article-title":"Current understanding of trigeminal ganglion structure and function in headache","volume":"39","author":"Messlinger","year":"2019","journal-title":"Cephalalgia Int. J. Headache"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1111\/j.1526-4610.2006.00675.x","article-title":"New migraine and pain research","volume":"47","author":"Hargreaves","year":"2007","journal-title":"Headache"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1517\/13543784.2015.960921","article-title":"CGRP antagonists and antibodies for the treatment of migraine","volume":"24","author":"Szok","year":"2015","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s10194-021-01335-2","article-title":"CGRP monoclonal antibodies in migraine: An efficacy and tolerability comparison with standard prophylactic drugs","volume":"22","author":"Vandervorst","year":"2021","journal-title":"J. Headache Pain"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1021\/acsptsci.9b00089","article-title":"Distinct Patterns of Internalization of Different Calcitonin Gene-Related Peptide Receptors","volume":"3","author":"Gingell","year":"2020","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S1474-4422(21)00409-9","article-title":"Calcitonin gene-related peptide-targeting drugs for migraine: How pharmacology might inform treatment decisions","volume":"21","author":"Goadsby","year":"2022","journal-title":"Lancet Neurol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1177\/0333102420983282","article-title":"Migraine therapeutics differentially modulate the CGRP pathway","volume":"41","author":"Bhakta","year":"2021","journal-title":"Cephalalgia Int. J. Headache"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/bph.15585","article-title":"CGRP receptor antagonists for migraine. Are they also AMY1 receptor antagonists?","volume":"179","author":"Garelja","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"964568","DOI":"10.3389\/fphys.2022.964568","article-title":"Editorial: Calcitonin Gene-Related Peptide: Novel Biology and Treatments","volume":"13","author":"Brain","year":"2022","journal-title":"Front. Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.2165\/00003088-200342130-00001","article-title":"Dietary effects on drug metabolism and transport","volume":"42","author":"Harris","year":"2003","journal-title":"Clin. Pharmacokinet."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"435","DOI":"10.2147\/NDT.S282565","article-title":"A Bidirectional View of Migraine and Diet Relationship","volume":"17","author":"Gazerani","year":"2021","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.neuropharm.2012.04.016","article-title":"Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres","volume":"63","author":"Baillie","year":"2012","journal-title":"Neuropharmacology"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Slavin, M., Bourguignon, J., Jackson, K., and Orciga, M.A. (2016). Impact of Food Components on in vitro Calcitonin Gene-Related Peptide Secretion\u2014A Potential Mechanism for Dietary Influence on Migraine. Nutrients, 8.","DOI":"10.3390\/nu8070406"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1744-8069-6-91","article-title":"Dietary grape seed polyphenols repress neuron and glia activation in trigeminal ganglion and trigeminal nucleus caudalis","volume":"6","author":"Cady","year":"2010","journal-title":"Mol. Pain"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1089\/ars.2010.3697","article-title":"Cocoa and chocolate in human health and disease","volume":"15","author":"Katz","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1073\/pnas.0510168103","article-title":"(\u2013)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans","volume":"103","author":"Schroeter","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Ramos, S., Mart\u00edn, M.A., and Goya, L. (2017). Effects of Cocoa Antioxidants in Type 2 Diabetes Mellitus. Antioxidants, 6.","DOI":"10.3390\/antiox6040084"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jep.2007.09.028","article-title":"Repression of calcitonin gene-related peptide expression in trigeminal neurons by a Theobroma cacao extract","volume":"115","author":"Abbey","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.brainres.2010.01.081","article-title":"Cocoa-enriched diets enhance expression of phosphatases and decrease expression of inflammatory molecules in trigeminal ganglion neurons","volume":"1323","author":"Cady","year":"2010","journal-title":"Brain Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s10194-020-01090-w","article-title":"The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: Post hoc analysis of a randomized double-blind placebo-controlled trial","volume":"21","author":"Ghorbani","year":"2020","journal-title":"J. Headache Pain"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.2174\/0929867326666190125155947","article-title":"Natural Products and their (Semi-)Synthetic Forms in the Treatment of Migraine: History and Current Status","volume":"27","author":"Tauchen","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4103\/ijpvm.IJPVM_405_20","article-title":"Effects of Curcumin Supplementation on Clinical Features and Inflammation, in Migraine Patients: A Double-Blind Controlled, Placebo Randomized Clinical Trial","volume":"12","author":"Rezaie","year":"2021","journal-title":"Int. J. Prev. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"727049","DOI":"10.3389\/fcell.2021.727049","article-title":"Synergistic Anti-inflammatory and Neuroprotective Effects of Cinnamomum cassia and Zingiber officinale Alleviate Diabetes-Induced Hippocampal Changes in Male Albino Rats: Structural and Molecular Evidence","volume":"9","author":"Almohaimeed","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1002\/ptr.6721","article-title":"Effect of cinnamon on migraine attacks and inflammatory markers: A randomized double-blind placebo-controlled trial","volume":"34","author":"Zareie","year":"2020","journal-title":"Phytother. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1017\/S0954422411000175","article-title":"Peripheral and central mechanisms involved in the control of food intake by dietary amino acids and proteins","volume":"25","author":"Fromentin","year":"2012","journal-title":"Nutr. Res. Rev."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"760914","DOI":"10.3389\/fnut.2021.760914","article-title":"The Role of the Human Hypothalamus in Food Intake Networks: An MRI Perspective","volume":"8","author":"Roger","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.peptides.2012.03.020","article-title":"Localization of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in human gastrointestinal tract","volume":"35","author":"Cottrell","year":"2012","journal-title":"Peptides"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1210\/en.2016-1510","article-title":"Endogenous Calcitonin Gene-Related Peptide Regulates Lipid Metabolism and Energy Homeostasis in Male Mice","volume":"158","author":"Liu","year":"2017","journal-title":"Endocrinology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s12031-018-1202-3","article-title":"An Intraperitoneal Treatment with Calcitonin Gene-Related Peptide (CGRP) Regulates Appetite, Energy Intake\/Expenditure, and Metabolism","volume":"67","author":"Sanford","year":"2019","journal-title":"J. Mol. Neurosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.bbr.2008.09.004","article-title":"Effect of calcitonin gene-related peptide (CGRP) on avian appetite-related processes","volume":"196","author":"Cline","year":"2009","journal-title":"Behav. Brain Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1439-0396.2009.00937.x","article-title":"The approach to the mechanism of calcitonin gene-related peptide-inducing inhibition of food intake","volume":"94","author":"Sun","year":"2010","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/cne.901900205","article-title":"The nucleus of the solitary tract in the monkey: Projections to the thalamus and brain stem nuclei","volume":"190","author":"Beckstead","year":"1980","journal-title":"J. Comp. Neurol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/cne.902930404","article-title":"Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat","volume":"293","author":"Herbert","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"4582","DOI":"10.1523\/JNEUROSCI.3729-14.2015","article-title":"Parabrachial calcitonin gene-related peptide neurons mediate conditioned taste aversion","volume":"35","author":"Carter","year":"2015","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3389\/fendo.2019.00399","article-title":"Editorial: Neuroendocrine Control of Feeding Behavior","volume":"10","author":"Luquet","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Church, T.S., Thomas, D.M., Tudor-Locke, C., Katzmarzyk, P.T., Earnest, C.P., Rodarte, R.Q., Martin, C.K., Blair, S.N., and Bouchard, C. (2011). Trends over 5 decades in U.S. occupation-related physical activity and their associations with obesity. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0019657"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e362","DOI":"10.1111\/j.1467-789X.2010.00791.x","article-title":"Migraine and obesity: Epidemiology, possible mechanisms and the potential role of weight loss treatment","volume":"12","author":"Bond","year":"2011","journal-title":"Obes. Rev."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/0196-9781(91)90147-H","article-title":"Calcitonin gene-related peptide in human obesity","volume":"12","author":"Zelissen","year":"1991","journal-title":"Peptides"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1530\/eje.1.02046","article-title":"Plasma calcitonin gene-related peptide is increased prior to obesity, and sensory nerve desensitization by capsaicin improves oral glucose tolerance in obese Zucker rats","volume":"153","author":"Gram","year":"2005","journal-title":"Eur. J. Endocrinol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1210\/en.2010-0284","article-title":"Mice lacking the neuropeptide alpha-calcitonin gene-related peptide are protected against diet-induced obesity","volume":"151","author":"Walker","year":"2010","journal-title":"Endocrinology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.2147\/DMSO.S275898","article-title":"Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications","volume":"13","author":"Wondmkun","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1001\/jamaneurol.2018.3960","article-title":"Associations Between Migraine and Type 2 Diabetes in Women: Findings from the E3N Cohort Study","volume":"76","author":"Fagherazzi","year":"2019","journal-title":"JAMA Neurol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"686398","DOI":"10.3389\/fneur.2021.686398","article-title":"Metabolic Aspects of Migraine: Association with Obesity and Diabetes Mellitus","volume":"12","author":"MaassenVanDenBrink","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1460-9568.2006.05261.x","article-title":"Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes","volume":"25","author":"Gram","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"419","DOI":"10.21037\/atm.2017.08.27","article-title":"Calcitonin gene-related peptide: Neuroendocrine communication between the pancreas, gut, and brain in regulation of blood glucose","volume":"5","author":"Pendharkar","year":"2017","journal-title":"Ann. Transl. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"100060","DOI":"10.1016\/j.metop.2020.100060","article-title":"Monoclonal therapy against calcitonin gene-related peptide lowers hyperglycemia and adiposity in type 2 diabetes mouse models","volume":"8","author":"Halloran","year":"2020","journal-title":"Metab. Open"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e00217","DOI":"10.1002\/edm2.217","article-title":"Tolerability of eptinezumab in overweight, obese or type 1 diabetes patients","volume":"4","author":"Baker","year":"2021","journal-title":"Endocrinol. Diabetes Metab."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Kim, J., Lee, S., and Rhew, K. (2022). Association between Gastrointestinal Diseases and Migraine. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19074018"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1212\/WNL.0000000000201332","article-title":"Role of Calcitonin Gene-Related Peptide on the Gastrointestinal Symptoms of Migraine-Clinical Considerations: A Narrative Review","volume":"99","author":"Ailani","year":"2022","journal-title":"Neurology"},{"key":"ref_98","first-page":"27","article-title":"Calcitonin gene-related peptide-mediated pharmacological effects in cardiovascular and gastrointestinal diseases (Review)","volume":"23","author":"Ma","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"820006","DOI":"10.3389\/fphys.2021.820006","article-title":"Constipation Caused by Anti-calcitonin Gene-Related Peptide Migraine Therapeutics Explained by Antagonism of Calcitonin Gene-Related Peptide\u2019s Motor-Stimulating and Prosecretory Function in the Intestine","volume":"12","author":"Holzer","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1111\/head.13795","article-title":"Two-Hour CGRP Infusion Causes Gastrointestinal Hyperactivity: Possible Relevance for CGRP Antibody Treatment","volume":"60","author":"Falkenberg","year":"2020","journal-title":"Headache J. Head Face Pain"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s10194-021-01247-1","article-title":"Galcanezumab for the prevention of high frequency episodic and chronic migraine in real life in Italy: A multicenter prospective cohort study (the GARLIT study)","volume":"22","author":"Vernieri","year":"2021","journal-title":"J. Headache Pain"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/ene.15563","article-title":"Maintenance of response and predictive factors of 1-year GalcanezumAb treatment in real-life migraine patients in Italy: The multicenter prospective cohort GARLIT study","volume":"30","author":"Vernieri","year":"2023","journal-title":"Eur. J. Neurol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.clinthera.2022.01.006","article-title":"Impact of Baseline Characteristics on the Efficacy and Safety of Eptinezumab in Patients with Migraine: Subgroup Analyses of PROMISE-1 and PROMISE-2","volume":"44","author":"Martin","year":"2022","journal-title":"Clin. Ther."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1177\/03331024221111526","article-title":"Effectiveness of anti-CGRP monoclonal antibodies on central symptoms of migraine","volume":"42","author":"Iannone","year":"2022","journal-title":"Cephalalgia Int. J. Headache"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/ene.15197","article-title":"Rapid response to galcanezumab and predictive factors in chronic migraine patients: A 3-month observational, longitudinal, cohort, multicenter, Italian real-life study","volume":"29","author":"Vernieri","year":"2022","journal-title":"Eur. J. Neurol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"460","DOI":"10.2174\/1871527320666211011110307","article-title":"CGRP and CGRP-Receptor as Targets of Migraine Therapy: Brain Prize-2021","volume":"21","author":"Tajti","year":"2022","journal-title":"CNS Neurol. Disord. 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