{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:43:28Z","timestamp":1790621008764,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The differences in outcomes after weaning off intravenous support (IVS) for chronic intestinal failure (IF) are unclear. Adult IF patients who are weaned off IVS at a tertiary care center (June 2019\u20132022) were included in this study, and nutritional and functional markers were assessed before, during, and after weaning. Short bowel syndrome (SBS) was present in 77\/98 of the IF patients, with different outcomes according to the final anatomy. The body weight and the BMI increased during IVS in those with a jejunocolonic (JC) anastomosis (p &lt; 0.001), but weight loss was significant during follow-up (p &lt; 0.001). Malnutrition was present in &gt;60%, with a reduced muscle mass, which was found using bioelectrical impedance analysis (BIA), in &gt;50% of SBS-JC patients. Although reduced hand-grip strength and sarcopenia were less common, the muscle quality, or phase angle (BIA), decreased during follow-up, also correlating with serum albumin and muscle mass (p \u2264 0.01). The muscle quality and albumin were low in the patients restarting IVS, which was only the case with \u226460 cm of small bowel. Closer follow-up and earlier treatment with teduglutide (TED) should be considered in these patients, as none of the TED-treated patients were malnourished or sarcopenic. Studies on the potential benefits of nutritional and physical interventions for low muscle mass and associations with outcomes are needed in chronic IF patients.<\/jats:p>","DOI":"10.3390\/nu15020338","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T03:02:06Z","timestamp":1673319726000},"page":"338","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Malnutrition with Low Muscle Mass Is Common after Weaning off Home Parenteral Nutrition for Chronic Intestinal Failure"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3195-4996","authenticated-orcid":false,"given":"Lucas","family":"Wauters","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospitals Leuven, 3000 Leuven, Belgium"},{"name":"Department of Gastroenterology and Nutrition Support, APHP Beaujon Hospital, 92110 Clichy, France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), University of Paris, UMR 1149, 75890 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4848-115X","authenticated-orcid":false,"given":"Sol\u00e8ne","family":"Dermine","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nutrition Support, APHP Beaujon Hospital, 92110 Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brune","family":"de Dreuille","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), University of Paris, UMR 1149, 75890 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Bettolo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nutrition Support, APHP Beaujon Hospital, 92110 Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"Hutinet","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nutrition Support, APHP Beaujon Hospital, 92110 Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashiq","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nutrition Support, APHP Beaujon Hospital, 92110 Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Lecoq","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nutrition Support, APHP Beaujon Hospital, 92110 Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lore","family":"Billiauws","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nutrition Support, APHP Beaujon Hospital, 92110 Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8952-7620","authenticated-orcid":false,"given":"Alexandre","family":"Nuzzo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nutrition Support, APHP Beaujon Hospital, 92110 Clichy, France"},{"name":"Laboratoire de Recherche Vasculaire Translationnelle (LVTS), Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Universit\u00e9 Paris Cit\u00e9, Bichat Hospital, U1148, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Corcos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nutrition Support, APHP Beaujon Hospital, 92110 Clichy, France"},{"name":"Laboratoire de Recherche Vasculaire Translationnelle (LVTS), Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Universit\u00e9 Paris Cit\u00e9, Bichat Hospital, U1148, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Joly","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nutrition Support, APHP Beaujon Hospital, 92110 Clichy, France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), University of Paris, UMR 1149, 75890 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.clnu.2014.08.017","article-title":"ESPEN endorsed recommendations: Definition and classification of intestinal failure in adults","volume":"34","author":"Pironi","year":"2015","journal-title":"Clin. Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.clnu.2016.01.020","article-title":"ESPEN guidelines on chronic intestinal failure in adults","volume":"35","author":"Pironi","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1136\/gutjnl-2018-318172","article-title":"Intravenous supplementation type and volume are associated with 1-year outcome and major complications in patients with chronic intestinal failure","volume":"69","author":"Pironi","year":"2020","journal-title":"Gut"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.clnu.2017.04.013","article-title":"Clinical classification of adult patients with chronic intestinal failure due to benign disease: An international multicenter cross-sectional survey","volume":"37","author":"Pironi","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.clnesp.2021.07.004","article-title":"Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome: An international multicenter survey","volume":"45","author":"Pironi","year":"2021","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.clnu.2012.08.007","article-title":"Determinants of home parenteral nutrition dependence and survival of 268 patients with non-malignant short bowel syndrome","volume":"32","author":"Amiot","year":"2013","journal-title":"Clin. Nutr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1097\/SLA.0000000000001100","article-title":"Mesenteric Infarction: Clinical Outcomes After Restoration of Bowel Continuity","volume":"262","author":"Adaba","year":"2015","journal-title":"Ann. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.surg.2019.12.001","article-title":"Gastrointestinal Tract Reconstruction in Adults with Ultra-Short Bowel Syndrome: Surgical and Nutritional Outcomes","volume":"168","author":"Cruz","year":"2020","journal-title":"Surgery"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Kopczynska, M., Carlson, G., Teubner, A., Abraham, A., Taylor, M., Burden, S.T., Hvas, C.L., Jepsen, P., and Lal, S. (2022). Long-Term Outcomes in Patients with Intestinal Failure Due to Short Bowel Syndrome and Intestinal Fistula. Nutrients, 14.","DOI":"10.3390\/nu14071449"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0016-5085(99)70388-4","article-title":"Long-term survival and parenteral nutrition dependence in adult patients with the short bowel syndrome","volume":"117","author":"Messing","year":"1999","journal-title":"Gastroenterology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/MED.0000000000000710","article-title":"Enterohormone therapy for short bowel syndrome","volume":"29","author":"Verbiest","year":"2022","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1007\/s10620-019-06032-4","article-title":"Increased Adiposity and Reduced Lean Body Mass in Patients with Short Bowel Syndrome","volume":"65","author":"Chiplunker","year":"2020","journal-title":"Dig. Dis. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.clnu.2019.03.015","article-title":"Survival and CT defined sarcopenia in patients with intestinal failure on home parenteral support","volume":"39","author":"Oke","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1016\/j.clnu.2017.09.010","article-title":"The prevalence of sarcopenia is markedly increased in patients with intestinal failure and associates with several risk factors","volume":"37","author":"Skallerup","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.clnu.2017.06.016","article-title":"Five-year survival and causes of death in patients on home parenteral nutrition for severe chronic and benign intestinal failure","volume":"37","author":"Joly","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.clnu.2020.03.005","article-title":"ESPEN guideline on home parenteral nutrition","volume":"39","author":"Pironi","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/ajg.2009.58","article-title":"Long-term outcome of chronic intestinal pseudo-obstruction adult patients requiring home parenteral nutrition","volume":"104","author":"Amiot","year":"2009","journal-title":"Am. J. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S0140-6736(73)90131-1","article-title":"Role of the colon in ileal-resection diarrhoea","volume":"301","author":"Cummings","year":"1973","journal-title":"Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.physio.2005.05.003","article-title":"Reference values for adult grip strength measured with a Jamar dynamometer: A descriptive meta-analysis","volume":"92","author":"Bohannon","year":"2006","journal-title":"Physiotherapy"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.clnu.2015.03.001","article-title":"Diagnostic criteria for malnutrition-An ESPEN Consensus Statement","volume":"34","author":"Cederholm","year":"2015","journal-title":"Clin. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.clnu.2018.08.002","article-title":"GLIM criteria for the diagnosis of malnutrition\u2013A consensus report from the global clinical nutrition community","volume":"38","author":"Cederholm","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: Revised European consensus on definition and diagnosis","volume":"48","author":"Bahat","year":"2019","journal-title":"Age Ageing"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/ajcn\/nqz242","article-title":"Differences in methodology impact estimates of survival and dependence on home parenteral support of patients with nonmalignant short bowel syndrome","volume":"111","author":"Fuglsang","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1016\/j.clnu.2018.07.036","article-title":"Intestinal failure in adults: Recommendations from the ESPEN expert groups","volume":"37","author":"Pironi","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1177\/014860719902300525","article-title":"Colonic Digestion and Absorption of Energy from Carbohydrates and Medium-Chain Fat in Small Bowel Failure","volume":"23","author":"Jeppesen","year":"1999","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1136\/gut.43.4.478","article-title":"The influence of a preserved colon on the absorption of medium chain fat in patients with small bowel resection","volume":"43","author":"Jeppesen","year":"1998","journal-title":"Gut"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"686","DOI":"10.3109\/00365529708996519","article-title":"Body Composition Changes Measured by Dual-Energy X-ray Absorptiometry in Patients Receiving Home Parenteral Nutrition","volume":"32","author":"Tjellesen","year":"1997","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.clnesp.2018.08.004","article-title":"Body composition predicts clinical outcome in patients with intestinal failure on long-term home parenteral nutrition","volume":"28","author":"Olesen","year":"2018","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Barril, G., Nogueira, A., Alvarez-Garc\u00eda, G., N\u00fa\u00f1ez, A., S\u00e1nchez-Gonz\u00e1lez, C., and Ruperto, M. (2022). Nutritional Predictors of Mortality after 10 Years of Follow-Up in Patients with Chronic Kidney Disease at a Multidisciplinary Unit of Advanced Chronic Kidney Disease. Nutrients, 14.","DOI":"10.3390\/nu14183848"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.clnu.2012.04.002","article-title":"Can phase angle determined by bioelectrical impedance analysis assess nutritional risk? A comparison between healthy and hospitalized subjects","volume":"31","author":"Kyle","year":"2012","journal-title":"Clin. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/gut.45.4.559","article-title":"Impaired meal stimulated glucagon-like peptide 2 response in ileal resected short bowel patients with intestinal failure","volume":"45","author":"Jeppesen","year":"1999","journal-title":"Gut"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1136\/gut.47.3.370","article-title":"Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon","volume":"47","author":"Jeppesen","year":"2000","journal-title":"Gut"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1177\/0148607116680791","article-title":"Independence from Parenteral Nutrition and Intravenous Fluid Support During Treatment with Teduglutide Among Patients with Intestinal Failure Associated With Short Bowel Syndrome","volume":"41","author":"Iyer","year":"2017","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Bioletto, F., D\u2019eusebio, C., Merlo, F.D., Aimasso, U., Ossola, M., Pellegrini, M., Ponzo, V., Chiarotto, A., De Francesco, A., and Ghigo, E. (2022). Efficacy of Teduglutide for Parenteral Support Reduction in Patients with Short Bowel Syndrome: A Systematic Review and Meta-Analysis. Nutrients, 14.","DOI":"10.3390\/nu14040796"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Zaczek, Z., Jurczak-Kobus, P., Panczyk, M., Braszczy\u0144ska-Sochacka, J., Majewska, K., Kunecki, M., D\u0105browska, K., and Sobocki, J. (2022). Changes in Parenteral Nutrition Requirements and BMI in Patients with Parenteral Nutrition-Dependent Short Bowel Syndrome after Stopping Teduglutide-9 Years of Follow-Up. Nutrients, 14.","DOI":"10.3390\/nu14081634"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/jpen.1686","article-title":"Results of Surgical and Medical Rehabilitation for Adult Patients with Type III Intestinal Failure in a Comprehensive Unit Today: Building a New Model to Predict Parenteral Nutrition Independency","volume":"44","author":"Gondolesi","year":"2020","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1177\/0148607116649222","article-title":"Use of Home Parenteral Nutrition in Post-Bariatric Surgery-Related Malnutrition","volume":"41","author":"Mundi","year":"2017","journal-title":"J. Parenter. Enter. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1097\/MPG.0000000000002090","article-title":"Growth, Body Composition, and Micronutrient Abnormalities During and After Weaning Off Home Parenteral Nutrition","volume":"67","author":"Neelis","year":"2018","journal-title":"J. Pediatr. Gastroenterol. Nutr."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/2\/338\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:05:20Z","timestamp":1760119520000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/2\/338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,10]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["nu15020338"],"URL":"https:\/\/doi.org\/10.3390\/nu15020338","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,10]]}}}