{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:54:36Z","timestamp":1780700076053,"version":"3.54.1"},"reference-count":56,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012633","name":"INNOPOLIS Foundation","doi-asserted-by":"publisher","award":["2022-DD-RD-0097"],"award-info":[{"award-number":["2022-DD-RD-0097"]}],"id":[{"id":"10.13039\/501100012633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012633","name":"INNOPOLIS Foundation","doi-asserted-by":"publisher","award":["KSN1823312"],"award-info":[{"award-number":["KSN1823312"]}],"id":[{"id":"10.13039\/501100012633","id-type":"DOI","asserted-by":"publisher"}]},{"name":"KIOM","award":["2022-DD-RD-0097"],"award-info":[{"award-number":["2022-DD-RD-0097"]}]},{"name":"KIOM","award":["KSN1823312"],"award-info":[{"award-number":["KSN1823312"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>We studied the activities of Siraitia grosvenorii extracts (SGE) on airway inflammation in a mouse model of chronic obstructive pulmonary disease (COPD) stimulated by cigarette smoke extract (CSE) and lipopolysaccharide (LPS), as well as in LPS-treated human bronchial epithelial cell line (BEAS-2B). SGE improved the viability of LPS-incubated BEAS-2B cells and inhibited the expression and production of inflammatory cytokines. SGE also attenuated the mitogen-activated protein kinase (MAPK)-nuclear factor-kappa B (NF-\u03baB) signaling activated by LPS stimulation in BEAS-2B cells. In mice stimulated by CSE and LPS, we observed the infiltration of immune cells into the airway after COPD induction. SGE reduced the number of activated T cells, B cells, and neutrophils in bronchoalveolar fluid (BALF), lung tissue, mesenteric lymph node, and peripheral blood mononuclear cells, as well as inhibited infiltration into organs and mucus production. The secretion of cytokines in BALF and the expression level of pro-inflammatory cytokines, mucin 5AC, Transient receptor potential vanilloid 1, and Transient receptor potential ankyrin 1 in lung tissue were alleviated by SGE. In addition, to investigate the activity of SGE on expectoration, we evaluated phenol red secretions in the trachea of mice. SGE administration showed the effect of improving expectoration through an increase in phenol red secretion. Consequently, SGE attenuates the airway inflammatory response in CSE\/LPS-stimulated COPD. These findings indicate that SGE may be a potential herbal candidate for the therapy of COPD.<\/jats:p>","DOI":"10.3390\/nu15020468","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T06:52:10Z","timestamp":1673851930000},"page":"468","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Siraitia grosvenorii Extract Attenuates Airway Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease Induced by Cigarette Smoke and Lipopolysaccharide"],"prefix":"10.3390","volume":"15","author":[{"given":"Mi-Sun","family":"Kim","sequence":"first","affiliation":[{"name":"Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 34054, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1711-0906","authenticated-orcid":false,"given":"Dong-Seon","family":"Kim","sequence":"additional","affiliation":[{"name":"Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 34054, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heung Joo","family":"Yuk","sequence":"additional","affiliation":[{"name":"Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 34054, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4598-1733","authenticated-orcid":false,"given":"Seung-Hyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Traditional Medicine and Bioscience, Daejeon University, 62 Daehak-ro, Dong-gu, Daejeon 34520, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4493-9787","authenticated-orcid":false,"given":"Won-Kyung","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Traditional Medicine and Bioscience, Daejeon University, 62 Daehak-ro, Dong-gu, Daejeon 34520, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geum Duck","family":"Park","sequence":"additional","affiliation":[{"name":"Suheung Research Center, Seongnam 13488, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Seok","family":"Kim","sequence":"additional","affiliation":[{"name":"Suheung Research Center, Seongnam 13488, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4742-6370","authenticated-orcid":false,"given":"Woo Jung","family":"Ham","sequence":"additional","affiliation":[{"name":"Suheung Research Center, Seongnam 13488, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5712-2215","authenticated-orcid":false,"given":"Yoon-Young","family":"Sung","sequence":"additional","affiliation":[{"name":"Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 34054, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1146\/annurev.med.54.101601.152209","article-title":"New concepts in chronic obstructive pulmonary disease","volume":"54","author":"Barnes","year":"2003","journal-title":"Annu. 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