{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:47:32Z","timestamp":1760147252648,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Italian Ministry of Health with Current Research funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Nutritional rehabilitation with weight restoration is an important step in patients hospitalised for anorexia nervosa (AN). Naso-gastric feeding (NGF) should be considered when oral nutrition (OF) and oral nutritional supplementation (ONS) are insufficient. We evaluated the role of NGF on short- and long-term outcomes, considering weight gain, the length of hospitalisation (LOS) and the time to relapse. We report on the characteristics of patients under 18 years of age with AN admitted to the Department of Emergency and Acceptance of the Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, between March 2019 and August 2022. Three hundred and fifteen patients were enrolled. We compared patients treated with NGF (group A) and patients without NGF (group B). Group A was characterised by a significantly lower BMI on admission and discharge, more frequent use of inpatient psychotropic therapy (IPDT) and longer hospital stay. The time to relapse was significantly longer in group A compared to group B. An early NGF setting correlates with a longer time to relapse and may be associated with a shorter LOS. A high caloric intake with a balanced nutritional formula provided by NGF allows an earlier recovery. The main advantages of this approach could be the rapid discharge of patients and a more effective psychological and social recovery.<\/jats:p>","DOI":"10.3390\/nu15030490","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T02:31:11Z","timestamp":1674009071000},"page":"490","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Early Naso-Gastric Feeding and Outcomes of Anorexia Nervosa Patients"],"prefix":"10.3390","volume":"15","author":[{"given":"Maria Rosaria","family":"Marchili","sequence":"first","affiliation":[{"name":"Department of Emergency, Acceptance and General Pediatrics, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Diamanti","sequence":"additional","affiliation":[{"name":"Hepatology, Gastroenterology and Nutrition Unit, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Zanna","sequence":"additional","affiliation":[{"name":"Anorexia Nervosa and Eating Disorders Unit, Child Neuropsychiatry, Department of Neuroscience, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5685-5468","authenticated-orcid":false,"given":"Giulia","family":"Spina","sequence":"additional","affiliation":[{"name":"Department of Emergency, Acceptance and General Pediatrics, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Mascolo","sequence":"additional","affiliation":[{"name":"University Hospital Pediatric Department, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Roversi","sequence":"additional","affiliation":[{"name":"University Hospital Pediatric Department, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedetta","family":"Guarnieri","sequence":"additional","affiliation":[{"name":"University Hospital Pediatric Department, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Mirra","sequence":"additional","affiliation":[{"name":"University Hospital Pediatric Department, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Testa","sequence":"additional","affiliation":[{"name":"University Hospital Pediatric Department, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4881-2038","authenticated-orcid":false,"given":"Umberto","family":"Raucci","sequence":"additional","affiliation":[{"name":"Department of Emergency, Acceptance and General Pediatrics, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Reale","sequence":"additional","affiliation":[{"name":"Department of Emergency, Acceptance and General Pediatrics, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9120-0424","authenticated-orcid":false,"given":"Alberto","family":"Villani","sequence":"additional","affiliation":[{"name":"Department of Emergency, Acceptance and General Pediatrics, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00165 Rome, Italy"},{"name":"Systems Medicine Department, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cuerda, C., Vasiloglou, M.F., and Arhip, L. (2019). Nutritional management and outcomes in malnourished medical inpatients: Anorexia Nervosa. J. Clin. Med., 8.","DOI":"10.3390\/jcm8071042"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0140-6736(20)30059-3","article-title":"Eating disorders","volume":"395","author":"Treasure","year":"2020","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/eat.23664","article-title":"What accounts for the high mortality of anorexia nervosa?","volume":"55","author":"Mehler","year":"2022","journal-title":"Int. J. Eat. Disord."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1001\/archgenpsychiatry.2011.74","article-title":"Mortality rates in patients with anorexia nervosa and other eating disorders. A meta analysis of 36 studies","volume":"68","author":"Arcelus","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40337-017-0145-3","article-title":"What happens after treatment? A systematic review of relapse, remission, and recovery in anorexia nervosa","volume":"5","author":"Khalsa","year":"2017","journal-title":"J. Eat. Disord."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1080\/14656566.2020.1748600","article-title":"Pharmacotherapeutic strategies for the treatment of anorexia nervosa\u2014Too much for one drug?","volume":"21","author":"Frank","year":"2020","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_7","first-page":"46","article-title":"Initial evaluation, diagnosis, and treatment of anorexia nervosa and bulimia nervosa","volume":"91","author":"Harrington","year":"2015","journal-title":"Am. Fam. Physician"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00431-018-3295-7","article-title":"Refeeding in anorexia nervosa","volume":"178","author":"Bargiacchi","year":"2018","journal-title":"Eur. J. Pediatr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/ncp.10187","article-title":"Enteral Nutrition via Nasogastric Tube for Refeeding Patients with Anorexia Nervosa: A Systematic Review","volume":"34","author":"Rizzo","year":"2018","journal-title":"Nutr. Clin. Pract."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e582","DOI":"10.1097\/pq9.0000000000000582","article-title":"Implementation of Standardized Care for the Medical Stabilization of Patients with Anorexia Nervosa Taraneh","volume":"7","author":"Shafii","year":"2022","journal-title":"Pediatr. Qual. Saf."},{"key":"ref_11","first-page":"178","article-title":"Parenteral Nutrition Safety and Clinical Practice Committees, American Society for Parenteral and Enteral Nutrition. ASPEN Consensus Recommendations for Refeeding Syndrome","volume":"35","author":"Silva","year":"2020","journal-title":"Nutr. Clin. Pract."},{"key":"ref_12","first-page":"674","article-title":"Five-Year Inpatient Management of Teenagers with Anorexia Nervosa: Focus on Nutritional Issues","volume":"74","author":"Trovato","year":"2022","journal-title":"J. Craniofacial Surg."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Pruccoli, J., Pelusi, M., Romagnoli, G., Malaspina, E., Moscano, F., and Parmeggiani, A. (2021). Timing of Psychopharmacological and Nutritional Interventions in the Inpatient Treatment of Anorexia Nervosa: An Observational Study. Brain Sci., 11.","DOI":"10.3390\/brainsci11091242"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1177\/1078390316657872","article-title":"Nasogastric Tube Feeding for Individuals with Anorexia Nervosa: An Integrative Review","volume":"22","author":"Kells","year":"2016","journal-title":"J. Am. Psychiatr. Nurses Assoc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s40337-021-00445-1","article-title":"A systematic review of enteral feeding by nasogastric tube in young people with eating disorders","volume":"9","author":"Hindley","year":"2021","journal-title":"J. Eat. Disord."},{"key":"ref_16","first-page":"191","article-title":"Diagnostic and Statistical Manual of Mental Disorders (DSM)","volume":"25","author":"Battle","year":"2013","journal-title":"Codas"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1136\/bmj.39238.399444.55","article-title":"Body mass index cut offs to define thinness in children and adolescents: International survey","volume":"335","author":"Cole","year":"2007","journal-title":"BMJ"},{"key":"ref_18","unstructured":"(2020). Eating Disorders: Recognition and Treatment, National Institute for Health and Care Excellence (NICE)."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/ejcn.2013.244","article-title":"Long-term effects of enteral feeding on growth and mental health in adolescents with anorexia nervosa--results of a retrospective German cohort study","volume":"68","author":"Nehring","year":"2014","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00787-008-0706-8","article-title":"Predictive factors of length of inpatient treatment in anorexia nervosa","volume":"18","author":"Strik","year":"2008","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40337-016-0132-0","article-title":"Outcomes of an inpatient refeeding protocol in youth with anorexia nervosa: Rady Children\u2019s Hospital San Diego\/University of California, San Diego","volume":"5","author":"Maginot","year":"2017","journal-title":"J. Eat. Disord."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.jadohealth.2013.06.005","article-title":"Shifting paradigms: Continuous nasogastric feeding with high caloric intakes in anorexia nervosa","volume":"53","author":"Agostino","year":"2013","journal-title":"J. Adolesc. Health"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.jadohealth.2013.05.014","article-title":"Higher caloric intake in hospitalized adolescents with anorexia nervosa is associated with reduced length of stay and no increased rate of refeeding syndrome","volume":"53","author":"Golden","year":"2013","journal-title":"J. Adolesc. Health"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jadohealth.2013.07.014","article-title":"Higher calorie diets increase rate of weight gain and shorten hospital stay in hospitalized adolescents with anorexia nervosa","volume":"53","author":"Garber","year":"2013","journal-title":"J. Adolesc. Health"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/eat.22482","article-title":"A systematic review of approaches to refeeding in patients with anorexia nervosa","volume":"49","author":"Garber","year":"2015","journal-title":"Int. J. Eat. Disord."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1001\/archgenpsychiatry.2010.128","article-title":"Randomized clinical trial comparing family-based treatment with adolescent-focused individual therapy for adolescents with anorexia nervosa","volume":"67","author":"Lock","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1017\/S1461145711000460","article-title":"Clinical psychopharmacology of eating disorders: A research update","volume":"15","author":"Hay","year":"2011","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"653482","DOI":"10.3389\/fpsyt.2021.653482","article-title":"Improvements on Clinical Status of Adolescents with Anorexia Nervosa in Inpatient and Day Hospital Treatment: A Retrospective Pilot Study","volume":"12","author":"Zanna","year":"2021","journal-title":"Front. Psychiatry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1093\/nutrit\/nuab121","article-title":"Blenderized formulations in home enteral nutrition: A narrative review about challenges in nutritional security and food safety","volume":"80","author":"Santos","year":"2022","journal-title":"Nutr. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.med.050208.200745","article-title":"Anorexia nervosa: Current status and future directions","volume":"61","author":"Attia","year":"2010","journal-title":"Annu. Rev. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1002\/eat.20398","article-title":"Genetic epidemiology, endophenotypes, and eating disorder classification","volume":"40","author":"Bulik","year":"2007","journal-title":"Int. J. Eat. Disord."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/3\/490\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:08:34Z","timestamp":1760119714000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/3\/490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,17]]},"references-count":31,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["nu15030490"],"URL":"https:\/\/doi.org\/10.3390\/nu15030490","relation":{},"ISSN":["2072-6643"],"issn-type":[{"type":"electronic","value":"2072-6643"}],"subject":[],"published":{"date-parts":[[2023,1,17]]}}}