{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:15:36Z","timestamp":1782922536536,"version":"3.54.5"},"reference-count":24,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>We aimed to investigate the number and prevalence of patients indicated for intravenous iron treatment in a large Korean population using criteria based on laboratory test results in an effort to extract indirect information on the need for intravenous iron treatment. Between 1 January 2019 and 31 December 2021, a total of 83,994 Korean patients (30,499 men and 53,495 women) with a median age of 46 years (interquartile range, 30\u201361) were evaluated using iron deficiency anemia\u2013associated laboratory tests and serum creatinine tests of estimated glomerular filtration rates. The overall prevalence of anemia (Hb \u2264 11 g\/dL) was 16.5%, and the proportion of patients with possible chronic kidney disease who had an estimated glomerular filtration rate &lt; 60 mL\/min\/1.73 m2 was 11.4%. The number of patients indicated for reimbursable intravenous iron treatment was higher in women than in men, higher in older patients, and higher in 2021 than in 2019 (all p &lt; 0.001). The prevalence of patients indicated for reimbursable intravenous iron treatment was up to 30.0% in those \u2265 80 years of age in 2019. The results of this study provide basic knowledge about the use of iron deficiency anemia-associated laboratory tests in planning nutritional support programs using an intravenous iron formulation in Korea.<\/jats:p>","DOI":"10.3390\/nu15030614","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T02:29:31Z","timestamp":1674700171000},"page":"614","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence of Iron Deficiency Anemia Indicated for Intravenous Iron Treatment in the Korean Population"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8266-2248","authenticated-orcid":false,"given":"Rihwa","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Green Cross Laboratories, Yongin 16924, Republic of Korea"},{"name":"Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3710-0828","authenticated-orcid":false,"given":"Gayoung","family":"Chun","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Center, Green Cross Laboratories, Yongin 16924, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Green Cross Laboratories, Yongin 16924, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4672-5811","authenticated-orcid":false,"given":"Sang Gon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Green Cross Laboratories, Yongin 16924, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Green Cross Laboratories, Yongin 16924, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1182\/hematology.2019000034","article-title":"Management of iron deficiency","volume":"2019","author":"Ning","year":"2019","journal-title":"Hematology"},{"key":"ref_2","unstructured":"GBD 2016 Disease and Injury Incidence and Prevalence Collaborators (2017). Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet, 390, 1211\u20131259."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(20)32594-0","article-title":"Iron deficiency","volume":"397","author":"Pasricha","year":"2021","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1056\/NEJMra1401038","article-title":"Iron-deficiency anemia","volume":"372","author":"Camaschella","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1053\/j.gastro.2020.06.046","article-title":"AGA Clinical Practice Guidelines on the Gastrointestinal Evaluation of Iron Deficiency Anemia","volume":"159","author":"Ko","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1136\/gutjnl-2021-325210","article-title":"British Society of Gastroenterology guidelines for the management of iron deficiency anaemia in adults","volume":"70","author":"Snook","year":"2021","journal-title":"Gut"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1111\/hdi.12560","article-title":"The available intravenous iron formulations: History, efficacy, and toxicology","volume":"21","author":"Auerbach","year":"2017","journal-title":"Hemodial. Int."},{"key":"ref_8","first-page":"137","article-title":"Prevention and management of acute reactions to intravenous iron in surgical patients","volume":"17","author":"Shander","year":"2019","journal-title":"Blood Transfus."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1182\/blood-2018-05-815944","article-title":"Iron deficiency","volume":"133","author":"Camaschella","year":"2019","journal-title":"Blood"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.5694\/mja2.50618","article-title":"Rapid increase in intravenous iron therapy for women of reproductive age in Australia","volume":"213","author":"Shand","year":"2020","journal-title":"Med. J. Aust."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.3324\/haematol.2018.205575","article-title":"Assessment of iron deficiency","volume":"103","author":"Hershko","year":"2018","journal-title":"Haematologica"},{"key":"ref_12","unstructured":"World Health Organization (2022, December 20). WHO Guideline on Use of Ferritin Concentrations to Assess Iron Status in Individuals and Populations. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789240000124."},{"key":"ref_13","unstructured":"World Health Organization (2022, December 20). Regional Office for Europe. Medicines Reimbursement Policies in Europe. Available online: https:\/\/apps.who.int\/iris\/handle\/10665\/342220."},{"key":"ref_14","unstructured":"(2022, December 20). Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease (KNOW-CKD), KSN NEWS Vol 16, Factsheet: Number of Iron Deficiency Anemia in Korean Patients with Chronic Kidney Disease. Available online: http:\/\/www.know-ckd.org\/ckd\/rang_board\/list.html?code=factsheet_kong."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Oh, K.H., Park, S.K., Park, H.C., Chin, H.J., Chae, D.W., Choi, K.H., Han, S.H., Yoo, T.H., Lee, K., and Kim, Y.S. (2014). KNOW-CKD (KoreaN cohort study for Outcome in patients with Chronic Kidney Disease): Design and methods. BMC Nephrol., 15.","DOI":"10.1186\/1471-2369-15-80"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3346\/jkms.2017.32.2.249","article-title":"The Prevalence and Management of Anemia in Chronic Kidney Disease Patients: Result from the KoreaN Cohort Study for Outcomes in Patients with Chronic Kidney Disease (KNOW-CKD)","volume":"32","author":"Ryu","year":"2017","journal-title":"J. Korean Med. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1056\/NEJMoa2102953","article-title":"New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race","volume":"385","author":"Inker","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Choi, R., Lee, S.G., and Lee, E.H. (2022). Alterations in Glomerular Filtration Rates Using Different Algorithms in the Korean Population Visiting Local Clinics and Hospitals. J. Clin. Med., 11.","DOI":"10.3390\/jcm11185339"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1080\/13696998.2022.2158661","article-title":"Estimation of the utilities of attributes of intravenous iron infusion treatment for patients with iron-deficiency anemia: A conjoint analysis in Japan","volume":"26","author":"Takeshima","year":"2023","journal-title":"J. Med. Econ."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.hoc.2015.11.002","article-title":"The global burden of anemia","volume":"30","author":"Kassebaum","year":"2016","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Choi, R., Cho, S.E., Lee, S.G., and Lee, E.H. (2022). Recent Information on Vitamin D Deficiency in an Adult Korean Population Visiting Local Clinics and Hospitals. Nutrients, 14.","DOI":"10.3390\/nu14091978"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"957437","DOI":"10.3389\/fmed.2022.957437","article-title":"Impact of Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) GFR Estimating Equations on CKD Prevalence and Classification Among Asians","volume":"9","author":"Betzler","year":"2022","journal-title":"Front. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.jiph.2022.07.003","article-title":"The impact of the COVID-19 pandemic in the healthcare utilization in Korea: Analysis of a nationwide survey","volume":"15","author":"Kang","year":"2022","journal-title":"J. Infect. Public Health"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/14740338.2021.1853098","article-title":"Improving the safety of intravenous iron treatments for patients with chronic kidney disease","volume":"20","author":"Kassianides","year":"2021","journal-title":"Expert Opin. Drug Saf."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/3\/614\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:15:20Z","timestamp":1760120120000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/3\/614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,25]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["nu15030614"],"URL":"https:\/\/doi.org\/10.3390\/nu15030614","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,25]]}}}