{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:00:06Z","timestamp":1787029206969,"version":"build-2736575974"},"reference-count":58,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:00:00Z","timestamp":1674691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82071593"],"award-info":[{"award-number":["82071593"]}]},{"name":"National Natural Science Foundation of China","award":["81974223"],"award-info":[{"award-number":["81974223"]}]},{"name":"National Natural Science Foundation of China","award":["81770833"],"award-info":[{"award-number":["81770833"]}]},{"name":"National Natural Science Foundation of China","award":["2021zzts0377"],"award-info":[{"award-number":["2021zzts0377"]}]},{"name":"National Natural Science Foundation of China","award":["D2022102"],"award-info":[{"award-number":["D2022102"]}]},{"name":"National Natural Science Foundation of China","award":["D202303107884"],"award-info":[{"award-number":["D202303107884"]}]},{"name":"Fundamental Research Funds for the Central Universities of Central South University","award":["82071593"],"award-info":[{"award-number":["82071593"]}]},{"name":"Fundamental Research Funds for the Central Universities of Central South University","award":["81974223"],"award-info":[{"award-number":["81974223"]}]},{"name":"Fundamental Research Funds for the Central Universities of Central South University","award":["81770833"],"award-info":[{"award-number":["81770833"]}]},{"name":"Fundamental Research Funds for the Central Universities of Central South University","award":["2021zzts0377"],"award-info":[{"award-number":["2021zzts0377"]}]},{"name":"Fundamental Research Funds for the Central Universities of Central South University","award":["D2022102"],"award-info":[{"award-number":["D2022102"]}]},{"name":"Fundamental Research Funds for the Central Universities of Central South University","award":["D202303107884"],"award-info":[{"award-number":["D202303107884"]}]},{"name":"Hunan Provincial Administration of Traditional Chinese Medicine Project","award":["82071593"],"award-info":[{"award-number":["82071593"]}]},{"name":"Hunan Provincial Administration of Traditional Chinese Medicine Project","award":["81974223"],"award-info":[{"award-number":["81974223"]}]},{"name":"Hunan Provincial Administration of Traditional Chinese Medicine Project","award":["81770833"],"award-info":[{"award-number":["81770833"]}]},{"name":"Hunan Provincial Administration of Traditional Chinese Medicine Project","award":["2021zzts0377"],"award-info":[{"award-number":["2021zzts0377"]}]},{"name":"Hunan Provincial Administration of Traditional Chinese Medicine Project","award":["D2022102"],"award-info":[{"award-number":["D2022102"]}]},{"name":"Hunan Provincial Administration of Traditional Chinese Medicine Project","award":["D202303107884"],"award-info":[{"award-number":["D202303107884"]}]},{"name":"Scientific Research Program of Hunan Provincial Health Commission","award":["82071593"],"award-info":[{"award-number":["82071593"]}]},{"name":"Scientific Research Program of Hunan Provincial Health Commission","award":["81974223"],"award-info":[{"award-number":["81974223"]}]},{"name":"Scientific Research Program of Hunan Provincial Health Commission","award":["81770833"],"award-info":[{"award-number":["81770833"]}]},{"name":"Scientific Research Program of Hunan Provincial Health Commission","award":["2021zzts0377"],"award-info":[{"award-number":["2021zzts0377"]}]},{"name":"Scientific Research Program of Hunan Provincial Health Commission","award":["D2022102"],"award-info":[{"award-number":["D2022102"]}]},{"name":"Scientific Research Program of Hunan Provincial Health Commission","award":["D202303107884"],"award-info":[{"award-number":["D202303107884"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Vitamin D deficiency (VDD) increases the risk for type 2 diabetes mellitus (T2DM), which might be related to insulin resistance (IR). We aimed to explore the association between the triglyceride-glucose (TyG) index, a reliable indicator of IR, and VDD in patients with T2DM. Methods: There were 1034 participants with T2DM enrolled in the Second Xiangya Hospital of Central South University. The TyG index was calculated as ln (fasting triglyceride (TG, mg\/dL) \u00d7 fasting blood glucose (mg\/dL)\/2). VDD was defined as 25-hydroxyvitamin D [25(OH)D] level &lt;50 nmol\/L. Results: Correlation analysis showed a negative association between the TyG index and 25(OH)D level. After adjustments for clinical and laboratory parameters, it was revealed that when taking the Q1 quartile of TyG index as a reference, an increasing trend of VDD prevalence was presented in the other three groups divided by TyG index quartiles, where the OR (95% CI) was 1.708 (1.132\u20132.576) for Q2, 2.041 (1.315\u20133.169) for Q3, and 2.543 (1.520\u20134.253) for Q4 (all p &lt; 0.05). Conclusions: Patients with higher TyG index were more likely to have an increased risk of VDD in T2DM population, which may be related to IR.<\/jats:p>","DOI":"10.3390\/nu15030639","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T02:30:38Z","timestamp":1674786638000},"page":"639","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Association between the Triglyceride-Glucose Index and Vitamin D Status in Type 2 Diabetes Mellitus"],"prefix":"10.3390","volume":"15","author":[{"given":"Qunyan","family":"Xiang","sequence":"first","affiliation":[{"name":"Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"},{"name":"Institute of Aging and Age-Related Disease Research, Central South University, Changsha 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"},{"name":"Institute of Aging and Age-Related Disease Research, Central South University, Changsha 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junkun","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"},{"name":"Institute of Aging and Age-Related Disease Research, Central South University, Changsha 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhen","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Nursing, Hunan Normal University School of Medicine, Changsha 410013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"},{"name":"Institute of Aging and Age-Related Disease Research, Central South University, Changsha 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"},{"name":"Institute of Aging and Age-Related Disease Research, Central South University, Changsha 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"},{"name":"Institute of Aging and Age-Related Disease Research, Central South University, Changsha 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3806-9260","authenticated-orcid":false,"given":"Jieyu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"},{"name":"Institute of Aging and Age-Related Disease Research, Central South University, Changsha 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"},{"name":"Institute of Aging and Age-Related Disease Research, Central South University, Changsha 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linsen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"},{"name":"Institute of Aging and Age-Related Disease Research, Central South University, Changsha 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"},{"name":"Institute of Aging and Age-Related Disease Research, Central South University, Changsha 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9835-4074","authenticated-orcid":false,"given":"Youshuo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha 410011, China"},{"name":"Institute of Aging and Age-Related Disease Research, Central South University, Changsha 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"109119","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res. 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