{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:01:12Z","timestamp":1791900072737,"version":"4.3.4"},"reference-count":60,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF)","doi-asserted-by":"publisher","award":["2021R1G1A1094322"],"award-info":[{"award-number":["2021R1G1A1094322"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF)","doi-asserted-by":"publisher","award":["20018499"],"award-info":[{"award-number":["20018499"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Technology Innovation program","award":["2021R1G1A1094322"],"award-info":[{"award-number":["2021R1G1A1094322"]}]},{"name":"Technology Innovation program","award":["20018499"],"award-info":[{"award-number":["20018499"]}]},{"name":"Soonchunhyang University Research Fund","award":["2021R1G1A1094322"],"award-info":[{"award-number":["2021R1G1A1094322"]}]},{"name":"Soonchunhyang University Research Fund","award":["20018499"],"award-info":[{"award-number":["20018499"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Iron deficiency anemia (IDA) is the most prevalent and common nutritional deficiency worldwide and is a global health problem with significant risk, particularly among women of reproductive age. Oral iron supplementation is the most widely used and cost-effective treatment for iron deficiency and IDA. However, there are limitations regarding side effects such as enteritis, treatment compliance, and bioavailability. Intestinal microbiome characteristic research has been recently conducted to overcome these issues, but more is needed. Against this background, a metagenomics study on the 16S gene in the feces of young women vulnerable to IDA was conducted. As a result of analyzing 16 normal subjects and 15 IDA patients, significant differences in bacterial community distribution were identified. In particular, a significant decrease in Faecalibacterium was characteristic in IDA patients compared with normal subjects. Furthermore, in the case of patients who recovered from IDA following iron supplementation treatment, it was confirmed that Faecalibacterium significantly recovered to normal levels. However, no significance in beta diversity was seen compared with before treatment. There were also no differences in the beta diversity results between the recovered and normal subjects. Therefore, intestinal dysbiosis during the disease state was considered to be restored as IDA improved. Although the results were derived from a limited number of subjects and additional research is needed, the results of this study are expected to be the basis for developing treatment and prevention strategies based on host\u2013microbiome crosstalk in IDA.<\/jats:p>","DOI":"10.3390\/nu15030691","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T09:18:21Z","timestamp":1675070301000},"page":"691","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["The Effects of Iron Deficiency on the Gut Microbiota in Women of Childbearing Age"],"prefix":"10.3390","volume":"15","author":[{"given":"Hoonhee","family":"Seo","sequence":"first","affiliation":[{"name":"Probiotics Microbiome Convergence Center, Soonchunhyang University, Asan-si 31538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8228-0218","authenticated-orcid":false,"given":"Seug Yun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Hematology & Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul 04401, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3602-7980","authenticated-orcid":false,"given":"Asad","family":"ul-Haq","sequence":"additional","affiliation":[{"name":"Probiotics Microbiome Convergence Center, Soonchunhyang University, Asan-si 31538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1260-7702","authenticated-orcid":false,"given":"Sujin","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan-si 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Probiotics Microbiome Convergence Center, Soonchunhyang University, Asan-si 31538, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Abdur","family":"Rahim","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan-si 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9148-4535","authenticated-orcid":false,"given":"Hyun-A","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan-si 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Ghorbanian","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan-si 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hematology & Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul 04401, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Hematology & Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul 04401, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8842-4761","authenticated-orcid":false,"given":"Kyoung Ha","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hematology & Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul 04401, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namsu","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Hematology & Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul 04401, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Ho","family":"Won","sequence":"additional","affiliation":[{"name":"Division of Hematology & Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul 04401, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Yeon","family":"Song","sequence":"additional","affiliation":[{"name":"Probiotics Microbiome Convergence Center, Soonchunhyang University, Asan-si 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