{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T19:09:42Z","timestamp":1774724982614,"version":"3.50.1"},"reference-count":60,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministry of Education, University, and Research","doi-asserted-by":"publisher","award":["2017SNRXH3"],"award-info":[{"award-number":["2017SNRXH3"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministry of Education, University, and Research","doi-asserted-by":"publisher","award":["PRA_2020_58"],"award-info":[{"award-number":["PRA_2020_58"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Pisa","award":["2017SNRXH3"],"award-info":[{"award-number":["2017SNRXH3"]}]},{"name":"University of Pisa","award":["PRA_2020_58"],"award-info":[{"award-number":["PRA_2020_58"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Eicosapentaenoic acid (EPA; 20:5) and docosahexaenoic acid (DHA; 22:6), two omega-3 poly-unsaturated fatty acids (PUFAs), are the main components in oil derived from fish and other marine organisms. EPA and DHA are commercially available as dietary supplements and are considered to be very safe and contribute to guaranteeing human health. Studies report that PUFAs have a role in contrasting neurodegenerative processes related to amyloidogenic proteins, such as \u03b2-amyloid for AD, \u03b1-synuclein in PD, and transthyretin (TTR) in TTR amyloidosis. In this context, we investigated if EPA and DHA can interact directly with TTR, binding inside the thyroxin-binding pockets (T4BP) that contribute to the tetramer stabilization. The data obtained showed that EPA and DHA can contribute to stabilizing the TTR tetramer through interactions with T4BP.<\/jats:p>","DOI":"10.3390\/nu15030749","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T03:47:33Z","timestamp":1675309653000},"page":"749","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Omega-3 PUFAs as a Dietary Supplement in Senile Systemic Amyloidosis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2762-1929","authenticated-orcid":false,"given":"Lidia","family":"Ciccone","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3547-7277","authenticated-orcid":false,"given":"Susanna","family":"Nencetti","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy"},{"name":"Interdepartmental Centre of Marine Pharmacology, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Rossello","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy"},{"name":"Interdepartmental Centre of Marine Pharmacology, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy"},{"name":"Research Centre E. Piaggio, University of Pisa, 56126 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0183-0850","authenticated-orcid":false,"given":"Lucia","family":"Barlettani","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1435-5676","authenticated-orcid":false,"given":"Nicol\u00f2","family":"Tonali","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique (CNRS), Universit\u00e9 Paris-Saclay, BioCIS, Bat. 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Piaggio, University of Pisa, 56126 Pisa, Italy"},{"name":"Department of Earth Science, University of Pisa, Via Santa Maria, 53, 56126 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.numecd.2017.11.001","article-title":"Hypertriglyceridemia and Omega-3 Fatty Acids: Their Often Overlooked Role in Cardiovascular Disease Prevention","volume":"28","author":"Arca","year":"2018","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"985451","DOI":"10.3389\/fnut.2022.985451","article-title":"The Beneficial Effects of Omega-3 Polyunsaturated Fatty Acids on Controlling Blood Pressure: An Umbrella Meta-Analysis","volume":"9","author":"Musazadeh","year":"2022","journal-title":"Front. 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