{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:15:18Z","timestamp":1783548918456,"version":"3.55.0"},"reference-count":121,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T00:00:00Z","timestamp":1675555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Iodine is an essential micronutrient and component of thyroid hormone. An adequate dietary iodine intake is critical to maintain and promote normal growth and development, especially during vulnerable life stages such as pregnancy and early infancy. The role of iodine in cognitive development is supported by numerous interventional and observational studies, and when iodine intake is too low, somatic growth is also impaired. This can be clearly seen in cases of untreated congenital hypothyroidism related to severe iodine deficiency, which is characterized, in part, by a short stature. Nevertheless, the impact of a less severe iodine deficiency on growth, whether in utero or postnatal, is unclear. Robust studies examining the relationship between iodine and growth are rarely feasible, including the aspect of examining the effect of a single micronutrient on a process that is reliant on multiple nutrients for optimal success. Conversely, excessive iodine intake can affect thyroid function and the secretion of optimal thyroid hormone levels; however, whether this affects growth has not been examined. This narrative review outlines the mechanisms by which iodine contributes to the growth process from conception onwards, supported by evidence from human studies. It emphasizes the need for adequate iodine public health policies and their robust monitoring and surveillance, to ensure coverage for all population groups, particularly those at life stages vulnerable for growth. Finally, it summarizes the other micronutrients important to consider alongside iodine when seeking to assess the impact of iodine on somatic growth.<\/jats:p>","DOI":"10.3390\/nu15040814","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T05:29:05Z","timestamp":1675661345000},"page":"814","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Optimizing Growth: The Case for Iodine"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1005-139X","authenticated-orcid":false,"given":"Jessica","family":"Rigutto-Farebrother","sequence":"first","affiliation":[{"name":"Laboratory of Nutrition and Metabolic Epigenetics, Institute of Food, Nutrition and Health, ETH Z\u00fcrich, LFV E 14.1, Schmelzbergstrasse 7, CH-8092 Z\u00fcrich, Switzerland"},{"name":"Global Center for the Development of the Whole Child, University of Notre Dame, 200 Visitation Hall, Notre Dame, IN 46556, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1152\/physrev.00030.2013","article-title":"Thyroid Hormone Regulation of Metabolism","volume":"94","author":"Forhead","year":"2014","journal-title":"Physiol. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"124","DOI":"10.23736\/S0026-4806.17.04884-4","article-title":"Historical aspects of iodine deficiency control","volume":"108","author":"Vanderpas","year":"2017","journal-title":"Minerva Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/mcn.12231","article-title":"Childhood stunting: A global perspective","volume":"12","author":"Branca","year":"2016","journal-title":"Matern. Child Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1089\/thy.1994.4.107","article-title":"The disorders induced by iodine deficiency","volume":"4","author":"Delange","year":"1994","journal-title":"Thyroid"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1016\/j.bbagen.2012.05.005","article-title":"Mechanisms of action of thyroid hormones in the skeleton","volume":"1830","author":"Wojcicka","year":"2013","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"ref_6","unstructured":"World Health Organization, UNICEF, and ICCIDD (2007). Assessment of Iodine Deficiency Disorders and Monitoring Their Elimination: A Guide for Programme Managers, WHO. [3rd ed.]. Available online: https:\/\/apps.who.int\/iris\/handle\/10665\/43781."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/S0140-6736(83)90636-0","article-title":"Iodine deficiency disorders (IDD) and their eradication","volume":"2","author":"Hetzel","year":"1983","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1148\/radiol.2272012051","article-title":"Sample size estimation: How many individuals should be studied?","volume":"227","author":"Eng","year":"2003","journal-title":"Radiology"},{"key":"ref_9","first-page":"664","article-title":"Avoiding bias in observational studies: Part 8 in a series of articles on evaluation of scientific publications","volume":"106","author":"Hammer","year":"2009","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"111173","DOI":"10.1016\/j.mce.2021.111173","article-title":"The hypothalamus-pituitary-thyroid (HPT)-axis and its role in physiology and pathophysiology of other hypothalamus-pituitary functions","volume":"525","author":"Effraimidis","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"8","DOI":"10.6065\/apem.2014.19.1.8","article-title":"Iodine and thyroid function","volume":"19","author":"Chung","year":"2014","journal-title":"Ann. Pediatr. Endocrinol. Metab."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Li, Z.-T., Zhai, R., Liu, H.-M., Wang, M., and Pan, D.-M. (2020). Iodine concentration and content measured by dual-source computed tomography are correlated to thyroid hormone levels in euthyroid patients: A cross-sectional study in China. BMC Med. Imaging, 20.","DOI":"10.1186\/s12880-020-0411-8"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.beem.2004.03.001","article-title":"The regulation of thyroid function during normal pregnancy: Importance of the iodine nutrition status","volume":"18","author":"Glinoer","year":"2004","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/S0140-6736(08)61005-3","article-title":"Iodine-deficiency disorders","volume":"372","author":"Zimmermann","year":"2008","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S2213-8587(14)70225-6","article-title":"Iodine deficiency and thyroid disorders","volume":"3","author":"Zimmermann","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"668S","DOI":"10.3945\/ajcn.2008.26811C","article-title":"Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: A review","volume":"89","author":"Zimmermann","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_17","unstructured":"World Health Organisation, Food and Agriculture Organisation of the United Nations (2004). Vitamin and Mineral Requirements in Human Nutrition, WHO. [2nd ed.]."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"European Food Safety Agency (2014). Scientific Opinion on Dietary Reference Values for iodine. EFSA J., 12, 1\u201357.","DOI":"10.2903\/j.efsa.2014.3660"},{"key":"ref_19","unstructured":"European Food Safety Agency (2004). Tolerable upper intake level on vitamins and minerals. Wei Sheng Yan Jiu J. Hyg. Res., 33, 771\u2013773."},{"key":"ref_20","unstructured":"Institute of Medicine (US) Panel on Micronutrients (2001). Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc, National Academies Press."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.jfca.2004.06.003","article-title":"Iodine content of food groups","volume":"18","author":"Haldimann","year":"2005","journal-title":"J. Food Compos. Anal."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1017\/S0007114519001041","article-title":"Effects of feed iodine concentrations and milk processing on iodine concentrations of cows\u2019 milk and dairy products, and potential impact on iodine intake in Swiss adults","volume":"122","author":"Galetti","year":"2019","journal-title":"Br. J. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00394-013-0597-4","article-title":"Influencing factors on iodine content of cow milk","volume":"53","author":"Flachowsky","year":"2014","journal-title":"Eur. J. Nutr."},{"key":"ref_24","unstructured":"Iodine Global Network (2023, February 04). Iodine Global Network Scorecard 2021. Available online: https:\/\/www.ign.org\/cm_data\/IGN_Global_Scorecard_2021_7_May_2021.pdf."},{"key":"ref_25","unstructured":"Mannar, V. (2021, March 28). Iodization Cost (via GiveWell.org). Available online: https:\/\/www.givewell.org\/international\/technical\/programs\/salt-iodization#footnote154_1aoy6n4."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/jn\/nxy015","article-title":"Universal salt iodization provides sufficient dietary iodine to achieve adequate iodine nutrition during the first 1000 days: A cross-sectional multicenter study","volume":"148","author":"Dold","year":"2018","journal-title":"J. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"777","DOI":"10.3389\/fendo.2019.00777","article-title":"Growth Hormone and Insulin-Like Growth Factor Action in Reproductive Tissues","volume":"10","author":"Ipsa","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.theriogenology.2008.12.015","article-title":"Involvement of growth hormone (GH) and insulin-like growth factor (IGF) system in ovarian folliculogenesis","volume":"71","author":"Silva","year":"2009","journal-title":"Theriogenology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/apa.13350","article-title":"Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development","volume":"105","author":"Ley","year":"2016","journal-title":"Acta Paediatr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1203\/00006450-200208000-00003","article-title":"Interactions between, G.H.; IGF-I, glucocorticoids, and thyroid hormones during skeletal growth","volume":"52","author":"Robson","year":"2002","journal-title":"Pediatr. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.semcdb.2011.07.009","article-title":"The role of iodine in human growth and development","volume":"22","author":"Zimmermann","year":"2011","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1051\/rnd:19890401","article-title":"Thyroid hormone and growth: Relationships with growth hormone effects and regulation","volume":"29","author":"Cabello","year":"1989","journal-title":"Reprod. Nutr. Dev."},{"key":"ref_33","first-page":"244","article-title":"Interactions between the thyroid hormones and the hormones of the growth hormone axis","volume":"1","author":"Laron","year":"2003","journal-title":"Pediatr. Endocrinol. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1089\/thy.2013.0344","article-title":"Intrinsic regulation of thyroid function by thyroglobulin","volume":"24","author":"Sellitti","year":"2014","journal-title":"Thyroid"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1210\/jcem-45-2-324","article-title":"Enhanced Peripheral Conversion of Thyroxine to Triiodothyronine During hGH Therapy in GH Deficient Children","volume":"45","author":"Sato","year":"1977","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/ajmg.c.31357","article-title":"Endocrine control of growth","volume":"163C","author":"Murray","year":"2013","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4248\/BR201302004","article-title":"Role and Mechanisms of Actions of Thyroid Hormone on the Skeletal Development","volume":"1","author":"Kim","year":"2013","journal-title":"Bone Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1210\/er.2015-1106","article-title":"Role of Thyroid Hormones in Skeletal Development and Bone Maintenance","volume":"37","author":"Bassett","year":"2016","journal-title":"Endocr. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1152\/physrev.2001.81.3.1097","article-title":"Physiological and Molecular Basis of Thyroid Hormone Action","volume":"81","author":"Yen","year":"2001","journal-title":"Physiol. Rev."},{"key":"ref_40","first-page":"3","article-title":"Thyroid hormone actions in cartilage and bone","volume":"2","author":"Williams","year":"2013","journal-title":"Eur. Thyroid J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bone.2008.03.019","article-title":"Iodothyronine deiodinase enzyme activities in bone","volume":"43","author":"Williams","year":"2008","journal-title":"Bone"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1001\/jamapediatrics.2016.0486","article-title":"Thyroid Disorders in Children and Adolescents: A Review","volume":"170","author":"Hanley","year":"2016","journal-title":"JAMA Pediatr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1159\/000363160","article-title":"Iodine deficiency in children","volume":"26","author":"Pearce","year":"2014","journal-title":"Endocr. Dev."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Hay, I., Hynes, K.L., and Burgess, J.R. (2019). Mild-to-Moderate Gestational Iodine Deficiency Processing Disorder. Nutrients, 11.","DOI":"10.3390\/nu11091974"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Hynes, K.L., Seal, J.A., Otahal, P., Oddy, W.H., and Burgess, J.R. (2019). Women Remain at Risk of Iodine Deficiency during Pregnancy: The Importance of Iodine Supplementation before Conception and Throughout Gestation. Nutrients, 11.","DOI":"10.3390\/nu11010172"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1089\/thy.2018.0305","article-title":"Iodine Intake is Associated with Thyroid Function in Mild to Moderately Iodine Deficient Pregnant Women","volume":"28","author":"Abel","year":"2018","journal-title":"Thyroid"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Abel, M.H., Caspersen, I.H., Sengpiel, V., Jacobsson, B., Meltzer, H.M., Magnus, P., Alexander, J., and Brants\u00e6ter, A.L. (2020). Insufficient maternal iodine intake is associated with subfecundity, reduced foetal growth, and adverse pregnancy outcomes in the Norwegian Mother, Father and Child Cohort Study. BMC Med., 18.","DOI":"10.1186\/s12916-020-01676-w"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"450","DOI":"10.3181\/00379727-106-26366","article-title":"Absorption of Potassium Iodide from Gastro-Intestinal Tract","volume":"106","author":"Small","year":"1961","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Nussey, S., and Whitehead, S. (2001). Endocrinology: An Integrated Approach, BIOS Scientific Publishers. Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK28\/.","DOI":"10.1201\/b15306"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00394-019-01927-4","article-title":"Effectiveness of increased salt iodine concentration on iodine status: Trend analysis of cross-sectional national studies in Switzerland","volume":"59","author":"Andersson","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1210\/er.2009-0041","article-title":"Thyroid Function and Human Reproductive Health","volume":"31","author":"Krassas","year":"2010","journal-title":"Endocr. Rev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/humrep\/dex379","article-title":"Delayed conception in women with low-urinary iodine concentrations: A population-based prospective cohort study","volume":"33","author":"Mills","year":"2018","journal-title":"Hum. Reprod."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1210\/edrv.18.3.0300","article-title":"The regulation of thyroid function in pregnancy: Pathways of endocrine adaptation from physiology to pathology","volume":"18","author":"Glinoer","year":"1997","journal-title":"Endocr. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"589","DOI":"10.4158\/EP13341.RA","article-title":"Thyroid Physiology in Pregnancy","volume":"20","author":"Moleti","year":"2014","journal-title":"Endocr. Pract."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/ki.1980.124","article-title":"Renal hemodynamics and tubular function normal human pregnancy","volume":"18","author":"Davison","year":"1980","journal-title":"Kidney Int."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"934104","DOI":"10.4061\/2011\/934104","article-title":"Iodine and pregnancy","volume":"2011","author":"Yarrington","year":"2011","journal-title":"J. Thyroid Res."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Zheng, J. (2012). Recent Advances in Research on the Human Placenta, Intech.","DOI":"10.5772\/1211"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1089\/thy.2010.0203","article-title":"The placenta as a compensatory iodine storage organ","volume":"21","author":"Burns","year":"2011","journal-title":"Thyroid"},{"key":"ref_59","first-page":"1092","article-title":"Effects of iodised salt and iodine supplements on prenatal and postnatal growth: A systematic review","volume":"9","author":"Farebrother","year":"2017","journal-title":"Ann. Nutr. Metab."},{"key":"ref_60","first-page":"246","article-title":"Prophylaxis of endemic goiter with iodized oil in rural Peru","volume":"30","author":"Pretell","year":"1972","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1530\/eje.0.1300547","article-title":"Prevention of iodine deficiency disorders by oral administration of lipiodol during pregnancy","volume":"130","author":"Chaouki","year":"1994","journal-title":"Eur. J. Endocrinol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.3945\/jn.114.193029","article-title":"Maternal Urinary Iodine Concentration up to 1.0 mg\/L Is Positively Associated with Birth Weight, Length, and Head Circumference of Male Offspring","volume":"144","author":"Rydbeck","year":"2014","journal-title":"J. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1530\/EJE-08-0716","article-title":"Iodine levels and thyroid hormones in healthy pregnant women and birth weight of their offspring","volume":"160","author":"Guxens","year":"2009","journal-title":"Eur. J. Endocrinol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/s41430-020-00796-z","article-title":"Iodine status of pregnant women with obesity from inner city populations in the United Kingdom","volume":"75","author":"Farebrother","year":"2021","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Snart, C.J.P.C., Threapleton, D.E., Keeble, C., Taylor, E., Waiblinger, D., Reid, S., Alwan, N.A., Mason, D., Azad, R., and Cade, J.E. (2020). Maternal iodine status, intrauterine growth, birth outcomes and congenital anomalies in a UK birth cohort. BMC Med., 18.","DOI":"10.1186\/s12916-020-01602-0"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Snart, C.J.P., Keeble, C., Taylor, E., Cade, J.E., Stewart, P.M., Zimmermann, M., Reid, S., Threapleton, D.E., Poston, L., and Myers, J.E. (2019). Maternal Iodine Status and Associations with Birth Outcomes in Three Major Cities in the United Kingdom. Nutrients, 11.","DOI":"10.3390\/nu11020441"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Torlinska, B., Bath, S.C., Janjua, A., Boelaert, K., and Chan, S.-Y. (2018). Iodine Status during Pregnancy in a Region of Mild-to-Moderate Iodine Deficiency is not Associated with Adverse Obstetric Outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC). Nutrients, 10.","DOI":"10.3390\/nu10030291"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1136\/adc.66.1.145","article-title":"Effects of maternal iodine supplementation during pregnancy","volume":"66","author":"Pharoah","year":"1991","journal-title":"Arch. Dis. Child."},{"key":"ref_69","unstructured":"Feingold, K.R., Anawalt, B., Boyce, A., Chrousos, G., de Herder, W.W., Dhatariya, K., Hofland, J., Dungan, K., and Hofland, J. (2000). Disorders of the Thyroid Gland in Infancy, Childhood and Adolescence, Endotext."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1089\/thy.1998.8.1185","article-title":"Screening for congenital hypothyroidism used as an indicator of the degree of iodine deficiency and of its control","volume":"8","author":"Delange","year":"1998","journal-title":"Thyroid"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1210\/er.2009-0011","article-title":"Iodine deficiency","volume":"30","author":"Zimmermann","year":"2009","journal-title":"Endocr. Rev."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S2213-8587(13)70155-4","article-title":"Direct iodine supplementation of infants versus supplementation of their breastfeeding mothers: A double-blind, randomised, placebo-controlled trial","volume":"2","author":"Bouhouch","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e13078","DOI":"10.1111\/mcn.13078","article-title":"Is breast milk iodine concentration an influential factor in growth- and obesity-related hormones and infants\u2019 growth parameters?","volume":"17","author":"Nazeri","year":"2021","journal-title":"Matern. Child Nutr."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Yang, J., Zhu, L., Li, X., Zheng, H., Wang, Z., Hao, Z., and Liu, Y. (2017). Maternal iodine status during lactation and infant weight and length in Henan Province, China. BMC Pregnancy Childbirth, 17.","DOI":"10.1186\/s12884-017-1569-0"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Fisher, J., Wang, J., George, N., Gearhart, J., and McLanahan, E. (2016). Dietary Iodine Sufficiency and Moderate Insufficiency in the Lactating Mother and Nursing Infant: A Computational Perspective. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0149300"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41430-018-0108-z","article-title":"IGF-I and IGFBP-3 concentrations at 2 years: Associations with anthropometry and milk consumption in an Indian cohort","volume":"72","author":"Wiley","year":"2018","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1017\/S1368980013001201","article-title":"Iodine status during pregnancy in India and related neonatal and infant outcomes","volume":"17","author":"Lean","year":"2014","journal-title":"Public Health Nutr."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1365-2265.1996.tb02063.x","article-title":"Effects of iodine deficiency on insulin-like growth factor-I, insulin-like growth factor-binding protein-3 levels and height attainment in malnourished children","volume":"45","author":"Osman","year":"1996","journal-title":"Clin. Endocrinol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1210\/jc.2006-1901","article-title":"Treatment of iodine deficiency in school-age children increases insulin-like growth factor (IGF)-I and IGF binding protein-3 concentrations and improves somatic growth","volume":"92","author":"Zimmermann","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_80","first-page":"215","article-title":"Serum insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 levels in severe iodine deficiency","volume":"44","author":"Yordam","year":"2002","journal-title":"Turk. J. Pediatr."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1093\/ajcn\/80.5.1283","article-title":"Triple fortification of salt with microcapsules of iodine, iron, and vitamin, A","volume":"80","author":"Zimmermann","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1093\/ajcn\/86.4.1040","article-title":"Vitamin A supplementation in iodine-deficient African children decreases thyrotropin stimulation of the thyroid and reduces the goiter rate","volume":"86","author":"Zimmermann","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/ajcn\/83.1.108","article-title":"Iodine supplementation improves cognition in iodine-deficient schoolchildren in Albania: A randomized, controlled, double-blind study","volume":"83","author":"Zimmermann","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.beem.2009.08.010","article-title":"Iodine excess","volume":"24","year":"2010","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0021-9258(18)57335-X","article-title":"Plasma inorganic iodide as a homeostatic regulator of thyroid function","volume":"174","author":"Wolff","year":"1948","journal-title":"J. Biol. Chem."},{"key":"ref_86","first-page":"223","article-title":"Iodine prophylaxis and nuclear accidents","volume":"50","year":"1999","journal-title":"Arch. Ind. Hyg. Toxicol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1089\/105072501300176462","article-title":"Iodine-Induced hypothyroidism","volume":"11","author":"Markou","year":"2001","journal-title":"Thyroid"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.jpeds.2012.05.057","article-title":"Congenital hypothyroidism caused by excess prenatal maternal iodine ingestion","volume":"161","author":"Connelly","year":"2012","journal-title":"J. Pediatr."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1089\/thy.2018.0658","article-title":"Impaired Gene Expression Due to Iodine Excess in the Development and Differentiation of Endoderm and Thyroid Is Associated with Epigenetic Changes","volume":"30","author":"Nunes","year":"2020","journal-title":"Thyroid"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e20153722","DOI":"10.1542\/peds.2015-3722","article-title":"Maternal Iodine Exposure: A Case of Fetal Goiter and Neonatal Hearing Loss","volume":"137","author":"Overcash","year":"2016","journal-title":"Pediatrics"},{"key":"ref_91","first-page":"344","article-title":"Perinatal goiter with increased iodine uptake and hypothyroidism due to excess maternal iodine ingestion","volume":"72","author":"Thomas","year":"2009","journal-title":"Horm. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1089\/thy.2004.14.1077","article-title":"Transient hypothyroidism or persistent hyperthyrotropinemia in neonates born to mothers with excessive iodine intake","volume":"14","author":"Nishiyama","year":"2004","journal-title":"Thyroid"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1515\/jpem-2018-0138","article-title":"Maternal iodine excess: An uncommon cause of acquired neonatal hypothyroidism","volume":"31","author":"Hamby","year":"2018","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.3945\/jn.113.179135","article-title":"Long-Term Exposure to Excessive Iodine from Water Is Associated with Thyroid Dysfunction in Children","volume":"143","author":"Sang","year":"2013","journal-title":"J. Nutr."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1210\/jc.2012-3952","article-title":"Thyroglobulin is a sensitive measure of both deficient and excess iodine intakes in children and indicates no adverse effects on thyroid function in the UIC range of 100-299 \u03bcg\/L: A UNICEF\/ICCIDD study group report","volume":"98","author":"Zimmermann","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1089\/thy.2018.0321","article-title":"Thyroglobulin Is Markedly Elevated in 6- to 24-Month-Old Infants at Both Low and High Iodine Intakes and Suggests a Narrow Optimal Iodine Intake Range","volume":"29","author":"Farebrother","year":"2019","journal-title":"Thyroid"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1210\/jc.2016-2829","article-title":"Dried blood spot thyroglobulin as a biomarker of iodine status in pregnant women","volume":"102","author":"Stinca","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1210\/jc.2014-3704","article-title":"Optimal and Safe Upper Limits of Iodine Intake for Early Pregnancy in Iodine-Sufficient Regions: A Cross-Sectional Study of 7190 Pregnant Women in China","volume":"100","author":"Shi","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/S0140-6736(11)60276-6","article-title":"Subclinical thyroid disease","volume":"379","author":"Cooper","year":"2012","journal-title":"Lancet"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0140-6736(16)00278-6","article-title":"Hyperthyroidism","volume":"388","author":"Lee","year":"2016","journal-title":"Lancet"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1056\/NEJMcp0801880","article-title":"Graves\u2019 Disease","volume":"358","author":"Brent","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1177\/2042018811408488","article-title":"Current concepts in graves\u2019 disease","volume":"2","author":"Girgis","year":"2011","journal-title":"Ther. Adv. Endocrinol. Metab."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1001\/archpedi.1970.02100070101015","article-title":"Hyperthyroidism Under 2 Years of Age: An Unusual Cause of Failure to Thrive","volume":"120","author":"Park","year":"1970","journal-title":"Am. J. Dis. Child."},{"key":"ref_104","first-page":"10","article-title":"Hyperthyroidism in children at the University Hospital in Dakar (Senegal)","volume":"28","author":"Boiro","year":"2017","journal-title":"Pan. Afr. Med. J."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40842-018-0054-7","article-title":"Graves\u2019 hyperthyroidism in pregnancy: A clinical review","volume":"4","author":"Nguyen","year":"2018","journal-title":"Clin. Diabetes Endocrinol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41574-021-00604-z","article-title":"Assessment and treatment of thyroid disorders in pregnancy and the postpartum period","volume":"18","author":"Lee","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.clp.2017.10.001","article-title":"Neonatal Thyrotoxicosis","volume":"45","author":"Samuels","year":"2018","journal-title":"Clin. Perinatol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0889-8529(18)30338-4","article-title":"Effects of thyroid hormones on bone and mineral metabolism","volume":"19","author":"Mosekilde","year":"1990","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.nutr.26.061505.111236","article-title":"The influence of iron status on iodine utilization and thyroid function","volume":"26","author":"Zimmermann","year":"2006","journal-title":"Annu. Rev. Nutr."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1297658","DOI":"10.1155\/2017\/1297658","article-title":"Selenium and Thyroid Disease: From Pathophysiology to Treatment","volume":"2017","author":"Ventura","year":"2017","journal-title":"Int. J. Endocrinol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1024\/0300-9831\/a000262","article-title":"The Role of Zinc in Thyroid Hormones Metabolism","volume":"89","author":"Severo","year":"2019","journal-title":"Int. Z. Vitam. Ernahr. J. Int. Vitaminol. Nutr."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.1210\/jc.2004-0862","article-title":"The Effects of Vitamin A Deficiency and Vitamin A Supplementation on Thyroid Function in Goitrous Children","volume":"89","author":"Zimmermann","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3177\/jnsv.26.327","article-title":"Effects of vitamin A deficiency on thyroid function and serum thyroxine levels in the rat","volume":"26","author":"Oba","year":"1980","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_114","first-page":"264","article-title":"Vitamin A-deficiency impairs the normal mannosylation, conformation and iodination of thyroglobulin: A new etiological approach to endemic goitre","volume":"44","author":"Ingenbleek","year":"1983","journal-title":"Exp. Suppl."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12967-019-1840-4","article-title":"Vitamin D and growth hormone in children: A review of the current scientific knowledge","volume":"17","author":"Esposito","year":"2019","journal-title":"J. Transl. Med."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Kim, D. (2017). The role of vitamin D in thyroid diseases. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18091949"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1530\/EJE-21-0171","article-title":"Global perspectives in endocrinology: Coverage of iodized salt programs and iodine status in 2020","volume":"185","author":"Zimmermann","year":"2021","journal-title":"Eur. J. Endocrinol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1210\/jc.2012-4249","article-title":"Mild iodine deficiency during pregnancy is associated with reduced educational outcomes in the offspring: 9-year follow-up of the gestational iodine cohort","volume":"98","author":"Hynes","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Hynes, K.L., Otahal, P., Burgess, J.R., Oddy, W.H., and Hay, I. (2017). Reduced Educational Outcomes Persist into Adolescence Following Mild Iodine Deficiency in Utero, Despite Adequacy in Childhood: 15-Year Follow-Up of the Gestational Iodine Cohort Investigating Auditory Processing Speed and Working Memory. Nutrients, 9.","DOI":"10.3390\/nu9121354"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S2213-8587(17)30331-5","article-title":"Iodine supplementation in pregnancy in mildly deficient regions","volume":"5","author":"Bath","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/nyas.14041","article-title":"Excess iodine intake: Sources, assessment, and effects on thyroid function","volume":"1446","author":"Farebrother","year":"2019","journal-title":"Ann. N. Y. Acad. Sci."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/4\/814\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:24:40Z","timestamp":1760120680000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/4\/814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,5]]},"references-count":121,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["nu15040814"],"URL":"https:\/\/doi.org\/10.3390\/nu15040814","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,5]]}}}