{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T15:00:20Z","timestamp":1770562820108,"version":"3.49.0"},"reference-count":30,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T00:00:00Z","timestamp":1675555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swiss National Science Foundation","award":["PP00P3_150531"],"award-info":[{"award-number":["PP00P3_150531"]}]},{"name":"Research Council of Kantonsspital Aarau","award":["PP00P3_150531"],"award-info":[{"award-number":["PP00P3_150531"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Measurement of skeletal muscle index (SMI) in computed tomography has been suggested to improve the objective assessment of muscle mass. While most studies have focused on lumbar vertebrae, we examine the association of SMI at the thoracic level with nutritional and clinical outcomes and response to nutritional intervention. Methods: We conducted a secondary analysis of EFFORT, a Swiss-wide, multicenter, randomized trial. We investigated the association of low SMI at the 12th thoracic vertebra (T12) with adverse outcome within 30 days after hospital admission (primary endpoint). Results: 663 of 2028 patients from the EFFORT trial had available CT scans for T12, and 519 among them also had available L3 scans. Mean SMI at T12 was 22.4 \u00b1 5.8 cm2\/m2 and 19.6 \u00b1 5.5 cm2\/m2 in male and female patients, respectively, and correlated well with nutritional parameters, including nutritional risk based on NRS 2002 (adjusted coefficient \u22120.63, 95%CI \u22121.25 to \u22120.01, p = 0.047), BMI (adjusted coefficient 0.74, 95%CI 0.66 to 0.82, p &lt; 0.001) and handgrip strength (adjusted coefficient 0.15, 95%CI 0.11 to 0.2, p &lt; 0.001). In multivariate regression analyses, low SMI was not a significant predictor for either clinical outcome or for treatment response. Results for SMI measured at L3 were similar, with only little prognostic value. Conclusions: Within medical patients at risk for malnutrition, SMI at thoracic vertebra provided low prognostic information regarding clinical outcomes and nutritional treatment response.<\/jats:p>","DOI":"10.3390\/nu15040817","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T05:29:05Z","timestamp":1675661345000},"page":"817","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association of Thoracic Skeletal Muscle Index with Clinical Outcome and Response to Nutritional Interventions in Patients at Risk of Malnutrition\u2014Secondary Analysis of a Randomized Trial"],"prefix":"10.3390","volume":"15","author":[{"given":"Leonie","family":"Mueller","sequence":"first","affiliation":[{"name":"Medical Faculty of the University of Berne, 3010 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Mentil","sequence":"additional","affiliation":[{"name":"Department Klinische Forschung (DKF), University of Basel, 4001 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Staub","sequence":"additional","affiliation":[{"name":"Department Klinische Forschung (DKF), University of Basel, 4001 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Griot","sequence":"additional","affiliation":[{"name":"Department Klinische Forschung (DKF), University of Basel, 4001 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Olpe","sequence":"additional","affiliation":[{"name":"Department Klinische Forschung (DKF), University of Basel, 4001 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felice","family":"Burn","sequence":"additional","affiliation":[{"name":"Department of Radiology Kantonsspital Aarau, 5000 Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Schindera","sequence":"additional","affiliation":[{"name":"Department of Radiology Kantonsspital Aarau, 5000 Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beat","family":"Mueller","sequence":"additional","affiliation":[{"name":"Medical University Department of Medicine, Kantonsspital Aarau, 5000 Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6400-4949","authenticated-orcid":false,"given":"Philipp","family":"Schuetz","sequence":"additional","affiliation":[{"name":"Medical University Department of Medicine, Kantonsspital Aarau, 5000 Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeno","family":"Stanga","sequence":"additional","affiliation":[{"name":"Division of Diabetology, Endocrinology, Nutritional Medicine & Metabolism, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annic","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"Medical University Department of Medicine, Kantonsspital Aarau, 5000 Aarau, Switzerland"},{"name":"Division of Diabetology, Endocrinology, Nutritional Medicine & Metabolism, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1470-2045(08)70153-0","article-title":"Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: A population-based study","volume":"9","author":"Prado","year":"2008","journal-title":"Lancet Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1177\/0148607115612054","article-title":"Prevalence of Sarcopenia and Its Impact on Postoperative Outcome in Patients With Crohn\u2019s Disease Undergoing Bowel Resection","volume":"41","author":"Zhang","year":"2017","journal-title":"J. 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