{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:22:34Z","timestamp":1769106154741,"version":"3.49.0"},"reference-count":35,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Grant-in-Aid for Scientific Research","award":["26507010"],"award-info":[{"award-number":["26507010"]}]},{"name":"Grant-in-Aid for Scientific Research","award":["JP17K09527"],"award-info":[{"award-number":["JP17K09527"]}]},{"name":"Grant-in-Aid for Scientific Research","award":["JP18K15904"],"award-info":[{"award-number":["JP18K15904"]}]},{"name":"Grant-in-Aid for Scientific Research","award":["JP21K08116"],"award-info":[{"award-number":["JP21K08116"]}]},{"name":"Grant-in-Aid for Scientific Research","award":["JP21K16034"],"award-info":[{"award-number":["JP21K16034"]}]},{"name":"Grant-in-Aid for Scientific Research","award":["20FC1027"],"award-info":[{"award-number":["20FC1027"]}]},{"name":"JSPS KAKENHI","award":["26507010"],"award-info":[{"award-number":["26507010"]}]},{"name":"JSPS KAKENHI","award":["JP17K09527"],"award-info":[{"award-number":["JP17K09527"]}]},{"name":"JSPS KAKENHI","award":["JP18K15904"],"award-info":[{"award-number":["JP18K15904"]}]},{"name":"JSPS KAKENHI","award":["JP21K08116"],"award-info":[{"award-number":["JP21K08116"]}]},{"name":"JSPS KAKENHI","award":["JP21K16034"],"award-info":[{"award-number":["JP21K16034"]}]},{"name":"JSPS KAKENHI","award":["20FC1027"],"award-info":[{"award-number":["20FC1027"]}]},{"name":"Ministry of Health, Labor and Welfare","award":["26507010"],"award-info":[{"award-number":["26507010"]}]},{"name":"Ministry of Health, Labor and Welfare","award":["JP17K09527"],"award-info":[{"award-number":["JP17K09527"]}]},{"name":"Ministry of Health, Labor and Welfare","award":["JP18K15904"],"award-info":[{"award-number":["JP18K15904"]}]},{"name":"Ministry of Health, Labor and Welfare","award":["JP21K08116"],"award-info":[{"award-number":["JP21K08116"]}]},{"name":"Ministry of Health, Labor and Welfare","award":["JP21K16034"],"award-info":[{"award-number":["JP21K16034"]}]},{"name":"Ministry of Health, Labor and Welfare","award":["20FC1027"],"award-info":[{"award-number":["20FC1027"]}]},{"name":"Japanese Center for Research on Women in Sport, Juntendo University","award":["26507010"],"award-info":[{"award-number":["26507010"]}]},{"name":"Japanese Center for Research on Women in Sport, Juntendo University","award":["JP17K09527"],"award-info":[{"award-number":["JP17K09527"]}]},{"name":"Japanese Center for Research on Women in Sport, Juntendo University","award":["JP18K15904"],"award-info":[{"award-number":["JP18K15904"]}]},{"name":"Japanese Center for Research on Women in Sport, Juntendo University","award":["JP21K08116"],"award-info":[{"award-number":["JP21K08116"]}]},{"name":"Japanese Center for Research on Women in Sport, Juntendo University","award":["JP21K16034"],"award-info":[{"award-number":["JP21K16034"]}]},{"name":"Japanese Center for Research on Women in Sport, Juntendo University","award":["20FC1027"],"award-info":[{"award-number":["20FC1027"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Malnutrition frequently coexists with heart failure (HF), leading to series of negative consequences. Cheyne\u2013Stokes respiration (CSR) is predominantly detected in patients with HF. However, the effect of CSR and malnutrition on the long-term prognosis of patients with acute decompensated HF (ADHF) remains unclear. We enrolled 162 patients with ADHF (median age, 62 years; 78.4% men). The presence of CSR was assessed using polysomnography and the controlling nutritional status score was assessed to evaluate the nutritional status. Patients were divided into four groups based on CSR and malnutrition. The primary outcome was all-cause mortality. In total, 44% of patients had CSR and 67% of patients had malnutrition. The all-cause mortality rate was 26 (16%) during the 35.9 months median follow-up period. CSR with malnutrition was associated with lower survival rates (log-rank p &lt; 0.001). Age, hemoglobin, albumin, lymphocyte count, total cholesterol, triglyceride, low-density lipoprotein cholesterol, creatinine, estimated glomerular filtration rate, B-type natriuretic peptide, administration of loop diuretics, apnea-hypopnea index and central apnea-hypopnea index were significantly different among all groups (p &lt; 0.05). CSR with malnutrition was independently associated with all-cause mortality. In conclusion, CSR with malnutrition is associated with a high risk of all-cause mortality in patients with ADHF.<\/jats:p>","DOI":"10.3390\/nu15040964","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T04:47:24Z","timestamp":1676436444000},"page":"964","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prognostic Value of Cheyne-Stokes Respiration and Nutritional Status in Acute Decompensated Heart Failure"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8504-0981","authenticated-orcid":false,"given":"Abidan","family":"Abulimiti","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Sleep and Sleep-Disordered Breathing Center, Juntendo University Hospital, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5747-7668","authenticated-orcid":false,"given":"Takatoshi","family":"Kasai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Sleep and Sleep-Disordered Breathing Center, Juntendo University Hospital, Tokyo 113-8421, Japan"},{"name":"Department of Cardiovascular Management and Remote Monitoring, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayaki","family":"Ishiwata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Sleep and Sleep-Disordered Breathing Center, Juntendo University Hospital, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miho","family":"Nishitani-Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoko","family":"Suda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Sleep and Sleep-Disordered Breathing Center, Juntendo University Hospital, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Shitara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichiro","family":"Yatsu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azusa","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5737-4386","authenticated-orcid":false,"given":"Megumi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2596-7720","authenticated-orcid":false,"given":"Takao","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Hiki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Daida","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Faculty of Health Science, Juntendo University, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Minamino","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan"},{"name":"Japan Agency for Medical Research and Development-Core Research for Evolutionary Medical Science and Technology (AMED-CREST), Japan Agency for Medical Research and Development, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1253\/circj.72.489","article-title":"Impending epidemic: Future projection of heart failure in Japan to the year 2055","volume":"72","author":"Okura","year":"2008","journal-title":"Circ. 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