{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:56:32Z","timestamp":1792522592631,"version":"4.5.0"},"reference-count":163,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Coffee is a popular and widely consumed beverage worldwide, with epidemiological studies showing reduced risk of cardiovascular disease, cancers and non-alcoholic fatty liver disease. However, few studies have investigated the health effects of the post-brewing coffee product, spent coffee grounds (SCG), from either hot- or cold-brew coffee. SCG from hot-brew coffee improved metabolic parameters in rats with diet-induced metabolic syndrome and improved gut microbiome in these rats and in humans; further, SCG reduced energy consumption in humans. SCG contains similar bioactive compounds as the beverage including caffeine, chlorogenic acids, trigonelline, polyphenols and melanoidins, with established health benefits and safety for human consumption. Further, SCG utilisation could reduce the estimated 6\u20138 million tonnes of waste each year worldwide from production of coffee as a beverage. In this article, we explore SCG as a major by-product of coffee production and consumption, together with the potential economic impacts of health and non-health applications of SCG. The known bioactive compounds present in hot- and cold-brew coffee and SCG show potential effects in cardiovascular disease, cancer, liver disease and metabolic disorders. Based on these potential health benefits of SCG, it is expected that foods including SCG may moderate chronic human disease while reducing the environmental impact of waste otherwise dumped in landfill.<\/jats:p>","DOI":"10.3390\/nu15040994","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T05:11:29Z","timestamp":1676524289000},"page":"994","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["The Potential of Spent Coffee Grounds in Functional Food Development"],"prefix":"10.3390","volume":"15","author":[{"given":"Elza","family":"Bevilacqua","sequence":"first","affiliation":[{"name":"School of Pharmacy and Medical Sciences, Griffith University, Gold Coast, QLD 4222, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9879-4985","authenticated-orcid":false,"given":"Vinicius","family":"Cruzat","sequence":"additional","affiliation":[{"name":"Faculty of Health, Southern Cross University, Gold Coast, QLD 4225, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0498-4209","authenticated-orcid":false,"given":"Indu","family":"Singh","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Medical Sciences, Griffith University, Gold Coast, QLD 4222, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roselyn B.","family":"Rose\u2019Meyer","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Medical Sciences, Griffith University, Gold Coast, QLD 4222, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5464-3376","authenticated-orcid":false,"given":"Sunil K.","family":"Panchal","sequence":"additional","affiliation":[{"name":"School of Science, Western Sydney University, Richmond, NSW 2753, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7837-991X","authenticated-orcid":false,"given":"Lindsay","family":"Brown","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Medical Sciences, Griffith University, Gold Coast, QLD 4222, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"ref_1","unstructured":"Yehia, E.-S. (2022). Trends and Innovations in Food Science, IntechOpen."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Samper, L.F., and Qui\u00f1ones-Ruiz, X.F. (2017). Towards a balanced sustainability vision for the coffee industry. Resources, 6.","DOI":"10.3390\/resources6020017"},{"key":"ref_3","unstructured":"Shahbandeh, M. (2022, November 26). Coffee Market: Worldwide Production 2003\/04\u20132020\/21. Available online: https:\/\/www.statista.com\/statistics\/263311\/worldwide-production-of-coffee\/."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.resconrec.2012.06.005","article-title":"Sustainable management of coffee industry by-products and value addition\u2014A review","volume":"66","author":"Murthy","year":"2012","journal-title":"Resour. Conserv. Recy."},{"key":"ref_5","unstructured":"Soloway, B. (2022, November 26). In Brazil\u2019s Coffee Industry, Some Workers Face \u2018Conditions Analogous to Slavery\u2019. Foreign Policy 13 April 2016. Available online: https:\/\/foreignpolicy.com\/2016\/04\/13\/in-brazils-coffee-industry-some-workers-face-conditions-analogous-to-slavery\/."},{"key":"ref_6","unstructured":"Pines, L. (2022, November 26). Brazil\u2019s Economy: Foreign Trade Figures Reveal Why They\u2019re a Major Global Player. Commodity.com 7 April 2021. Available online: https:\/\/commodity.com\/data\/brazil\/."},{"key":"ref_7","unstructured":"Ozbun, T. (2022, November 26). Brazil: Coffee Production 2010\u20132020. Statista: 2022. Available online: https:\/\/www.statista.com\/statistics\/806275\/production-coffee-volume-brazil\/."},{"key":"ref_8","unstructured":"United Nation Environment Programme (2022, November 26). Coffee, Environmental Degradation and Smallholder Livelihoods. Available online: https:\/\/www.unep.org\/resources\/newsletter\/coffee-environmental-degradation-and-smallholder-livelihoods."},{"key":"ref_9","unstructured":"Moore, V. (2022, November 26). The Environmental Impact of Coffee Production: What\u2019s Your Coffee Costing the Planet?. Available online: https:\/\/www.sustainablebusinesstoolkit.com\/environmental-impact-coffee-trade\/."},{"key":"ref_10","unstructured":"Varcho, A.L. (2022, November 26). 2.2 A Bitter Brew-Coffee Production, Deforestation, Soil Erosion and Water Contamination. Available online: https:\/\/ohiostate.pressbooks.pub\/sciencebites\/chapter\/a-bitter-brew-coffee-production-deforestation-soil-erosion-and-water-contamination\/."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1205\/095758204323162319","article-title":"Environmental issues and management in primary coffee processing","volume":"82","author":"Chanakya","year":"2004","journal-title":"Process Saf. Environ. Prot."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jconhyd.2018.08.008","article-title":"Environmental risk assessment for sustainable pesticide use in coffee production","volume":"219","author":"Azevedo","year":"2018","journal-title":"J. Contam. Hydrol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ecoenv.2017.03.011","article-title":"Impacts of discarded coffee waste on human and environmental health","volume":"141","author":"Fernandes","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"123800","DOI":"10.1016\/j.biortech.2020.123800","article-title":"A review on valorization of spent coffee grounds (SCG) towards biopolymers and biocatalysts production","volume":"314","author":"Bhosale","year":"2020","journal-title":"Bioresour. Technol."},{"key":"ref_15","first-page":"26","article-title":"Integrated strategies for water removal and lipid extraction from coffee industry residues","volume":"29","author":"Efthymiopoulos","year":"2018","journal-title":"Sustain. Energy Technol. Assess."},{"key":"ref_16","first-page":"36","article-title":"The blooming of coffee industry: Its waste problem and utilization through management option: A review","volume":"37","author":"Gemechu","year":"2020","journal-title":"J. Biol. Chem. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/bs.afnr.2019.10.002","article-title":"Chapter Three\u2014Chemical composition and health properties of coffee and coffee by-products","volume":"Volume 91","year":"2020","journal-title":"Advances in Food and Nutrition Research"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Dur\u00e1n-Aranguren, D.D., Robledo, S., Gomez-Restrepo, E., Arboleda Valencia, J.W., and Tarazona, N.A. (2021). Scientometric overview of coffee by-products and their applications. Molecules, 26.","DOI":"10.3390\/molecules26247605"},{"key":"ref_19","unstructured":"Ridder, M. (2022, November 26). Major Coffee Importing Countries Worldwide 2020. Statista: 2022. Available online: https:\/\/www.statista.com\/statistics\/1096400\/main-import-countries-for-coffee-worldwide\/."},{"key":"ref_20","unstructured":"Misachi, J. (2022, November 26). Which States Grow Coffee?. Available online: https:\/\/www.worldatlas.com\/articles\/which-states-grow-coffee.html."},{"key":"ref_21","unstructured":"Knoema DataHub (2023, January 10). United States of America\u2014Green Coffee Production Quantity. Available online: https:\/\/knoema.com\/atlas\/United-States-of-America\/topics\/Agriculture\/Crops-Production-Quantity-tonnes\/Coffee-production."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"114390","DOI":"10.1016\/j.envres.2022.114390","article-title":"Microplastics in take-out food: Are we over taking it?","volume":"215","author":"Bai","year":"2022","journal-title":"Environ. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1039\/C8NA00210J","article-title":"Nanoplastics formed during the mechanical breakdown of daily-use polystyrene products","volume":"1","author":"Ekvall","year":"2019","journal-title":"Nanoscale Adv."},{"key":"ref_24","unstructured":"PlanetArk (2016). Coffee Go Ground, Planet Ark Environmental Foundation. Available online: https:\/\/planetark.org\/newsroom\/archive\/1059."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodchem.2018.12.101","article-title":"Spent coffee grounds improve the nutritional value in elements of lettuce (Lactuca sativa L.) and are an ecological alternative to inorganic fertilizers","volume":"282","author":"Delgado","year":"2019","journal-title":"Food Chem."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Iriondo-DeHond, A., Iriondo-DeHond, M., and Del Castillo, M.D. (2020). Applications of compounds from coffee processing by-products. Biomolecules, 10.","DOI":"10.3390\/biom10091219"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"35776","DOI":"10.1007\/s11356-018-2359-6","article-title":"Converting environmental risks to benefits by using spent coffee grounds (SCG) as a valuable resource","volume":"25","author":"Stylianou","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1039\/C9FO00288J","article-title":"The sources and mechanisms of bioactive ingredients in coffee","volume":"10","author":"Hu","year":"2019","journal-title":"Food Funct."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1002\/jsfa.11647","article-title":"Review on factors affecting coffee volatiles: From seed to cup","volume":"102","author":"Wang","year":"2022","journal-title":"J. Sci. Food Agric."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Claassen, L., Rinderknecht, M., Porth, T., R\u00f6hnisch, J., Seren, H.Y., Scharinger, A., Gottstein, V., Noack, D., Schwarz, S., and Winkler, G. (2021). Cold brew coffee\u2014Pilot studies on definition, extraction, consumer preference, chemical characterization and microbiological hazards. Foods, 10.","DOI":"10.20944\/preprints202103.0158.v1"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1039\/c2fo30048f","article-title":"Coffee melanoidins: Structures, mechanisms of formation and potential health impacts","volume":"3","author":"Moreira","year":"2012","journal-title":"Food Funct."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"730343","DOI":"10.3389\/fnut.2021.730343","article-title":"Interest of coffee melanoidins as sustainable healthier food ingredients","volume":"8","year":"2021","journal-title":"Front. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1080\/10408398.2019.1708264","article-title":"Acrylamide in coffee: Formation and possible mitigation strategies\u2014A review","volume":"60","author":"Schouten","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/waste1010002","article-title":"Spent coffee grounds characterization and reuse in composting and soil amendment","volume":"1","author":"Bomfim","year":"2022","journal-title":"Waste"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Olechno, E., Pu\u015bcion-Jakubik, A., Zujko, M.E., and Socha, K. (2021). Influence of various factors on caffeine content in coffee brews. Foods, 10.","DOI":"10.3390\/foods10061208"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"17979","DOI":"10.1038\/s41598-017-18247-4","article-title":"The effect of time, roasting temperature, and grind size on caffeine and chlorogenic acid concentrations in cold brew coffee","volume":"7","author":"Fuller","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.foodres.2018.10.022","article-title":"What kind of coffee do you drink? An investigation on effects of eight different extraction methods","volume":"116","author":"Angeloni","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"8440","DOI":"10.1038\/s41598-019-44886-w","article-title":"Effect of grinding, extraction time and type of coffee on the physicochemical and flavour characteristics of cold brew coffee","volume":"9","author":"Cordoba","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Batali, M.E., Lim, L.X., Liang, J., Yeager, S.E., Thompson, A.N., Han, J., Ristenpart, W.D., and Guinard, J.X. (2022). Sensory analysis of full immersion coffee: Cold brew is more floral, and less bitter, sour, and rubbery than hot brew. Foods, 11.","DOI":"10.3390\/foods11162440"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Angeloni, S., Scortichini, S., Fiorini, D., Sagratini, G., Vittori, S., Neiens, S.D., Steinhaus, M., Zheljazkov, V.D., Maggi, F., and Caprioli, G. (2020). Characterization of odor-active compounds, polyphenols, and fatty acids in coffee silverskin. Molecules, 25.","DOI":"10.3390\/molecules25132993"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.wasman.2017.10.042","article-title":"A spent coffee grounds based biorefinery for the production of biofuels, biopolymers, antioxidants and biocomposites","volume":"72","author":"Karmee","year":"2018","journal-title":"Waste Manag."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"115851","DOI":"10.1016\/j.carbpol.2020.115851","article-title":"Polysaccharide-rich fraction of spent coffee grounds as promising biomaterial for films fabrication","volume":"233","author":"Batista","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"110083","DOI":"10.1016\/j.jfoodeng.2020.110083","article-title":"Development and characterization of biopolymeric films of galactomannans recovered from spent coffee grounds","volume":"289","author":"Coelho","year":"2021","journal-title":"J. Food Eng."},{"key":"ref_44","unstructured":"Australian Government (2022, November 26). Plastics; Department of Agriculture, Water and the Environment: 2022, Available online: https:\/\/www.awe.gov.au\/environment\/protection\/waste\/plastics-and-packaging."},{"key":"ref_45","unstructured":"European Commission (2022, November 29). Communication from the Commission to the European Parliament, the Council, the European Economic and Social Committee and the Committee of the Regions; COM 650 Final; European Commission: Comission Work Programme 2018. Available online: https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/HTML\/?uri=CELEX:52017DC0650&from=en."},{"key":"ref_46","unstructured":"(2022, November 29). Fortune Business Insights. The Global Green Packaging Market Size was USD 258.35 Billion in 2020. The Market is Projected to Grow from USD 267.83 Billion in 2021 to USD 385.34 Billion by 2028; Fortune Business Insight: 2022. Available online: https:\/\/www.fortunebusinessinsights.com\/green-packaging-market-105113."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"20445","DOI":"10.1038\/s41598-021-99938-x","article-title":"Valorization of products from grounded-coffee beans","volume":"11","author":"Gouws","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_48","unstructured":"Whiitelaw, A. (2022, November 29). Record-High Fertiliser Prices in Australia Could Disrupt Food Supplies. The Guardian 12 November 2021. Available online: https:\/\/www.theguardian.com\/australia-news\/2021\/nov\/12\/record-high-fertiliser-prices-in-australia-could-disrupt-food-supplies."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"114075","DOI":"10.1016\/j.jenvman.2021.114075","article-title":"Spent coffee grounds by-products and their influence on soil C\u2013N dynamics","volume":"302","author":"Delgado","year":"2022","journal-title":"J. Environ. Manag."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.wasman.2016.10.020","article-title":"Effect of different rates of spent coffee grounds (SCG) on composting process, gaseous emissions and quality of end-product","volume":"59","author":"Santos","year":"2017","journal-title":"Waste Manag."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"7966","DOI":"10.1016\/j.biortech.2011.05.073","article-title":"Evaluation of three composting systems for the management of spent coffee grounds","volume":"102","author":"Liu","year":"2011","journal-title":"Bioresour. Technol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"125925","DOI":"10.1016\/j.biortech.2021.125925","article-title":"Conversion of spent coffee grounds into vermicompost","volume":"341","author":"Hanc","year":"2021","journal-title":"Bioresour. Technol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"110007","DOI":"10.1016\/j.rser.2020.110007","article-title":"Added-value molecules recovery and biofuels production from spent coffee grounds","volume":"131","author":"Battista","year":"2020","journal-title":"Renew. Sustain. Energy Rev."},{"key":"ref_54","unstructured":"United Nations Climate Change (2022). The Paris Agreement, United Nations Climate Change. Available online: https:\/\/unfccc.int\/process-and-meetings\/the-paris-agreement\/the-paris-agreement."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.biortech.2014.06.032","article-title":"Ultrasound-assisted production of biodiesel and ethanol from spent coffee grounds","volume":"167","author":"Rocha","year":"2014","journal-title":"Bioresour. Technol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.fbp.2019.08.010","article-title":"Conceptualization of a spent coffee grounds biorefinery: A review of existing valorisation approaches","volume":"118","author":"Massaya","year":"2019","journal-title":"Food Bioprod. Process."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.biombioe.2016.07.006","article-title":"Production of crude bio-oil via direct liquefaction of spent K-Cups","volume":"95","author":"Yang","year":"2016","journal-title":"Biomass Bioenergy"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.foodchem.2017.05.142","article-title":"Encapsulation of antioxidant phenolic compounds extracted from spent coffee grounds by freeze-drying and spray-drying using different coating materials","volume":"237","author":"Ballesteros","year":"2017","journal-title":"Food Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1080\/10942912.2021.1977657","article-title":"Evaluation of fatty acids, phenolics and bioactivities of spent coffee grounds prepared from Vietnamese coffee","volume":"24","author":"Vu","year":"2021","journal-title":"Int. J. Food Prop."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.foodchem.2016.07.173","article-title":"Use of spent coffee grounds as food ingredient in bakery products","volume":"216","author":"Morales","year":"2017","journal-title":"Food Chem."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Klingel, T., Kremer, J.I., Gottstein, V., Rajcic de Rezende, T., Schwarz, S., and Lachenmeier, D.W. (2020). A review of coffee by-products including leaf, flower, cherry, husk, silver skin, and spent grounds as novel foods within the European Union. Foods, 9.","DOI":"10.3390\/foods9050665"},{"key":"ref_62","unstructured":"Gaston, S. (2022, November 26). 12 Delicious Food Recipes with Coffee Grouds in Them. Available online: https:\/\/www.roastycoffee.com\/recipes-with-ground-coffee\/."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Castaldo, L., Lombardi, S., Gaspari, A., Rubino, M., Izzo, L., Narv\u00e1ez, A., Ritieni, A., and Grosso, M. (2021). In vitro bioaccessibility and antioxidant activity of polyphenolic compounds from spent coffee grounds-enriched cookies. Foods, 10.","DOI":"10.3390\/foods10081837"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.lwt.2012.08.001","article-title":"Coffee silverskin as a source of dietary fiber in bread-making: Optimization of chemical treatment using response surface methodology","volume":"50","author":"Pourfarzad","year":"2013","journal-title":"LWT Food Sci. Technol."},{"key":"ref_65","unstructured":"Gaille, B. (2022, November 26). 18 Food Additives Industry Statistics and Trends. Available online: https:\/\/brandongaille.com\/18-food-additives-industry-statistics-and-trends\/#:~:text=If%20all%20possible%20additives%20are%20figured%20into%20the,their%20foods%20be%20free%20of%20any%20artificial%20additives."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Franca, A.S., and Oliveira, L.S. (2022). Potential uses of spent coffee grounds in the food industry. Foods, 11.","DOI":"10.3390\/foods11142064"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Rojas-Gonz\u00e1lez, A., Figueroa-Hern\u00e1ndez, C.Y., Gonz\u00e1lez-Rios, O., Su\u00e1rez-Quiroz, M.L., Gonz\u00e1lez-Amaro, R.M., Hern\u00e1ndez-Estrada, Z.J., and Rayas-Duarte, P. (2022). Coffee chlorogenic acids incorporation for bioactivity enhancement of foods: A review. Molecules, 27.","DOI":"10.3390\/molecules27113400"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s13197-021-05032-5","article-title":"The wastes of coffee bean processing for utilization in food: A review","volume":"59","author":"Arya","year":"2022","journal-title":"J. Food Sci. Technol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Okur, I., Soyler, B., Sezer, P., Oztop, M.H., and Alpas, H. (2021). Improving the recovery of phenolic compounds from spent coffee grounds (SCG) by environmentally friendly extraction techniques. Molecules, 26.","DOI":"10.3390\/molecules26030613"},{"key":"ref_70","first-page":"325","article-title":"GC-MS analysis, phenolic compounds quantification, antioxidant, and antibacterial activities of the hydro-alcoholic extract of spent coffee grounds","volume":"10","author":"Bouhlal","year":"2020","journal-title":"J. Biol. Active Prod. Nat."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Coelho, J.P., Robalo, M.P., Boyadzhieva, S., and Stateva, R.P. (2021). Microwave-assisted extraction of phenolic compounds from spent coffee grounds. Process optimization applying design of experiments. Molecules, 26.","DOI":"10.3390\/molecules26237320"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ultsonch.2016.05.005","article-title":"Development and validation of ultrasound-assisted solid-liquid extraction of phenolic compounds from waste spent coffee grounds","volume":"34","author":"Ponmurugan","year":"2017","journal-title":"Ultrason. Sonochem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1039\/D0RA09379C","article-title":"Recycling of spent coffee grounds for useful extracts and green composites","volume":"11","author":"Leow","year":"2021","journal-title":"RSC Adv."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"126618","DOI":"10.1016\/j.biortech.2021.126618","article-title":"An integrated process for conversion of spent coffee grounds into value-added materials","volume":"346","author":"Song","year":"2022","journal-title":"Bioresour. Technol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Lauberts, M., Mierina, I., Pals, M., Latheef, M.A., and Shishkin, A. (2023). Spent coffee grounds valorization in biorefinery context to obtain valuable products using different extraction approaches and solvents. Plants, 12.","DOI":"10.3390\/plants12010030"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.1096\/fj.201902416RR","article-title":"Modulation of gut microbiota by spent coffee grounds attenuates diet-induced metabolic syndrome in rats","volume":"34","author":"Bhandarkar","year":"2020","journal-title":"FASEB J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ijfoodmicro.2009.01.011","article-title":"Impact of coffee consumption on the gut microbiota: A human volunteer study","volume":"130","author":"Jaquet","year":"2009","journal-title":"Int. J. Food Microbiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/1574-6968.12142","article-title":"Influence of coffee (Coffea arabica) and galacto-oligosaccharide consumption on intestinal microbiota and the host responses","volume":"343","author":"Nakayama","year":"2013","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Nehlig, A. (2022). Effects of coffee on the gastro-intestinal tract: A narrative review and literature update. Nutrients, 14.","DOI":"10.3390\/nu14020399"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez, S., Salazar, N., Ruiz-Saavedra, S., G\u00f3mez-Mart\u00edn, M., de Los Reyes-Gavil\u00e1n, C.G., and Gueimonde, M. (2020). Long-term coffee consumption is associated with fecal microbial composition in humans. Nutrients, 12.","DOI":"10.3390\/nu12051287"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1021\/acs.jafc.8b06604","article-title":"Spent coffee grounds extract, rich in mannooligosaccharides, promotes a healthier gut microbial community in a dose-dependent manner","volume":"67","author":"Pastoriza","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1017\/S0007114514003948","article-title":"In vitro colonic metabolism of coffee and chlorogenic acid results in selective changes in human faecal microbiota growth","volume":"113","author":"Mills","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_83","first-page":"e13204","article-title":"Spent coffee (Coffea arabica L.) grounds promote satiety and attenuate energy intake: A pilot study","volume":"44","year":"2020","journal-title":"J. Food Biochem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1039\/C9FO01021A","article-title":"Antioxidant dietary fiber isolated from spent coffee (Coffea arabica L.) grounds improves chronotype and circadian locomotor activity in young adults","volume":"10","author":"Madrid","year":"2019","journal-title":"Food Funct."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.foodchem.2016.05.175","article-title":"Spent coffee grounds, an innovative source of colonic fermentable compounds, inhibit inflammatory mediators in vitro","volume":"212","year":"2016","journal-title":"Food Chem."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Oliveira Batista, J., Car Cordeiro, C., Klososki, S.J., Mongruel Eleut\u00e9rio Dos Santos, C., Le\u00e3o, G.M.C., Pimentel, T.C., and Rosset, M. (2022). Spent coffee grounds improve the nutritional value and technological properties of gluten-free cookies. J. Culin. Sci. Technol.","DOI":"10.1080\/15428052.2022.2026266"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.wasman.2019.07.009","article-title":"Extraction, identification and quantification of polyphenols from spent coffee grounds by chromatographic methods and chemometric analyses","volume":"96","author":"Madrid","year":"2019","journal-title":"Waste Manag."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e4519","DOI":"10.1002\/jms.4519","article-title":"An analytical method for the simultaneous quantification of 30 bioactive compounds in spent coffee ground by HPLC-MS\/MS","volume":"55","author":"Angeloni","year":"2020","journal-title":"J. Mass Spectrom."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1291\/hypres.28.711","article-title":"Antihypertensive effect of green coffee bean extract on mildly hypertensive subjects","volume":"28","author":"Kozuma","year":"2005","journal-title":"Hypertens. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1080\/10641960600798655","article-title":"The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension","volume":"28","author":"Watanabe","year":"2006","journal-title":"Clin. Exp. Hypertens."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1093\/ajcn\/78.4.728","article-title":"Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: Glycemic effects of chlorogenic acid and caffeine","volume":"78","author":"Johnston","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.freeradbiomed.2021.10.012","article-title":"Changes in the plasma lipidome of healthy subjects after coffee consumption reveal potential cardiovascular benefits: A randomized controlled trial","volume":"176","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1080\/09637486.2019.1585763","article-title":"Chlorogenic acid-enriched green coffee bean extract affects arterial stiffness assessed by the cardio-ankle vascular index in healthy men: A pilot study","volume":"70","author":"Suzuki","year":"2019","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1089\/jmf.2017.0110","article-title":"Effect of chlorogenic acid administration on glycemic control, insulin secretion, and insulin sensitivity in patients with impaired glucose tolerance","volume":"21","year":"2018","journal-title":"J. Med. Food"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1017\/S0007114517003439","article-title":"Effects of green coffee extract supplementation on anthropometric indices, glycaemic control, blood pressure, lipid profile, insulin resistance and appetite in patients with the metabolic syndrome: A randomised clinical trial","volume":"119","author":"Roshan","year":"2018","journal-title":"Br. J. Nutr."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1271\/bbb.120518","article-title":"Inhibitory activity of chlorogenic acids in decaffeinated green coffee beans against porcine pancreas lipase and effect of a decaffeinated green coffee bean extract on an emulsion of olive oil","volume":"76","author":"Narita","year":"2012","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.nutres.2018.11.002","article-title":"Chlorogenic acid attenuates high-carbohydrate, high-fat diet-induced cardiovascular, liver, and metabolic changes in rats","volume":"62","author":"Bhandarkar","year":"2019","journal-title":"Nutr. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.2174\/1389201021666200318124922","article-title":"Effects and mechanism of chlorogenic acid on weight loss","volume":"21","author":"Zhong","year":"2020","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1212\/WNL.0000000000004568","article-title":"Caffeine as symptomatic treatment for Parkinson disease (Caf\u00e9-PD): A randomized trial","volume":"89","author":"Postuma","year":"2017","journal-title":"Neurology"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1037\/a0038213","article-title":"Time of day and caffeine influence some neuropsychological tests in the elderly","volume":"27","author":"Walters","year":"2015","journal-title":"Psychol. Assess."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.3389\/fpsyg.2016.01764","article-title":"Caffeine enhances memory performance in young adults during their non-optimal time of day","volume":"7","author":"Sherman","year":"2016","journal-title":"Front. Psychol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s11011-018-0338-8","article-title":"Trigonelline protects hippocampus against intracerebral A\u03b2(1-40) as a model of Alzheimer\u2019s disease in the rat: Insights into underlying mechanisms","volume":"34","author":"Baluchnejadmojarad","year":"2019","journal-title":"Metab. Brain Dis."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"16424","DOI":"10.1038\/s41598-020-73514-1","article-title":"Trigonelline recovers memory function in Alzheimer\u2019s disease model mice: Evidence of brain penetration and target molecule","volume":"10","author":"Farid","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s11011-017-0147-5","article-title":"Trigonelline insulates against oxidative stress, proinflammatory cytokines and restores BDNF levels in lipopolysaccharide induced cognitive impairment in adult mice","volume":"33","author":"Chowdhury","year":"2018","journal-title":"Metab. Brain Dis."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejphar.2018.08.025","article-title":"Trigonelline inhibits caspase 3 to protect \u03b2 cells apoptosis in streptozotocin-induced type 1 diabetic mice","volume":"836","author":"Liu","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_106","first-page":"23","article-title":"Effect of trigonelline and ethanol extract of Iraqi Fenugreek seeds on oxidative stress in alloxan diabetic rabbits","volume":"12","author":"Hamadi","year":"2012","journal-title":"J. Assoc. Arab Univ. Basic Appl. Sci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1248\/bpb.22.679","article-title":"Trigonelline-induced neurite outgrowth in human neuroblastoma SK-N-SH cells","volume":"22","author":"Tohda","year":"1999","journal-title":"Biol. Pharm. Bull."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"10016","DOI":"10.1021\/jf0718291","article-title":"Effect of in vitro enzymatic digestion on antioxidant activity of coffee melanoidins and fractions","volume":"55","author":"Morales","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1021\/jf8027842","article-title":"Antimicrobial activity of coffee melanoidins\u2014A study of their metal-chelating properties","volume":"57","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1007\/s00726-012-1222-1","article-title":"Activation of the transcription factor Nrf2 in macrophages, Caco-2 cells and intact human gut tissue by Maillard reaction products and coffee","volume":"44","author":"Sauer","year":"2013","journal-title":"Amino Acids"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/mnfr.200700509","article-title":"Characterization of high molecular weight coffee fractions and their fermentation by human intestinal microbiota","volume":"53","author":"Reichardt","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1007\/s00394-017-1379-1","article-title":"The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: A comprehensive review of the literature","volume":"56","author":"Tajik","year":"2017","journal-title":"Eur. J. Nutr."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"e13795","DOI":"10.1111\/jfbc.13795","article-title":"Chlorogenic acid and caffeine combination attenuates adipogenesis by regulating fat metabolism and inhibiting adipocyte differentiation in 3T3-L1 cells","volume":"45","author":"Kong","year":"2021","journal-title":"J. Food Biochem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1080\/10826068.2020.1786699","article-title":"The chemistry of chlorogenic acid from green coffee and its role in attenuation of obesity and diabetes","volume":"50","author":"Pimpley","year":"2020","journal-title":"Prep. Biochem. Biotechnol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/ptr.4751","article-title":"Chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up-regulating the gene expression of PPAR-\u03b1 in hypercholesterolemic rats induced with a high-cholesterol diet","volume":"27","author":"Wan","year":"2013","journal-title":"Phytother. Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.mehy.2004.03.037","article-title":"A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk","volume":"64","author":"McCarty","year":"2005","journal-title":"Med. Hypotheses"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"6247306","DOI":"10.1155\/2018\/6247306","article-title":"Smilax aristolochiifolia root extract and its compounds chlorogenic acid and astilbin inhibit the activity of \u03b1-amylase and \u03b1-glucosidase enzymes","volume":"2018","year":"2018","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/1570159X13666141210215655","article-title":"Caffeine: Cognitive and physical performance enhancer or psychoactive drug?","volume":"13","author":"Cappelletti","year":"2015","journal-title":"Curr. Neuropharmacol."},{"key":"ref_119","unstructured":"Institute of Medicine (US) Committee on Military Nutrition Research (2022, November 29). 2. Pharmacology of caffeine, Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK223808\/."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1056\/NEJMra1816604","article-title":"Coffee, caffeine, and health","volume":"383","author":"Hu","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_121","first-page":"834060","article-title":"Caffeine\u2019s vascular mechanisms of action","volume":"2010","author":"Echeverri","year":"2010","journal-title":"Int. J. Vasc. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0165-0173(92)90012-B","article-title":"Caffeine and the central nervous system: Mechanisms of action, biochemical, metabolic and psychostimulant effects","volume":"17","author":"Nehlig","year":"1992","journal-title":"Brain Res. Brain Res. Rev."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00213-021-06054-9","article-title":"Caffeine and attentional control: Improved and impaired performance in healthy older adults and Parkinson\u2019s disease according to task demands","volume":"239","author":"Sharma","year":"2022","journal-title":"Psychopharmacology"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1212\/WNL.0000000000004898","article-title":"Caffeine and Parkinson disease: A possible diagnostic and pathogenic breakthrough","volume":"90","author":"Munoz","year":"2018","journal-title":"Neurology"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"602697","DOI":"10.3389\/fnins.2020.602697","article-title":"Caffeine and Parkinson\u2019s disease: Multiple benefits and emerging mechanisms","volume":"14","author":"Ren","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1001\/jama.283.20.2674","article-title":"Association of coffee and caffeine intake with the risk of Parkinson disease","volume":"283","author":"Ross","year":"2000","journal-title":"JAMA"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1212\/WNL.0b013e318263570d","article-title":"Caffeine for treatment of Parkinson disease: A randomized controlled trial","volume":"79","author":"Postuma","year":"2012","journal-title":"Neurology"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e003089","DOI":"10.1161\/JAHA.115.003089","article-title":"Caffeine consumption and cardiovascular risks: Little cause for concern","volume":"5","author":"Wilson","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s00394-016-1179-z","article-title":"Caffeine and cardiovascular diseases: Critical review of current research","volume":"55","author":"Zulli","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1161\/CIRCULATIONAHA.113.005925","article-title":"Long-term coffee consumption and risk of cardiovascular disease: A systematic review and a dose-response meta-analysis of prospective cohort studies","volume":"129","author":"Ding","year":"2014","journal-title":"Circulation"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Saimaiti, A., Zhou, D.-D., Li, J., Xiong, R.-G., Gan, R.-Y., Huang, S.-Y., Shang, A., Zhao, C.-N., Li, H.-Y., and Li, H.-B. (2022). Dietary sources, health benefits, and risks of caffeine. Crit. Rev. Food Sci. Nutr.","DOI":"10.1080\/10408398.2022.2074362"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.2174\/092986712801323171","article-title":"Trigonelline: A plant alkaloid with therapeutic potential for diabetes and central nervous system disease","volume":"19","author":"Zhou","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/19390211.2017.1329244","article-title":"A review on biosynthesis, analytical techniques, and pharmacological activities of trigonelline as a plant alkaloid","volume":"15","author":"Mohamadi","year":"2018","journal-title":"J. Diet. Suppl."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"7909703","DOI":"10.1155\/2020\/7909703","article-title":"The effect of coffee on pharmacokinetic properties of drugs: A review","volume":"2020","author":"Belayneh","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"ref_135","unstructured":"Gupta, R.C. (2016). Nutraceuticals, Academic Press."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.plantsci.2006.03.017","article-title":"Changes in content and biosynthetic activity of caffeine and trigonelline during growth and ripening of Coffea arabica and Coffea canephora fruits","volume":"171","author":"Koshiro","year":"2006","journal-title":"Plant Sci."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Soca\u0142a, K., Szopa, A., Serefko, A., Poleszak, E., and Wla\u017a, P. (2020). Neuroprotective effects of coffee bioactive compounds: A review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010107"},{"key":"ref_138","unstructured":"National Institute of Aging (2022, November 27). What Causes Alzheimer\u2019s Disease?, Available online: https:\/\/www.nia.nih.gov\/health\/what-causes-alzheimers-disease."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jchromb.2013.12.001","article-title":"Preliminary studies on trigonelline as potential anti-Alzheimer disease agent: Determination by hydrophilic interaction liquid chromatography and modeling of interactions with \u03b2-amyloid","volume":"968","author":"Makowska","year":"2014","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nrn3880","article-title":"Immune attack: The role of inflammation in Alzheimer disease","volume":"16","author":"Heppner","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_141","unstructured":"Liu, H.-W., and Mander, L. (2010). Comprehensive Natural Products II, Elsevier."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.foodcont.2016.12.019","article-title":"NMR quantification of 16-O-methylcafestol and kahweol in Coffea canephora var. robusta beans from different geographical origins","volume":"75","author":"Finotello","year":"2017","journal-title":"Food Cont."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.foodchem.2017.12.034","article-title":"16-O-methylcafestol is present in ground roast Arabica coffees: Implications for authenticity testing","volume":"248","author":"Gunning","year":"2018","journal-title":"Food Chem."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1146\/annurev.nutr.17.1.305","article-title":"The cholesterol-raising factor from coffee beans","volume":"17","author":"Urgert","year":"1997","journal-title":"Annu. Rev. Nutr."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1056\/NEJM198306163082405","article-title":"The Troms\u00f8 heart study. Does coffee raise serum cholesterol?","volume":"308","author":"Thelle","year":"1983","journal-title":"N. Engl. J. Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1365-2796.1998.00386.x","article-title":"Absorption and urinary excretion of the coffee diterpenes cafestol and kahweol in healthy ileostomy volunteers","volume":"244","author":"Meyboom","year":"1998","journal-title":"J. Intern. Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/pros.23753","article-title":"Coffee diterpenes kahweol acetate and cafestol synergistically inhibit the proliferation and migration of prostate cancer cells","volume":"79","author":"Iwamoto","year":"2019","journal-title":"Prostate"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s13000-016-0580-5","article-title":"The clinicopathological significance of angiogenesis in hindgut neuroendocrine tumors obtained via an endoscopic procedure","volume":"11","author":"Okubo","year":"2016","journal-title":"Diagn. Pathol."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Ren, Y., Wang, C., Xu, J., and Wang, S. (2019). Cafestol and kahweol: A review on their bioactivities and pharmacological properties. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20174238"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1021\/acs.jnatprod.5b00481","article-title":"Cafestol, a bioactive substance in coffee, stimulates insulin secretion and increases glucose uptake in muscle cells: Studies in vitro","volume":"78","author":"Mellbye","year":"2015","journal-title":"J. Nat. Prod."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.cmet.2009.03.012","article-title":"AMPK: An emerging drug target for diabetes and the metabolic syndrome","volume":"9","author":"Zhang","year":"2009","journal-title":"Cell Metab."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.febslet.2004.05.070","article-title":"Suppressive effects of the kahweol and cafestol on cyclooxygenase-2 expression in macrophages","volume":"569","author":"Kim","year":"2004","journal-title":"FEBS Lett."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.foodchem.2011.03.075","article-title":"Melanoidins produced by the Maillard reaction: Structure and biological activity","volume":"128","author":"Wang","year":"2011","journal-title":"Food Chem."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1039\/c0fo00156b","article-title":"Estimation of dietary intake of melanoidins from coffee and bread","volume":"2","author":"Fogliano","year":"2011","journal-title":"Food Funct."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"7138","DOI":"10.1021\/jf800999a","article-title":"Roasting effects on formation mechanisms of coffee brew melanoidins","volume":"56","author":"Bekedam","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"126309","DOI":"10.1016\/j.foodchem.2020.126309","article-title":"Bioactivity of food melanoidins is mediated by gut microbiota","volume":"316","author":"Rajakaruna","year":"2020","journal-title":"Food Chem."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3920\/BM2020.0057","article-title":"Short chain fatty acids in human gut and metabolic health","volume":"11","author":"Blaak","year":"2020","journal-title":"Benef. Microbes"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1126\/science.aao5774","article-title":"Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes","volume":"359","author":"Zhao","year":"2018","journal-title":"Science"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1007\/s00217-007-0815-5","article-title":"Antioxidant activity and protective effects of green and dark coffee components against human low density lipoprotein oxidation","volume":"227","author":"Ames","year":"2008","journal-title":"Eur. Food Res. Technol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0308-8146(96)00162-8","article-title":"Metal ion complexation by products of the Maillard reaction","volume":"58","author":"Morrissey","year":"1997","journal-title":"Food Chem."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"11653","DOI":"10.1021\/jf802018c","article-title":"Isolation of high molecular weight components and contribution to the protective activity of coffee against lipid peroxidation in a rat liver microsome system","volume":"56","author":"Daglia","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s00726-010-0774-1","article-title":"Physiological relevance of dietary melanoidins","volume":"42","author":"Morales","year":"2012","journal-title":"Amino Acids"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jff.2018.01.024","article-title":"Clinical trials using functional foods provide unique challenges","volume":"45","author":"Brown","year":"2018","journal-title":"J. Funct. 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